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STEPS (Study To Examine Parent, Patient/Dental Provider Systems) to prevent human papillomavirus (HPV)-related cancers: A formative assessment of HPV educational engagement of the dental practice

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Preventive Oncology & epidemiology 2025年第1期3卷

作者： Kelsey H. Jordan Julie A. Stephens Michael L. Pennell Electra D. Paskett a Division of Population Sciences Comprehensive Cancer Center The Ohio State University Columbus OH USA b Center for Biostatistics Department of Biomedical Informatics College of Medicine The Ohio State University Columbus OH USA c Division of Biostatistics College of Public Health The Ohio State University Columbus OH USA a Division of Population Sciences Comprehensive Cancer Center The Ohio State University Columbus OH USAd Division of Epidemiology College of Public Health The Ohio State University Columbus OH USAe Division of Cancer Prevention and Control Department of Internal Medicine College of Medicine The Ohio State University Columbus OH USA

Objective:Dental clinic oropharyngeal human papillomavirus (HPV) patient education remains understudied. Using descriptive analysis, this study aimed to understand Appalachian Ohio dental clinics’ provider knowledge on HPV, structural compositions for education, patient education approaches, and ***:Surveyed Appalachian Ohio general and pediatric dentists responded to HPV education attitude statements and estimated their HPV vaccine recommendation frequency. Staff completed environmental scans about staff composition, structural capacity for general education, and HPV educational efforts and materials. Descriptive analyses were compared by clinic ***:All dentists (n= 14) believed patients were at-risk for HPV-related cancers and most (≥64%) agreed that the HPV vaccine was safe and effective. Most felt unprepared to educate patients on HPV (64%) and few frequently recommended the HPV vaccine (14%). No clinic shared materials with patients despite most having sufficient display space (75% for ≥2 material types). Older dentist clinics were more actively engaged in HPV education, made more vaccine recommendations, and had more capacity for additional education; younger dentist clinics had more personnel that were more confident in their communication skills and the HPV ***:Appalachian dentists rarely educated patients about HPV. Targeted educational materials and training are needed to support providers in providing patient education.

关键词： Human papillomavirus (HPV) oropharyngeal cancer (cancer/papillomavirus) vaccine preventive dentistry educational activities

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Tumor markers CA15-3, CA125, CEA and breast cancer survival by molecular subtype: a cohort study

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Breast cancer (Tokyo, Japan) 2020年第4期27卷 621-630页

作者： Junxian Li Luyang Liu Ziwei Feng Xin Wang Yubei Huang Hongji Dai Liwen Zhang Fangfang Song Dezheng Wang Pengyu Zhang Baoshan Ma Haixin Li Hong Zheng Fengju Song Kexin Chen Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Key Laboratory of Molecular Cancer Epidemiology Tianjin Medical University Cancer Institute and Hospital Huanhu Xi Road Tiyuan Bei Hexi District Tianjin 300060 People's Republic of China. Tianjin Centers for Disease Control and Prevention Tianjin 300011 People's Republic of China. Department of Clinical Laboratory National Clinical Research Center for Cancer Key Laboratory of Molecular Cancer Epidemiology Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 People's Republic of China. College of Information Science and Technology Liaoning Province Dalian Maritime University Dalian 116026 People's Republic of China. Department of Cancer Biobank National Clinical Research Center for Cancer Key Laboratory of Molecular Cancer Epidemiology Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 People's Republic of China. Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Key Laboratory of Molecular Cancer Epidemiology Tianjin Medical University Cancer Institute and Hospital Huanhu Xi Road Tiyuan Bei Hexi District Tianjin 300060 People's Republic of China. songfengju@***. Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Key Laboratory of Molecular Cancer Epidemiology Tianjin Medical University Cancer Institute and Hospital Huanhu Xi Road Tiyuan Bei Hexi District Tianjin 300060 People's Republic of China. chenkexin@***.

