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Acquisition of the enhanced Maritime Prepositioning Force, MPF(E), Ship

NAVAL ENGINEERS JOURNAL 1999年第1期111卷 15-26页

作者： Mazumdar, T Sandison, J DuFlocq, R Thpan Mazurndar:is a Deputy Ship Design Manager from Naval Surface Warfare Center Carderock Division. He was the Design Manager for the Engineering and Design Phase ofthe Enhanced Maritime Prepositioning Fme Ship (MPF(E)). Cuwently Mt: M2.zumdar is Deputy Ship Design Manager in NAVSEA 030 for the LHD and LSD classes of ships. Mr. Mazumdar was awarded a BSE in Naval Architecture and Marine Engineering from the University of Michigan in 1981 and an MS in Computer Science fiom Virginia Tech in 1988. He also possesses an International ChiejEngineer License (Motot unlimited). Mr. Mancmdar has been an Associate Member of WAME since 1981. James C. Sandison:is a Senior Ship Design Manager (SDM) for surface ships in the Nawl Sea Systems Command (NAVSEA03D3C). He has a long tem practical background in design construction and testing of surface ships. Starting in NAVSEC as a diving and salvage systems engineer for the Bathyscaph TRIESTE he has been involved with most ofthe Nays Mine Warfare and Auxiliary ships from naval architect to the present Senior Ship Design Manager for the Strategic Sealift Program. Mr: Sandison entered the U.S. Navy in 1956 in the (diesel) Submarine Service. Afterward he “went to sea in sailing ships and completed an apprenticeship as a wooden shipbuildex. In 1971 he graduated from the University of Michigan with a BSE in Naval Architecture and Marine Engineering and was employed by NAVSEC. His latest additional duties have been as engineering coordinator on board the USS CONSTITUTION for her 200th anniversary sail. Mr. Sandison is a member of SNAME ASNE and the U.S. Naval Institute. Rick DuFlocq has over 24 years of combined project management mechanical system and general awangmmt design and design documentation experience the last 14 years urith Advance Marine Enterprises (AME). He has fmjmned this wurk on a wide variety of ships and auxiliary crafl including submarines primarily for the U.S. Navy and the Military Sealift Command (MSC). He has worked for both shiprards and marine eng

The paper will describe the streamlined acquisition process involved in the procurement, and conversion, of the first two of three Enhanced Maritime Prepositioning Force (MPF(E)) ships. This program was one of the first programs undertaken within the Government's new policy of Acquisition Reform, which resulted in the development of "performance based" requirements for these ships. This program is notable in that one prime contractor is responsible for the accomplishment of all phases, and that the contractors participating were not shipyards as is usually the fashion for Government ship acquisition programs. Also of note, was that after the conversion contracts were awarded, responsibility for the conduct of detail design, conversion, and operation and maintenance of the ship was transferred from the NAVSEA Sealift program Office (PMS 385) to the Military Sealift Command (MSC). The first part of the paper will describe the basic mission of the MPF(E) ships, and a description of the origin of the program requirements. The second part of the paper will chronicle in detail the portions of the engineering design and specification development process, which will include descriptions of the unique digital data recording and tracking systems developed by the Government MPF(E) Design Support Team to support the acquisition phases of the procurement. The third and final part of the paper will elaborate on the conversion contract awards and the transition of the program from PMS 385 to MSC.

关键词： Naval vessels

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Interactive tools for signal processing education. The signal processing instructional facility (SPIF lab) at Washington State University

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computer Applications in engineering Education 1993年第6期1卷 517-517页

作者： Bamberger, R.H. Signal Processing Instructional Facility School of Electrical Engineering and Computer Science Washington State University Pullman WA 99164-2752 Dr. Roberto H. Bamberger:was born on January 30 1965 in Buenos Aires Argentina. He received his B.E.E and PhD from the Georgia Institute of Technology in 1986 and 1990 respectively. Currently Dr. Bamberger is an assistant professor in the School of Electrical Engineering and Computer Science at Washington State University. Dr. Bamberger's research program is focused on the design implementation and application of multidimensional multirate filter banks subband image and video compression analysis of nonstationary data and application of digital signal processing techniques in the design of analog and mixed-mode integrated circuits. Dr. Bamberger is the founder and director of the Signal Processing Instructional Facility (SPIF Lab) at Washington State University. The SPIF Lab features interactive multimedia-based tools for teaching concepts related to linear systems theory. Dr. Bamberger is active in developing multimedia-based instructional laboratories for a variety of other topics as well. In addition to his teaching and research programs Dr. Bamberger is an associate editor for theIEEE Transactions on Signal Processingand a member of the editorial board forComputer Applications in Engineering Education. Dr. Bamberger is also advisor to the WSU Student Branch of the IEEE and assistant director of the WSU Cougar Marching Band. Dr. Bamberger is a member of Phi Eta Sigma Eta Kappa Nu Tau Beta Pi and Kappa Kappa Psi.

