检索结果-内蒙古大学图书馆

Correction to: Hormonal modulation of ESR1 mutant metastasis

Oncogene 2022年第3期41卷 460页

作者： Guowei Gu Lin Tian Sarah K Herzog Yassine Rechoum Luca Gelsomino Meng Gao Lili Du Jin-Ah Kim Derek Dustin Hin Ching Lo Amanda R Beyer David G Edwards Thomas Gonzalez Anna Tsimelzon Helen J Huang Natalie M Fernandez Sandra L Grimm Susan G Hilsenbeck Dan Liu Jun Xu Alyssa Alaniz Shunqiang Li Gordon B Mills Filip Janku Ralf Kittler Xiang H-F Zhang Cristian Coarfa Charles E Foulds W Fraser Symmans Sebastiano Andò Suzanne A W Fuqua Lester & Sue Smith Breast Center Baylor College of Medicine Houston TX USA. Department of Molecular and Cellular Biology Baylor College of Medicine Houston TX USA. Department of Pharmacy Health and Nutritional Sciences University of Calabria Rende Italy. Cancer Biology & Genetics Program Memorial Sloan Kettering Cancer Center New York NY USA. Integrative Molecular and Biomedical Sciences Program Baylor College of Medicine Houston TX USA. Department of Systems Biology MD Anderson Cancer Center Houston TX USA. Department of Pathology and Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX USA. Interdepartmental Program in Translational Biology and Molecular Medicine Baylor College of Medicine Houston TX USA. Department of Investigational Cancer Therapeutics The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Biochemistry and Molecular Biology Baylor College of Medicine Houston TX USA. Dan L Duncan Cancer Center Baylor College of Medicine Houston TX USA. Department of Internal Medicine Division of Oncology Washington University School of Medicine Saint Louis MO USA. Department of Cell Development and Cancer Biology Knight Cancer Institute Oregon Health and Science University Portland OR USA. Eugene McDermott Center for Human Growth and Development and Department of Pharmacology UT Southwestern Medical Center Dallas TX USA. Center for Precision Environmental Health Baylor College of Medicine Houston TX USA. Lester & Sue Smith Breast Center Baylor College of Medicine Houston TX USA. sfuqua@bcm.edu. Department of Molecular and Cellular Biology Baylor College of Medicine Houston TX USA. sfuqua@bcm.edu. Dan L Duncan Cancer Center Baylor College of Medicine Houston TX USA. sfuqua@bcm.edu.

来源：评论

学校读者我要写书评

暂无评论

1504MO Phase II trial of Pembrolizumab and OLApaRib (POLAR) maintenance for select patients (pts) with metastatic pancreatic cancer (mPC) with (A) homologous recombination deficiency (HRD), (B) non-core HRD (ncHRD) and (C) exceptional response to platinum

引用

Annals of Oncology 2024年 35卷 S922-S922页

作者： W. Park C.O’ Connor J. Chou C. Schwartz M. Larsen A. Varghese K. Yu F. Balogun J. Yang S. Katz D. Kelsen S. Umeda C. Bandlamudi N. Riaz M. Berger V. Balachandran D. Peer M. Capanu C. Iacobuzio-Donahue E.M. O'Reilly Gastrointestinal Oncology Service Memorial Sloan Kettering Cancer Center David M. Rubenstein Center for Pancreatic Cancer Research Weill Cornell Medical College Parker Institute for Cancer Immunotherapy New York NY USA Gastrointestinal Oncology Service Memorial Sloan Kettering Cancer Center New York NY USA Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center David M. Rubenstein Center for Pancreatic Cancer Research New York NY USA Department of Nursing Memorial Sloan Kettering Cancer Center David M. Rubenstein Center for Pancreatic Cancer Research New York NY USA Gastrointestinal Oncology Service Memorial Sloan Kettering Cancer Center David M. Rubenstein Center for Pancreatic Cancer Research Weill Cornell Medical College New York NY USA Department of Radiology MSKCC New York NY USA Department of Pathology Memorial Sloan Kettering Cancer Center David M. Rubenstein Center for Pancreatic Cancer Research New York NY USA Marie-Josée & Henry R. Kravis Center for Molecular Oncology Memorial Sloan Kettering Cancer Center New York NY USA Department of Radiology MSKCC - Memorial Sloan Kettering Cancer Center New York NY USA Department of Surgery Memorial Sloan Kettering David M. Rubenstein Center for Pancreatic Cancer Research New York NY USA Computational & Systems Biology Program Memorial Sloan Kettering Cancer Center David M. Rubenstein Center for Pancreatic Cancer Research New York NY USA