BACKGROUND:The burden of breast cancer has grown rapidly in China during recent decades. However, the association between tumor markers (CA15-3, CA125, and CEA) and breast cancer survival among certain molecular subtypes is unclear; we described this association in a large, population-based study. METHODS:We conducted a cohort study including 10,836 women according to the Tianjin Breast cancer Cases Cohort. Demographic and epidemiologic data were collected by a structured face-to-face questionnaire. Clinico-pathological parameters were abstracted from medical records, and follow-up information was obtained once a year by telephone. The primary endpoints were breast cancer-specific survival (BCSS) and disease-free survival (DFS). We utilized the Cox proportional hazard model to calculate hazard ratios (HRs) and 95% confidence intervals (CI). RESULTS:Among all patients, elevated CA15-3 and CEA exhibited consistently and statistically significant reduced BCSS compared with normal ones (CA15-3: HR 1.54, 95% CI 1.01-2.34; CEA: HR 2.45, 95% CI 1.40-4.30). Similar patterns of association were observed for DFS (CA15-3: HR 2.09, 95% CI 1.44-3.02; CEA: HR 2.71, 95% CI 1.71-4.27). Moreover, in luminal A subtype, high CA15-3 and CEA levels were associated with decreased BCSS (CA15-3: HR 4.47, 95% CI 2.04-9.81; CEA: HR 3.79, 95% CI 1.68-8.55) and DFS (CA15-3: HR 4.06, 95% CI 2.29-7.18, CEA: HR 3.41, 95% CI 1.75-6.64). In basal-like subtype, elevated CEA conferred reduction for BCSS (HR 5.13, 95% CI 1.65-15.9). However, no association was observed between CA125 and breast cancer outcome. CONCLUSIONS:Preoperative CA15-3 and CEA levels differ in breast cancer molecular subtypes and yield strong prognostic information in Chinese women with breast cancer. Measuring CA15-3 and CEA levels before surgery may have the potential in predicting breast cancer survival and offering patients' personalized treatment strategy among luminal A and basal-like subtypes.

关键词： Breast cancer Molecular subtype Survival TBCCC Tumor marker

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Correction: Polygenic risk modeling for prediction of epithelial ovarian cancer risk

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European journal of human genetics : EJHG 2022年第5期30卷 630-631页

