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Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

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Nature communications 2021年第1期12卷 2986页

作者： Juliette Coignard Michael Lush Jonathan Beesley Tracy A O'Mara Joe Dennis Jonathan P Tyrer Daniel R Barnes Lesley McGuffog Goska Leslie Manjeet K Bolla Muriel A Adank Simona Agata Thomas Ahearn Kristiina Aittomäki Irene L Andrulis Hoda Anton-Culver Volker Arndt Norbert Arnold Kristan J Aronson Banu K Arun Annelie Augustinsson Jacopo Azzollini Daniel Barrowdale Caroline Baynes Heko Becher Marina Bermisheva Leslie Bernstein Katarzyna Białkowska Carl Blomqvist Stig E Bojesen Bernardo Bonanni Ake Borg Hiltrud Brauch Hermann Brenner Barbara Burwinkel Saundra S Buys Trinidad Caldés Maria A Caligo Daniele Campa Brian D Carter Jose E Castelao Jenny Chang-Claude Stephen J Chanock Wendy K Chung Kathleen B M Claes Christine L Clarke J Margriet Collée Don M Conroy Kamila Czene Mary B Daly Peter Devilee Orland Diez Yuan Chun Ding Susan M Domchek Thilo Dörk Isabel Dos-Santos-Silva Alison M Dunning Miriam Dwek Diana M Eccles A Heather Eliassen Christoph Engel Mikael Eriksson D Gareth Evans Peter A Fasching Henrik Flyger Florentia Fostira Eitan Friedman Lin Fritschi Debra Frost Manuela Gago-Dominguez Susan M Gapstur Judy Garber Vanesa Garcia-Barberan Montserrat García-Closas José A García-Sáenz Mia M Gaudet Simon A Gayther Andrea Gehrig Vassilios Georgoulias Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Anna González-Neira Mark H Greene Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A Haiman Niclas Håkansson Per Hall Ute Hamann Patricia A Harrington Steven N Hart Wei He Frans B L Hogervorst Antoinette Hollestelle John L Hopper Darling J Horcasitas Peter J Hulick David J Hunter Evgeny N Imyanitov Agnes Jager Anna Jakubowska Paul A James Uffe Birk Jensen Esther M John Michael E Jones Rudolf Kaaks Pooja Middha Kapoor Beth Y Karlan Renske Keeman Elza Khusnutdinova Johanna I Kiiski Yon-Dschun Ko Veli-Matti Kosma Peter Kraft Allison W Kurian Yael Laitman Diether Lambrechts Loic Le Marchand Jenny Lester Fabienne Lesueur Tricia Lindstrom Adria Lopez-Fernández Jennifer T Loud Craig Luccarini Arto Mannermaa Siranou Genetic Epidemiology of Cancer team Inserm U900 Paris France. Institut Curie Paris Paris France. Mines ParisTech Fontainebleau Paris France. Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care University of Cambridge Cambridge UK. PSL University Paris Paris France. Paris Sud University Orsay France. Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute Brisbane QLD Australia. Centre for Cancer Genetic Epidemiology Department of Oncology University of Cambridge Cambridge UK. Family Cancer Clinic The Netherlands Cancer Institute Antoni van Leeuwenhoek hospital Amsterdam The Netherlands. Immunology and Molecular Oncology Unit Veneto Institute of Oncology IOV - IRCCS Padua Italy. Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Department of Health and Human Services Bethesda MD USA. Department of Clinical Genetics Helsinki University Hospital University of Helsinki Helsinki Finland. Fred A. Litwin Center for Cancer Genetics Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital Toronto ON Canada. Department of Molecular Genetics University of Toronto Toronto ON Canada. Department of Epidemiology Genetic Epidemiology Research Institute University of California Irvine Irvine CA USA. Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ) Heidelberg Germany. Department of Gynaecology and Obstetrics University Hospital of Schleswig-Holstein Campus Kiel Christian-Albrechts University Kiel Kiel Germany. Institute of Clinical Molecular Biology University Hospital of Schleswig-Holstein Campus Kiel Christian-Albrechts University Kiel Kiel Germany. Department of Public Health Sciences and Cancer Research Institute Queen's University Kingston ON Canada. Department of Breast Medical Oncology University of Texas MD Anderson Cancer Center Houston TX USA. Department of Cancer Epidemiology Clinical Sciences

A Correction to this paper has been published: https://***/10.1038/s41467-021-23162-4.

