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Correction: Gender differences among patients with drug resistant tuberculosis and HIV co-infection in Uganda: a countrywide retrospective cohort study

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BMC infectious diseases 2023年第1期23卷 44页

作者： Joseph Baruch Baluku David Mukasa Felix Bongomin Anna M Stadelman Edwin Nuwagira Sabine Haller Kauthrah Ntabadde Stavia Turyahabwe Division of Pulmonology Kiruddu National Referral Hospital Kampala Uganda. bbjoe18@***. Makerere University Lung Institute PO Box 26343 Kampala Uganda. bbjoe18@***. Complex Diseases and Genome Epidemiology Graduate School of Public Health Seoul National University Seoul South Korea. Department of Medical Microbiology & Immunology Faculty of Medicine Gulu University Gulu Uganda. Division of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MN USA. Infectious Diseases Unit Department of Medicine Mbarara University of Science and Technology Mbarara Uganda. Department of Public and Global Health Epidemiology Biostatistics & Prevention Institute University of Zurich Zurich Switzerland. MRC/UVRI & LSHTM Uganda Research Unit Entebbe Uganda. National Tuberculosis and Leprosy Control Program Ministry of Health Kampala Uganda.

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Randomised recruitment in estimating genital human papillomavirus prevalence - Authors' reply

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The Lancet. Global health 2024年第1期12卷 e31页

作者： Laia Bruni Ginesa Albero Jane Rowley Melanie Taylor Nathalie Broutet Cancer Epidemiology Research Program Catalan Institute of Oncology-IDIBELL L'Hospitalet de Llobregat Barcelona 08908 Spain Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP CB06/02/0073) Madrid Spain. Electronic address: lbruni@***. Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP CB06/02/0073) Madrid Spain. Department of Global HIV Hepatitis and Sexually Transmitted Infections Programmes World Health Organization Geneva Switzerland. Department of Global HIV Hepatitis and Sexually Transmitted Infections Programmes World Health Organization Geneva Switzerland Division of STD Prevention Centers for Disease Control and Prevention Atlanta GA USA. Department of Sexual and Reproductive Health and Research World Health Organization Geneva Switzerland.

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

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Nature 2024年第8003期627卷 347-357页

作者： Ken Suzuki Konstantinos Hatzikotoulas Lorraine Southam Henry J Taylor Xianyong Yin Kim M Lorenz Ravi Mandla Alicia Huerta-Chagoya Giorgio E M Melloni Stavroula Kanoni Nigel W Rayner Ozvan Bocher Ana Luiza Arruda Kyuto Sonehara Shinichi Namba Simon S K Lee Michael H Preuss Lauren E Petty Philip Schroeder Brett Vanderwerff Mart Kals Fiona Bragg Kuang Lin Xiuqing Guo Weihua Zhang Jie Yao Young Jin Kim Mariaelisa Graff Fumihiko Takeuchi Jana Nano Amel Lamri Masahiro Nakatochi Sanghoon Moon Robert A Scott James P Cook Jung-Jin Lee Ian Pan Daniel Taliun Esteban J Parra Jin-Fang Chai Lawrence F Bielak Yasuharu Tabara Yang Hai Gudmar Thorleifsson Niels Grarup Tamar Sofer Matthias Wuttke Chloé Sarnowski Christian Gieger Darryl Nousome Stella Trompet Soo-Heon Kwak Jirong Long Meng Sun Lin Tong Wei-Min Chen Suraj S Nongmaithem Raymond Noordam Victor J Y Lim Claudia H T Tam Yoonjung Yoonie Joo Chien-Hsiun Chen Laura M Raffield Bram Peter Prins Aude Nicolas Lisa R Yanek Guanjie Chen Jennifer A Brody Edmond Kabagambe Ping An Anny H Xiang Hyeok Sun Choi Brian E Cade Jingyi Tan K Alaine Broadaway Alice Williamson Zoha Kamali Jinrui Cui Manonanthini Thangam Linda S Adair Adebowale Adeyemo Carlos A Aguilar-Salinas Tarunveer S Ahluwalia Sonia S Anand Alain Bertoni Jette Bork-Jensen Ivan Brandslund Thomas A Buchanan Charles F Burant Adam S Butterworth Mickaël Canouil Juliana C N Chan Li-Ching Chang Miao-Li Chee Ji Chen Shyh-Huei Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Mary Cushman John Danesh Swapan K Das H Janaka de Silva George Dedoussis Latchezar Dimitrov Ayo P Doumatey Shufa Du Qing Duan Kai-Uwe Eckardt Leslie S Emery Daniel S Evans Michele K Evans Krista Fischer James S Floyd Ian Ford Oscar H Franco Timothy M Frayling Barry I Freedman Pauline Genter Hertzel C Gerstein Vilmantas Giedraitis Clicerio González-Villalpando Maria Elena González-Villalpando Penny Gordon-Larsen Myron Gross Lindsay A Guare Sophie Hackinger Liisa Hakaste Sohee Han Andrew T Hattersley Christian Herder Momoko Horikoshi Annie-Green Howard Willa Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research Division of Musculoskeletal and Dermatological Sciences University of Manchester Manchester UK. Department of Diabetes and Metabolic Diseases Graduate School of Medicine University of Tokyo Tokyo Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. konstantinos.hatzikotoulas@helmholtz-munich.de. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA. British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Heart and Lung Research Institute University of Cambridge Cambridge UK. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA. Corporal Michael J. Crescenz VA Medical Center Philadelphia PA USA. Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London L

