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Global, regional, and national sex-specific burden and control of the HIV epidemic, 1990–2019, for 204 countries and territories: the Global Burden of Diseases Study 2019

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The Lancet HIV 2021年第10期8卷 e633-e651页

作者： Jahagirdar, Deepa Walters, Magdalene K. Novotney, Amanda Brewer, Edmond D. Frank, Tahvi D. Carter, Austin Biehl, Molly H. Abbastabar, Hedayat Abhilash, E.S. Abu-Gharbieh, Eman Abu-Raddad, Laith Jamal Adekanmbi, Victor Adeyinka, Daniel Adedayo Adnani, Qorinah Estiningtyas Sakilah Afzal, Saira Aghababaei, Soodabeh Ahinkorah, Bright Opoku Ahmad, Sajjad Ahmadi, Keivan Ahmadi, Sepideh Ahmadpour, Ehsan Ahmed, Muktar Beshir Rashid, Tarik Ahmed Salih, Yusra Ahmed Aklilu, Addis Akram, Tayyaba Akunna, Chisom Joyqueenet Al Hamad, Hanadi Alahdab, Fares Alanezi, Fahad Mashhour Aleksandrova, Ekaterina A. Alene, Kefyalew Addis Ali, Liaqat Alipour, Vahid Almustanyir, Sami Alvis-Guzman, Nelson Ameyaw, Edward Kwabena Amu, Hubert Andrei, Catalina Liliana Andrei, Tudorel Anvari, Davood Arabloo, Jalal Aremu, Olatunde Arulappan, Judie Atnafu, Desta Debalkie Quintanilla, Beatriz Paulina Ayala Ayza, Muluken Altaye Azari, Samad Darshan, B.B. Banach, Maciej Bärnighausen, Till Winfried Barra, Fabio Barrow, Amadou Basu, Sanjay Bazargan-Hejazi, Shahrzad Belay, Habtamu Gebrehana Berheto, Tezera Moshago Bezabhe, Woldesellassie Mequanint Bezabih, Yihienew Mequanint Bhagavathula, Akshaya Srikanth Bhardwaj, Nikha Bhardwaj, Pankaj Bhattacharyya, Krittika Bibi, Sadia Bijani, Ali Bisignano, Catherine Bolarinwa, Obasanjo Afolabi Boloor, Archith Boltaev, Azizbek A. Briko, Nikolay Ivanovich Buonsenso, Danilo Burkart, Katrin Butt, Zahid A. Cao, Chao Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Choudhari, Sonali Gajanan Chu, Dinh-Toi Couto, Rosa A.S. Cowden, Richard G. Dachew, Berihun Assefa Dadras, Omid Dagnew, Amare Belachew Dahlawi, Saad M.A. Dai, Xiaochen Dandona, Lalit Dandona, Rakhi das Neves, José Degenhardt, Louisa Demeke, Feleke Mekonnen Desta, Abebaw Alemayehu Deuba, Keshab Dhamnetiya, Deepak Dhungana, Govinda Prasad Dianatinasab, Mostafa Diaz, Daniel Djalalinia, Shirin Doan, Linh Phuong Dorostkar, Fariba Edinur, Hisham Atan Effiong, Andem Eftekharzadeh, Sahar El Sayed Zaki, Maysaa Elayedath, Rajesh Elhadi, Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Division of Allergy and Infectious Diseases University of Washington Seattle WA United States Department of Global Health University of Washington Seattle WA United States School of Social Work University of Washington Seattle WA United States Department of Medicine University of Washington Seattle WA United States Vagelos College of Physicians and Surgeones Columbia University Medical Center New York NY United States Division of Data Analytics and Delivery for Impact WHO Geneva Switzerland Advanced Diagnostic and Interventional Radiology Research Centre Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Centre Tehran University of Medical Sciences Tehran Iran School of Public Health Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Paediatric Chronic Kidney Disease Research Centre Tehran University of Medical Sciences Tehran Iran Department of Psychiatry Tehran University of Medical Sciences Tehran Iran Metabolomics and Genomics Research Centre Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Centre Tehran University of Medical Sciences Tehran Iran Research Centre for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Non-Communicable Diseases Research Centre Tehran University of Medical Sciences Tehran Iran Department of Botany Sree Narayana Guru College Chelannur Kozhikode India Clinical Sciences Department University of Sharjah Sharjah United Arab Emirates Mass Communication Department University of Sharjah Sharjah United Arab Emirates Department of Health-Care Policy and Research Weill Cornell Medical College in Qatar Doha Qatar Department of Population Medicine Ca