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Corrigendum to: Environmental Sampling for Severe Acute Respiratory Syndrome Coronavirus 2 During a COVID-19 Outbreak on the Diamond Princess Cruise Ship

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The Journal of infectious diseases 2021年第3期223卷 540页

作者： Takuya Yamagishi Makoto Ohnishi Nobuaki Matsunaga Kensaku Kakimoto Hajime Kamiya Kiyoko Okamoto Motoi Suzuki Yoshiaki Gu Mikiyo Sakaguchi Taichi Tajima Saho Takaya Norio Ohmagari Makoto Takeda Shutoku Matsuyama Kazuya Shirato Naganori Nao Hideki Hasegawa Tsutomu Kageyama Ikuyo Takayama Shinji Saito Koji Wada Retsu Fujita Hiroki Saito Keiji Okinaka Mathew Griffith Amy Elizabeth Parry Brenda Barnetson James Leonard Takaji Wakita Infectious Disease Surveillance Center National Institute of Infectious Diseases Tokyo Japan. National Institute of Infectious Diseases Tokyo Japan. Antimicrobial Resistance Clinical Research Center National Center for Global Health and Medicine Tokyo Japan. Field Epidemiology Training Program National Institute of Infectious Diseases Tokyo Japan. Disease Control and Prevention Center National Center for Global Health and Medicine Tokyo Japan. Department of Virology III National Institute of Infectious Diseases Tokyo Japan. Influenza Virus Research Center National Institute of Infectious Diseases Tokyo Japan. Graduate School of Public Health International University of Health and Welfare Chiba Japan. Innovation & Research Support Center International University of Health and Welfare Chiba Japan. Department of Emergency and Critical Care Medicine Yokohama City Seibu Hospital St. Marianna University School of Medicine Yokohama Japan. Division of General Internal Medicine National Cancer Center Hospital East Chiba Japan. Health Emergency Programme World Health Organization Western Pacific Regional Office Manila Philippines. Department of Health Services Princess Cruises USA.

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Author Correction: Strong associations between chromosomal aberrations in blood lymphocytes and the risk of urothelial and squamous cell carcinoma of the bladder

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Scientific reports 2018年第1期8卷 8183页

作者： Hongkun Wang Ying Wang Krishna K Kota Bing Sun Bhaskar Kallakury Nabiel N Mikhail Douaa Sayed Ahmed Mokhtar Doaa Maximous Etemad H Yassin Scarlett X Sun Xiaofei Chen Christopher A Loffredo Yun-Ling Zheng Department of Biostatistics Bioinformatics and Biomathematics Lombardi Comprehensive Cancer Center Georgetown University Medical Center Washington DC USA. Cancer Prevention and Control Program Lombardi Comprehensive Cancer Center Georgetown University Medical Center Washington DC USA. Department of Pathology Lombardi Comprehensive Cancer Center Georgetown University Medical Center Washington DC USA. South Egypt Cancer Institute Assiut University Assiut Egypt. Department of Biostatistics Bioinformatics and Biomathematics Lombardi Comprehensive Cancer Center Georgetown University Medical Center Washington DC USA. yz37@georgetown.edu. Cancer Prevention and Control Program Lombardi Comprehensive Cancer Center Georgetown University Medical Center Washington DC USA. yz37@georgetown.edu.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

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Le potentiel inflammatoire du régime alimentaire : un facteur clé impliqué dans la promotion d’un vieillissement en bonne santé

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Nutrition Clinique et Métabolisme 2018年第4期32卷 332-333页

作者： K.E. Assmann M. Adjibade N. Shivappa J.R. Hébert M.D. Wirth M. Touvier T. Akbaraly S. Hercberg P. Galan C. Julia E. Kesse-Guyot Équipe de recherche en épidémiologie nutritionnelle (EREN) UMR U1153 Inserm/U1125 Inra/Cnam/Université Paris 13 centre de recherche en épidémiologie et statistiques Sorbonne Paris Cité Bobigny France Connecting Health Innovations LLC Cancer Prevention and Control Program and Department of Epidemiology and Biostatistics Arnold School of Public Health University of South Carolina Columbia États-Unis Department of Epidemiology and Public Health University College London Londres Royaume-Uni MMDN EPHE Inserm U1198 université de Montpellier Montpellier Département de Santé publique hôpital Avicenne Bobigny France

Introduction et but de l’étude L’inflammation systémique de bas grade semble être impliquée dans l’étiologie de nombreuses maladies chroniques liées à l’âge, ainsi que dans ...

