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EPH15 A Simulation Modeling Study to Support Personalized Breast cancer prevention and Early Detection in High-Risk Women

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Value in Health 2022年第7期25卷 S436-S436页

作者： Jayasekera, J Zhao, A Georgetown University Medical Center and Cancer Prevention and Control Program Georgetown-Lombardi Comprehensive Cancer Center Washington DC USA Georgetown University Washington DC USA

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Hair product use and urinary biomarker concentrations of non-persistent endocrine disrupting chemicals among reproductive-aged Black women

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Chemosphere 2024年 361卷 142442页

作者： Schildroth, Samantha Geller, Ruth J. Wesselink, Amelia K. Lovett, Sharonda M. Bethea, Traci N. Claus Henn, Birgit Harmon, Quaker E. Taylor, Kyla M. Calafat, Antonia M. Wegienka, Ganesa Gaston, Symielle A. Baird, Donna D. Wise, Lauren A. Department of Epidemiology Boston University School of Public Health BostonMA United States Office of Minority Health & Health Disparities Research Georgetown Lombardi Comprehensive Cancer Institute Washington DC United States Department of Environmental Health Boston University School of Public Health BostonMA United States National Institute of Environmental Health Sciences DurhamNC United States National Toxicology Program National Institute of Environmental Health Sciences NC United States Division of Laboratory Sciences Centers for Disease Control and Prevention AtlantaGA United States Henry Ford Health System Detroit MI United States

Background: Studies have shown an association between hair product use and adverse health outcomes. Scientists have hypothesized that exposure to endocrine-disrupting chemicals (EDCs) drives these associations, but few studies have directly evaluated associations between hair product use and biomarkers of EDCs. Even more limited are studies of Black women, who frequently use EDC-containing products (e.g., hair relaxers). Objective: We estimated associations between hair product use and EDC biomarker concentrations. Methods: We leveraged cross-sectional data from the Study of Environment, Lifestyle, and Fibroids, a cohort of females aged 23–34 years who self-identified as Black/African American from the Detroit-metropolitan area (USA;n = 425). On structured questionnaires, participants reported their past 24-h and past 12-month use of hair products, including relaxers/straighteners/perms, styling products, moisturizers, oils, and hair food. We quantified urinary concentrations of 19 phthalate/phthalate alternative metabolites, 7 phenols, and 4 parabens using high performance liquid chromatography isotope dilution tandem mass spectrometry. EDC biomarker concentrations were creatinine-adjusted and natural log-transformed. We used multivariable linear regression to estimate mean percent differences in EDC biomarker concentrations and 95% confidence intervals (CIs) associated with hair product use, adjusting for sociodemographic confounders. Results: Hair product use was associated with greater concentrations of multiple EDC biomarkers. Notably, use of hair products in the previous 24 h (compared with non-use) was associated with 16.2% (95% CI = 0.7%, 35.9%), 35.0% (95% CI = 2.6%, 77.6%), and 32.3% (95% CI = 8.8%, 92.0%) higher concentrations of mono-isobutyl phthalate, methyl paraben, and ethyl paraben, respectively. Use of hair relaxers/straighteners/perms, styling products, moisturizers, oils, and hair food in the past 12 months was also associated with higher concent

关键词： Phenols

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Development and Feasibility testing of a Highly Anti-Inflammatory Indian-Adapted Mediterranean Diet for Coronary Artery Disease Patients

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Indian Heart Journal 2024年 76卷 S25-S26页

作者： Ambuj Roy Archna Singh Megha Suresh Anudeep P. P Sherry Price Sabiha Khan Kamar Ali Neha Bakshi James R. Hebert Suparna Ghosh Jerath Department of Cardiology AIIMS New Delhi India Department of Biochemistry AIIMS New Delhi India Connecting Health Innovations LLC Columbia SC USA Cancer Prevention and Control Program Arnold School of Public Health University of South Carolina

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Inequities in childhood cancer research: A scoping review

EJC Paediatric Oncology

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EJC Paediatric Oncology 2024年 4卷 100171-100171页

