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检索条件"机构=Cancer Data Science Program"
250 条 记 录,以下是1-10 订阅
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ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response (04 July, 10.1038/s42255-024-01090-z)
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NATURE METABOLISM 2024年 第7期6卷 1417-1417页
作者: Lim, Lisha Qiu Jin Adler, Lital Hajaj, Emma Soria, Leandro R. Perry, Rotem Ben-Tov Darzi, Naama Brody, Ruchama Furth, Noa Lichtenstein, Michal Bab-Dinitz, Elizabeta Porat, Ziv Melman, Tevie Brandis, Alexander Malitsky, Sergey Itkin, Maxim Aylon, Yael Ben-Dor, Shifra Orr, Irit Pri-Or, Amir Seger, Rony Shaul, Yoav Ruppin, Eytan Oren, Moshe Perez, Minervo Meier, Jordan Brunetti-Pierri, Nicola Shema, Efrat Ulitsky, Igor Erez, Ayelet Department of Molecular Cell Biology Weizmann Institute of Science Rehovot Israel Department of Medicine D Beilinson Hospital Petah Tikva Israel Telethon Institute of Genetics and Medicine Pozzuoli Italy Department of Translational Medicine Medical Genetics University of Naples Federico II Naples Italy Scuola Superiore Meridionale (SSM School of Advanced Studies) Genomics and Experimental Medicine Program University of Naples Federico II Naples Italy Department of Immunology and Regenerative Biology Weizmann Institute of Science Rehovot Israel Department of Molecular Neuroscience Weizmann Institute of Science Rehovot Israel Department of Biochemistry and Molecular Biology The Institute for Medical Research Israel-Canada Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel Department of Life Sciences Core Facilities Weizmann Institute of Science Rehovot Israel The De Botton Protein Profiling Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine Weizmann Institute of Science Rehovot Israel Cancer Data Science Lab Center for Cancer Research National Cancer Institute National Institute of Health Bethesda MD USA
Downregulation of the urea cycle enzyme argininosuccinate synthase (ASS1) in multiple tumors is associated with a poor prognosis partly because of the metabolic diversion of cytosolic aspartate for pyrimidine synthesi...
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A T cell resilience model associated with response to immunotherapy in multiple tumor types (May, 10.1038/s41591-022-01799-y, 2022)
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NATURE MEDICINE 2022年 第10期28卷 2219-2219页
作者: Zhang, Yu Vu, Trang Palmer, Douglas C. Kishton, Rigel J. Gong, Lanqi Huang, Jiao Nguyen, Thanh Chen, Zuojia Smith, Cari Livak, Ferenc Paul, Rohit Day, Chi-Ping Wu, Chuan Merlino, Glenn Aldape, Kenneth Guan, Xin-yuan Jiang, Peng Cancer Data Science Laboratory Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD USA Department of Clinical Oncology The University of Hong Kong Hong Kong China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China Surgery Branch National Cancer Institute National Institutes of Health Bethesda MD USA Laboratory of Pathology Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD USA Experimental Immunology Branch Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD USA Laboratory Animal Science Program Leidos Biomedical Research Inc Frederick MD USA Flow Cytometry Core Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD USA Office of the Director Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD USA Laboratory of Cancer Biology and Genetics Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD USA
Despite breakthroughs in cancer immunotherapy, most tumor-reactive T cells cannot persist in solid tumors due to an immunosuppressive environment. We developed Tres (tumor-resilient T cell, https://***/), a computatio... 详细信息
来源: 评论
Identify Non-mutational p53 Functional Deficiency in Human cancers
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Genomics, Proteomics & Bioinformatics 2024年 第5期22卷 85-98页
作者: Qianpeng Li Yang Zhang Sicheng Luo Zhang Zhang Ann L.Oberg David E.Kozono Hua Lu Jann N.Sarkaria Lina Ma Liguo Wang National Genomics Data Center China National Center for BioinformationBeijing 100101China Beijing Institute of Genomics Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Division of Computational Biology Mayo Clinic College of Medicine and ScienceRochesterMN 55905USA Department of Radiation Oncology Dana-Farber Cancer Institute and Brigham and Women's HospitalBostonMA 02215USA Department of Biochemistry&Molecular Biology and Tulane Cancer Center Tulane University School of MedicineNew OrleansLA 70112USA Department of Radiation Oncology Mayo Clinic College of Medicine and ScienceRochesterMN 55905USA Department of Biochemistry and Molecular Biology Mayo Clinic College of Medicine and ScienceRochesterMN 55905USA Bioinformatics and Computational Biology Graduate Program University of Minnesota RochesterRochesterMN 55904USA
An accurate assessment of p53's functional statuses is critical for cancer genomic ***,there is a significant challenge in identifying tumors with non-mutational p53 inactivation which is not detectable through DN... 详细信息
来源: 评论
Privacy-Preserving Dashboard for F.A.I.R Head and Neck cancer data supporting multi-centered collaborations  14
Privacy-Preserving Dashboard for F.A.I.R Head and Neck Cance...
