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Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Dec, 10.1038/s41467-019-13824-9, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 1-1页

作者： Sieverling, Lina Hong, Chen Koser, Sandra D. Ginsbach, Philip Kleinheinz, Kortine Hutter, Barbara Braun, Delia M. Cortes-Ciriano, Isidro Xi, Ruibin Kabbe, Rolf Park, Peter J. Eils, Roland Schlesner, Matthias Brors, Benedikt Rippe, Karsten Jones, David T. W. Feuerbach, Lars Division of Applied Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Faculty of Biosciences Heidelberg University 69120 Heidelberg Germany Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Institute of Pharmacy and Molecular Biotechnology and BioQuant Heidelberg University Heidelberg Germany German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Heidelberg Germany Heidelberg Center for Personalized Oncology (DKFZ-HIPO) German Cancer Research Center (DKFZ) Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Division of Chromatin Networks German Cancer Research Center (DKFZ) and BioQuant 69120 Heidelberg Germany Department of Biomedical Informatics Harvard Medical School Boston Massachusetts 02115 USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge CB2 1EW UK Ludwig Center at Harvard Medical School Boston Massachusetts 02115 USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge UK Ludwig Center at Harvard Medical School Boston MA USA School of Mathematical Sciences and Center for Statistical Science Peking University Beijing 100871 China Heidelberg University Heidelberg Germany New BIH Digital Health Center Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin Berlin Germany Bioi

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Ten new insights in climate science 2024

One Earth

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One Earth 2025年

作者： Schaeffer, Roberto Schipper, E. Lisa F. Ospina, Daniel Mirazo, Paula Alencar, Ane Anvari, Mehrnaz Artaxo, Paulo Biresselioglu, Mehmet Efe Blome, Tanja Boeckmann, Melanie Brink, Ebba Broadgate, Wendy Bustamante, Mercedes Cai, Wenju Canadell, Josep G. Cardinale, Roberto Chidichimo, Maria Paz Ditlevsen, Peter Eicker, Ursula Feron, Sarah Fikru, Mahelet G. Fuss, Sabine Gaye, Amadou T. Gustafsson, Örjan Harring, Niklas He, Cheng Hebden, Sophie Heilemann, Adrian Hirota, Marina Janardhanan, Nandakumar Juhola, Sirkku Jung, Tae Yong Kejun, Jiang Kilkiș, Şiir Kumarasinghe, Nilushi Lapola, David Lee, June-Yi Levis, Carolina Lusambili, Adelaide Maasakkers, Joannes D. MacIntosh, Claire Mahmood, Jemilah Mankin, Justin S. Marchegiani, Pía Martin, Maria Mukherji, Aditi Muñoz-Erickson, Tischa A. Niazi, Zeenat Nyangon, Joseph Pandipati, Santosh Perera, Amarasinghage T.D. Persad, Geeta Persson, Åsa Redman, Aaron Riipinen, Ilona Rockström, Johan Roffe, Sarah Roy, Joyashree Sakschewski, Boris Samset, Bjørn H. Schlosser, Peter Sharifi, Ayyoob Shih, Wan-Yu Sioen, Giles B. Sokona, Youba Stammer, Detlef Suk, Sunhee Thiam, Djiby Thompson, Vikki Tullos, Erin van Westen, René M. Vargas Falla, Ana Maria Vecellio, Daniel J. Worden, John Wu, Henry C. Xu, Chi Yang, Yang Zachariah, Mariam Zhang, Zhen Ziervogel, Gina Federal University of Rio de Janeiro Rio de Janeiro Brazil University of Bonn Bonn Germany Future Earth Secretariat Stockholm Sweden Arizona State University Tempe AZ United States Amazon Environmental Research Institute (IPAM) Brasilia Brazil Fraunhofer Institute for Algorithms and Scientific Computing SCAI St. Augustin Germany Potsdam Institute for Climate Impact Research (PIK) Potsdam Germany University of São Paulo São Paulo Brazil İzmir University of Economics İzmir Turkey Climate Service Center Germany (GERICS) Helmholtz-Zentrum Hereon Hamburg Germany University of Bremen Bremen Germany Lund University Lund Sweden University of Brasilia Brasilia Brazil Ocean University of China Qingdao China Xiamen University Xiamen China Commonwealth Scientific and Industrial Research Organisation (CSIRO) Environment Canberra ACT Australia University College London London United Kingdom National Scientific and Technical Research Council (CONICET) Buenos Aires Argentina National University of San Martin Buenos Aires Argentina University of Copenhagen Copenhagen Denmark Concordia University Montreal QC Canada University of Groningen Groningen Netherlands Missouri University of Science and Technology Rolla MO United States Mercator Research Institute on Global Commons and Climate Change (MCC) Berlin Germany Humboldt-University of Berlin Berlin Germany Cheikh Anta Diop University Dakar Senegal Stockholm University Stockholm Sweden University of Gothenburg Gothenburg Sweden Institute of Epidemiology Helmholtz Zentrum München—German Research Center for Environmental Health (GmbH) Neuherberg Germany European Space Agency (ESA) - European Centre for Space Applications and Telecommunications (ECSAT) Oxford United Kingdom Federal University of Santa Catarina Florianopolis Brazil Institute for Global Environmental Strategies (IGES) Hayama Japan University of Helsinki Helsinki Finland Yonsei University Graduate Seoul South Korea Chinese Academy of Macroeconomic