Introduction et but de l’étude L’inflammation systémique de bas grade semble être impliquée dans l’étiologie de nombreuses maladies chroniques liées à l’âge, ainsi que dans le déclin du fonctionnement physique et cognitif au cours du vieillissement. Pourtant, aucune étude n’a encore étudié l’association entre le potentiel inflammatoire du régime alimentaire et un modèle multidimensionnel du vieillissement en bonne santé (VBS). L’objectif de notre étude était ainsi d’examiner la relation entre le potentiel pro- ou anti-inflammatoire de l’alimentation en milieu de la vie, mesuré par le Dietary Inflammatory Index (DII), et le VBS évalué 13 ans plus tard. Matériel et méthodes Nous avons analysé des données de l’étude ***, qui était initialement un essai randomisé en double-aveugle, testant l’efficacité d’une supplémentation journalière, pendant 8 ans (1994–2002), en vitamines et minéraux antioxydants à doses nutritionnelles sur l’incidence de cancer et de maladies cardiovasculaires. Les données utilisées pour définir le statut du VBS ont été recueillies 5 ans après la fin de l’essai initial, (2007–2009). La population d’étude considérée pour nos recherches était constituée de 2796 participants sans diabète, ni maladies cardiovasculaires ou cancer à l’inclusion (1994–1995). Le VBS a été défini selon 8 critères : l’absence de maladie chronique majeure au cours du suivi, le bon fonctionnement physique et cognitif, l’absence de limitations dans les activités instrumentales de la vie quotidienne, l’absence de symptômes dépressifs, l’absence de limitations dans la vie sociale (liées à la santé), la bonne santé globale perçue et l’absence de douleurs entraînant des limitations du fonctionnement quotidien. Le Dietary Inflammatory Index (DII), a été calculé à partir de données issues d’enregistrements de 24 h (moyenne = 10 enregistrements/sujet entre 1994 et 1996). Afin d’estimer les risques relatifs (RR) caractérisant l’association entre le DII et le VBS, nous avons

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Addition of estimated cardiorespiratory fitness to the clinical assessment of 10-year coronary heart disease risk in asymptomatic men

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Preventive Medicine Reports 2017年 7卷 30-37页

作者： Gander, Jennifer C. Sui, Xuemei Hébert, James R. Lavie, Carl J. Hazlett, Linda J. Cai, Bo Blair, Steven N. Department of Surgery Emory University School of Medicine Atlanta GA United States Department of Exercise Science Arnold School of Public Health University of South Carolina Columbia SC United States Department of Epidemiology and Biostatistics Arnold School of Public Health University of South Carolina Columbia SC United States South Carolina Statewide Cancer Prevention and Control Program University of South Carolina Columbia SC United States Department of Cardiovascular Diseases John Ochsner Heart and Vascular Institute Ochsner Clinical School-the University of Queensland School of Medicine New Orleans LA United States

The Framingham Risk Score (FRS) was developed to quantify a patient's coronary heart disease (CHD) risk. Non-exercise estimated CRF (e-CRF) may provide a clinically practical method for describing cardiorespiratory fitness. We computed e-CRF and tested its association with the FRS and CHD. Male participants (n = 29,854) in the Aerobics Center Longitudinal Study (ACLS) who completed a baseline examination between 1979–2002 were followed for 12 years to determine incident CHD defined by self-report of myocardial infarction, revascularization, or CHD mortality. e-CRF was defined from a 7-item scale and categorized using age-specific tertiles. Multivariable survival analysis determined associations between FRS, e-CRF, and CHD. Interaction between e-CRF and FRS was tested by stratified analysis by ‘low’ and ‘moderate or high’ 10-year CHD risk. Men with high e-CRF were significantly (p-value < 0.0001) younger, and less likely to be smokers, compared to men with low e-CRF. Multivariable survival analysis reported men with high e-CRF were 29% (HR = 0.71;95% 0.56, 0.88) less likely to experience a CHD event compared to men with low e-CRF. Stratified analyses showed men with ‘low’ 10-year FRS predicted CHD risk and high e-CRF had a 28% (HR = 0.72;95% CI 0.57, 0.91) lower CHD-mortality risk compared to men with low e-CRF, no association was found in this group and men with moderate e-CRF. Men who were more fit had a decreased risk for CHD compared to men in the lowest third of fitness. Estimated CRF may add clinical value to the FRS and help clinicians better predict long-term CHD risk. © 2017 The Authors

