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检索条件"机构=Cancer Data Science Program"
252 条 记 录,以下是31-40 订阅
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Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants (Vol 15, 2742, 2024)
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NATURE COMMUNICATIONS 2024年 第1期15卷 1-18页
作者: Hayes, Tikvah K. Aquilanti, Elisa Persky, Nicole S. Yang, Xiaoping Kim, Erica E. Brenan, Lisa Goodale, Amy B. Alan, Douglas Sharpe, Ted Shue, Robert E. Westlake, Lindsay Golomb, Lior Silverman, Brianna R. Morris, Myshal D. Fisher, Ty Running Beyene, Eden Li, Yvonne Y. Cherniack, Andrew D. Piccioni, Federica Hicks, J. Kevin Chi, Andrew S. Cahill, Daniel P. Dietrich, Jorg Batchelor, Tracy T. Root, David E. Johannessen, Cory M. Meyerson, Matthew Department of Medical Oncology Dana-Farber Cancer Institute & Harvard Medical School Boston MA USA Cancer Program The Broad Institute of M.I.T. and Harvard Cambridge MA USA Genetic Perturbation Platform The Broad Institute of M.I.T. and Harvard Cambridge MA USA Data Science Platform The Broad Institute of M.I.T. and Harvard Cambridge Cambridge MA USA Summer Honors Undergraduate Research Program Harvard Medical School Boston MA USA Department of Pathology H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA Center for Neuro-Oncology Division of Neuro-Oncology Massachusetts General Hospital Boston MA USA Department of Neurology Division of Neuro-Oncology Massachusetts General Hospital Boston MA USA Department of Neurology Brigham and Women’s Hospital & Harvard Medical School Boston MA USA
The epidermal growth factor receptor, EGFR, is frequently activated in lung cancer and glioblastoma by genomic alterations including missense mutations. The different mutation spectra in these diseases are reflected i...
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Development,validation,and transportability of several machine-learned,non-exercise-based VO_(2max)prediction models for older adults
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Journal of Sport and Health science 2024年 第5期13卷 611-620页
作者: Benjamin T.Schumacher Michael J.LaMonte Andrea Z.LaCroix Eleanor M.Simonsick Steven P.Hooker Humberto Parada Jr. John Bellettiere Arun Kumar Herbert Wertheim School of Public Health and Human Longevity Science University of California San DiegoLa JollaCA 92093USA Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego Moores Cancer Center La JollaCA 92093USA Computer Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA
Background:There exist few maximal oxygen uptake(VO_(2max))non-exercise-based prediction equations,fewer using machine learning(ML),and none specifically for older *** direct measurement of VO_(2max)is infeasible in l... 详细信息
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ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis (vol 53, pg 403, 2021)
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NATURE GENETICS 2021年 第6期53卷 935-935页
作者: Granja, Jeffrey M. Corces, M. Ryan Pierce, Sarah E. Bagdatli, S. Tansu Choudhry, Hani Chang, Howard Y. Greenleaf, William J. Department of Genetics Stanford University School of Medicine Stanford CA USA Program in Biophysics Stanford University Stanford CA USA Center for Personal Dynamic Regulomes Stanford University Stanford CA USA Department of Pathology Stanford University School of Medicine Stanford CA USA Gladstone Institute of Neurological Disease Gladstone Institute of Data Science and Biotechnology San Francisco CA USA Department of Neurology University of California San Francisco San Francisco CA USA Program in Cancer Biology Stanford University School of Medicine Stanford CA USA Department of Biochemistry Faculty of Science Cancer and Mutagenesis Unit King Fahd Center for Medical Research King Abdulaziz University Jeddah Saudi Arabia Howard Hughes Medical Institute Stanford University Stanford CA USA Department of Applied Physics Stanford University Stanford CA USA Chan Zuckerberg Biohub San Francisco CA USA
The advent of single-cell chromatin accessibility profiling has accelerated the ability to map gene regulatory landscapes but has outpaced the development of scalable software to rapidly extract biological meaning fro... 详细信息
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Fast and scalable image search for histology
arXiv
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arXiv 2021年
作者: Chen, Chengkuan Lu, Ming Y. Williamson, Drew F.K. Chen, Tiffany Y. Schaumberg, Andrew J. Mahmood, Faisal Department of Pathology Brigham and Women's Hospital Harvard Medical School BostonMA United States Cancer Program Broad Institute of Harvard and Mit CambridgeMA United States Cancer Data Science Dana-Farber Cancer Institute BostonMA United States
The expanding adoption of digital pathology has enabled the curation of large repositories of histology whole slide images (WSIs), which contain a wealth of information. Similar pathology image search offers the oppor... 详细信息
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Impact of Molecular Ontogeny on Hematological Recovery in AML Patients Treated with Hypomethylating Agent Plus Venetoclax Therapy
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Blood 2024年 144卷 5175-5175页
作者: Josh Zhang Shai O. Shimony Yiwen Liu Eno Inyang Evan C. Chen Luis E. Aguirre Rebecca P. Bystrom Benjamin Rolles Richard M. Stone Daniel J. DeAngelo Emily Tiao Maximilian Stahl Department of Pharmacy Dana-Farber Cancer Institute Boston MA Adult Leukemia Program Dana-Farber Cancer Institute Boston MA Data Science Dana-Farber Cancer Institute Boston MA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA Dana-Farber Cancer Institute Boston MA
Introduction : Therapy with hypomethylating agents (HMA) plus venetoclax (VEN) is approved for patients (pts) unfit to receive intensive chemotherapy in newly diagnosed acute myeloid leukemia (AML). However, many pts ...