The years 2023 and 2024 were characterized by unprecedented warming across the globe, underscoring the urgency of climate action. Robust science advice for decision makers on subjects as complex as climate change requires deep cross- and interdisciplinary understanding. However, navigating the ever-expanding and diverse peer-reviewed literature on climate change is enormously challenging for individual researchers. We elicited expert input through an online questionnaire (188 respondents from 45 countries) and prioritized 10 key advances in climate-change research with high policy relevance. The insights span a wide range of areas, from changes in methane and aerosol emissions to the factors shaping citizens’ acceptance of climate policies. This synthesis and communications effort forms the basis for a science-policy report distributed to party delegations ahead of the 29th session of the Conference of the Parties (COP29) to inform their positions and arguments on critical issues, including heat-adaptation planning, comprehensive mitigation strategies, and strengthened governance in energy-transition minerals value chains. © 2025 The Authors

关键词： adaptation climate policy climate science governance just transition mitigation resilience science policy

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Physical conductor OPPC integrity monitoring in overhead transmission line using communication fiber optic technologies

CIGRE Session 46

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CIGRE Session 46 2016年 2016-August卷

作者： Nascimento, Carlos A.M. Rosolem, Joao B. Dini, Danilo C. Hortencio, Claudio A. Aguiar, Joao Guilherme D. CEMIG - Companhia Energética de Minas Gerais Brazil CPqD Research and Development Center in Telecommunications Brazil

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Adaptive nonsymmetrical demodulation based on machine learning to mitigate time-varying impairments

Adaptive nonsymmetrical demodulation based on machine learni...

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2016 IEEE Avionics and Vehicle Fiber-Optics and Photonics Conference, AVFOP 2016

作者： Torres, Jhon J. Granada Chiuchiarelli, Andrea Thomas, Varghese A. Ralph, Stephen E. Soto, Ana M. Cardenas Gonzalez, Neil Guerrero Universidad de Antioquia GITA Research Group Calle 67 No 53-108 Medellín Colombia CPqD Foundation-Research and Development Center in Telecommunications CampinasSP 13086-902 Brazil School of Electrical and Computer Engineering Georgia Institute of Technology AtlantaGA30318 United States Tyndall National Institute Photonics System Group Lee Maltings Dyke Parade Cork Ireland

ISBN: (纸本)9781509015993

Future terabit optical communication systems will rely on higher order Quadrature Amplitude Modulation (QAM) formats to improve the spectral efficiency (SE). However, these formats exhibit a higher sensitivity to linear as well as non-linear impairments throughout the optical link [1, 2]. These impairments may be time-varying in nature arising from mechanical disturbance in optical fibers, temperature variations in the components and small variations of the bias control of the IQ optical modulators for example. Unlike optical noise, these degradations may have a probability density function (PDF) that is non-Gaussian and therefore may shift the centroids (mean value) of the received symbols from their ideal constellation positions by different extents, Fig 1a. Thus, employing non-symmetrical decision boundaries by means of machine learning techniques may improve the overall system performance with high computational efficiency in contradistinction to complex linear equalization or computationally heavy non-linear mitigation techniques [2, 3]. Furthermore, an area that has not been well explored is the use of digital techniques at the receiver for tracking and compensating the effects of fast time-varying link parameters. Here, we demonstrate an adaptive machine learning-based nonsymmetrical decision technique relying on clustering to mitigate time-varying impairments such as IQ imbalance, bias drift, and phase noise. We experimentally verified its effectiveness in a 16QAM Nyquist system at 16 Gbaud for back-to-back (B2B) and 250 km links. © 2016 IEEE.

关键词： Probability density function

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Analysis of the Impact on Power Quality During the Recharge of Electric Vehicles and Vehicle-to-Grid Functionality

Analysis of the Impact on Power Quality During the Recharge ...