Background: The sustainable development goals (SDGs) aim to end HIV/AIDS as a public health threat by 2030. Understanding the current state of the HIV epidemic and its change over time is essential to this effort. This study assesses the current sex-specific HIV burden in 204 countries and territories and measures progress in the control of the epidemic. Methods: To estimate age-specific and sex-specific trends in 48 of 204 countries, we extended the Estimation and Projection Package Age-Sex Model to also implement the spectrum paediatric model. We used this model in cases where age and sex specific HIV-seroprevalence surveys and antenatal care-clinic sentinel surveillance data were available. For the remaining 156 of 204 locations, we developed a cohort-incidence bias adjustment to derive incidence as a function of cause-of-death data from vital registration systems. The incidence was input to a custom Spectrum model. To assess progress, we measured the percentage change in incident cases and deaths between 2010 and 2019 (threshold >75% decline), the ratio of incident cases to number of people living with HIV (incidence-to-prevalence ratio threshold <0·03), and the ratio of incident cases to deaths (incidence-to-mortality ratio threshold <1·0). Findings: In 2019, there were 36·8 million (95% uncertainty interval [UI] 35·1–38·9) people living with HIV worldwide. There were 0·84 males (95% UI 0·78–0·91) per female living with HIV in 2019, 0·99 male infections (0·91–1·10) for every female infection, and 1·02 male deaths (0·95–1·10) per female death. Global progress in incident cases and deaths between 2010 and 2019 was driven by sub-Saharan Africa (with a 28·52% decrease in incident cases, 95% UI 19·58–35·43, and a 39·66% decrease in deaths, 36·49–42·36). Elsewhere, the incidence remained stable or increased, whereas deaths generally decreased. In 2019, the global incidence-to-prevalence ratio was 0·05 (95% UI 0·05–0·06) and the global incidence-to-mortality ratio was

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A Roadmap for Cloud SECO: EcoData and the New Actors in IoT Era

A Roadmap for Cloud SECO: EcoData and the New Actors in IoT ...

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International Conference on Distributed Computing in Sensor systems (DCOSS)

作者： Marcelo França Rodrigo Santos Claudia Werner IBM - International Business Machines Brazil COPPE/UFRJ - Federal University of Rio de Janeiro Rio de Janeiro Brazil Computer Science and Systems Engineering Department COPPE/UFRJ - Federal University of Rio de Janeiro Rio de Janeiro Brazil

This paper's main goal is to structure an initial research on the Software Ecosystem (SECO) field, regarding the so called CAMSS (Cloud, Analytics, Mobile, Social and Security) and IoT (Internet of Things) technologies. Our main goal is to share our first ideas and some observations we have been conducting in an empirical way. As such, Cloud SECOs bring the ecosystem environment to another level, with new challenges in all three dimensions: technology, social and business. Besides that, we have been observing a possible shift in the center of some SECOs, i.e., Those "things" connected to the Internet have introduced new players - at least in the sense they interact with the environment by providing data. As new software architectures and technologies emerge to support the new scenario being drawn, our research tries to characterize this new ecosystem and identify challenges, providing a roadmap that could help new entrants.

关键词： Companies Cloud computing Ecosystems Mobile communication Security

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Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱

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现代生物医学进展 2017年第15期17卷 I0003-I0003页

作者： Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson Computational and Systems Biology Genome Institute of Singapore Singapore Developmental Cellomics Laboratory Genome Institute of Singapore Singapore Department of Computer Science and Engineering and Center for Computational Biology Indraprastha Institute of Information Technology Delhi India Synthetic Biology Genome Institute of Singapore Singapore Cancer Therapeutics and Stratified Oncology Genome Institute of Singapore Singapore Department of Medical Oncology National Cancer Centre Singapore Singapore Department of Pathology Singapore General Hospital Singapore Department of Colorectal Surgery Singapore General Hospital Singapore Data Analytics Department Institute for Infocomm Research Singapore Program in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore The Jackson Laboratory for Genomic Medicine Farmington Connecticut USA Department of Genetics and Genome Sciences Institute for Systems Genomics University of Connecticut Farmington Connecticut USA Department of Biological Sciences National University of Singapore Singapore.

结合单细胞基因组学和计算机技术，一个研究团队（包括来自杰克逊实验室（JAx）单细胞生物学主任Paul Robson博士在内）鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测... 详细信息

结合单细胞基因组学和计算机技术，一个研究团队（包括来自杰克逊实验室（JAx）单细胞生物学主任Paul Robson博士在内）鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别，我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。”

关键词：单细胞分析结直肠癌癌细胞 Nat 细胞组成肿瘤病计算机技术细胞生物学

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Early detection of epilepsy seizures based on a weightless neural network

Early detection of epilepsy seizures based on a weightless n...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Kleber de Aguiar Felipe M. G. França Valmir C. Barbosa César A. D. Teixeira Systems Engineering and Computer Science Program Federal University of Rio de Janeiro Rio de Janeiro RJ Brazil Centre for Informatics and Systems (CISUC) University of Coimbra Coimbra Portugal