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

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Correction to: CC16 polymorphisms in asthma, asthma subtypes, and asthma control in adults from the Agricultural Lung Health Study

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Respiratory Research 2022年第1期23卷 1-1页

作者： K. C. Gribben P. A. Farazi T. D. LeVan A. B. Wyss S. J. London J. A. Poole C. Wichman M. Richards-Barber D. M. Umbach L. E. Beane Freeman P. K. Henneberger Department of Epidemiology University of Nebraska Medical Center Omaha NE 68198 USA Department of Internal Medicine Division of Pulmonary Critical Care and Sleep University of Nebraska Medical Center Omaha NE 68198 USA Epidemiology Branch Department of Health and Human Services National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park NC USA Department of Internal Medicine Division of Allergy and Immunology University of Nebraska Medical Center Omaha NE 68198 USA Department of Biostatistics University of Nebraska Medical Center Omaha NE 68198 USA Westat Durham NC USA Biostatistics and Computational Biology Branch Department of Health and Human Services National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park NC USA Occupational and Environmental Epidemiology Branch National Cancer Institute Bethesda MD USA Respiratory Health Division National Institute for Occupational Safety and Health Centers for Disease Control and Prevention Morgantown WV USA

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Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification

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Nature communications 2025年第1期16卷 4852页

作者： Maria Zanti Denise G O'Mahony Michael T Parsons Leila Dorling Joe Dennis Nicholas J Boddicker Wenan Chen Chunling Hu Marc Naven Kristia Yiangou Thomas U Ahearn Christine B Ambrosone Irene L Andrulis Antonis C Antoniou Paul L Auer Caroline Baynes Clara Bodelon Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Kristen D Brantley Nicola J Camp Archie Campbell Jose E Castelao Melissa H Cessna Jenny Chang-Claude Fei Chen Georgia Chenevix-Trench Don M Conroy Kamila Czene Arcangela De Nicolo Susan M Domchek Thilo Dörk Alison M Dunning A Heather Eliassen D Gareth Evans Peter A Fasching Jonine D Figueroa Henrik Flyger Manuela Gago-Dominguez Montserrat García-Closas Gord Glendon Anna González-Neira Felix Grassmann Andreas Hadjisavvas Christopher A Haiman Ute Hamann Steven N Hart Mikael B A Hartman Weang-Kee Ho James M Hodge Reiner Hoppe Sacha J Howell Anna Jakubowska Elza K Khusnutdinova Yon-Dschun Ko Peter Kraft Vessela N Kristensen James V Lacey Jingmei Li Geok Hoon Lim Sara Lindström Artitaya Lophatananon Craig Luccarini Arto Mannermaa Maria Elena Martinez Dimitrios Mavroudis Roger L Milne Kenneth Muir Katherine L Nathanson Rocio Nuñez-Torres Nadia Obi Janet E Olson Julie R Palmer Mihalis I Panayiotidis Alpa V Patel Paul D P Pharoah Eric C Polley Muhammad U Rashid Kathryn J Ruddy Emmanouil Saloustros Elinor J Sawyer Marjanka K Schmidt Melissa C Southey Veronique Kiak-Mien Tan Soo Hwang Teo Lauren R Teras Diana Torres Amy Trentham-Dietz Thérèse Truong Celine M Vachon Qin Wang Jeffrey N Weitzel Siddhartha Yadav Song Yao Gary R Zirpoli Melissa S Cline Peter Devilee Sean V Tavtigian David E Goldgar Fergus J Couch Douglas F Easton Amanda B Spurdle Kyriaki Michailidou Biostatistics Unit The Cyprus Institute of Neurology & Genetics Nicosia Cyprus. Department of Medical Genetics Oslo University Hospital Oslo Norway. Population Health Program QIMR Berghofer Medical Research Institute Brisbane Queensland Australia. Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care University of Cambridge Cambridge UK. Department of Quantitative Health Sciences Division of Computational Biology Mayo Clinic Rochester MN USA. Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA. Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Department of Health and Human Services Bethesda MD USA. Department of Cancer Prevention and Control Roswell Park Comprehensive Cancer Institute Buffalo NY USA. Fred A. Litwin Center for Cancer Genetics Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital Toronto Ontario Canada. Department of Molecular Genetics University of Toronto Toronto Ontario Canada. Division of Biostatistics Data Science Institute and Cancer Center Medical College of Wisconsin Milwaukee WI USA. Centre for Cancer Genetic Epidemiology Department of Oncology University of Cambridge Cambridge UK. Department of Population Science American Cancer Society Atlanta GA USA. Radiation Oncology Research Unit Hannover Medical School Hannover Germany. Copenhagen General Population Study Herlev and Gentofte Hospital Copenhagen University Hospital Herlev Denmark. Department of Clinical Biochemistry Herlev and Gentofte Hospital Copenhagen University Hospital Herlev Denmark. Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark. Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA. Department of Internal Medicine and Huntsman Cancer Institute University of Utah Salt Lake City UT USA. Centre for Genomic and Experimental Medicine Institute of Genetics & Cancer The University of Ed

Clinical genetic testing identifies variants causal for hereditary cancer, information that is used for risk assessment and clinical management. Unfortunately, some variants identified are of uncertain clinical significance (VUS), complicating patient management. Case-control data is one evidence type used to classify VUS. As an initiative of the Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) Analytical Working Group we analyze germline sequencing data of BRCA1 and BRCA2 from 96,691 female breast cancer cases and 302,116 controls from three studies: the BRIDGES study of the Breast cancer Association Consortium, the cancer Risk Estimates Related to Susceptibility consortium, and the UK Biobank. We observe 11,207 BRCA1 and BRCA2 variants, with 6909 being coding, covering 23.4% of BRCA1 and BRCA2 VUS in ClinVar and 19.2% of ClinVar curated (likely) benign or pathogenic variants. Case-control likelihood ratio (ccLR) evidence is highly consistent with ClinVar assertions for (likely) benign or pathogenic variants; exhibiting 99.1% sensitivity and 95.3% specificity for BRCA1 and 93.3% sensitivity and 86.6% specificity for BRCA2. This approach provides case-control evidence for 787 unclassified variants; these include 579 with strong or moderate benign evidence and 10 with strong pathogenic evidence for which ccLR evidence is sufficient to alter clinical classification.