The Signal Processing Instructional Facility (SPIF Lab) is an experiment in using in interactive multimedia for teaching concepts related to linear systems theory and signal processing. The goals of the SPIF lab are to augment, enhance, and interconnect sophomore, junior, and senior level courses with the common thread of linear systems and transforms by unifying the experimentation medium. In this fashion, physical phenomenon is returned to the forefront of engineering education. The laboratory features powerful Mathematica Notebooks (a form of hypertext) and interactive applications that use dedicated DSP microprocessors.

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Tissue tropisms of avian influenza A viruses affect their spillovers from wild bird to domestic swine

Tissue tropisms of avian influenza A viruses affect their sp...

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作者： Xiaojian Zhang Fred L.Cunningham Lei Li Katie Hanson-Dorr Alicia Olivier Liyuan Liu Brandon S.Schmit Minhui Guan Jacqueline M.Nolting Andrew S.Bowman Mia Kim Torchetti Thomas J.DeLiberto Xiu-Feng Wan Missouri University Center for Research on Influenza Systems Biology (CRISB) University of Missouri Bond Life Sciences Center University of Missouri Department of Molecular Microbiology and Immunology School of Medicine University of Missouri Department of Basic Sciences College of Veterinary Medicine Mississippi State University Mississippi Field Station National Wildlife Research Center Wildlife Services Animal and Plant Health Inspection Service U.S. Department of Agriculture Department of Population and Pathobiology College of Veterinary Medicine Mississippi State University National Wildlife Disease Program Wildlife Services Animal and Plant Health Inspection Service U.S. Department of Agriculture Department of Veterinary Preventive Medicine The Ohio State University National Veterinary Services Laboratories Veterinary Services U.S. Department of Agriculture Department of Electrical Engineering & Computer Science College of Engineering University of Missouri Department of Pathobiology College of Veterinary Medicine University of Missouri MU Informatics Institute University of Missouri

Having both avian-like receptors (?±2,3-linked sialic acid, SA2,3Gal) and human-like receptors (?±2,6-linked sialic acid, SA2,6Gal), swine are proposed as??úmixing vessel??ùfor generating influenza pandemic strains. Laboratory experiments suggested all HA subtypes of influenza A virus (IAV) can infect swine. However, only sporadic cases of avian

关键词： Tissue tropisms of avian influenza A viruses affect their spillovers from wild bird to domestic swine

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Workshop on imaging science development for cancer prevention and preemption

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Cancer Biomarkers 2007年第1期3卷 1-33页