This work introduces a new methodology for the early detection of epileptic seizure based on the WiSARD weightless neural network model and a new approach in terms of preprocessing the electroencephalogram (EEG) data. WiSARD has, among other advantages, the capacity of perform the training phase in a very fast way. This speed in training is due to the fact that WiSARD's neurons work like Random Access Memories (RAM) addressed by input patterns. Promising results were obtained in the anticipation of seizure onsets in four representative patients from the European Database on Epilepsy (EPILEPSIAE). The proposed seizure early detection WNN architecture was explored by varying the detection anticipation (δ) in the 2 to 30 seconds interval, and by adopting 2 and 3 seconds as the width of the Sliding Observation Window (SOW) input. While in the most challenging patient (A) one obtained accuracies from 99.57% (δ=2s; SOW=3s) to 72.56% (δ=30s; SOW=2s), patient D seizures could be detected in the 99.77% (δ=2s; SOW=2s) to 99.93% (δ=30s; SOW=3s) accuracy interval.

关键词： Electroencephalography Accuracy Training Databases Biological neural networks Epilepsy Feature extraction

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Elephant Herding Optimization

Elephant Herding Optimization

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International Symposium on Computational and Business Intelligence (ISCBI)

作者： Gai-Ge Wang Suash Deb Leandro dos S. Coelho School of Computer Science and Technology Jiangsu Normal University Xuzhou China Dept. of Computer Science & Engineering Cambridge Institute of Technology Ranchi INDIA Industrial and Systems Engineering Graduate Program Pontifical Catholic University of Parana Curitiba Brazil

In this paper, a new kind of swarm-based metaheuristic search method, called Elephant Herding Optimization (EHO), is proposed for solving optimization tasks. The EHO method is inspired by the herding behavior of elephant group. In nature, the elephants belonging to different clans live together under the leadership of a matriarch, and the male elephants will leave their family group when they grow up. These two behaviors can be modelled into two following operators: clan updating operator and separating operator. In EHO, the elephants in each clan are updated by its current position and matriarch through clan updating operator. It is followed by the implementation of the separating operator which can enhance the population diversity at the later search phase. To demonstrate its effectiveness, EHO is benchmarked by fifteen test cases comparing with BBO, DE and GA. The results show that EHO can find the better values on most benchmark problems than those three metaheuristic algorithms.

关键词： Optimization Benchmark testing Sociology Statistics Particle swarm optimization Electronic mail Search methods

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Proceedings of the 16th Annual UT-KBRIN Bioinformatics Summit 2016: proceedings

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BMC Proceedings 2017年第9期11卷 1-6页

作者： L. Leon Dent Sammed N. Mandape Siddharth Pratap Jianan Dong Jamaine Davis Jennifer A. Gaddy Kofi Amoah Steve Damo Dana R. Marshall Jacob Jones Toni Brandt Gilberto Diaz Qingguo Wang Todd Gary Ashwini Yenamandra Marina Z. Ghattas Marwa Elrakaiby Ramy K. Aziz Hamdallah H. Zedan Moamen Elmassry Marwa ElRakaiby Mariam Lotfy Jarrad Marcel Rania A. Khattab Maha M. Abdelfattah Jack A. Gilbert Pouya Dini Shavahn C. Loux Kirsten E. Scoggin Alejandro Esteller-Vico Edward L. Squires Mats H. T. Troedsson Barry A. Ball Peter Daels Kalpani De Silva Ernest Bailey Joel C. Stephens Theodore S. Kalbfleisch Christine E. Dolin Lauren G. Poole Gavin E. Arteel Michael L. Merchant Daniel W. Wilkey Michelle T. Barati Eric C. Rouchka Richard M. Higashi Teresa W-M Fan Hunter Moseley Andrew N Lane Department of Surgery Meharry Medical College Nashville TN 37208 USA Bioinformatics Core Meharry Medical College Nashville TN 37208 USA Department of Biochemistry and Cancer Biology Meharry Medical College Nashville TN 37208 USA Department of Medicine Vanderbilt University Medical Center Nashville TN 37232 USA Department of Life and Physical Sciences Fisk University Nashville TN 37208 USA Department of Pathology Anatomy and Cell Biology Meharry Medical College Nashville TN 37208 USA College of Computing and Technology Lipscomb University 1 University Park Drive Nashville TN 37204 USA Vanderbilt University Medical Center Nashville TN 37232 USA Office of Research Middle Tennessee State University 1301 East Main St Murfreesboro TN 37132 USA Department of Microbiology and Immunology Faculty of Pharmacy Cairo University Cairo Egypt Department of Biological Sciences Texas Tech University Lubbock TX 79409 USA Clinical Operations Department Ray-Clinical Research Organization Giza Egypt Genomic and Systems Biology Bioscience Division Argonne National Laboratory Argonne IL 60439 USA Research Institute of Ophthalmology Giza Egypt Department of Surgery University of Chicago Chicago IL 60637 USA Microbial Ecology Group Argonne National Laboratory Argonne IL 60439 USA Department of Veterinary Science University of Kentucky Lexington KY 40536 USA Department of Reproduction Faculty of Veterinary Medicine University of Gent Merelbeke Belgium Interdisciplinary Studies Program: Specialization in Bioinformatics University of Louisville Louisville KY 40292 USA Department of Veterinary Science University of Kentucky Lexington KY 40506 USA Genomics GPS Guilford CT 06437 USA Department of Biochemistry and Molecular Genetics School of Medicine University of Louisville Louisville KY 40292 USA Department of Pharmacology & Toxicology University of Louisville Louisville KY 40202 USA Department of Medicine University of Louisville