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Reply to V Gianfredi et al

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Advances in nutrition (Bethesda, Md.) 2022年第2期13卷 685-686页

作者： Wolfgang Marx Nicola Veronese Jaimon Kelly Sam Collins Gina L Trakman Alexandra Wade Melissa Lane Hajara Aslam Adrienne O'Neil James R Hebert Lauren Blekkenhorst Michael Berk Felice Jacka From Deakin University The Institute for Mental and Physical Health and Clinical Translation (IMPACT) Food & Mood Centre School of Medicine Barwon Health Geelong Victoria Australia. Electronic address: wolf.marx@deakin.edu.au. Aging Branch Neuroscience Institute National Research Council Padova Italy. Centre of Applied Health Economics Griffith University Brisbane Queensland Australia Menzies Health Institute Queensland Griffith University Gold Coast Queensland Australia. From Deakin University The Institute for Mental and Physical Health and Clinical Translation (IMPACT) Food & Mood Centre School of Medicine Barwon Health Geelong Victoria Australia. Department of Dietetics Nutrition and Sport La Trobe University Melbourne Victoria Australia. Alliance for Research in Exercise Nutrition and Activity Allied Health and Human Performance University of South Australia Adelaide South Australia Australia. Melbourne School of Population & Global Health University of Melbourne Melbourne Victoria Australia. Department of Epidemiology and Biostatistics and Cancer Prevention and Control Program Arnold School of Public Health University of South Carolina Columbia SC USA Department of Nutrition Connecting Health Innovations LLC Columbia SC USA. School of Medical and Health Sciences Edith Cowan University Joondalup Western Australia Australia Medical School The University of Western Australia Perth Western Australia Australia. Black Dog Institute Sydney New South Wales Australia James Cook University Townsville Queensland Australia Centre for Adolescent Health Murdoch Children's Research Institute Melbourne Victoria Australia.

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Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