来源：评论

学校读者我要写书评

暂无评论

On the convergence of the maximum likelihood estimator for the transition rate under a 2-state symmetric model

arXiv

引用

arXiv 2019年

作者： Ho, Lam Si Tung Dinh, Vu Matsen, Frederick A. Suchard, Marc A. Department of Mathematics and Statistics Dalhousie University HalifaxNS Canada Department of Mathematical Sciences University of Delaware Program in Computational Biology Fred Hutchinson Cancer Research Center Departments of Biomathematics Biostatistics and Human Genetics University of California Los Angeles United States

Maximum likelihood estimators are used extensively to estimate unknown parameters of stochastic trait evolution models on phylogenetic trees. Although the MLE has been proven to converge to the true value in the independent-sample case, we cannot appeal to this result because trait values of different species are correlated due to shared evolutionary history. In this paper, we consider a 2-state symmetric model for a single binary trait and investigate the theoretical properties of the MLE for the transition rate in the large-tree limit. Here, the large-tree limit is a theoretical scenario where the number of taxa increases to infinity and we can observe the trait values for all species. Specifically, we prove that the MLE converges to the true value under some regularity conditions. These conditions ensure that the tree shape is not too irregular, and holds for many practical scenarios such as trees with bounded edges, trees generated from the Yule (pure birth) process, and trees generated from the coalescent point process. Our result also provides an upper bound for the distance between the MLE and the true value. Copyright © 2019, The Authors. All rights reserved.

关键词： Maximum likelihood estimation

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization

引用

Nature structural & molecular biology 2023年第7期30卷 1048页

作者： Jennifer Zagelbaum Allana Schooley Junfei Zhao Benjamin R Schrank Elsa Callen Shan Zha Max E Gottesman André Nussenzweig Raul Rabadan Job Dekker Jean Gautier Institute for Cancer Genetics Columbia University Vagelos College of Physicians and Surgeons New York NY USA. Integrated Program in Cellular Molecular and Biomedical Studies Columbia University Vagelos College of Physicians and Surgeons New York NY USA. Department of Systems Biology University of Massachusetts Medical School Worcester MA USA. Department of Systems Biology Columbia University Vagelos College of Physicians and Surgeons New York NY USA. The University of Texas MD Anderson Cancer Center Houston TX USA. Laboratory of Genome Integrity National Institutes of Health Bethesda MD USA. Department of Pathology and Cell Biology and Department of Pediatrics Columbia University Vagelos College of Physicians and Surgeons New York NY USA. Herbert Irving Comprehensive Cancer Center Columbia University Vagelos College of Physicians and Surgeons New York NY USA. Department of Biochemistry and Biophysics Columbia University Vagelos College of Physicians and Surgeons New York NY USA. Howard Hughes Medical Institute Chevy Chase MD USA. Institute for Cancer Genetics Columbia University Vagelos College of Physicians and Surgeons New York NY USA. jg130@cumc.columbia.edu. Herbert Irving Comprehensive Cancer Center Columbia University Vagelos College of Physicians and Surgeons New York NY USA. jg130@cumc.columbia.edu. Department of Genetics and Development Columbia University Vagelos College of Physicians and Surgeons New York NY USA. jg130@cumc.columbia.edu.