关键词： Cardiorespiratory fitness Cardiovascular disease Chronic disease Exercise capacity Framingham risk score Men Risk

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Engagement and attrition in Internet smoking cessation interventions: Insights from a cross-sectional survey of "one-hit-wonders"

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Internet Interventions 2016年 5卷 23-29页

作者： Saul, Jessie E. Amato, Michael S. Cha, Sarah Graham, Amanda L. North American Research and Analysis Inc. Faribault MN United States Schroeder Institute for Tobacco Research and Policy Studies Truth Initiative Washington DC United States Department of Oncology Georgetown University Medical Center/Cancer Prevention and Control Program Lombardi Comprehensive Cancer Center Washington DC United States

Introduction: Internet interventions can reach large numbers of individuals. However, low levels of engagement and high rates of follow-up attrition are common, presenting major challenges to evaluation. This study investigated why registrants of an Internet smoking cessation intervention did not return after joining ("one hit wonders"), and explored the impact of graduated incentives on survey response rates and responder characteristics. Methods: A sample of "one hit wonders" that registered on a free smoking cessation website between 2014 and 2015 were surveyed. The initial invitation contained no incentive. Subsequent invitations were sent to random subsamples of non-responders from each previous wave offering $25 and $50 respectively. Descriptive statistics characterized respondents on demographic characteristics, reasons for not returning, and length of time since last visit. Differences were investigated with Fisher's Exact tests, Kruskal-Wallis, and logistic regression. Results: Of 8779 users who received the initial invitation, 132 completed the survey (1.5%). Among those subsequently offered a $25 incentive, 127 (3.7%) responded. Among those offered a $50 incentive, 97 responded (5.7%). The most common reasons endorsed for not returning were being unable to quit (51%), not having enough time (33%), having forgotten about the website (28%), and not being ready to quit (21%). Notably, however, 23% reported not returning because they had successfully quit smoking. Paid incentives yielded a higher proportion of individuals who were still smoking than the $0 incentive (72% vs. 61%). Among $0 and $25 responders, likelihood of survey response decreased with time since registration;the $50 incentive removed the negative effect of time-since-registration on probability of response. Conclusions: One third of participants that had disengaged from an Internet intervention reported abstinence at follow-up, suggesting that low levels of engagement are not synonymous wit

关键词： Attrition Engagement Incentive Smoking cessation Survey methods

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Author Correction: Validating a breast cancer score in Spanish women. The MCC-Spain study

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Scientific reports 2020年第1期10卷 5980页

作者： Trinidad Dierssen-Sotos Inés Gómez-Acebo Camilo Palazuelos Pablo Fernández-Navarro Jone M Altzibar Carmen González-Donquiles Eva Ardanaz Mariona Bustamante Jessica Alonso-Molero Carmen Vidal Juan Bayo-Calero Adonina Tardón Dolores Salas Rafael Marcos-Gragera Víctor Moreno Paz Rodriguez-Cundin Gemma Castaño-Vinyals María Ederra Laura Vilorio-Marqués Pilar Amiano Beatriz Pérez-Gómez Nuria Aragonés Manolis Kogevinas Marina Pollán Javier Llorca CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain. dierssent@unican.es. University of Cantabria - IDIVAL Santander Spain. dierssent@unican.es. CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain. University of Cantabria - IDIVAL Santander Spain. Cancer and Environmental Epidemiology Unit National Center for Epidemiology Carlos III Institute of Health Madrid Spain. Cancer Epidemiology Research Group Oncology and Hematology Area IIS Puerta de Hierro (IDIPHIM) Madrid Spain. Breast Cancer Screening Programme Basque Health Department Osakidetza Spain. Grupo de Investigación Interacciones Gen-Ambiente y Salud Universidad de León León Spain. Navarra Public Health Institute Navarra Spain. IdiSNA Navarra Institute for Health Research Pamplona Spain. ISGlobal Centre for Research in Environmental Epidemiology (CREAL) Barcelona Spain. Centre for Genomic Regulation (CRG) the Barcelona Institute of Science and Technology Barcelona Spain. Universitat Pompeu Fabra (UPF) Barcelona Spain. Cancer Prevention and Control Program Catalan Institute of Oncology-IDIBELL L'Hospitalet de Llobregat Barcelona Spain. Complejo Hospitalario Universitario de Huelva Centro de Investigación en Salud y Medio Ambiente (CYSMA) Universidad de Huelva Huelva Spain. IUOPA Universidad de Oviedo Asturias Spain. Valencia Cancer and Public Health Area FISABIO - Public Health Valencia Spain. General Directorate Public Health Valencian Community Valencia Spain. Catalan Institute of Oncology Girona Spain. Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain. University Hospital Marques de Valdecilla - IDIVAL Santander Spain. IMIM (Hospital Del Mar Medical Research Institute) Barcelona Spain. Public Health Division of Gipuzkoa BioDonostia Research Institute San Sebastian Spain. School of Public Health Athens Greece.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Software for administering the National cancer Institute’s patient-reported outcomes version of the common terminology criteria for adverse events: Usability study