作者： Eileen O Dareng Jonathan P Tyrer Daniel R Barnes Michelle R Jones Xin Yang Katja K H Aben Muriel A Adank Simona Agata Irene L Andrulis Hoda Anton-Culver Natalia N Antonenkova Gerasimos Aravantinos Banu K Arun Annelie Augustinsson Judith Balmaña Elisa V Bandera Rosa B Barkardottir Daniel Barrowdale Matthias W Beckmann Alicia Beeghly-Fadiel Javier Benitez Marina Bermisheva Marcus Q Bernardini Line Bjorge Amanda Black Natalia V Bogdanova Bernardo Bonanni Ake Borg James D Brenton Agnieszka Budzilowska Ralf Butzow Saundra S Buys Hui Cai Maria A Caligo Ian Campbell Rikki Cannioto Hayley Cassingham Jenny Chang-Claude Stephen J Chanock Kexin Chen Yoke-Eng Chiew Wendy K Chung Kathleen B M Claes Sarah Colonna Linda S Cook Fergus J Couch Mary B Daly Fanny Dao Eleanor Davies Miguel de la Hoya Robin de Putter Joe Dennis Allison DePersia Peter Devilee Orland Diez Yuan Chun Ding Jennifer A Doherty Susan M Domchek Thilo Dörk Andreas du Bois Matthias Dürst Diana M Eccles Heather A Eliassen Christoph Engel Gareth D Evans Peter A Fasching James M Flanagan Renée T Fortner Eva Machackova Eitan Friedman Patricia A Ganz Judy Garber Francesca Gensini Graham G Giles Gord Glendon Andrew K Godwin Marc T Goodman Mark H Greene Jacek Gronwald Eric Hahnen Christopher A Haiman Niclas Håkansson Ute Hamann Thomas V O Hansen Holly R Harris Mikael Hartman Florian Heitz Michelle A T Hildebrandt Estrid Høgdall Claus K Høgdall John L Hopper Ruea-Yea Huang Chad Huff Peter J Hulick David G Huntsman Evgeny N Imyanitov Claudine Isaacs Anna Jakubowska Paul A James Ramunas Janavicius Allan Jensen Oskar Th Johannsson Esther M John Michael E Jones Daehee Kang Beth Y Karlan Anthony Karnezis Linda E Kelemen Elza Khusnutdinova Lambertus A Kiemeney Byoung-Gie Kim Susanne K Kjaer Ian Komenaka Jolanta Kupryjanczyk Allison W Kurian Ava Kwong Diether Lambrechts Melissa C Larson Conxi Lazaro Nhu D Le Goska Leslie Jenny Lester Fabienne Lesueur Douglas A Levine Lian Li Jingmei Li Jennifer T Loud Karen H Lu Jan Lubiński Phuong L Mai Siranoush Manoukian Jeffrey R Marks Ra University of Cambridge Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care Cambridge UK. University of Cambridge Centre for Cancer Genetic Epidemiology Department of Oncology Cambridge UK. Center for Bioinformatics and Functional Genomics Cedars-Sinai Medical Center Los Angeles CA USA. Radboud University Medical Center Radboud Institute for Health Sciences Nijmegen The Netherlands. Netherlands Comprehensive Cancer Organisation Utrecht The Netherlands. The Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital Family Cancer Clinic Amsterdam The Netherlands. Veneto Institute of Oncology IOV-IRCCS Immunology and Molecular Oncology Unit Padua Italy. Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital Fred A. Litwin Center for Cancer Genetics Toronto ON Canada. University of Toronto Department of Molecular Genetics Toronto ON Canada. University of California Irvine Department of Epidemiology Genetic Epidemiology Research Institute Irvine CA USA. N.N. Alexandrov Research Institute of Oncology and Medical Radiology Minsk Belarus. 'Agii Anargiri' Cancer Hospital Athens Greece. University of Texas MD Anderson Cancer Center Department of Breast Medical Oncology Houston TX USA. Lund University Department of Cancer Epidemiology Clinical Sciences Lund Sweden. Vall d'Hebron Institute of Oncology Hereditary cancer Genetics Group Barcelona Spain. University Hospital of Vall d'Hebron Department of Medical Oncology Barcelona Spain. Rutgers Cancer Institute of New Jersey Cancer Prevention and Control Program New Brunswick NJ USA. Landspitali University Hospital Department of Pathology Reykjavik Iceland. University of Iceland BMC (Biomedical Centre) Faculty of Medicine Reykjavik Iceland. University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg Department of Gynecology and Obstetrics Comprehensive Cancer Center ER-EMN Erlangen Germany. Vanderbilt University School of Medicine Division of Epide

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Obesity, Dietary inflammation, and Frailty among Older Adults: Evidence from the National Health and Nutrition Examination Survey

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Journal of Nutrition in Gerontology and Geriatrics 2019年第1期38卷 18-32页

作者： Lohman, Matthew C. Resciniti, Nicholas V. Wirth, Michael D. Shivappa, Nitin Hébert, James R. Department of Epidemiology and Biostatistics Arnold School of Public Health University of South Carolina Columbia SC United States Cancer Prevention and Control Program University of South Carolina Columbia SC United States College of Nursing University of South Carolina Columbia SC United States Connecting Health Innovations LLC Columbia SC United States

Knowledge related to the relationship between obesity and frailty is limited. This study aimed to investigate associations between obesity, dietary inflammation, and frailty among older adults. Study data came from National Health and Nutrition Examination Survey (2007–2014) examinations of adults age ≥60 years (n = 7182). Dietary inflammatory potential was determined using the Dietary Inflammatory Index (DII ^® ) derived from 24-h dietary recall. We analyzed independent and joint associations of obesity and DII with frailty to evaluate interaction. Multivariable logistic regression revealed that both obesity (Odds Ratio [OR] = 2.24, 95% CI: 1.68, 2.99) and moderately pro-inflammatory DII (OR = 1.68, 95% CI: 1.10, 2.58) were independently associated with greater frailty prevalence. A negative multiplicative interaction between obesity and highest pro-inflammatory diet also was found (adjusted odds in non-obese and obese were 2.07 and 2.37, respectively;p = 0.046). Results indicate the importance of considering obesity and dietary inflammatory potential when screening for frailty or developing treatments. © 2019, © 2019 Taylor & Francis Group, LLC.