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Leukemia 2023年第10期37卷 2142页

作者： Sonja I Berndt Joseph Vijai Yolanda Benavente Nicola J Camp Alexandra Nieters Zhaoming Wang Karin E Smedby Geffen Kleinstern Henrik Hjalgrim Caroline Besson Christine F Skibola Lindsay M Morton Angela R Brooks-Wilson Lauren R Teras Charles Breeze Joshua Arias Hans-Olov Adami Demetrius Albanes Kenneth C Anderson Stephen M Ansell Bryan Bassig Nikolaus Becker Parveen Bhatti Brenda M Birmann Paolo Boffetta Paige M Bracci Paul Brennan Elizabeth E Brown Laurie Burdett Lisa A Cannon-Albright Ellen T Chang Brian C H Chiu Charles C Chung Jacqueline Clavel Pierluigi Cocco Graham Colditz Lucia Conde David V Conti David G Cox Karen Curtin Delphine Casabonne Immaculata De Vivo Arjan Diepstra W Ryan Diver Ahmet Dogan Christopher K Edlund Lenka Foretova Joseph F Fraumeni Attilio Gabbas Hervé Ghesquières Graham G Giles Sally Glaser Martha Glenn Bengt Glimelius Jian Gu Thomas M Habermann Christopher A Haiman Corinne Haioun Jonathan N Hofmann Theodore R Holford Elizabeth A Holly Amy Hutchinson Aalin Izhar Rebecca D Jackson Ruth F Jarrett Rudolph Kaaks Eleanor Kane Laurence N Kolonel Yinfei Kong Peter Kraft Anne Kricker Annette Lake Qing Lan Charles Lawrence Dalin Li Mark Liebow Brian K Link Corrado Magnani Marc Maynadie James McKay Mads Melbye Lucia Miligi Roger L Milne Thierry J Molina Alain Monnereau Rebecca Montalvan Kari E North Anne J Novak Kenan Onel Mark P Purdue Kristin A Rand Elio Riboli Jacques Riby Eve Roman Gilles Salles Douglas W Sborov Richard K Severson Tait D Shanafelt Martyn T Smith Alexandra Smith Kevin W Song Lei Song Melissa C Southey John J Spinelli Anthony Staines Deborah Stephens Heather J Sutherland Kaitlyn Tkachuk Carrie A Thompson Hervé Tilly Lesley F Tinker Ruth C Travis Jenny Turner Celine M Vachon Claire M Vajdic Anke Van Den Berg David J Van Den Berg Roel C H Vermeulen Paolo Vineis Sophia S Wang Elisabete Weiderpass George J Weiner Stephanie Weinstein Nicole Wong Doo Yuanqing Ye Meredith Yeager Kai Yu Anne Zeleniuch-Jacquotte Yawei Zhang Tongzhang Zheng Elad Ziv Joshua Sampson Nilanjan Chatterjee Kenn Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Md USA. berndts@mail.nih.gov. Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA. Cancer Epidemiology Research Programme Catalan Institute of Oncology-IDIBELL L'Hospitalet de Llobregat Barcelona Spain. CIBER de Epidemiología y Salud Pública (CIBERESP) Barcelona Spain. Department of Internal Medicine and Huntsman Cancer Institute University of Utah School of Medicine Salt Lake City UT USA. Institute for Immunodeficiency University Medical Center Freiburg Freiburg Germany. Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis TN USA. Laboratory of Translational Genomics Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Department of Medicine Solna Karolinska Institutet Stockholm Sweden. Hematology Center Karolinska University Hospital Stockholm Sweden. School of Public Health University of Haifa Haifa Israel. Department of Epidemiology Research Division of Health Surveillance and Research Statens Serum Institut Copenhagen Denmark. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark. Department of Haematology Rigshospitalet Copenhagen Denmark. Danish Cancer Society Research Center Danish Cancer Society Copenhagen Denmark. Centre Hospitalier de Versailles Le Chesnay France. Université Paris-Saclay UVSQ Inserm Équipe "Exposome et Hérédité" CESP Villejuif France. Department of Hematology and Medical Oncology Emory University School of Medicine Atlanta GA USA. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Md USA. Genome Sciences Centre BC Cancer Agency Vancouver BC Canada. Department of Biomedical Physiology and Kinesiology Simon Fraser University Burnaby BC Canada. Department of Population Science American Cancer Society Atlanta GA USA. Department of Medical Epidemiology and Biostatistics Karolinska In

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Fatal police violence by race and state in the USA, 1980–2019: a network meta-regression

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The Lancet 2021年第10307期398卷 1239-1255页