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Novel strategy for disease risk prediction incorporating predicted gene expression and DNA methylation data:a multi-phased study of prostate cancer
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cancer Communications 2021年 第12期41卷 1387-1397页
作者: Chong Wu Jingjing Zhu Austin King Xiaoran Tong Qing Lu Jong Y.Park Liang Wang Guimin Gao Hong-Wen Deng Yaohua Yang Karen E.Knudsen Timothy R.Rebbeck Jirong Long Wei Zheng Wei Pan David V.Conti Christopher A Haiman Lang Wu Department of Statistics Florida State UniversityTallahasseeFL 32304USA Cancer Epidemiology Division Population Sciences in the Pacific ProgramUniversity of Hawaii Cancer CenterUniversity of Hawaii at ManoaHonoluluHI 96813USA Department of Epidemiology and Biostatistics Michigan State UniversityEast LansingMI 48824USA Department of Biostatistics University of FloridaGainesvilleFL 32603USA Department of Cancer Epidemiology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612USA Department of Tumor Biology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612USA Department of Public Health Sciences University of ChicagoChicagoIL 60637USA Center of Bioinformatics and Genomics Department of Global Biostatistics and Data ScienceTulane UniversityNew OrleansLA 70112USA Division of Epidemiology Department of MedicineVanderbilt Epidemiology CenterVanderbilt-Ingram Cancer CenterVanderbilt University Medical CenterNashvilleTN 37203USA Department of Cancer Biology Sidney Kimmel Cancer CenterThomas Jefferson UniversityPhiladelphiaPA 19107USA Department of Medical Oncology Dana-Farber Cancer InstituteBostonMA 02215USA Department of Epidemiology Harvard TH Chan School of Public HealthBostonMA 02115USA Division of Biostatistics University of MinnesotaMinneapolisMN 55455USA Department of Preventive Medicine Keck School of MedicineUniversity of Southern California/Norris Comprehensive Cancer CenterLos AngelesCA 90033USA
Background:DNA methylation and gene expression are known to play important roles in the etiology of human diseases such as prostate cancer(PCa).However,it has not yet been possible to incorporate information of DNA me... 详细信息
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Polygenic risk modeling for prediction of epithelial ovarian cancer risk (vol 30, pg 349, 2021)
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EUROPEAN JOURNAL OF HUMAN GENETICS 2022年 第5期30卷 630-631页
作者: Dareng, Eileen O. Tyrer, Jonathan P. Barnes, Daniel R. Jones, Michelle R. Yang, Xin Aben, Katja K. H. Adank, Muriel A. Agata, Simona Andrulis, Irene L. Anton-Culver, Hoda Antonenkova, Natalia N. Aravantinos, Gerasimos Arun, Banu K. Augustinsson, Annelie Balmana, Judith Bandera, Elisa V. Barkardottir, Rosa B. Barrowdale, Daniel Beckmann, Matthias W. Beeghly-Fadiel, Alicia Benitez, Javier Bermisheva, Marina Bernardini, Marcus Q. Bjorge, Line Black, Amanda Bogdanova, Natalia V. Bonanni, Bernardo Borg, Ake Brenton, James D. Budzilowska, Agnieszka Butzow, Ralf Buys, Saundra S. Cai, Hui Caligo, Maria A. Campbell, Ian Cannioto, Rikki Cassingham, Hayley Chang-Claude, Jenny Chanock, Stephen J. Chen, Kexin Chiew, Yoke-Eng Chung, Wendy K. Claes, Kathleen B. M. Colonna, Sarah Cook, Linda S. Couch, Fergus J. Daly, Mary B. Dao, Fanny Davies, Eleanor de la Hoya, Miguel de Putter, Robin Dennis, Joe DePersia, Allison Devilee, Peter Diez, Orland Ding, Yuan Chun Doherty, Jennifer A. Domchek, Susan M. Dork, Thilo du Bois, Andreas Durst, Matthias Eccles, Diana M. Eliassen, Heather A. Engel, Christoph Evans, Gareth D. Fasching, Peter A. Flanagan, James M. Fortner, Renee T. Machackova, Eva Friedman, Eitan Ganz, Patricia A. Garber, Judy Gensini, Francesca Giles, Graham G. Glendon, Gord Godwin, Andrew K. Goodman, Marc T. Greene, Mark