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies

引用

Nature immunology 2022年第8期23卷 1285页

作者： Emily R Kansler Saïda Dadi Chirag Krishna Briana G Nixon Efstathios G Stamatiades Ming Liu Fengshen Kuo Jing Zhang Xian Zhang Kristelle Capistrano Kyle A Blum Kate Weiss Ross M Kedl Guangwei Cui Koichi Ikuta Timothy A Chan Christina S Leslie A Ari Hakimi Ming O Li Immunology Program Memorial Sloan Kettering Cancer Center New York NY USA. Louis V. Gerstner Jr. Graduate School of Biomedical Sciences Memorial Sloan Kettering Cancer Center New York NY USA. Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA. Immunology and Microbial Pathogenesis Graduate Program Weill Cornell Graduate School of Medical Sciences Cornell University New York NY USA. Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY USA. Department of Immunology and Microbiology University of Colorado Anschutz Medical Campus Aurora CO USA. Laboratory of Immune Regulation Department of Virus Research Institute for Frontier Life and Medical Sciences Kyoto University Kyoto Japan. Department of Urology Memorial Sloan Kettering Cancer Center New York NY USA. Immunology Program Memorial Sloan Kettering Cancer Center New York NY USA. lim@***. Louis V. Gerstner Jr. Graduate School of Biomedical Sciences Memorial Sloan Kettering Cancer Center New York NY USA. lim@***. Immunology and Microbial Pathogenesis Graduate Program Weill Cornell Graduate School of Medical Sciences Cornell University New York NY USA. lim@***.

来源：评论

学校读者我要写书评

暂无评论

Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice

引用

Cell Reports 2023年第5期42卷 112499页

作者： Moore, Timothy M. Lee, Sindre Olsen, Thomas Morselli, Marco Strumwasser, Alexander R. Lin, Amanda J. Zhou, Zhenqi Abrishami, Aaron Garcia, Steven M. Bribiesca, Jennifer Cory, Kevin Whitney, Kate Ho, Theodore Ho, Timothy Lee, Joseph L. Rucker, Daniel H. Nguyen, Christina Q.A. Anand, Akshay T.S. Yackly, Aidan Mendoza, Lorna Q. Leyva, Brayden K. Aliman, Claudia Artiga, Daniel J. Meng, Yonghong Charugundla, Sarada Pan, Calvin Jedian, Vida Seldin, Marcus M. Ahn, In Sook Diamante, Graciel Blencowe, Montgomery Yang, Xia Mouisel, Etienne Pellegrini, Matteo Turcotte, Lorraine P. Birkeland, Kåre I. Norheim, Frode Drevon, Christian A. Lusis, Aldons J. Hevener, Andrea L. Division of Cardiology Diabetes and Hypertension Department of Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles CA United States Division of Endocrinology Diabetes and Hypertension Department of Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles CA United States Department of Transplantation Institute of Clinical Medicine Faculty of Medicine University of Oslo Oslo Norway Department of Nutrition Institute of Basic Medical Sciences Faculty of Medicine University of Oslo Oslo Norway Department of Molecular Cell and Developmental Biology University of California Los Angeles Los Angeles CA United States UCLA-DOE Institute for Genomics and Proteomics University of California Los Angeles Los Angeles CA United States Institute for Quantitative and Computational Biosciences – The Collaboratory University of California Los Angeles Los Angeles CA United States Department of Chemical and Systems Biology Stanford School of Medicine Stanford CA United States Department of Biological Chemistry and Center for Epigenetics and Metabolism University of California Irvine Irvine CA United States Molecular Cellular and Integrative Physiology Interdepartmental Program University of California Los Angeles Los Angeles CA United States Department of Integrative Biology and Physiology University of California Los Angeles Los Angeles CA United States Institute for Quantitative and Computational Biosciences University of California Los Angeles Los Angeles CA United States Institute of Metabolic and Cardiovascular Diseases UMR1297 Inserm Paul Sabatier University Toulouse France Department of Biological Sciences Dana & David Dornsife College of Letters Arts and Sciences University of Southern California Los Angeles CA United States Department of Human Genetics University of California Los Angeles Los Angeles CA United States Department of Microbiology Immunology and Molecular Geneti

Physical activity is associated with beneficial adaptations in human and rodent metabolism. We studied over 50 complex traits before and after exercise intervention in middle-aged men and a panel of 100 diverse strains of female mice. Candidate gene analyses in three brain regions, muscle, liver, heart, and adipose tissue of mice indicate genetic drivers of clinically relevant traits, including volitional exercise volume, muscle metabolism, adiposity, and hepatic lipids. Although ∼33% of genes differentially expressed in skeletal muscle following the exercise intervention are similar in mice and humans independent of BMI, responsiveness of adipose tissue to exercise-stimulated weight loss appears controlled by species and underlying genotype. We leveraged genetic diversity to generate prediction models of metabolic trait responsiveness to volitional activity offering a framework for advancing personalized exercise prescription. The human and mouse data are publicly available via a user-friendly Web-based application to enhance data mining and hypothesis development. © 2023 The Authors