作者： Hunleth, Jean Burack, Sarah Kaufman, Lindsey Mohrmann, Caroline Shato, Thembekile Wiedenman, Eric Njelesani, Janet Department of Surgery Washington University School of Medicine in St. Louis St. Louis United States Division of Pediatric Hematology/Oncology Washington University in St. Louis United States Implementation Science Center for Cancer Control and Prevention Research Center Washington University in St. Louis St. Louis United States Physician Learning Program Faculty of Medicine and Dentistry University of Alberta Edmonton Canada Department of Occupational Therapy New York University New York United States

An integral part of understanding and then designing programs to reduce childhood cancer inequities includes adequate representation of people with cancer in research, including children. A scoping review was carried out to understand how cancer research is oriented toward inequities and to identify who has participated in childhood qualitative cancer research. A systematic search identified 119 qualitative studies that met inclusion criteria, with most studies taking place in high-income countries (n=84). Overall, data were lacking on social determinants of health at multiple levels—structural, household, child, and guardian. Only 29 studies reported on race and/or ethnicity, with the majority of those including predominantly or all white children. Six articles included socioeconomic information, and across most articles, attention was absent to the financial ramifications of cancer care. Limited reporting of sociodemographics highlights a broader issue of neglecting key demographics and social factors that contribute to inequities. © 2024 The Authors

关键词： cancer disparities Childhood cancer Pediatric cancer Qualitative research Scoping review

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Estimation of the risk of lung cancer in women participating in a population-based breast cancer screening program

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Archivos de Bronconeumología (English Edition) 2020年第5期56卷 277-281页

作者： Adrián González-Marrón Juan Carlos Martín-Sánchez Ferrán Garcia-Alemany Encarna Martínez-Martín Nuria Matilla-Santander Àurea Cartanyà-Hueso Carmen Vidal Montse García Jose M. Martínez-Sánchez Group of Evaluation of Health Determinants and Health Policies Universitat Internacional de Catalunya Sant Cugat del Vallès Spain Screening Cancer Unit Cancer Prevention and Control Program Institut Català d’Oncologia L’Hospitalet de Llobregat Barcelona Spain Cancer Epidemiology and Cancer Prevention Program T.H. Chan School of Public Health Boston MA USA

Introduction Lung cancer mortality is increasing in women. In Spain, estimates suggest that lung cancer mortality may soon surpass breast cancer mortality, the main cause of cancer mortality among women. The aim of this study was to estimate the proportion of women at high risk of developing lung cancer in a group of participants in a population-based breast cancer screening program. Methods Cross-sectional study in a sample of women who participated in a population-based breast cancer screening program in 2016 in Hospitalet de Llobregat n = 1,601. High risk of lung cancer was defined according to the inclusion criteria of the National Lung Screening Trial (NLST) and the Dutch-Belgian randomized lung cancer screening trial (NELSON). Results Around 20% of smokers according to NLST and 40% of smokers according to NELSON criteria, and around 20% of former smokers according to both criteria, are at high risk of developing lung cancer. A positive and statistically significant trend is observed between the proportion of women at high risk and nicotine dependence measured with the brief Fagerström Test. Conclusions A high proportion of participants in this breast cancer screening program have a high risk of developing lung cancer and would be eligible to participate in a lung cancer screening program. Population-based breast cancer screening programs may be useful to implement lung cancer primary prevention activities. Introducción La mortalidad por cáncer de pulmón está aumentando en mujeres. Se ha proyectado que en España pueda superar a la mortalidad por cáncer de mama, la principal causa de mortalidad por cáncer en mujeres, en pocos años. El objetivo de este estudio es estimar la proporción de mujeres que presentan alto riesgo de desarrollar cáncer de pulmón en un grupo de participantes en un cribado poblacional de cáncer de mama. Métodos Estudio transversal de una muestra de mujeres que participaron en un cribado poblacional de cáncer de mama en el año 2016 en Hospita

关键词： Lung cancer Smoking Secondary prevention Primary prevention Tobacco Cáncer de pulmón Fumar Prevención secundaria Prevención primaria Tabaco

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Mediators of a Multimodal Sexual Dysfunction Intervention Among Hematopoietic Stem Cell Transplant Recipients

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Transplantation and Cellular Therapy 2025年第2期31卷 S367-S367页