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IEEE PES Innovative Smart Grid Technologies Conference Europe

作者： Daniel R. Pinto Vitor T. Arioli Glaucio R. T. Hax Ricardo T. Borges Wendell W. Teixeira Converged Networks Directory Power Systems Area Centre for Research and Development in Telecommunications Foundation (CPqD) Campinas Brazil Department of Systems and Energy University of Campinas (UNICAMP) Campinas Brazil Strategy and Innovation Directory Companhia Paulista de Força e Luz (CPFL) Campinas Brazil

The growth of the fleet of electric vehicles (EVs), has represented a new load to the electric system by recharging their batteries from the power distribution network. Because they require power levels greater than the usual equipment and remain connected for long periods during recharges, EVs can affect the quality of the power supply. In addition, some vehicle brands have the Vehicle-to-Grid (V2G) functionality, which is the possibility of returning the energy stored in the battery to the electric grid. Characterizing these behaviors will allow the Electric Power Distributors to understand the operation of these technologies connected to their networks and to plan the necessary adaptations so that it supports a massive penetration. In this way, this work aims to identify the impacts of these EVs on the power quality. The study was carried out from an extensive set of measurements realized in commercial EVs and in real use.

关键词： Harmonic Distortion Power Quality Distribution Grid Electric Vehicles Recharge Vehicle-to-Grid

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Adaptive nonsymmetrical demodulation based on machine learning to mitigate time-varying impairments

Adaptive nonsymmetrical demodulation based on machine learni...

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IEEE Conference on Avionics Fiber-Optics and Photonics, AVFOP

作者： Jhon J. Granada Torres Andrea Chiuchiarelli Varghese A. Thomas Stephen E. Ralph Ana M. Cárdenas Soto Neil Guerrero González GITA Research Group Universidad de Antioquia Medellin CO CPqD Foundation???Research and Development Center in Telecommunications Campinas SP Brazil School of Electrical and Computer Engineering Georgia Institute of Technology Atlanta GA USA Photonics System Group Tyndall National Institute Cork Ireland

We proposed and experimentally demonstrated a machine learning-based nonsymmetrical demodulation technique for a DSP-enabled receiver, with the aim of enabling time-varying nonlinear mitigation. Experimental results showed that nonsymmetrical demodulation can reduce the SER by up to 0.7 decades, when assuming time frames consisting of 10 k symbols and fiber transmission of 250 km. The proposed technique is transparent to the specific source of nonlinearity, which makes it simple yet robust. This machine learning method may also allow simplification of the standard demodulation blocks in particular the equalizer. Employing short time windows for demodulation further enables inline optical monitoring, which is a valuable diagnostic tool for future terabit optical communication systems.

关键词： Optical noise Demodulation Signal to noise ratio Optical fiber communication Receivers Clustering algorithms

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Challenges and current state of implementation of an IP platform for Brazil's ATM communications 15

Challenges and current state of implementation of an IP plat...

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2015 15th Annual Integrated Communication, Navigation and Surveillance Conference, ICNS 2015

作者： Nassif, Nadia A. Martins, Luciano Silva, Fernando C.C. Manoel, P. Dos S. Costa, Rodolfo S. Pacitti, Marcos De C. Belchior, Marcos A.V. CPqD - Research and Development Center in Telecommunications Campinas SP Brazil DECEA - Department of Air Space Control Rio de Janeiro RJ Brazil

ISBN: (纸本)9781479989522

This paper presents challenges and current implementation state of an IP platform to support ATM communications (Radio, Telephony, Surveillance Data, etc.) in the SISCEAB (Brazilian Integrated Airspace Control System) taking into account the national plan for CNS/ATM development. This IP platform comprises Voice Communication System (VCS), Ground Radio Stations (GRS) and Surveillance Systems (RADAR) based on IP Standards and Protocols as well as an IP/MPLS backbone to interconnect them. The paper describes the current scenario of Brazilian Aeronautical Telecommunication Network (ATN) as well as future scenarios and challenges to support the safe and gradual migration to a new infrastructure based on IP technology following EUROCAE (European Organisation for Civil Aviation Equipment) Standards and ICAO Recommendations. It also presents the basic infrastructure of the Information and Communications Systems Qualification Laboratory for SISCEAB (LQCEA) built at cpqd (a Brazilian Telecom research center) which will be used to test and validate the IP platform performance and equipment interoperability before they are deployed operationally. In addition, it presents an overview of the systemic tests executed to analyze and validate this new platform which have contributed to the project progress. Finally, this paper gives an overview about the next steps of ATN communications implementation in Brazil. © 2015 IEEE.

关键词： Interoperability

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development and performance analysis of a photonic-assisted RF amplifier

Development and performance analysis of a photonic-assisted ...