H. Gronwald, Jacek Hahnen, Eric Haiman, Christopher A. Hakansson, Niclas Hamann, Ute Hansen, Thomas V. O. Harris, Holly R. Hartman, Mikael Heitz, Florian Hildebrandt, Michelle A. T. Hogdall, Estrid Hogdall, Claus K. Hopper, John L. Huang, Ruea-Yea Huff, Chad Hulick, Peter J. Huntsman, David G. Imyanitov, Evgeny N. Isaacs, Claudine Jakubowska, Anna James, Paul A. Janavicius, Ramunas Jensen, Allan Johannsson, Oskar Th. John, Esther M. Jones, Michael E. Kang, Daehee Karlan, Beth Y. Karnezis, Anthony Kelemen, Linda E. Khusnutdinova, Elza Kiemeney, Lambertus A. Kim, Byoung-Gie Kjaer, Susanne K. Komenaka, Ian Kupryjanczyk, Jolanta Kurian, Allison W. Kwong, Ava Lambrechts, Diether Larson, Melissa C. Lazaro, Conxi L University of Cambridge Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care Cambridge UK University of Cambridge Centre for Cancer Genetic Epidemiology Department of Oncology Cambridge UK Center for Bioinformatics and Functional Genomics Cedars-Sinai Medical Center Los Angeles CA USA Radboud University Medical Center Radboud Institute for Health Sciences Nijmegen The Netherlands Netherlands Comprehensive Cancer Organisation Utrecht The Netherlands The Netherlands Cancer Institute—Antoni van Leeuwenhoek hospital Family Cancer Clinic Amsterdam The Netherlands Veneto Institute of Oncology IOV—IRCCS Immunology and Molecular Oncology Unit Padua Italy Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital Fred A. Litwin Center for Cancer Genetics Toronto ON Canada University of Toronto Department of Molecular Genetics Toronto ON Canada University of California Irvine Department of Epidemiology Genetic Epidemiology Research Institute Irvine CA USA N.N. Alexandrov Research Institute of Oncology and Medical Radiology Minsk Belarus ‘Agii Anargiri’ Cancer Hospital Athens Greece University of Texas MD Anderson Cancer Center Department of Breast Medical Oncology Houston TX USA Lund University Department of Cancer Epidemiology Clinical Sciences Lund Sweden Vall d’Hebron Institute of Oncology Hereditary cancer Genetics Group Barcelona Spain University Hospital of Vall d’Hebron Department of Medical Oncology Barcelona Spain Rutgers Cancer Institute of New Jersey Cancer Prevention and Control Program New Brunswick NJ USA Landspitali University Hospital Department of Pathology Reykjavik Iceland University of Iceland BMC (Biomedical Centre) Faculty of Medicine Reykjavik Iceland University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg Department of Gynecology and Obstetrics Comprehensive Cancer Center ER-EMN Erlangen Germany Vanderbilt University School of Medicine Division of Epidemiology Department
Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive pe... 详细信息
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graph-GPA 2.0: A Graphical Model for Multi-disease Analysis of GWAS Results with Integration of Functional Annotation data
arXiv
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arXiv 2022年
作者: Deng, Qiaolan Nam, Jin Hyun Yilmaz, Ayse Selen Chang, Won Pietrzak, Maciej Li, Lang Kim, Hang J. Chung, Dongjun The Interdisciplinary PhD program in Biostatistics The Ohio State University ColumbusOH United States Division of Big Data Science Korea University Sejong Campus Sejong Korea Republic of Department of Biomedical Informatics The Ohio State University ColumbusOH United States Division of Statistics and Data Science University of Cincinnati CincinnatiOH United States Pelotonia Institute for Immuno-Oncology The James Comprehensive Cancer Center The Ohio State University ColumbusOH United States
Motivation: Genome-wide association studies (GWAS) have successfully identified a large number of genetic variants associated with traits and diseases. However, it still remains challenging to fully understand functio...