作者： Nelson, Ashley M., PhD Reese, Jennifer Barsky, PhD Traeger, Lara, PhD Greer, Joseph A., PhD Temel, Jennifer, MD Bober, Sharon, PhD Pepper, Julia Newcomb, Richard Andrew, MD El-Jawahri, Areej R., MD Psychiatry Massachusetts General Hospital Boston MA Cancer Prevention and Control Program Fox Chase Cancer Center Philadelphia PA Psychology Massachusetts General Hospital Boston MA Medicine Massachusetts General Hospital Boston MA Dana Farber Cancer Institute Boston MA Massachusetts General Hospital Boston MA Medicine Division of Hematology & Oncology Massachusetts General Hospital Boston MA

IntroductionSexual dysfunction is a common and persistent complication following hematopoietic stem cell transplant (HSCT). We developed and tested a multimodal sexual dysfunction intervention consisting of three monthly visits with trained transplant clinicians focused on addressing biopsychosocial causes of sexual dysfunction. We previously demonstrated that this intervention led to improvements in sexual function and quality of life (QOL) and reductions in anxiety and depression symptoms. ObjectivesOur aim for the present study was to examine the degree to which the effects of the sexual dysfunction intervention on patient-reported QOL and mood symptoms were accounted for by changes in sexual function and satisfaction. MethodsWe conducted a secondary analysis of a randomized clinical trial investigating a multimodal sexual dysfunction intervention versus enhanced standard care for HSCT survivors between 2/2019 and 2/2023. Participants completed self-report measures of sexual function (i.e., PROMIS SexFS domains of sexual satisfaction, interest, and orgasm), QOL (FACT-BMT), and anxiety and depression symptoms (HADS) at baseline and 3 months post-enrollment. We used causal mediation with bootstrapping to assess whether changes in sexual function domains mediated intervention effects on patient-reported QOL and mood symptoms at 3 months controlling for baseline values. ResultsIn total, 125 HSCT recipients ( M age=55 years, 33% female, 73% allogeneic HSCT) participated. Changes in sexual satisfaction, interest, and orgasm mediated the intervention effects on 3-month QOL (indirect effect = 7.20, 95%CI 2.74, 11.65; indirect effect = 4.21, 95%CI 0.67, 7.74, indirect effect = 5.92, 95%CI 2.20, 9.65, respectively) and depression symptoms (indirect effect = -1.03, 95%CI -1.79, -0.28; indirect effect = -0.65, 95%CI -1.23, -0.06; indirect effect = -0.72, 95%CI -1.38, -0.05, respectively). Changes in sexual satisfaction, but not interest or orgasm, mediated effects on 3-month

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Randomized Trial of a Multimodal Intervention to Enhance Sexual Function and Quality of Life (QOL) in Hematopoietic Stem Cell Transplant (HSCT) Survivors

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Transplantation and Cellular Therapy 2024年第2期30卷 S342-S342页

作者： El-Jawahri, Areej R., MD Reese, Jennifer Barsky, PhD Traeger, Lara, PhD Dizon, Don, MD Bober, Sharon, PhD Vanderklish, Julie, CNP Horick, Nora Newcomb, Richard Andrew, MD DeFilipp, Zachariah, MD Chen, Dr. Yi-Bin, MD Temel, Jennifer, MD Massachusetts General Hospital Boston MA Cancer Prevention and Control Program Fox Chase Cancer Center Philadelphia PA Psychology Massachusetts General Hospital Boston MA Rhode Island Hospital Rhode Island RI Dana Farber Cancer Institute Boston MA Hematopoietic Cell Transplant and Cellular Therapy Program Massachusetts General Hospital Boston MA Medicine Division of Hematology & Oncology Massachusetts General Hospital Boston MA Medicine Massachusetts General Hospital Boston MA