关键词： CP: Metabolism CP: Molecular biology exercise genetics HMDP multi-omics physical activity physiology systems biology

来源：评论

学校读者我要写书评

暂无评论

Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

引用

Nature communications 2022年第1期13卷 7573页

作者： Wei Jiao Gurnit Atwal Paz Polak Rosa Karlic Edwin Cuppen Alexandra Danyi Jeroen de Ridder Carla van Herpen Martijn P Lolkema Neeltje Steeghs Gad Getz Quaid D Morris Lincoln D Stein Computational Biology Program Ontario Institute for Cancer Research Toronto ON Canada. Department of Molecular Genetics University of Toronto Toronto ON Canada. Vector Institute Toronto ON Canada. Broad Institute of MIT and Harvard Cambridge MA USA. Harvard Medical School Boston MA USA. Center for Cancer Research Massachusetts General Hospital Boston MA USA. Department of Oncological Sciences Icahn School of Medicine at Mount Sinai 15 1425 Madison Ave. New York NY USA. Bioinformatics Group Division of Molecular Biology Department of Biology Faculty of Science University of Zagreb Horvatovac 102a Zagreb Croatia. Hartwig Medical Foundation Science Park 408 Amsterdam The Netherlands. Center for Molecular Medicine and Oncode Institute University Medical Center Utrecht Utrecht The Netherlands. Center for Molecular Medicine University Medical Center Utrecht Utrecht The Netherlands. Radboud University Medical Center Nijmegen The Netherlands. Department of Medical Oncology Erasmus MC Cancer Institute University Medical Center Rotterdam Dr. Molewaterplein 40 3015 GD Rotterdam The Netherlands. Department of Medical Oncology The Netherlands Cancer Institute Plesmanlaan 121 1066 CX Amsterdam The Netherlands. Department of Pathology Massachusetts General Hospital Boston MA USA. University of Toronto Toronto ON Canada. Computational Biology Program Ontario Institute for Cancer Research Toronto ON Canada. lincoln.stein@***. Department of Molecular Genetics University of Toronto Toronto ON Canada. lincoln.stein@***.

来源：评论

学校读者我要写书评

暂无评论

Author Correction: The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci

引用

Nature computational science 2023年第7期3卷 658页

作者： Gengjie Jia Yu Li Xue Zhong Kanix Wang Milton Pividori Rabab Alomairy Aniello Esposito Hatem Ltaief Chikashi Terao Masato Akiyama Koichi Matsuda David E Keyes Hae Kyung Im Takashi Gojobori Yoichiro Kamatani Michiaki Kubo Nancy J Cox James Evans Xin Gao Andrey Rzhetsky Shenzhen Branch Guangdong Laboratory of Lingnan Modern Agriculture Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China. jiagengjie@***. Computational Bioscience Research Center King Abdullah University of Science and Technology Thuwal Saudi Arabia. Computer Science Program Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology Thuwal Saudi Arabia. Department of Computer Science and Engineering The Chinese University of Hong Kong Hong Kong People's Republic of China. Department of Medicine and Vanderbilt Genetics Institute Vanderbilt University Medical Center Nashville TN US. Department of Medicine Institute of Genomics and Systems Biology Committee on Genomics Genetics and Systems Biology University of Chicago Chicago IL US. Department of Operations Business Analytics and Information Systems University of Cincinnati Cincinnati OH US. Department of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia PA US. Extreme Computing Research Center Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology Thuwal Saudi Arabia. College of Computer Science and Engineering University of Jeddah Jeddah Saudi Arabia. HPE HPC/AI EMEA Research Laboratory Bristol UK. RIKEN Center for Integrative Medical Sciences Yokohama Japan. Clinical Research Center Shizuoka General Hospital Shizuoka Japan. Department of Applied Genetics The School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan. Department of Ophthalmology Graduate School of Medical Sciences Kyushu University Fukuoka Japan. Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan. Biological and Environmenta