作者： Sharara, Fablina Wool, Eve E. Bertolacci, Gregory J. Weaver, Nicole Davis Balassyano, Shelly Watson, Alexandrea Dippenaar, Ilse N. Cunningham, Matthew Fuller, John E. Marczak, Laurie B. Johnson, Catherine Owens Roth, Gregory A. Abedi, Aidin Acuna, Juan Manuel Advani, Shailesh M. Agasthi, Pradyumna Alahdab, Fares Al-Aly, Ziyad Antony, Catherine M. Assari, Shervin Awan, Asma Tahir Basu, Sanjay Bell, Arielle Wilder Braithwaite, Dejana Burkart, Katrin Chew, Adrienne Cho, Daniel Youngwhan Chowdhury, Mohiuddin Ahsanul Kabir Dai, Xiaochen Daoud, Farah Dharmaratne, Samath Dhamminda Dwyer-Lindgren, Laura Elgendy, Islam Y. Fares, Jawad Farwati, Medhat Fisher, James L. Gholamrezanezhad, Ali Gopalani, Sameer Vali Grada, Ayman Guha, Avirup Hafezi-Nejad, Nima Haider, Mohammad Rifat Hay, Simon I. Hossain, Md Mahbub Ikuta, Kevin S. Islam, Jessica Y. Jabbarinejad, Roxana Khatab, Khaled Khubchandani, Jagdish Kim, Daniel Kimokoti, Ruth W. Kisa, Adnan Krishnamoorthy, Vijay Krohn, Kris J. Lawrence, Wayne R. LeGrand, Kate E. Lim, Stephen S. Lin, Ziqiang Liu, Xuefeng Mahmoudi, Morteza Martinez-Piedra, Ramon Mehta, Kala M. Miller, Ted R. Moitra, Modhurima Mokdad, Ali H. Morrison, Shane Douglas Murray, Christopher J.L. Nápoles, Anna María Nsoesie, Elaine Okanyene Odell, Christopher M. Pawar, Shrikant Perez-Stable, Eliseo J. Pilz, Tessa M. Ram, Pradhum Reiner, Robert C. Roberts, Nicholas L.S. Salehi, Sana Sanabria, Juan Schwebel, David C. Sheikh, Aziz Sigfusdottir, Inga Dora Singh, Jasvinder A. Spurlock, Emma Elizabeth Sykes, Bryan L. Tadbiri, Hooman Tleyjeh, Imad I. Tsai, Alexander C. Vos, Theo Wu, Chenkai Yandrapalli, Srikanth Yunusa, Ismaeel Zand, Ramin Zhang, Wangjian Naghavi, Mohsen Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Division of Cardiology University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Division of Plastic Surgery University of Washington Seattle WA United States Division of Allergy and Infectious Diseases University of Washington Seattle WA United States Department of Anesthesiology & Pain Medicine University of Washington Seattle WA United States Department of Orthopaedic Surgery University of Southern California Los Angeles CA United States Department of Radiology University of Southern California Los Angeles CA United States Department of Epidemiology and Population Health Khalifa University Abu Dhabi United Arab Emirates FIU Robert Stempel College of Public Health & Social Work Florida International University Miami FL United States Terasaki Institute for Biomedical Innovation Los Angeles CA United States School of Medicine Georgetown University Washington DC United States Department of Cardiovascular Medicine Mayo Clinic Scottsdale AZ United States Mayo Evidence-based Practice Center Mayo Clinic Foundation for Medical Education and Research Rochester MN United States John T Milliken Department of Internal Medicine Washington University in St Louis St Louis MO United States Clinical Epidemiology Center Department of Veterans Affairs St Louis MO United States Department of Family Medicine Charles R Drew University of Medicine and Science Los Angeles CA United States School of Nursing and Health Sciences Capella University Minneapolis MN United States Continuing Education Grant Writing Academy University of Nevada Las Vegas NV United States Center for Primary Care Harvard University Boston MA United States Department of Global Health and Social Medicine Harvard University Boston MA United States Division of Cardiology Harvard University Bos

Background: The burden of fatal police violence is an urgent public health crisis in the USA. Mounting evidence shows that deaths at the hands of the police disproportionately impact people of certain races and ethnicities, pointing to systemic racism in policing. Recent high-profile killings by police in the USA have prompted calls for more extensive and public data reporting on police violence. This study examines the presence and extent of under-reporting of police violence in US Government-run vital registration data, offers a method for correcting under-reporting in these datasets, and presents revised estimates of deaths due to police violence in the USA. Methods: We compared data from the USA National Vital Statistics System (NVSS) to three non-governmental, open-source databases on police violence: Fatal Encounters, Mapping Police Violence, and The Counted. We extracted and standardised the age, sex, US state of death registration, year of death, and race and ethnicity (non-Hispanic White, non-Hispanic Black, non-Hispanic of other races, and Hispanic of any race) of each decedent for all data sources and used a network meta-regression to quantify the rate of under-reporting within the NVSS. Using these rates to inform correction factors, we provide adjusted estimates of deaths due to police violence for all states, ages, sexes, and racial and ethnic groups from 1980 to 2019 across the USA. Findings: Across all races and states in the USA, we estimate 30 800 deaths (95% uncertainty interval [UI] 30 300–31 300) from police violence between 1980 and 2018;this represents 17 100 more deaths (16 600–17 600) than reported by the NVSS. Over this time period, the age-standardised mortality rate due to police violence was highest in non-Hispanic Black people (0·69 [95% UI 0·67–0·71] per 100 000), followed by Hispanic people of any race (0·35 [0·34–0·36]), non-Hispanic White people (0·20 [0·19–0·20]), and non-Hispanic people of other races (0·15 [0·14– 0·16]). This var