BackgroundSexual dysfunction is the most common complication affecting HSCT survivors and is associated with worse psychological distress and patient QOL. Yet, interventions to address sexual dysfunction in HSCT survivors are lacking. MethodsWe conducted a single center randomized clinical trial of a multimodal intervention to address sexual dysfunction in autologous and allogeneic HSCT survivors who were at least 3 months post-HSCT and endorsed sexual dysfunction causing distress. Patients were randomly assigned to the intervention or usual care. Intervention participants met with a trained HSCT clinician for three monthly visits that focused on 1) assessing the causes of their sexual dysfunction; 2) educating and empowering patients to address sexual health concerns; and 3) implementing therapeutic interventions (e.g., vaginal lubrication, medications, intimacy exercises, etc.). We assessed patient global satisfaction with sex, interest in sex, orgasm pleasure, erectile function, vaginal discomfort (PROMIS), QOL (Functional Assessment of cancer Therapy-Bone Marrow Transplant [FACT-BMT]), and psychological distress (Hospital Anxiety and Depression-Scale [HADS]) at baseline and 3 months after enrollment. The primary endpoint was to compare patient global satisfaction with sex at three months between the study groups. We used linear regression models, adjusting for baseline scores, to evaluate the intervention effects on study outcomes at three months. ResultsWe enrolled 74.0% (125/169) of eligible patients (mean age = 55.5 (SD=14.0), 67% male). Overall, 93.7% (60/64) of those randomized to the intervention attended all three intervention visits. At 3 months, patients randomized to the intervention reported improved global satisfaction with sex (B=4.7, P<0.001), interest in sex (B=1.3, P<0.001), orgasm pleasure (B=3.3, P<0.001), erectile function (B=10.9, P<0.001), and vaginal discomfort (B=-9.6, P=0.008) compared to those assigned to usual care. Intervention partici

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Multimodal Mobile Application to Address Sexual Dysfunction in Hematopoietic Stem Cell Transplant (HCT) Survivors

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Transplantation and Cellular Therapy 2024年第2期30卷 S45-S45页

作者： El-Jawahri, Areej R., MD Reese, Jennifer Barsky, PhD Traeger, Lara, PhD Dizon, Don, MD Bober, Sharon, PhD Vanderklish, Julie, CNP Newcomb, Richard Andrew, MD DeFilipp, Zachariah, MD Chen, Dr. Yi-Bin, MD Temel, Jennifer, MD Massachusetts General Hospital Boston MA Cancer Prevention and Control Program Fox Chase Cancer Center Philadelphia PA Psychology Massachusetts General Hospital Boston MA Rhode Island Hospital Rhode Island RI Dana Farber Cancer Institute Boston MA Hematopoietic Cell Transplant and Cellular Therapy Program Massachusetts General Hospital Boston MA Medicine Division of Hematology & Oncology Massachusetts General Hospital Boston MA Medicine Massachusetts General Hospital Boston MA

BackgroundSexual dysfunction is the most common complication affecting HCT survivors and is associated with worse patient-reported quality of life (QOL) and psychological distress. Yet, interventions to address sexual dysfunction in HCT survivors are lacking. MethodsWe conducted a pilot randomized trial of a multimodal mobile application (SHIFT) to address sexual dysfunction for patients with hematologic malignancies who were at least 3 months post autologous or allogeneic HCT and endorsed sexual dysfunction causing distress. Patients were randomly assigned to SHIFT or enhanced usual care. Intervention participants met with a trained HCT clinician for a brief clinical exam to address biological causes of sexual dysfunction and were then provided access to SHIFT for 8 weeks. SHIFT consists of five modules focused on educating and empowering patients to address their sexual health concerns and addressing the biologic, interpersonal, social, and psychological causes of sexual dysfunction. Patients assigned to enhanced usual care met with the trained HCT clinician for a brief clinical exam and they were not given access to SHIFT. The primary endpoint was feasibility, defined a priori as at least 60% of eligible patients enrolling and 60% of those enrolled completing at least 70% of the SHIFT modules. We assessed patient global satisfaction with sex, interest in sex, orgasm pleasure (PROMIS), QOL (Functional Assessment of cancer Therapy-Bone Marrow Transplant [FACT-BMT]), and psychological distress (Hospital Anxiety and Depression-Scale [HADS]) at baseline and 8 weeks. To assess the usability of SHIFT, we used the System Usability Scale (>80 indicates excellent usability). We a priori identified a p-value <0.25 as promising for preliminary efficacy in this pilot study. ResultsWe enrolled 64.2% (61/95) of eligible patients (mean age = 57.2 (SD=14.2), 60% male). In the intervention group, 70.0% completed ≥ 80% of the SHIFT modules, and 66.7% completed all SHIFT modules. Pa