作者： Kelloff, Gary J. Sullivan, Daniel C. Baker, Houston Clarke, Lawrence P. Nordstrom, Robert Tatum, James L. Dorfman, Gary S. Jacobs, Paula Berg, Christine D. Pomper, Martin G. Birrer, Michael J. Tempero, Margaret Higley, Howard R. Petty, Brenda Gumbs Sigman, Caroline C. Maley, Carlo Sharma, Prateek Wax, Adam Ginsberg, Gregory G. Dannenberg, Andrew J. Hawk, Ernest T. Messing, Edward M. Grossman, H. Barton Harisinghani, Mukesh Bigio, Irving J. Griebel, Donna Henson, Donald E. Fabian, Carol J. Ferrara, Katherine Fantini, Sergio Schnall, Mitchell D. Zujewski, Jo Anne Hayes, Wendy Klein, Eric A. DeMarzo, Angelo Ocak, Iclal Ketterling, Jeffrey A. Tempany, Clare Shtern, Faina Parnes, Howard L. Gomez, Jorge Srivastava, Sudhir Szabo, Eva Lam, Stephen Seibel, Eric J. Massion, Pierre McLennan, Geoffrey Cleary, Kevin Suh, Robert Burt, Randall W. Pfeiffer, Ruth M. Hoffman, John M. Roy, Hemant K. Wang, Thomas Limburg, Paul J. El-Deiry, Wafik S. Papadimitrakopoulou, Vali Hittelman, Walter N. MacAulay, Calum Veltri, Robert W. Solomonzz, Diane Jeronimo, Jose Richards-Kortum, Rebecca Johnson, Karen A. Viner, Jaye L. Stratton, Steven P. Rajadhyaksha, Milind Dhawan, Atam NIH/NCI/DCTD Cancer Imaging Program Bethesda MD United States NIH/NCI/DCTD Cancer Imaging Program NCI-Frederick Frederick MD United States NIH/NCI/DCP Early Detection Research Group Bethesda MD United States The Johns Hopkins University School of Medicine Departments of Radiology Pharmacology and Oncology Division of Neuroradiology Baltimore MD United States NIH/NCI/CCR Cell and Cancer Biology Branch Bethesda MD United States University of California San Francisco Department of Medicine Division of Medical Oncology San Francisco CA United States CCS Associates Inc. Mountain View CA United States Wistar Institute Molecular and Cellular Oncogenesis Program Philadelphia PA United States University of Kansas School of Medicine VA Hospital Kansas City MO United States Duke University Department of Biomedical Engineering Medical Physics Program Durham NC United States University of Pennsylvania School of Medicine Department of Gastroenterology Philadelphia PA United States New York Presbyterian Hospital Weill Medical College of Cornell University New York NY United States NIH/NCI/OD Office of Centers for Training and Resources Bethesda MD United States University of Rochester Medical Center Department of Urology Rochester NY United States University of Texas MD Anderson Cancer Center Department of Urology Houston TX United States Massachusetts General Hospital Abdominal Imaging/Interventional Radiology Boston MA United States Boston University Biomedical Engineering Electrical and Computer Engineering and Physics Boston MA United States NIH/NCI/DCP Gastrointestinal and Other Cancers Research Group Bethesda MD United States The George Washington University Cancer Institute Office of Cancer Prevention and Control Washington DC United States University of Kansas Cancer Center Clinical Oncology Kansas City KS United States University of California Davis Department of Biomedical Engineering Davis CA United States Tufts University De

The concept of intraepithelial neoplasm (IEN) as a near-obligate precursor of cancers has generated opportunities to examine drug or device intervention strategies that may reverse or retard the sometimes lengthy process of carcinogenesis. Chemopreventive agents with high therapeutic indices, well-monitored for efficacy and safety, are greatly needed, as is development of less invasive or minimally disruptive visualization and assessment methods to safely screen nominally healthy but at-risk patients, often for extended periods of time and at repeated intervals. Imaging devices, alone or in combination with anticancer drugs, may also provide novel interventions to treat or prevent precancer.

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26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 Antwerp, Belgium. 15-20 July 2017 Abstracts

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BMC NEUROscience 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

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Author Correction: Effect of de novo transcriptome assembly on transcript quantification

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Scientific reports 2019年第1期9卷 18041页

作者： Ping-Han Hsieh Yen-Jen Oyang Chien-Yu Chen Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei 10617 Taiwan. Department of Computer Science and Information Engineering National Taiwan University Taipei 10617 Taiwan. Department of Bio-Industrial Mechatronics Engineering National Taiwan University Taipei 10617 Taiwan. chienyuchen@ntu.edu.tw. Genome and Systems Biology Program National Taiwan University and Academia sinica Taipei 10617 Taiwan. chienyuchen@ntu.edu.tw.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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NEW TECHNOLOGY IN OIL CONTENT MONITORS

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NAVAL ENGINEERS JOURNAL 1989年第2期101卷 48-55页

作者： NARDELLA, JA RAW, TT STOKES, GH John A. Nardella is the life-cycle manager for oil content monitor equipment for the Naval Sea Systems Command Washington D.C. He has an M.S. degree in chemical engineering from the Pennsylvania State University and is a licensed professional engineer in the Commonwealth of Virginia. Dr. Timothy T. Raw is the principal investigator responsible for the oil contamination monitor project. He has a doctorate in physical chemistry from Rensselear Polytechnical Institute and a B.A. in chemistry and computer science from Saint Louis University. Dr. Raw is currently a staff member at Anheuser Busch Inc. in Saint Louis. Dr. Grant H. Stokes is responsible for the technical management of Geo-Centers Inc. Boston operation. He has doctorate and M. S. degrees in physics from Princeton University and a B.A. from Colorado College. Previous to joining Geo-Centers Inc. he was a staff member in the Laser Fusion Program at Los Alamos National Laboratory.