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Corrigendum to 'Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and cancer': [Annals of Oncology Volume 31, Issue 1, January 2020, Pages 103-114]

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Annals of oncology : official journal of the European Society for Medical Oncology 2021年第9期32卷 1201页

作者： J M Genkinger K Wu M Wang D Albanes A Black P A van den Brandt K A Burke M B Cook S M Gapstur G G Giles E Giovannucci G G Goodman P J Goodman N Håkansson T J Key S Männistö L Le Marchand L M Liao R J MacInnis M L Neuhouser E A Platz N Sawada J M Schenk V L Stevens R C Travis S Tsugane K Visvanathan L R Wilkens A Wolk S A Smith-Warner Department of Epidemiology Mailman School of Public Health Columbia University Medical Center New York USA Cancer Epidemiology Program Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York USA. Electronic address: jg3081@columbia.edu. Department of Nutrition Harvard TH Chan School of Public Health Boston USA. Department of Epidemiology Harvard TH Chan School of Public Health Boston USA Department of Biostatistics Harvard TH Chan School of Public Health Boston USA Department of Medicine Harvard Medical School Boston USA. Division of Cancer Epidemiology and Genetics National Cancer Institute NIH DHHS Bethesda USA. Department of Epidemiology GROW-School for Oncology and Developmental Biology Maastricht University Maastricht The Netherlands. Department of Epidemiology Mailman School of Public Health Columbia University Medical Center New York USA. Behavioral and Epidemiology Research Group American Cancer Society Atlanta USA. Cancer Epidemiology and Intelligence Division Cancer Council Victoria Melbourne Australia Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health University of Melbourne Melbourne Australia. Department of Nutrition Harvard TH Chan School of Public Health Boston USA Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle USA. SWOG Statistical Center Seattle USA. Division of Nutritional Epidemiology Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden. Cancer Epidemiology Unit Nuffield Department of Population Health University of Oxford Oxford UK. Department of Public Health Solutions National Institute for Health and Welfare Helsinki Finland. Epidemiology Program University of Hawaii Cancer Center Honolulu USA. Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore USA. Epidemiology and Prevention Group Center for Public Health Sciences National Cancer Center Tokyo Japan. Division

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The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

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Nature Communications 2022年第1期13卷 1-14页

