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检索条件"机构=Cancer Data Science Program"
253 条 记 录,以下是11-20 订阅
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The exposome and pancreatic cancer, lifestyle and environmental risk factors for PDAC
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Seminars in cancer Biology 2025年 113卷 100-129页
作者: Peduzzi, Giulia Archibugi, Livia Farinella, Riccardo de Leon Pisani, Ruggero Ponz Vodickova, Ludmila Vodicka, Pavel Kraja, Bledar Sainz, Juan Bars-Cortina, David Daniel, Neil Silvestri, Roberto Uysal-Onganer, Pinar Landi, Stefano Dulińska-Litewka, Joanna Comandatore, Annalisa Campa, Daniele Hughes, David J. Rizzato, Cosmeri Department of Biology University of Pisa Pisa Italy Pancreato-Biliary Endoscopy and Endosonography Division Pancreas Translational and Clinical Research Center IRCCS Ospedale San Raffaele Milan Italy Biomedical Center Martin Bioinformatic Center Comenius University in Bratislava Jessenius Faculty of Medicine in Martin Slovakia Faculty of Medicine and Biomedical Center in Pilsen Charles University Pilsen Czech Republic University Clinic of Gastrohepatology University Hospital Center Mother Teresa Tirana Albania Department of Biochemistry and Molecular Biology University of Granada Granada Spain Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP) Madrid 28029 Spain GENYO. Centre for Genomics and Oncological Research. Genomic Oncology department Granada Spain Instituto de Investigación Biosanitaria Ibs.Granada Granada Spain Institut Català d'Oncologia (ICO) IDIBELL Unit of Biomarkers and Susceptibility (UBS) Oncology Data Analytics Program (ODAP) Catalan Institute of Oncology (ICO) L′Hospitalet del Llobregat Barcelona Spain Institut Català d'Oncologia (ICO) IDIBELL ONCOBELL Program Bellvitge Biomedical Research Institute (IDIBELL) L′Hospitalet de Llobregat Barcelona Spain Molecular Epidemiology of Cancer Group UCD Conway Institute School of Biomolecular and Biomedical Science University College Dublin Dublin Ireland Cancer Mechanisms and Biomarkers Research Group School of Life Sciences University of Westminster London United Kingdom Chair of Medical Biochemistry Medical College Jagiellonian University Krakow Poland General Surgery Unit Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa Italy
Pancreatic cancer (PC), particularly pancreatic ductal adenocarcinoma (PDAC), is a significant global health issue with high mortality rates. PDAC, though only 3 % of cancer diagnoses, causes 7 % of cancer deaths due ... 详细信息
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AI-driven 3D Spatial Transcriptomics
arXiv
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arXiv 2025年
作者: Almagro-Pérez, Cristina Song, Andrew H. Weishaupt, Luca Kim, Ahrong Jaume, Guillaume Williamson, Drew F.K. Hemker, Konstantin Lu, Ming Y. Singh, Kritika Chen, Bowen Le, Long Phi Baras, Alexander S. Jiang, Sizun Bashashati, Ali Liu, Jonathan T.C. Mahmood, Faisal Department of Pathology Mass General Brigham Harvard Medical School BostonMA United States Cancer Program Broad Institute of Harvard and MIT CambridgeMA United States Data Science Program Dana-Farber Cancer Institute BostonMA United States Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology CambridgeMA United States Department of Pathology Pusan National University Busan Korea Republic of Department of Pathology and Laboratory Medicine Emory University School of Medicine AtlantaGA United States Department of Computer Science & Technology University of Cambridge Cambridge United Kingdom Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology CambridgeMA United States Rutgers Robert Wood Johnson Medical School New BrunswickNJ United States Department of Pathology Johns Hopkins Hospital BaltimoreMD United States Department of Biomedical Engineering Johns Hopkins Hospital BaltimoreMD United States Broad Institute of Harvard and MIT CambridgeMA United States Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School BostonMA United States Department of Pathology Dana Farber Cancer Institute BostonMA United States Department of Pathology and Laboratory Medicine University of British Columbia VancouverBC Canada School of Biomedical Engineering University of British Columbia VancouverBC Canada Department of Mechanical Engineering Bioengineering Laboratory Medicine & Pathology University of Washington SeattleWA United States Harvard Data Science Initiative Harvard University CambridgeMA United States