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JMIR Human Factors 2018年第3期5卷 e10070页

作者： Schoen, Martin W. Basch, Ethan Hudson, Lori L. Chung, Arlene E. Mendoza, Tito R. Mitchell, Sandra A. St. Germain, Diane Baumgartner, Paul Sit, Laura Rogak, Lauren J. Shouery, Marwan Shalley, Eve Reeve, Bryce B. Fawzy, Maria R. Bhavsar, Nrupen A. Cleeland, Charles Schrag, Deborah Dueck, Amylou C. Abernethy, Amy P. Division of Hematology and Medical Oncology Department of Internal Medicine Saint Louis University School of Medicine Saint Louis MO United States Division of Hematology/Oncology Department of Medicine University of North Carolina School of Medicine 170 Manning Drive Chapel Hill NC United States Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY United States Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill NC United States Department of Health Policy and Management Gillings School of Public Health University of North Carolina Chapel Hill NC United States Duke Clinical Research Institute Duke University Durham NC United States Division of General Medicine and Clinical Epidemiology Department of Medicine University of North Carolina School of Medicine Chapel Hill NC United States Division of General Pediatrics and Adolescent Medicine Department of Pediatrics Program on Health and Clinical Informatics University of North Carolina School of Medicine Chapel Hill NC United States Department of Symptom Research University of Texas MD Anderson Cancer Center Houston TX United States Division of Cancer Control and Population Sciences National Cancer Institute Rockville MD United States Division of Cancer Prevention National Cancer Institute Rockville MD United States SemanticBits Herndon VA United States Center for Biomedical Informatics and Information Technology National Cancer Institute Rockville MD United States Duke Cancer Institute Durham NC United States FHI 360 Durham NC United States Division of General Internal Medicine Duke University School of Medicine Durham NC United States Division of Population Sciences Dana-Farber Cancer Institute Boston MA United States Alliance Statistics and Data Center Mayo Clinic Scottsdale AZ United States Flatiron Health New York NY United States

Background: The US National cancer Institute (NCI) developed software to gather symptomatic adverse events directly from patients participating in clinical trials. The software administers surveys to patients using items from the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) through Web-based or automated telephone interfaces and facilitates the management of survey administration and the resultant data by professionals (clinicians and research associates). Objective: The purpose of this study was to iteratively evaluate and improve the usability of the PRO-CTCAE software. Methods: Heuristic evaluation of the software functionality was followed by semiscripted, think-aloud protocols in two consecutive rounds of usability testing among patients with cancer, clinicians, and research associates at 3 cancer centers. We conducted testing with patients both in clinics and at home (remotely) for both Web-based and telephone interfaces. Furthermore, we refined the software between rounds and retested. Results: Heuristic evaluation identified deviations from the best practices across 10 standardized categories, which informed initial software improvement. Subsequently, we conducted user-based testing among 169 patients and 47 professionals. Software modifications between rounds addressed identified issues, including difficulty using radio buttons, absence of survey progress indicators, and login problems (for patients) as well as scheduling of patient surveys (for professionals). The initial System Usability Scale (SUS) score for the patient Web-based interface was 86 and 82 (P=.22) before and after modifications, respectively, whereas the task completion score was 4.47, which improved to 4.58 (P=.39) after modifications. Following modifications for professional users, the SUS scores improved from 71 to 75 (P=.47), and the mean task performance improved significantly (4.40 vs 4.02;P=.001). Conclusions: Software modificati