来源：评论

学校读者我要写书评

暂无评论

The impact of breast radiotherapy on the tumor genome and immune ecosystem

引用

Cell Reports 2025年第5期44卷 115703页

作者： Schalck, Aislyn Tran, Tuan Li, Jianzhuo Sei, Emi Bai, Shanshan Hu, Min Lin, Jerome Bright, Scott J. Reddick, Samuel Yang, Fei Batra, Harsh Contreras, Alejandro Raso, Maria Gabriela Stauder, Michael C. Hoffman, Karen E. Reddy, Jay P. Nead, Kevin T. Smith, Benjamin D. Sawakuchi, Gabriel O. Woodward, Wendy A. Watowich, Stephanie S. Litton, Jennifer K. Bedrosian, Isabelle Mittendorf, Elizabeth A. Le-Petross, Huong Navin, Nicholas E. Shaitelman, Simona F. Department of Systems Biology University of Texas MD Anderson Cancer Center Houston 77030 TX United States of Biological Sciences University of Texas Houston 770303 TX United States Department of Radiation Physics University of Texas MD Anderson Cancer Center Houston 77030 TX United States Department of Breast Radiation Oncology University of Texas MD Anderson Cancer Center Houston 77030 TX United States Vanderbilt University School of Medicine Nashville 37232 TN United States Department of Translational Molecular Pathology University of Texas MD Anderson Cancer Center Houston 77030 TX United States Janssen China Research & Development Johnson&Johnson Shanghai 201210 China Department of Anatomical Pathology University of Texas MD Anderson Cancer Center Houston 77030 TX United States Department of Epidemiology University of Texas MD Anderson Cancer Center Houston 77030 TX United States Department of Immunology University of Texas MD Anderson Cancer Center Houston 77030 TX United States Department of Breast Medical Oncology University of Texas MD Anderson Cancer Center Houston 77030 TX United States Department of Breast Surgical Oncology University of Texas MD Anderson Cancer Center Houston 77030 TX United States Division of Breast Surgery Department of Surgery Brigham and Women's Hospital Boston 02115 MA United States Breast Oncology Program Dana-Farber Brigham Cancer Center Boston 02115 MA United States Harvard Medical School Boston 02115 MA United States Department of Breast Imaging University of Texas MD Anderson Cancer Center Houston 77030 TX United States Department of Bioinformatics and Computational Biology University of Texas MD Anderson Cancer Center Houston 77030 TX United States

Radiotherapy is a pillar of breast cancer treatment;however, it remains unclear how radiotherapy modulates the tumor microenvironment. We investigated this question in a cohort of 20 patients with estrogen-receptor positive (ER⁺) breast tumors who received neoadjuvant radiotherapy. Tumor biopsies were collected before and 7 days postradiation. Single-cell DNA sequencing (scDNA-seq) and scRNA-seq were conducted on 8 and 11 patients, respectively, at these two time points. The scRNA data showed increased infiltration of naive-like CD4 T cells and an early, activated CD8 T cell population following radiotherapy. Radiotherapy also eliminated existing cytotoxic T cells and resulted in myeloid cell increases. In tumor cells, the scDNA-seq data showed a high genomic selection of subclones in half of the patients with high ER expression, while the remaining number had low genomic selection and an interferon response. Collectively, these data provide insight into the impact of radiotherapy in ER⁺ breast cancer patients. © 2025 The Author(s)

关键词： breast cancer CP: cancer genomics radiation single cell tumor microenvironment

来源：评论

学校读者我要写书评

暂无评论

P305: COMPREHENSIVE TRANSCRIPTIONAL AND CYTOGENETIC PROFILING IMPROVES CLASSIFICATION AND DETECTION OF RISK-STRATIFYING MARKERS IN THE B-OTHER PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA

引用

HemaSphere 2022年第S3期6卷

作者： Ž. Antić P. Chouvarine J. Lentes C. Schröder J. Alten A. Möricke M. Brüggemann E. Carrillo-de Santa Pau T. Illig T. Laguna D. M. Schewe M. Stanulla M. Tang M. Zimmermann M. Schrappe B. Schlegelberger G. Cario A. K. Bergmann Institute of Human Genetics Hannover Medical School Hannover Berlin-Frankfurt-Münster ALL Study Group Germany (BFM-G) Department of Pediatrics Kiel Germany Department of Hematology University Medical Center Schleswig-Holstein Campus Kiel Kiel Germany Computational Biology Group Precision Nutrition and Cancer Research Program IMDEA Food Institute Madrid Spain University Children's Hospital Medical Faculty Otto-von-Guericke-University-Magdeburg Magdeburg Pediatric Hematology and Oncology Hannover Medical School Hannover Germany

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：