International antipollution requirements have been legislated to regulate the oil content of bilge effluent from ships. In response to these standards, the U.S. Navy is currently in the process of installing pollution abatement equipment on all vessels. The equipment will consist of an oil-water separator in the bilge discharge line, followed by an oil content monitor which makes the final decision on whether or not the water is clean enough to be pumped overboard. The monitor is required to make a real-time measurement of oil concentration in the range 15 ± 5 to 100 ± 20 ppm for flow rates up to 50 gal/min. and possibly in the presence of interfering contaminants, such as rust. This paper presents the results of the current effort to develop a monitor which satisfies all of these requirements and is sufficiently rugged for fleet deployment. The monitor under development employs two fiber optic systems and a small microprocessor. The first optical system measures the concentration of particles in the flow as a function of their sizes, using small angle forward scattering. The second determines what percentage of the particles in the flow are oil, using large angle scattering. The microprocessor takes the data from the two optical systems and calculates the oil concentration in the flow. Since the particle size is measured by the monitor, no sample preparation is required and the monitor may be placed directly in the discharge line where it responds to changes in oil content in less than one second. In addition, this monitor can notify the operator of impending oil-water separator failure associated with passing large oil particles. A demonstration monitor consisting of the forward scattering unit has been successfully tested at the NavSea oil pollution abatement test facility at the Naval Ship systems engineering Station at Philadelphia. The monitor agrees well with chemical means of measuring oil content. Results of this comparison and laboratory test of a prototyp

关键词： Water Pollution

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Author Correction: The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci

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Nature computational science 2023年第7期3卷 658页

作者： Gengjie Jia Yu Li Xue Zhong Kanix Wang Milton Pividori Rabab Alomairy Aniello Esposito Hatem Ltaief Chikashi Terao Masato Akiyama Koichi Matsuda David E Keyes Hae Kyung Im Takashi Gojobori Yoichiro Kamatani Michiaki Kubo Nancy J Cox James Evans Xin Gao Andrey Rzhetsky Shenzhen Branch Guangdong Laboratory of Lingnan Modern Agriculture Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China. jiagengjie@***. Computational Bioscience Research Center King Abdullah University of Science and Technology Thuwal Saudi Arabia. Computer Science Program Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology Thuwal Saudi Arabia. Department of Computer Science and Engineering The Chinese University of Hong Kong Hong Kong People's Republic of China. Department of Medicine and Vanderbilt Genetics Institute Vanderbilt University Medical Center Nashville TN US. Department of Medicine Institute of Genomics and Systems Biology Committee on Genomics Genetics and Systems Biology University of Chicago Chicago IL US. Department of Operations Business Analytics and Information Systems University of Cincinnati Cincinnati OH US. Department of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia PA US. Extreme Computing Research Center Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology Thuwal Saudi Arabia. College of Computer Science and Engineering University of Jeddah Jeddah Saudi Arabia. HPE HPC/AI EMEA Research Laboratory Bristol UK. RIKEN Center for Integrative Medical Sciences Yokohama Japan. Clinical Research Center Shizuoka General Hospital Shizuoka Japan. Department of Applied Genetics The School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan. Department of Ophthalmology Graduate School of Medical Sciences Kyushu University Fukuoka Japan. Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan. Biological and Environmenta

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Building a quantum engineering undergraduate program