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14th International Conference on Semantic Web Applications and Tools for Health Care and Life sciences, SWAT4HCLS 2023
作者: Gouthamchand, Varsha Choudhury, Ananya Hoebers, Frank Wesseling, Frederik Welch, Mattea Kim, Sejin Haibe-Kains, Benjamin Kazmierska, Joanna Dekker, Andre van Soest, Johan Wee, Leonard GROW School of Oncology and Reproduction Maastricht University Medical Centre+ Maastricht Netherlands Clinical Data Science Faculty of Health Medicine and Life Sciences Maastricht University Maastricht Netherlands Radiation Medicine Program Princess Margaret Cancer Centre University Health Network TorontoON Canada Dept of Radiation Oncology Greater Poland Cancer Centre II Poznan Poland Brightlands Institute for Smart Society Faculty of Science and Engineering Maastricht University Heerlen Netherlands
Research in modern healthcare requires vast volumes of data from various healthcare centers across the globe. It is not always feasible to centralize clinical data without compromising privacy. A tool addressing these... 详细信息
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Molecular Mechanisms Promoting Long-Term Cytopenia after BCMA CAR-T Therapy in Multiple Myeloma
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BLOOD 2024年 144卷 4798-4799页
作者: [Anonymous] Hematology and Cell Therapy Department. Clinica Universidad de Navarra. IdiSNA. Pamplona Spain Hemato-Oncology Program. Cima Universidad de Navarra. IdiSNA. Pamplona Spain Computational Biology Program. Cima Universidad de Navarra. IdiSNA. Pamplona Spain Immunology and Immunotherapy Department. Clinica Universidad de Navarra. Pamplona Spain Centro de Investigación Biomedica en Red de Cancer (CIBERONC). Madrid Spain Cancer Center Clinica Universidad de Navarra (CCUN). Pamplona Spain Cancer Center Clinica Universidad de Navarra (CCUN) Pamplona Spain Immunology and Immunotherapy Program. Cima Universidad de Navarra. IdiSNA. Pamplona Spain Center for Data Science and Artificial Intelligence Institute (DATAI) Universidad de Navarra Pamplona Pamplona Spain Hematology and Cell Therapy Department Clinica Universidad de Navarra IdiSNA Pamplona Spain Centro de Investigación Biomedica en Red de Cancer (CIBERONC) Madrid Spain
Hematologic toxicity, specifically prolonged cytopenia, is a common side effect associated with CAR-T therapies, being particularly severe in patients with relapsed/refractory Multiple Myeloma (MM) (1). However, to da...
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CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors
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Cellular & Molecular Immunology 2024年 第10期21卷 1089-1108页
作者: Lei Peng Giacomo Sferruzza Luojia Yang Liqun Zhou Sidi Chen Department of Genetics Yale University School of MedicineNew HavenCTUSA System Biology Institute Yale UniversityWest HavenCTUSA Combined Program in the Biological and Biomedical Sciences Yale UniversityNew HavenCTUSA Molecular Cell Biology Geneticsand Development ProgramYale UniversityNew HavenCTUSA Immunobiology Program Yale UniversityNew HavenCTUSA Yale Comprehensive Cancer Center Yale University School of MedicineNew HavenCTUSA Department of Neurosurgery Yale University School of MedicineNew HavenCTUSA Yale Stem Cell Center Yale University School of MedicineNew HavenCTUSA Yale Liver Center Yale University School of MedicineNew HavenCTUSA Yale Center for Biomedical Data Science Yale University School of MedicineNew HavenCTUSA Yale Center for RNA Science and Medicine Yale University School of MedicineNew HavenCTUSA
In the past decade,chimeric antigen receptor(CAR)-T cell therapy has emerged as a promising immunotherapeutic approach for combating cancers,demonstrating remarkable efficacy in relapsed/refractory hematological malig... 详细信息
来源: 评论
Deep-learning triage of 3D pathology data for improved disease detection while reducing pathologist workloads
Deep-learning triage of 3D pathology data for improved disea...