关键词： Dietary inflammation frailty interaction obesity

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Publisher Correction: Performance and effectiveness of hepatocellular carcinoma screening in individuals with HBsAg seropositivity in China: a multicenter prospective study

Nature cancer

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Nature cancer 2023年第9期4卷 1396页

作者： Hongmei Zeng Maomao Cao Changfa Xia Dongmei Wang Kun Chen Zheng Zhu Ruiying Fu Shaokai Zhang Jinyi Zhou Huadong Wang Xianyun Qi Shuguang Dai Yong Chen Zhong Sun Hao Ding Qingwen Li Hui Zhao Xuehong Zhang Jakub Morze John S Ji Feng Sun Xueqin Yu Chunfeng Qu Wanqing Chen National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of China. Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of China. State Key Laboratory of Molecular Oncology and Department of Immunology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of China. Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of China. Department of Cancer Epidemiology Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital Henan Engineering Research Center of Cancer Prevention and Control Henan International Joint Laboratory of Cancer Prevention Zhengzhou People's Republic of China. Department for Chronic Non-communicable Diseases Control Jiangsu Provincial Center for Disease Control and Prevention (Public Health Research Institute of Jiangsu Province) Nanjing People's Republic of China. Department of Chronic Non-communicable Diseases Prevention and Treatment Anhui Provincial Center for Disease Control and Prevention Hefei People's Republic of China. Department of Chronic Non-communicable Diseases Prevention and Treatment Yingdong Center for Disease Control and Prevention Fuyang People's Republic of China. Sheyang Center for Disease Control and Prevention Yancheng People's Republic of China. Binhai Center for Disease Control and Prevention Yancheng People's Republic of China. Dancheng Center for Disease Control and Prevention Zhoukou People's Republic of China. Mengcheng Center for Dise

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Secular trends in incidence of lung cancer by histological type in Beijing, China, 2000-2016

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Chinese Journal of cancer Research 2019年第2期31卷 306-315页

作者： Lei Yang Ning Wang Yannan Yuan Shuo Liu Huichao Li Jing Tian Jiafu Ji Aiguo Ren Department of Epidemiology and Biostatistics School of Public Health Peking University Institute of Reproductive and Child Health Peking University/National Health Commission Key Laboratory of Reproductive Health (Peking University) Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Beijing Office for Cancer Prevention and Control Peking University Cancer Hospital & Institute Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Center of Gastrointestinal Surgery Peking University Cancer Hospital & Institute

Objective: The objective of this study was to characterize secular trends in the sex-specific, age-standardized incidence of lung cancer by histological type in Beijing, China, from 2000 to 2016 based on data from a populationbased cancer ***: Data on the incidence of cancer from 2000 to 2016 were obtained from the Beijing cancer *** examined trends in the sex-specific, age-standardized incidence of lung cancer by histological type using a Joinpoint regression ***: A total of 117,409 cases of lung cancer were diagnosed from 2000 to 2016. Overall, 73,062(62.23%)patients were males. The most common histological type among both sexes was adenocarcinoma; however, the proportion of adenocarcinoma differed significantly between males and females(45.36% vs. 77.14%, respectively,P<0.0001). The age-standardized incidence of total lung cancer increased from 2000 to 2010 with an annual percent change(APC) of 2.2% [95% confidence interval(95% CI), 1.5% to 2.9%] and stabilized thereafter. Among males, the incidence of total lung cancer peaked in 2008 and then decreased slightly, with an APC of-1.1%(95%CI,-2.1% to-0.1%). Among females, the incidence increased continuously during the study period, with an APC of 1.4%(95% CI, 0.9% to 1.9%). The incidence of squamous cell carcinoma decreased significantly in recent years among both sexes, with APCs of-2.6%(95% CI,-4.5% to-0.6%) from 2007 to 2016 for males and-5.4%(95%CI,-7.2% to-3.6%) from 2004 to 2016 for females. In contrast, the incidence of adenocarcinoma increased continuously throughout the study period, by APCs of 4.0%(95% CI, 2.6% to 5.4%) for males and 6.2%(95% CI,4.8% to 7.6%) for females. The incidence of small cell carcinoma peaked in 2007 and stabilized thereafter among males, whereas it peaked in 2012 and then decreased with an APC of-14.7%(95% CI,-25.3% to-2.6%) among females. The incidence of large cell carcinoma and other specified malignant neoplasm did not change much,whereas the inc