arXiv

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arXiv 2021年

作者： Asfaw, Abraham Blais, Alexandre Brown, Kenneth R. Candelaria, Jonathan Cantwell, Christopher Carr, Lincoln D. Combes, Joshua Debroy, Dripto M. Donohue, John M. Economou, Sophia E. Edwards, Emily Fox, Michael F.J. Girvin, Steven M. Ho, Alan Hurst, Hilary M. Jacob, Zubin Johnson, Blake R. Johnston-Halperin, Ezekiel Joynt, Robert Kapit, Eliot Klein-Seetharaman, Judith Laforest, Martin Lewandowski, H.J. Lynn, Theresa W. McRae, Corey Rae H. Merzbacher, Celia Michalakis, Spyridon Narang, Prineha Oliver, William D. Palsberg, Jens Pappas, David P. Raymer, Michael G. Reilly, David J. Saffman, Mark Searles, Thomas A. Shapiro, Jeffrey H. Singh, Chandralekha IBM Quantum IBM T. J. Watson Research Center Yorktown HeightsNY United States Institut Quantique Département de Physique Université de Sherbrooke SherbrookeQCJ1K 2R1 Canada Canadian Institute for Advanced Research TorontoONM5G 1M1 Canada The Duke Quantum Center Department of Physics Department of Electrical and Computer Engineering Department of Chemistry Duke University DurhamNC27708 United States SystemX Program Department of Electrical Engineering Stanford University StanfordCA94305 United States Department of Physics and Astronomy University of Southern California Los AngelesCA90089 United States The Quantum Engineering Program Department of Physics Colorado School of Mines GoldenCO80401 United States The Department of Electrical Computer and Energy Engineering University of Colorado Boulder BoulderCO80309 United States The Institute for Quantum Computing University of Waterloo WaterlooONN2L 3G1 Canada The Department of Physics Virginia Tech BlacksburgVA24061 United States The IQUIST University of Illinois Urbana-Champaign UrbanaIL61801 United States JILA National Institute of Standards and Technology The University of Colorado BoulderCO80309 United States Department of Physics University of Colorado Boulder BoulderCO80309 United States The Department of Physics Imperial College London Prince Consort Road LondonSW7 2AZ United Kingdom The Yale Quantum Institute Department of Physics Yale University New HavenCT06520 United States Google Research VeniceCA90291 United States The Department of Physics & Astronomy San José State University San JoséCA95192 United States The School of Electrical and Computer Engineering Purdue University Indiana West Lafayatte47907 United States The Department of Physics The Ohio State University ColumbusOH43210 United States The Department of Physics University of Wisconsin-Madison 1150 University Avenue MadisonWI53706 United States The Quantitative Biosciences and Engineering

The rapidly growing quantum information science and engineering (QISE) industry will require both quantum-aware and quantum-proficient engineers at the bachelor's level. We provide a roadmap for building a quantum engineering education program to satisfy this need. For quantum-aware engineers, we describe how to design a first quantum engineering course accessible to all STEM students. For the education and training of quantum-proficient engineers, we detail both a quantum engineering minor accessible to all STEM majors, and a quantum track directly integrated into individual engineering majors. We propose that such programs typically require only three or four newly developed courses that complement existing engineering and science classes available on most larger campuses. We describe a conceptual quantum information science course for implementation at any post-secondary institution, including community colleges and military schools. QISE presents extraordinary opportunities to work towards rectifying issues of inclusivity and equity that continue to be pervasive within engineering. We present a plan to do so and describe how quantum engineering education presents an excellent set of education research opportunities. Finally, we outline a hands-on training plan on quantum hardware, a key component of any quantum engineering program, with a variety of technologies including optics, atoms and ions, cryogenic and solid-state technologies, nanofabrication, and control and readout electronics. Our recommendations provide a flexible framework that can be tailored for academic institutions ranging from teaching and undergraduate-focused two- and four-year colleges to research-intensive universities. © 2021, CC BY.

关键词： engineering education

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Identifying the best machine learning algorithms for brain tumor segmentation, progression assessment, and overall survival prediction in the BRATS challenge