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SBMO/IEEE MTT-S International Microwave and Optoelectronics Conference, IMOC 2015

作者： Cañas-Estrada, N. Arismar, Cerqueira S. Noque, D.F. Borges, R.M. Gonzalez, Neil Guerrero Oliveira, J.C.R.F. Laboratory WOCA National Institute of Telecommunications Santa Rita do SapucaíMG Brazil Research and Development Center of Telecommunications CPqD CampinasSP Brazil BrPhotonics CampinasSP Brazil

ISBN: (纸本)9781467394925

This work contributes to the area of microwave photonics applied to telecommunication systems in two ways. Initially, a photonic-assisted RF amplifier is proposed and experimentally validated. It takes advantage of the Four-wave Mixing (FWM) optical nonlinear effect, ensured by launching two high optical power carriers into a highly nonlinear fiber. The RF gain is defined as the difference between the electrical power photodetected using a FWM product and that from the conventional RoF system at the same optical power level. Experimental results demonstrate 24 dB gain after photodetection of the first FWM product. Furthermore, a performance analysis based on numerical simulations is reported in order to propose a high capacity intensity modulated radio over fiber architecture for future broadband access optical-wireless networks. Bit-error-rate curves of a 10 Gbit/s NRZ signal in different conditions of optical signal to noise ratio (OSNR) are presented for illustrating the applicability of the proposed photonics-based RF device. © 2015 IEEE.

关键词： Radio-over-fiber

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Performance comparison of a custom emulation-based test environment against a real-world LTE testbed 15

Performance comparison of a custom emulation-based test envi...

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2015 Workshop on NS-3, WNS3 2015

作者： Sakai, Sérgio Gambugge, Gilberto Takaki, Ricardo Seki, Jorge Bazzo, Juliano Miranda, João Paulo CPqD -Research and Development Center on Telecommunications R. Dr. Ricardo Benetton Martins s/n Campinas/SPCEP 13086-902 Brazil

ISBN: (纸本)9781450333757

Notwithstanding the value of Long Term Evolution (LTE) towards an improved user experience in next-generation networks, its associated high complexity is known to place computational and time burdens on testing tasks involving real-world platforms. Simulation is currently the tool most widely used to tackle this issue. LENA, for instance, is an open source simulator based on NS-3 that allows the design, evaluation, and validation of LTE networks. Despite of modeling the main LTE elements and interfaces, one limitation of LENA is that it docs not support the use of external traffic entities in conjunction with the simulation. In this paper, we describe how the NS-3 LENA LTE framework can be customized for use in an emulation-based test environment that allows a wider variety of real-world applications to be run over the simulated links. To validate our emulation results, we use as benchmark a testbed that differs from the aforementioned test environment in that the NS-3 server running the simulated network is replaced with a network made up of real-world platforms. Initial validation results, based on limited tests using an industry-standard VoIP test tool and iperf throughput tool, demonstrate that NS-3 LTE models can deliver voice quality and latency as good as an experimental testbed using actual LTE equipment over a range of signal-to-noise ratios. Similar conclusions arc also drawn for throughput, thus confirming the suitability of our emulation approach as a viable means to predict performance in real LTE networks. The good agreement of our experimental results is possible not only because the same functionality is implemented in both experiments but due to the use of the same traffic generation tools in the simulated and real-world LTE networks not possible in standard LENA simulation. © 2015 ACM.

关键词： Testbeds

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A DSL for configuration management of integrated network management system 17

A DSL for configuration management of integrated network man...

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17th International Conference on Enterprise Information Systems, ICEIS 2015

作者： Pieroni, Rosangela Penteado, Rosângela Aparecida Dellosso Department of Computing Federal University of São Carlos São Carlos SP13565-905 Brazil CPqD Research and Development Center In Telecommunications Campinas SP13086-902 Brazil

ISBN: (纸本)9789897580963

A management system of networks that takes all elements into consideration, regardless of the network technology, is one of the most emphasized requests by telecommunication companies. However, developing this system is not a trivial task. Furthermore, the software development process based on source code makes the task even more complex and requires a great effort of the developers to perform code update and maximize the reuse of software artifacts to insert a new network technology. In this paper, we propose a DSL approach to specify new network technologies into integrated network management system developed by a real company. An experiment was conducted according to all steps proposed by Wohlin (Wohlin et al., 2000) to validate our DSL approach versus specialization of classes with the purpose of increasing advantages with respect to time and number of errors inserted in the source code. Although the time spent to develop the application using the two approaches was not statistically different, all other results obtained such as code generated automatically without present errors and all comments reported by the participants regarding the ease of use of DSL, it encourages the development of new DSLs to others functions of the integrated network management system. Copyright © 2015 SCITEPRESS - Science and Technology Publications.

关键词： Software design

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