关键词： Lung cancer secular trends incidence Beijing cancer registration

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Absenteeism and Health Behavior Trends Associated With Acute Respiratory Illness Before and During the COVID-19 Pandemic in a Community Household Cohort, King County, Washington

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AJPM Focus 2024年第4期3卷 100248-100248页

作者： Chung, Erin Wang, Yongzhe Chow, Eric J. Emanuels, Anne Heimonen, Jessica Ogokeh, Constance E. Rolfes, Melissa A. Hughes, James P. Uyeki, Timothy M. Starita, Lea M. Hoag, Samara Boeckh, Michael Englund, Janet A. Chu, Helen Y. Department of Pediatrics University of Washington Seattle Children's Hospital Seattle WA United States Division of Allergy and Infectious Diseases Department of Medicine University of Washington Seattle WA United States Public Health - Seattle & King County Seattle WA United States Department of Epidemiology University of Washington Seattle WA United States Influenza Division National Center for Immunization and Respiratory Diseases Centers for Disease Control and Prevention Georgia Atlanta Georgia Military and Health Research Foundation Laurel Maryland United States Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle WA United States Department of Biostatistics University of Washington Seattle WA United States Fred Hutchinson Cancer Research Center Seattle WA United States Brotman Baty Institute for Precision Medicine Seattle WA United States Department of Genome Sciences University of Washington Seattle WA United States Student Health Services Seattle Public Schools Seattle WA United States University of Washington School of Medicine Seattle WA United States

Introduction: Longitudinal data on how acute respiratory illness (ARI) affects behavior, namely school or work participation, and nonpharmaceutical intervention (NPI) usage before and during the COVID-19 pandemic is limited. The authors assessed how ARIs and specific symptoms affected school, work, and health-related behaviors over time. Methods: From November 2019 to June 2021, participating households with children in King County, Washington, were remotely monitored for ARI symptoms weekly. Following ARIs, participants reported illness-related effects on school, work, and NPI use. Using logistic regression with generalized estimating equations, the authors examined associations between symptoms and behaviors. Results: Of 1,861 participants, 581 (31%) from 293 households reported 884 ARIs and completed one-week follow-up surveys. Compared with the prepandemic period, during the period of the pandemic pre–COVID-19 vaccine, ARI-related school (56% vs 10%, p<0.001) absenteeism decreased and masking increased (3% vs 28%, p<0.001). After vaccine authorization in December 2020, more ARIs resulted in masking (3% vs 48%, p<0.001), avoiding contact with non-household members (26% vs 58%, p<0.001), and staying home (37% vs 69%, p<0.001) compared with the prepandemic period. Constitutional symptoms such as fever were associated with work disruptions (OR=1.91;95% CI=1.06, 3.43), staying home (OR=1.55;95% CI=1.06, 2.27), and decreased contact with non-household members (OR=1.58;95% CI=1.05, 2.36). Conclusions: This remote household study permitted uninterrupted tracking of behavioral changes in families with children before and during the COVID-19 pandemic, identifying increased use of some NPIs when ill but no additional illness-associated work or school disruptions. © 2024 The Authors

关键词： absenteeism COVID-19 households illness behavior non-pharmaceutical interventions viral infections

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Response to Dekker, Stege, and Versteeg

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Journal of the National cancer Institute 2021年第10期113卷 1436-1437页