A comprehensive three-dimensional (3D) map of tissue architecture and gene expression is crucial for illuminating the complexity and heterogeneity of tissues across diverse biomedical applications1. However, most spat... 详细信息
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Tumor Immunophenotypic Correlates in Patients Aged 80 Years or Older With Non-Small Cell Lung cancer and Outcomes to First-Line Pembrolizumab in PD-L1 High (≥50%) Patients
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Clinical Lung cancer 2025年 第4期26卷 288-298.e8页
作者: Barrichello, Adriana P.C. Elkrief, Arielle Ricciuti, Biagio Ganta, Teja Marron, Thomas U. Wang, Xinan Lotter, William Lindsay, James Santo, Valentina Cortellini, Alessio Sharma, Bijaya Felt, Kristen Pfaff, Kathleen Lamberti, Giuseppe Pecci, Federica Federico, Alessandro Di Makarem, Maisam Gandhi, Malini M. Nguyen, Tom Haradon, Danielle Vaz, Victor R. Johnson, Bruce E. Debnath, Neha Wang, Yinghong Kuang, Andrew G. Saeed, Anwaar Radford, Maluki Lovly, Christine M. Nebhan, Caroline A. Pinato, David J. Rodig, Scott J. Schoenfeld, Adam J. Awad, Mark M. Alessi, Joao V. Naqash, Abdul Rafeh Lowe Center for Thoracic Oncology Dana-Farber Cancer Institute Boston MA United States Thoracic Oncology Center Memorial Sloan Kettering Cancer Center New York NY United States Tisch Cancer Institute Icahn School of Medicine at Mount Sinai New York NY United States Department of Environmental Health Harvard T.H. Chan School of Public Health Harvard University Boston MA United States Department of Data Science Dana-Farber Cancer Institute Boston MA United States Department of Surgery and Cancer Imperial College London Faculty of Medicine Hammersmith Hospital London United Kingdom ImmunoProfile Brigham and Women's Hospital and Dana-Farber Cancer Institute Boston MA United States Center for Immuno-oncology Dana-Farber Cancer Institute Boston MA United States Department of Gastroenterology Hepatology & Nutrition University of Texas MD Anderson Cancer Center Houston TX United States Department of Internal Medicine Baylor College of Medicine Houston TX United States Division of Medical Oncology Department of Medicine Kansas University Medical Center Westwood KS United States Department of Medicine and Vanderbilt-Ingram Cancer Center Vanderbilt University Nashville TN United States Department of Pathology Brigham and Women's Hospital Boston MA United States Medical Oncology/TSET Phase 1 Program Stephenson Cancer Center University of Oklahoma Oklahoma City OK United States
Background: Non-small cell lung cancer (NSCLC) patients aged ≥80 years [y] are underrepresented in clinical trials. We evaluated whether age correlates with a distinct immunophenotype or impacts outcomes to first-lin... 详细信息
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Expression of HLA-B35 Is Associated with an Increased Risk of CMV Viremia and Clinically Significant CMV Infection in Patients Receiving Ptcy-Based Hematopoietic Cell Transplantation
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Transplantation and Cellular Therapy 2025年 第2期31卷 S519-S519页