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Wait, but Tylenol is Acetaminophen… Investigating and Improving Language Models' Ability to Resist Requests for Misinformation
arXiv
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arXiv 2024年
作者: Chen Gao, Mingye Sasse, Kuleen Hartvigsen, Tom Anthony, Brian Fan, Lizhou Aerts, Hugo Gallifant, Jack Bitterman, Danielle Program Mass General Brigham Harvard Medical School BostonMA United States Department of Radiation Oncology Brigham and Women’s Hospital Dana-Farber Cancer Institute BostonMA United States Computational Health Informatics Program Boston Children’s Hospital Harvard Medical School BostonMA United States Massachusetts Institute of Technology CambridgeMA United States Johns Hopkins University BaltimoreMD United States Department of Data Science University of Virginia CharlottesvilleVA United States Radiology and Nuclear Medicine GROW & CARIM Maastricht University Netherlands
Background: Large language models (LLMs) are trained to follow directions, but this introduces a vulnerability to blindly comply with user requests even if they generate wrong information. In medicine, this could acce...
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Correction: Spatial organization of B lymphocytes and prognosis prediction in patients with gastric cancer
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Gastric cancer : official journal of the International Gastric cancer Association and the Japanese Gastric cancer Association 2025年 2025 May 16页
作者: Ryan Yong Kiat Tay Manavi Sachdeva Haoran Ma Young-Woo Kim Myeong-Cherl Kook Hyunki Kim Jae-Ho Cheong Lindsay C Hewitt Katharina Nekolla Günter Schmidt Takaki Yoshikawa Takashi Oshima Tomio Arai Supriya Srivastava Ming Teh Xuewen Ong Su Ting Tay Taotao Sheng Joseph J Zhao Patrick Tan Heike I Grabsch Raghav Sundar Yong Loo Lin School of Medicine National University of Singapore 1E Kent Ridge Road Singapore 119228 Singapore. Department of Haematology-Oncology National University Cancer Institute National University Hospital Singapore Singapore. Cancer and Stem Cell Biology Program Duke-NUS Medical School Singapore Singapore. Department of Cancer Policy and Population Health National Cancer Center Graduate School of Cancer Science and Policy and Center for Gastric Cancer and Department of Surgery National Cancer Center Goyang Republic of Korea. Center for Gastric Cancer Department of Pathology National Cancer Center Goyang Republic of Korea. Department of Pathology Yonsei University College of Medicine Seoul Republic of Korea. Department of Surgery Yonsei University College of Medicine Seoul Republic of Korea. Department of Pathology GROW Research Institute for Oncology and Reproduction Maastricht University Medical Center+ Maastricht The Netherlands. Department of Precision Medicine GROW School for Oncology and Reproduction Maastricht University Center+ Maastricht The Netherlands. Computational Pathology Oncology R&D AstraZeneca Munich Germany. Department of Surgery Kanagawa Cancer Center Yokohama Japan. Department of Surgery Yokohama City University Yokohama Japan. Department of Surgery Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan. Department of Pathology Tokyo Metropolitan Institute for Geriatrics and Gerontology Tokyo Japan. Department of Medicine National University of Singapore Singapore Singapore. Department of Pathology National University Hospital Singapore Singapore. Genome Institute of Singapore Agency for Science Technology and Research Singapore Singapore. Cancer Science Institute of Singapore National University of Singapore Singapore Singapore. Cellular and Molecular Research National Cancer Centre Singapore Singapore. Singhealth/Duke-NUS Institute of Precision Medicine National Heart Centre Singapore
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