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Microscopy Histopathology and Analytics, Microscopy 2024 - Part of Optica Biophotonics Congress: Biomedical Optics
作者: Gao, Gan Wang, Fiona Brenes, David Song, Andrew H. Chow, Sarah S.L. Mahmood, Faisal Liu, Jonathan T.C. Department of Mechanical Engineering University of Washington SeattleWA98195 United States Department of Computer Science University of Washington SeattleWA98195 United States Department of Pathology Brigham and Women's Hospital Harvard Medical School BostonMA02115 United States Department of Pathology Massachusetts General Hospital Harvard Medical School BostonMA02114 United States Cancer Program Broad Institute of Harvard and MIT CambridgeMA02142 United States Data Science Program Dana-Farber Cancer Institute BostonMA02215 United States Department of Bioengineering University of Washington SeattleWA98195 United States Department of Laboratory Medicine & Pathology University of Washington School of Medicine SeattleWA98195 United States
3D pathology can potentially improve disease detection, but the datasets are too large to review. We're developing a deep-learning-based triage method to identify the highest-risk 2D sections within 3D pathology d... 详细信息
来源: 评论
BENCHMARKING COMMUNITY DRUG RESPONSE PREDICTION MODELS: dataSETS, MODELS, TOOLS, AND METRICS FOR CROSS-dataSET GENERALIZATION ANALYSIS
arXiv
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arXiv 2025年
作者: Partin, Alexander Vasanthakumari, Priyanka Narykov, Oleksandr Wilke, Andreas Koussa, Natasha Jones, Sara E. Zhu, Yitan Overbeek, Jamie C. Jain, Rajeev Fernando, Gayara Demini Sanchez-Villalobos, Cesar Garcia-Cardona, Cristina Mohd-Yusof, Jamaludin Chia, Nicholas Wozniak, Justin M. Ghosh, Souparno Pal, Ranadip Brettin, Thomas S. Weil, M. Ryan Stevens, Rick L. Division of Data Science and Learning Argonne National Laboratory LemontIL United States Frederick National Laboratory for Cancer Research Cancer Data Science Initiatives Cancer Research Technology Program FrederickMD United States Department of Statistics University of Nebraska–Lincoln LincolnNE United States Department of Electrical & Computer Engineering Texas Tech University LubbockTX United States Division of Computer Computational and Statistical Sciences Los Alamos National Laboratory Los AlamosNM United States Department of Computer Science The University of Chicago ChicagoIL United States
Deep learning (DL) and machine learning (ML) models have shown promise in drug response prediction (DRP), yet their ability to generalize across datasets remains an open question, raising concerns about their real-wor... 详细信息
来源: 评论
Through the Lens of Patient Partners: Challenges in Accrual of Older Adults to NCI Clinical Trials
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Journal of the National cancer Institute - Monographs 2022年 第60期2022卷 125-134页
作者: BrintzenhofeSzoc, Karlynn Canin, Beverly Casas-Silva, Esmeralda Denicoff, Andrea Braun-Inglis, Christa Okado, Izumi Bakos, Alexis Oncology Social Work Kent School of Social Work University of Louisville Louisville KY United States SCOREboard Patient Advocate Board The Cancer and Aging Research Group United States Center for Biomedical Informatics and Information Technology Informatics and Data Science Program National Institutes of Health National Cancer Institute Rockville MD United States Division of Cancer Treatment and Diagnosis Cancer Therapy and Evaluation Program National Institutes of Health National Cancer Institute Rockville MD United States Clinical Faculty UH Nancy Atmospera-Walch School of Nursing University of Hawaii Cancer Center Hawaii M U NCORP Honolulu HI United States University of HawaiiCancer Center Honolulu HI United States Division of Cancer Prevention Community Oncology and Prevention Trials Research Group National Institutes of Health National Cancer Institute Rockville MD United States
The workshop “Engaging Older Adults in cancer Clinical Trials Conducted in the NCI Clinical Trials Network: Challenges and Opportunities” included a Patient Stakeholder Workgroup that explored the needs and concerns...
来源: 评论
APIR:Aggregating Universal Proteomics database Search Algorithms for Peptide Identification with FDR Control
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Genomics, Proteomics & Bioinformatics 2024年 第2期22卷 171-187页
作者: Yiling Elaine Chen Xinzhou Ge Kyla Woyshner MeiLu McDermott Antigoni Manousopoulou Scott B.Ficarro Jarrod A.Marto Kexin Li Leo David Wang Jingyi Jessica Li Department of Statistics and Data Science University of CaliforniaLos AngelesCA 90095USA Department of Immuno-Oncology Beckman Research InstituteCity of Hope National Medical CenterDuarteCA 91010USA Department of Quantitative and Computational Biology University of Southern CaliforniaLos AngelesCA 90089USA Department of Cancer Biology and Blais Proteomics Center Dana-Farber Cancer InstituteDepartment of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02215USA Department of Pediatrics City of Hope National Medical CenterDuarteCA 91010USA Bioinformatics Interdepartmental Program University of CaliforniaLos AngelesCA 90095USA Department of Human Genetics University of CaliforniaLos AngelesCA 90095USA Department of Computational Medicine University of CaliforniaLos AngelesCA 90095USA Department of Biostatistics University of CaliforniaLos AngelesCA 90095USA
Advances in mass spectrometry(MS)have enabled high-throughput analysis of proteomes in biological *** state-of-the-art MS data analysis relies on database search algorithms to quantify proteins by identifying peptide... 详细信息
来源: 评论