作者: Little, Jessica S., MD Hebert, Kyle, MS Neuberg, Donna, ScD Nikiforow, Sarah, MD, PhD Gooptu, Mahasweta, MD Shapiro, Roman M., MD Koreth, John, MBBS, DPhil Antin, Joseph H., MD Cutler, Corey S., MD MPH Soiffer, Robert J., MD Ritz, Jerome, MD Romee, Rizwan, MD Ho, Dr. Vincent T., MD Issa, Nicolas, M.D. Baden, Lindsey, MD Dulery, Remy, MD, PhD Prockop, Susan E., MD Division of Stem Cell Transplantation and Cellular Therapy Dana-Farber Cancer Institute and Harvard Medical School Boston MA Division of Infectious Diseases Brigham and Women's Hospital Boston MA Department of Data Science Dana-Farber Cancer Institute Boston MA Department of Data Science Dana Farber Cancer Institute Boston MA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA Department of Medical Oncology Dana-Farber Cancer Institute and Harvard Medical School Boston MA Dana-Farber Cancer Institute Boston MA Division of Stem Cell Transplant and Cellular Therapy Dana-Farber Cancer Institute and Harvard Medical School Boston MA Hematopoietic Stem Cell Transplant Program Dana Farber Cancer Institute Boston Children's Hospital and Harvard Medical School Boston MA
IntroductionHematopoietic cell transplant (HCT) with post-transplant cyclophosphamide (PTCy) for graft-versus-host disease (GvHD) prophylaxis carries a higher risk of cytomegalovirus (CMV) infections despite letermovi...
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Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial
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The Lancet Oncology 2025年 第5期26卷 559-570页
作者: Lou, Emil Choudhry, Modassir S Starr, Timothy K Folsom, Timothy D Bell, Jason Rathmann, Blaine DeFeo, Anthony P Kim, Jihyun Slipek, Nicholas Jin, Zhaohui Sumstad, Darin Klebanoff, Christopher A Ladner, Katherine Sarkari, Akshat McIvor, R Scott Murray, Thomas A Miller, Jeffrey S Rao, Madhuri Jensen, Eric Ankeny, Jacob Khalifa, Mahmoud A Chauhan, Anil Spilseth, Benjamin Dixit, Ajay Provenzano, Paolo P Pan, Wenjing Weber, Daniel Byrne-Steele, Miranda Henley, Tom McKenna, David H Johnson, Matthew J Webber, Beau R Moriarity, Branden S Department of Medicine Division of Hematology Oncology and Transplantation University of Minnesota Minneapolis MN United States Department of Obstetrics Gynecology and Women's Health University of Minnesota Minneapolis MN United States Department of Pediatrics University of Minnesota Minneapolis MN United States Masonic Cancer Center University of Minnesota Minneapolis MN United States Center for Genome Engineering University of Minnesota Minneapolis MN United States Department of Genetics Cell Biology and Development University of Minnesota Minneapolis MN United States Department of Biomedical Engineering University of Minnesota Minneapolis MN United States Center for Multiparametric Imaging of Tumor Immune Microenvironments University of Minnesota Minneapolis MN United States Stem Cell Institute University of Minnesota Minneapolis MN United States Intima Bioscience New York NY United States Deparment of Medical Oncology Mayo Clinic Rochester MN United States Cell Therapy Clinical Laboratory University of Minnesota Medical School Minneapolis MN United States Division of Biostatistics and Health Data Science University of Minnesota Medical School Minneapolis MN United States Department of Surgery University of Minnesota Medical School Minneapolis MN United States Department of Laboratory Medicine and Pathology University of Minnesota Medical School Minneapolis MN United States Department of Radiology University of Minnesota Medical School Minneapolis MN United States Department of Medicine Human Oncology and Pathogenesis Program and Parker Institute for Cancer Immunotherapy Memorial Sloan Kettering Cancer Center New York NY United States Department of Radiology University of Kansas Medical Center Kansas City KS United States Division of Gastroenterology Hepatology and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati OH United States iRepertoire Huntsville AL United States
Background: Over the past decade, immunotherapeutic strategies—mainly targeting the PD-1–PD-L1 immune checkpoint axis—have altered cancer treatment for many solid tumours, but few patients with gastrointestinal for...