作者： Reiner, Robert C. Welgan, Catherine A. Troeger, Christopher E. Baumann, Mathew M. Weiss, Daniel J. Deshpande, Aniruddha Blacker, Brigette F. Miller-Petrie, Molly K. Earl, Lucas Bhatt, Samir Abolhassani, Hassan Abosetugn, Akine Eshete Abu-Gharbieh, Eman Adekanmbi, Victor Adetokunboh, Olatunji O. Aghaali, Mohammad Aji, Budi Alahdab, Fares Al-Aly, Ziyad Alhassan, Robert Kaba Ali, Saqib Alizade, Hesam Aljunid, Syed Mohamed Almasi-Hashiani, Amir Al-Mekhlafi, Hesham M. Altirkawi, Khalid A. Alvis-Guzman, Nelson Amare, Azmeraw T. Amini, Saeed Amugsi, Dickson A. Ancuceanu, Robert Andrei, Catalina Liliana Ansari, Fereshteh Anvari, Davood Appiah, Seth Christopher Yaw Arabloo, Jalal Aremu, Olatunde Atout, Maha Moh’d Wahbi Ausloos, Marcel Ausloos, Floriane Ayanore, Martin Amogre Aynalem, Yared Asmare Azene, Zelalem Nigussie Badawi, Alaa Baig, Atif Amin Banach, Maciej Bedi, Neeraj Bhagavathula, Akshaya Srikanth Bhandari, Dinesh Bhardwaj, Nikha Bhardwaj, Pankaj Bhattacharyya, Krittika Bhutta, Zulfiqar A. Bijani, Ali Birhanu, Tesega Tesega Mengistu Bitew, Zebenay Workneh Boloor, Archith Brady, Oliver J. Butt, Zahid A. Car, Josip Carvalho, Felix Casey, Daniel C. Chattu, Vijay Kumar Chowdhury, Mohiuddin Ahsanul Kabir Chu, Dinh-Toi Coelho, Camila H. Cook, Aubrey J. Damiani, Giovanni Daoud, Farah Gela, Jiregna Darega Darwish, Amira Hamed Daryani, Ahmad Das, Jai K. Davis Weaver, Nicole Deribe, Kebede Desalew, Assefa Dharmaratne, Samath Dhamminda Dianatinasab, Mostafa Diaz, Daniel Djalalinia, Shirin Dorostkar, Fariba Dubljanin, Eleonora Duko, Bereket Dwyer-Lindgren, Laura Effiong, Andem El Sayed Zaki, Maysaa El Tantawi, Maha Enany, Shymaa Fattahi, Nazir Feigin, Valery L. Fernandes, Eduarda Ferrara, Pietro Fischer, Florian Foigt, Nataliya A. Folayan, Morenike Oluwatoyin Foroutan, Masoud Frostad, Joseph Jon Fukumoto, Takeshi Gaidhane, Abhay Motiramji Gebrekrstos, Hailemikael Gebrekidan G. K. Gebremeskel, Leake Gebreslassie, Assefa Ayalew Gething, Peter W. Gezae, Kebede Embaye Ghadiri, Keyghobad Ghashghaee, Ahmad Golechha, Mahaveer Gubar Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Malaria Atlas Project University of Oxford Oxford United Kingdom Imperial College London London United Kingdom Department of Laboratory Medicine Karolinska University Hospital Huddinge Sweden Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Public Health Debre Berhan University Debre Berhan Ethiopia Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Population Health Sciences King’s College London London United Kingdom Centre of Excellence for Epidemiological Modelling and Analysis Stellenbosch University Stellenbosch South Africa Department of Global Health Stellenbosch University Cape Town South Africa Department of Epidemiology and Biostatistics Qom University of Medical Sciences Qom Iran Faculty of Medicine and Public Health Jenderal Soedirman University Purwokerto Indonesia Mayo Evidence-based Practice Center Mayo Clinic Foundation for Medical Education and Research Rochester MN United States John T. Milliken Department of Internal Medicine Washington University in St. Louis St. Louis MO United States Clinical Epidemiology Center Department of Veterans Affairs St Louis MO United States Institute of Health Research University of Health and Allied Sciences Ho Ghana Department of Information Systems College of Economics and Political Science Sultan Qaboos University Muscat Oman Infectious and Tropical Disease Research Center Hormozgan University of Medical Sciences Bandar Abbas Iran Department of Health Policy and Management Kuwait University Safat Kuwait International Centre for Casemix and Clinical Coding National University of Malaysia Bandar Tun Razak Malaysia Department of Epidemiology Arak University of Medical Sciences Arak Iran Medical Research Center

Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival. © 2022, The Author(s).

关键词： Biogeography epidemiology Infectious diseases Malaria

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