arXiv

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arXiv 2018年

作者： Bakas, Spyridon Reyes, Mauricio Jakab, Andras Bauer, Stefan Rempfler, Markus Crimi, Alessandro Shinohara, Russell Takeshi Berger, Christoph Ha, Sung Min Rozycki, Martin Prastawa, Marcel Alberts, Esther Lipkova, Jana Freymann, John Kirby, Justin Bilello, Michel Fathallah-Shaykh, Hassan M. Wiest, Roland Kirschke, Jan Wiestler, Benedikt Colen, Rivka Kotrotsou, Aikaterini Lamontagne, Pamela Marcus, Daniel Milchenko, Mikhail Nazeri, Arash Weber, Marc-Andr Mahajan, Abhishek Baid, Ujjwal Gerstner, Elizabeth Kwon, Dongjin Acharya, Gagan Agarwal, Manu Alam, Mahbubul Albiol, Alberto Albiol, Antonio Albiol, Francisco J. Alex, Varghese Allinson, Nigel Amorim, Pedro H.A. Amrutkar, Abhijit Anand, Ganesh Andermatt, Simon Arbel, Tal Arbelaez, Pablo Avery, Aaron Azmat, Muneeza Pranjal, B. Bai, Wenjia Banerjee, Subhashis Barth, Bill Batchelder, Thomas Batmanghelich, Kayhan Battistella, Enzo Beers, Andrew Belyaev, Mikhail Bendszus, Martin Benson, Eze Bernal, Jose Bharath, Halandur Nagaraja Biros, George Bisdas, Sotirios Brown, James Cabezas, Mariano Cao, Shilei Cardoso, Jorge M. Carver, Eric N. Casamitjana, Adri Castillo, Laura Silvana Cat, Marcel Cattin, Philippe Cérigues, Albert Chagas, Vinicius S. Chandra, Siddhartha Chang, Yi-Ju Chang, Shiyu Chang, Ken Chazalon, Joseph Chen, Shengcong Chen, Wei Chen, Jefferson W. Chen, Zhaolin Cheng, Kun Choudhury, Ahana Roy Chylla, Roger Clrigues, Albert Colleman, Steven Colmeiro, Ramiro German Rodriguez Combalia, Marc Costa, Anthony Cui, Xiaomeng Dai, Zhenzhen Dai, Lutao Daza, Laura Alexandra Deutsch, Eric Ding, Changxing Dong, Chao Dong, Shidu Dudzik, Wojciech Eaton-Rosen, Zach Egan, Gary Escudero, Guilherme Estienne, Tho Everson, Richard Fabrizio, Jonathan Fan, Yong Fang, Longwei Feng, Xue Ferrante, Enzo Fidon, Lucas Fischer, Martin French, Andrew P. Fridman, Naomi Fu, Huan Fuentes, David Gao, Yaozong Gates, Evan Gering, David Gholami, Amir Gierke, Willi Glocker, Ben Gong, Mingming Gonzlez-Vill, Sandra Grosges, T. Guan, Yuanfang Guo, Sheng Gupta, Sudeep Han, Woo-Sup Han, Il Song Harmuth, Ko Center for Biomedical Image Computing and Analytics University of Pennsylvania PhiladelphiaPA United States Department of Radiology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Institute for Surgical Technology and Biomechanics University of Bern Bern Switzerland Center for MR-Research University Children's Hospital Zurich Zurich Switzerland Support Centre for Advanced Neuroimaging Inselspital Institute for Diagnostic and Interventional Neuroradiology Bern University Hospital Bern Switzerland University Hospital of Zurich Zurich Switzerland Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Philadelphia United States Image-Based Biomedical Modeling Group Technical University of Munich Munich Germany Icahn School of Medicine Mount Sinai Health System New YorkNY United States Leidos Biomedical Research Inc. Frederick National Laboratory for Cancer Research FrederickMD21701 United States Cancer Imaging Program National Cancer Institute National Institutes of Health BethesdaMD20814 United States Department of Neurology University of Alabama at Birmingham BirminghamAL United States Department of Diagnostic Radiology University of Texas MD Anderson Cancer Center HoustonTX United States Department of Psychology Washington University St. LouisMO United States Neuroimaging Informatics and Analysis Center Washington University St. LouisMO United States Department of Radiology Washington University St. LouisMO United States Institute of Diagnostic and Interventional Radiology Pediatric Radiology and Neuroradiology University Medical Center Rostock Ernst-Heydemann-Str. 6 Rostock18057 Germany Tata Memorial Centre Homi Bhabha National Institute Mumbai India Shri Guru Gobind Singhji Institute of Engineering and Technology Nanded India NVIDIA Santa Clara

Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic core, active and non-enhancing core. This intrinsic heterogeneity is also portrayed in their radio-phenotype, as their sub-regions are depicted by varying intensity profiles disseminated across multi-parametric magnetic resonance imaging (mpMRI) scans, reflecting varying biological properties. Their heterogeneous shape, extent, and location are some of the factors that make these tumors difficult to resect, and in some cases inoperable. The amount of resected tumor is a factor also considered in longitudinal scans, when evaluating the apparent tumor for potential diagnosis of progression. Furthermore, there is mounting evidence that accurate segmentation of the various tumor sub-regions can offer the basis for quantitative image analysis towards prediction of patient overall survival. This study assesses the state-of-the-art machine learning (ML) methods used for brain tumor image analysis in mpMRI scans, during the last seven instances of the International Brain Tumor Segmentation (BraTS) challenge, i.e., 2012-2018. Specifically, we focus on i) evaluating segmentations of the various glioma sub-regions in pre-operative mpMRI scans, ii) assessing potential tumor progression by virtue of longitudinal growth of tumor sub-regions, beyond use of the RECIST/RANO criteria, and iii) predicting the overall survival from pre-operative mpMRI scans of patients that underwent gross total resection. Finally, we investigate the challenge of identifying the best ML algorithms for each of these tasks, considering that apart from being diverse on each instance of the challenge, the multi-institutional mpMRI BraTS dataset has also been a continuously evolving/growing dataset. Copyright © 2018, The Authors. All rights reserved.

关键词： Tumors

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