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Correction to: Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy (Nature Biotechnology, (2025), 10.1038/s41587-024-02535-2)
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Nature Biotechnology 2025年
作者: Zhang, Feifei Chow, Ryan D. He, Emily Dong, Chuanpeng Xin, Shan Mirza, Daniyal Feng, Yanzhi Tian, Xiaolong Verma, Nipun Majety, Medha Zhang, Yueqi Wang, Guangchuan Chen, Sidi Department of Genetics Yale University School of Medicine New HavenCT United States System Biology Institute Yale University West HavenCT United States Center for Cancer Systems Biology Yale University West HavenCT United States M.D.–Ph.D. Program Yale University West HavenCT United States Molecular Cell Biology Genetics and Development Program Yale University New HavenCT United States Yale College New HavenCT United States Immunobiology Program Yale University New HavenCT United States Department of Therapeutic Radiology Yale University School of Medicine New HavenCT United States Department of Neurosurgery Yale University School of Medicine New HavenCT United States Yale Comprehensive Cancer Center Yale University School of Medicine New HavenCT United States Yale Stem Cell Center Yale University School of Medicine New HavenCT United States Yale Center for Biomedical Data Science Yale University School of Medicine New HavenCT United States Key Laboratory of Multi-Cell Systems Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Shanghai China
Correction to: Nature Biotechnologyhttps://***/10.1038/s41587-024-02535-2, published online 16 January 2025. In the version of the article initially published, Sidi Chen was incorrectly associated with a present addre...
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High-resolution dynamic imaging of chromatin DNA communication using Oligo-LiveFISH
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Cell 2025年
作者: Zhu, Yanyu Balaji, Ashwin Han, Mengting Andronov, Leonid Roy, Anish R. Wei, Zheng Chen, Crystal Miles, Leanne Cai, Sa Gu, Zhengxi Tse, Ariana Yu, Betty Chentzu Uenaka, Takeshi Lin, Xueqiu Spakowitz, Andrew J. Moerner, W.E. Qi, Lei S. Department of Bioengineering Stanford University Stanford 94305 CA United States Department of Chemistry Stanford University Stanford 94305 CA United States Biophysics PhD Program Stanford University Stanford 94305 CA United States Computational Biology Program Public Health Sciences Division and Translational Data Science IRC Fred Hutchinson Cancer Center Seattle 98109 WA United States Department of Chemical Engineering Stanford University Stanford 94305 CA United States Department of Materials Science and Engineering Stanford University Stanford 94305 CA United States Institute for Stem Cell Biology & Regenerative Medicine and Department of Pathology Stanford University School of Medicine Stanford 94305 CA United States Sarafan ChEM-H Stanford University Stanford 94305 CA United States Chan Zuckerberg Biohub San Francisco 94080 CA United States
Three-dimensional (3D) genome dynamics are crucial for cellular functions and disease. However, real-time, live-cell DNA visualization remains challenging, as existing methods are often confined to repetitive regions,... 详细信息
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The dynamic immune behavior of primary and metastatic ovarian carcinoma
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npj Precision Oncology 2025年 第1期9卷 1-12页
作者: Stur, Elaine Peng, Fuduan Teng, Pang-Ning Bayraktar, Emine Hu, Min Corvigno, Sara Brown, David J. Lee, Sanghoon Moore, Kathleen N. Bateman, Nicholas W. Darcy, Kathleen M. Maxwell, George L. P. Conrads, Thomas Sahni, Nidhi Vázquez-García, Ignacio Shah, Sohrab P. Celestino, Joseph D. Fleming, Nicole Navin, Nicholas E. Wang, Linghua Sood, Anil K. Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston TX United States Department of Genomic Medicine The University of Texas MD Anderson Cancer Center Houston TX United States Gynecologic Cancer Center of Excellence The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. Walter Reed National Military Medical Center Bethesda 20889 MD United States Department of Gynecologic Surgery and Obstetrics Uniformed Services University of the Health Sciences Walter Reed National Military Medical Center Bethesda MD United States Department of Genetics The University of Texas MD Anderson Cancer Center Houston TX United States Obstetrics and Gynecology Stephenson Cancer Center Stephenson Cancer Center at the University of Oklahoma Health Sciences Center/Sarah Cannon Research Institute Oklahoma City OK United States Women’s Health Integrated Research Center Women’s Service Line Inova Health System Falls Church VA United States Department of Epigenetics and Molecular Carcinogenesis The University of Texas MD Anderson Cancer Center Baylor College of Medicine Houston TX United States Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center Houston TX United States Quantitative and Computational Biosciences Program Baylor College of Medicine Houston TX United States Computational Oncology Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY United States The Halvorsen Center for Computational Oncology Memorial Sloan Kettering Cancer Center Boston MA United States Irving Institute for Cancer Dynamics Columbia University Cambridge 10027 MA United States Department of Systems Biology The University of Texas MD Anderson Cancer Center Houston MA United States The James P. Allison Institute The University of Texas MD Anderson Cancer Center Houston 77030 TX United States The Institute for Data Sc
Patients with high-grade serous ovarian carcinoma (HGSC) are usually diagnosed with advanced-stage disease, and the tumors often have immunosuppressive characteristics. Together, these factors are important for diseas...
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A decomposition of Fisher’s information to inform sample size for developing fair and precise clinical prediction models - Part 2: time-to-event outcomes
arXiv
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arXiv 2025年
作者: Riley, Richard D. Collins, Gary S. Archer, Lucinda While, Rebecca Legha, Amardeep Kirton, Laura Dhiman, Paula Sadatsafavi, Mohsen Adderley, Nicola J. Alderman, Joseph MarGn, Glen P. Ensor, Joie Department of Applied Health Sciences School of Health Sciences College of Medicine and Health University of Birmingham Birmingham United Kingdom Birmingham Biomedical Research Centre Birmingham United Kingdom Centre for Sta?s?cs in Medicine Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences University of Oxford OxfordOX3 7LD United Kingdom Cancer Research UK Clinical Trials Unit Ins?tute of Cancer and Genomic Sciences College of Medical and Dental Sciences University of Birmingham Birmingham United Kingdom Respiratory Evalua?on Sciences Program Faculty of Pharmaceu?cal Sciences The University of Bri?sh Columbia Vancouver Canada Ins?tute of Inflamma?on and Ageing College of Medicine and Health University of Birmingham Birmingham United Kingdom Queen Elizabeth Hospital University Hospitals Birmingham NHS Founda?on Trust Birmingham United Kingdom Division of Informatics Imaging and Data Science Faculty of Biology Medicine and Health University of Manchester Manchester Academic Health Science Centre Manchester United Kingdom
Background When developing a clinical predicGon model using Gme-to-event data (i.e., with censoring and different lengths of follow-up), previous research focuses on the sample size needed to minimise overfifng and pr... 详细信息
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Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences (vol 108, pg 5626, 2011)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF scienceS OF THE UNITED STATES OF AMERICA 2011年 第37期108卷 15535-15535页
作者: Tao, Yongguang Xi, Sichuan Shan, Jigui Maunakea, Alika Che, Anney Briones, Victorino Lee, Eunice Y. Geiman, Theresa Huang, Jiaqiang Stephens, Robert Leighty, Robert M. Zhao, Keji Muegge, Kathrin [a]Basic Science Program Laboratory of Cancer Prevention [b]Advanced Biomedical Computing Center and [d]Data Management Services Science Applications International Corporation Frederick Inc. National Cancer Institute Frederick Frederick MD 21702 and [c]Laboratory of Molecular Immunology National Heart Lung and Blood Institute National Institutes of Health Bethesda MD 20817
DNA methylation is critical for normal development and plays important roles in genome organization and transcriptional regulation. Although DNA methyltransferases have been identified, the factors that establish and ... 详细信息
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