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Associations Between Transportation Barriers in the Context of Other Social Needs and cancer Screening Adherence

AJPM Focus

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AJPM Focus 2025年

作者： Anna M. Morenz Gloria Coronado Lingmei Zhou Celia Valenzuela Joshua M. Liao Department of Medicine University of Arizona Tucson AZ Cancer Prevention and Control Program University of Arizona Cancer Center Tucson AZ Program on Policy Evaluation and Learning in the Pacific Northwest University of Washington Seattle WA Department of Epidemiology and Biostatistics Mel and Enid Zuckerman College of Public Health University of Arizona Tucson AZ Department of Medicine University of Washington Seattle WA Department of Obstetrics and Gynecology University of Arizona Tucson AZ Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX

Introduction Socioeconomic inequities in breast and cervical cancer screening persist and may be driven by unmet social needs, such as transportation barriers. The association between transportation barriers and screening adherence, while adjusting for other social needs, remains poorly characterized. Methods A cross-sectional analysis of 2023 National Health Interview Survey data was conducted from October to December 2024. Multivariable logistic regression was used to assess associations between transportation barriers and breast and cervical cancer screening adherence. Results A total of 5851 (survey-weighted 42.3 million) and 8461 (survey-weighted 78.6 million) individuals were eligible for breast and cervical cancer screening, respectively. In adjusted analyses, transportation barriers were associated with lower likelihood of breast cancer screening (adjusted OR 0.6, 95% CI 0.5-0.9) but no difference in the likelihood of cervical cancer screening (adjusted OR 0.9, 95% CI 0.7-1.1). Low income, lack of health insurance, and low levels of formal education were also associated with lower adherence for both breast and cervical cancer screening. Conclusion After accounting for other social needs, transportation barriers are associated with lower likelihood of breast cancer screening – an inequity that may benefit from public health and health care interventions. Additional work is needed to understand the relationship between socioeconomic status and cervical cancer screening adherence to inform future interventions.

关键词： cancer screening transportation barriers social needs women’s health

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Expanding access to cancer peer support: development of a website to deliver written peer support that meets patients' individual emotional and informational needs while reducing potential harms

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Procedia computer science 2022年 206卷 195-205页

作者： Katrin Bovbjerg Kristi Graves Margaret Waltz David Farrell Betina Yanez Anthony Chicaiza Rahma Omar Rebecca Thompson Mariska Kop Alyssa N Van Denburg Danielle Lorch Scott D Rowley Christine Rini Northwestern University Feinberg School of Medicine Dept of Medical Social Sciences 625 N. Michigan Ave 21-00 Chicago IL 60611 USA. Georgetown University Lombardi Comprehensive Cancer Center Cancer Prevention and Control Program 2115 Wisconsin Ave N Ste. 300 Washington DC 20007 USA. University of North Carolina School of Medicine Department of Social Medicine 333 S Columbia St Chapel Hill NC 27516 USA. People Designs Inc. 1304 Broad Street Durham NC 27705 USA. Robert H. Lurie Comprehensive Cancer Center of Northwestern University 675 N St Clair St. Floor 21 Suite 100 Chicago IL 60611 USA. John Theurer Cancer Center at Hackensack University Medical Center 92 2nd Street Hackensack NJ 07601 USA.

cancer patients often want information from "peers" with the same diagnosis or treatment. To increase access to this valuable resource, we developed a website to deliver written peer support to cancer patients undergoing stem cell transplant. Because little evidence describes how to optimize benefits or reduce potential harms of written peer support, we gathered multiple forms of stakeholder feedback to inform the website's ethical approach, personalization, design, function, and content: a Community Advisory Board; a longitudinal study of patients' written peer support needs and motivations; focus groups; semi-structured interviews; and usability testing. Findings provide a rich foundation for website development.

关键词： hematopoietic stem cell transplant stakeholder engagement website development written peer support

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