关键词： Adverse events cancer clinical trials Patient-reported outcomes PRO-CTCAE Symptoms Usability

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Corrigendum to "Spumaretroviruses: Updated taxonomy and nomenclature" [Virology 516 (2018) 158-164]

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Virology 2019年 528卷 208-208页

作者： Arifa S Khan Jochen Bodem Florence Buseyne Antoine Gessain Welkin Johnson Jens H Kuhn Jacek Kuzmak Dirk Lindemann Maxine L Linial Martin Löchelt Magdalena Materniak-Kornas Marcelo A Soares William M Switzer Laboratory of Retroviruses US Food and Drug Administration Silver Spring MD 20993 USA. Electronic address: arifa.khan@fda.hhs.gov. Institut für Virologie und Immunbiologie Universität Würzburg Würzburg Germany. Unit of Epidemiology and Physiopathology of Oncogenic Viruses Institut Pasteur Paris France Centre National de la Recherche Scientifique CNRS UMR3569 Paris France. Biology Department Boston College Chestnut Hill MA 02467 USA. Integrated Research Facility at Fort Detrick National Institute of Allergy and Infectious Diseases National Institutes of Health Frederick MD 21702 USA. Department of Biochemistry National Veterinary Research Institute Puławy Poland. Institute of Virology Technische Universität Dresden Dresden Germany. Division of Basic Sciences Fred Hutchinson Cancer Research Center Seattle WA 98109 USA. Research Program Infection Inflammation and Cancer German Cancer Research Center (DFKZ) Heidelberg Germany. Instituto Nacional de Câncer and Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil. Laboratory Branch Division of HIV/AIDS Prevention Centers for Disease Control and Prevention Atlanta GA 30329 USA.

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Risk Model for Colorectal cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study (vol 7, 43263, 2017)

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SCIENTIFIC REPORTS 2017年第1期7卷 1-12页

作者： Ibanez-Sanz, Gemma Diez-Villanueva, Anna Henar Alonso, M. Rodriguez-Moranta, Francisco Perez-Gomez, Beatriz Bustamante, Mariona Martin, Vicente Llorca, Javier Amiano, Pilar Ardanaz, Eva Tardon, Adonina Jimenez-Moleon, Jose J. Peiro, Rosana Alguacil, Juan Navarro, Carmen Guino, Elisabet Binefa, Gemma Fernandez-Navarro, Pablo Espinosa, Anna Davila-Batista, Veronica Molina, Antonio Jose Palazuelos, Camilo Castano-Vinyals, Gemma Aragones, Nuria Kogevinas, Manolis Pollan, Marina Moreno, Victor Cancer Prevention and Control Program Catalan Institute of Oncology-IDIBELL L'Hospitalet de Llobregat Spain. CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain. Gastroenterology Department Bellvitge University Hospital-IDIBELL L'Hospitalet de Llobregat Spain. Environmental and Cancer Epidemiology Department National Center of Epidemiology - Instituto de Salud Carlos III Madrid Spain. Oncology and Hematology Area IIS Puerta De Hierro Cancer Epidemiology Research Group Madrid Spain. ISGlobal Centre for Research in Environmental Epidemiology (CREAL) Barcelona Spain. Instituto de Biomedicina (IBIOMED). Grupo de investigación en interacciones gen ambiente y salud. Universidad de León León Spain. Universidad de Cantabria - IDIVAL Santander Spain. Public Health Division of Gipuzkoa Biodonostia Research Institute San Sebastian Spain. Navarra Public Health Institute Navarra Spain. University Institute of Oncology of Asturias (IUOPA) Universidad de Oviedo Oviedo Spain. Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA) Hospitales Universitarios de Granada Granada Spain. Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana FISABIO-Salud Pública Valencia. Centre for Research in Health and Environment (CYSMA) Universidad de Huelva Huelva Spain. Department of Epidemiology IMIB-Arrixaca and Department of Health and Social Sciences Murcia Regional Health Council Universidad de Murcia Murcia Spain. IMIM (Hospital Del Mar Medical Research Institute) Barcelona Spain. Universitat Pompeu Fabra (UPF) Barcelona Spain. School of Public Health Athens Greece. Cancer Prevention and Control Program Catalan Institute of Oncology-IDIBELL L'Hospitalet de Llobregat Spain. v.moreno@***. CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain. v.moreno@***. Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain. v.moreno@iconcologia.net.

Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5 quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1 quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.

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