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Wave algorithm for recruitment in swarm robotics

Lecture Notes in Computer Science (including subseries Lectu...

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Lecture Notes in computer science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2015年 9156卷 3-13页

作者： Silva, Luneque Nedjah, Nadia Systems Engineering and Computer Science Program Federal University of Rio de Janeiro Rio de Janeiro Brazil Department of Electronics Engineering and Telecommunications State University of Rio de Janeiro Rio de Janeiro Brazil

In the last decades, studies on swarm robotics have grown significantly, with different new aspects becoming of interest in research. Although the primary interest in swarm robotics should be the application, which is the task that robots should perform, other aspects are also studied. For instance, in a robotic swarm, it may be necessary to select the robots that would perform a given task, aiming at a division of labor among the members. A similar problem is that of robot recruitment, required when a specific robot needs assistance to execute some tasks and thus needs to recruit other robots of the swarm to do so. In this paper, a distributed algorithm, termed the wave algorithm, is exploited to perform the recruitment based mainly on robot message passing to neighboring robots. © Springer International Publishing Switzerland 2015.

关键词： Message passing

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PB-09Alpha-synuclein Binds Unconventional Microtubules That Have a Unique Function

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Microscopy 2017年第SUPPL_1期66卷 i37-i37页

作者： Toba, Shiori Jin, Mingyue Yamada, Masami Matsumoto, Sakiko Yasunaga, Takuo Fukunaga, Yuko Miyazawa, Atsuo Kojima, Hiroaki Arai, Yoshiyuki Nagai, Takeharu Hirotsune, Shinji Osaka City Univ. Grad. Sch. of Medicine Present address: Dept. of Emergency Medical Technology Hirosaki University of Health and Welfare Junior College Faculty of Computer Science and Systems Engineering Kyushu Inst. of Technology Fukuoka Japan JST-SENTAN JST-CREST Grad. Sch. of Life Science Univ. of Hyogo RSC-Univ. of Hyogo Leading Program Center RIKEN SPring-8 Center Advanced ICT Research Inst. National Inst. of Information and Communications Technology and Inst. of Scientific and Industrial Research Osaka Univ. Japan.

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25th Annual Computational Neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts

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BMC NEUROscience 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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Multi-Layered Alert Filtration and Feedback Cycle using Brahms Model

Multi-Layered Alert Filtration and Feedback Cycle using Brah...

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International Conference on Advanced computer science Applications and Technologies

作者： Abid Ghaffar Mohamed Ridza Wahiddin Asadullah Shaikh Akhlaq Ahmad Department of Computer Science Foundation Year Program Umm Al-Qura University Department of Computer Science Kulliyyah of Information and Communication Technology International Islamic University Malaysia Department of Computer Science and Information Systems Najran University College of Engineering and Islamic Architecture Umm Al Qura University

ISBN: (纸本)9781509004256

Customer service improvement is directly related with organizational standards and productivity. Employees activities have certain objectives to be followed but sometimes outcomes are different than expected. Human error while performing regular job activities cause sufficient losses and difficult to address. Management faces real challenges while dealing with employee related issues and sometimes becomes unproductive. We propose Brahms Model with multi layered alert filtration and feedback cycle which would address the human error in the system and generate the filtered alerts in the form of sms or by emails. This is especially useful for Human-computer Interfacing (HCI) Scenarios. Controlling human error and addressing real issues may protect any institution from severe damage and losses. Efficiency of a customer service department can be improved and maximized by multi-layered alert filtration system using Brahms Model.

关键词： Brahms Model Customer Service Improvement Context Aware Applications Alert Generation and Filtration Organizational behaviour Human computer Interfacing

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