作者： Jeanne S Mandelblatt Xingtao Zhou Brent J Small Jaeil Ahn Wanting Zhai Tim Ahles Martine Extermann Deena Graham Paul B Jacobsen Heather Jim Brenna C McDonald Sunita K Patel James C Root Andrew J Saykin Harvey Jay Cohen Judith E Carroll Department of Oncology Cancer Prevention and Control Program Georgetown-Lombardi Comprehensive Cancer Center Georgetown University Washington DC USA. Department of Biostatistics Bioinformatics and Biomathematics Georgetown-Lombardi Comprehensive Cancer Center Georgetown University Washington DC USA. School of Aging Studies University of South Florida and Health Outcome and Behavior Program and Biostatistics Resource Core H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida Tampa FL USA. Department of Biostatistics Bioinformatics and Biomathematics Georgetown-Lombardi Comprehensive Cancer Center Georgetown University Washington DC USA. Department of Psychiatry and Behavioral Sciences Memorial Sloan-Kettering Cancer Center New York NY USA. Department of Oncology Moffitt Cancer Center University of South Florida Tampa FL USA. John Theurer Cancer Center Hackensack NJ USA. Division of Cancer Control and Population Sciences Healthcare Delivery Research Program National Cancer Institute National Institutes of Health Bethesda MD USA. Department of Health Outcomes and Behavior Moffitt Cancer Center and Research Institute University of South Florida Tampa FL USA. Department of Radiology and Imaging Sciences and the Melvin and Bren Simon Cancer Center Center for Neuroimaging Indiana University School of Medicine Indianapolis IN USA. Departments of Population Sciences and Supportive Care Medicine City of Hope Comprehensive Cancer Center Duarte CA USA. Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center New York NY USA. Departments of Psychiatry and Anesthesiology Weill Medical College of Cornell University New York NY USA. Department of Radiology and Imaging Sciences and the Melvin and Bren Simon Cancer Center Center for Neuroimaging Indiana University School of Medicine Indianapolis IN USA. Department of Medicine Duke University School of Medicine Durham NC USA. UCLA Department of

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Correlates of Non-Persistent Endocrine Disrupting Chemical Mixtures Among Reproductive-Aged Black Women in Detroit, Michigan

SSRN

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SSRN 2022年

作者： Schildroth, Samantha Wise, Lauren A. Wesselink, Amelia K. Bethea, Traci N. Fruh, Victoria Taylor, Kyla W. Calafat, Antonia M. Baird, Donna D. Henn, Birgit Claus Department of Environmental Health Boston University School of Public Health BostonMA United States Department of Epidemiology Boston University School of Public Health BostonMA United States Office of Minority Health & Health Disparities Research Georgetown Lombardi Comprehensive Cancer Center WashingtonDC United States National Toxicology Program National Institute of Environmental Health Sciences National Institutes of Health Department of Health and Human Services Research Triangle Park NC United States Division of Laboratory Sciences Centers for Disease Control and Prevention AtlantaGA United States National Institute of Environmental Health Sciences DurhamNC United States

Black women are exposed to multiple non-persistent endocrine disrupting chemicals (EDCs) at higher concentrations compared with white women. Using baseline data from a prospective cohort study of reproductive-aged Black women (N= 751), we characterized profiles of EDC mixtures and identified correlates of exposure. At baseline, we quantified biomarkers of 16 phthalates, 7 phenols, 4 parabens, and triclocarban in urine and collected covariate data through self-administered questionnaires and interviews. We used principal component analysis (PCA) and k- means clustering to describe EDC mixture profiles. Associations between correlates and PCs were estimated as the mean difference (β) in PC scores, while associations between correlates and cluster membership were estimated as the odds ratio (OR) of cluster membership with 95% confidence intervals (CIs). Personal care product use was consistently associated with profiles of higher biomarker concentrations of non-persistent EDCs. Use of nail polish, feminine hygiene products, and sunscreen was associated with a mixture of phthalate and some phenol biomarkers using both methods. Current vaginal ring use was strongly associated with higher concentrations of high molecular weight phthalate biomarkers (from k- means clustering: OR= 2.42, 95% CI= 1.28, 4.59;from PCA: β= -0.32, 95% CI= -0.71, 0.07). Several dietary, reproductive, and demographic correlates were also associated with mixtures of EDC biomarkers. These findings suggest that personal care product use may be a main source of exposure to multiple non-persistent EDCs among reproductive-aged Black women, and that targeted strategies (e.g., reducing use of certain products or canned food consumption) should be implemented to reduce exposure to multiple EDCs among Black women. © 2022, The Authors. All rights reserved.

关键词： Phenols

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Discovery of an Inherited Variant Associated with Susceptibility to Secondary Acute Lymphoblastic Leukemia (ALL) after Lenalidomide Maintenance and Autologous HCT for Multiple Myeloma (MM)

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Transplantation and Cellular Therapy 2024年第2期30卷 S99-S100页

作者： Zhu, Qianqian, PhD Herr, Megan, PhD Liang, Shuyi Hu, Qiang, MD, PhD Singh, Prashant K, PhD Gao, Xinyu Pasquini, Marcelo C. Leonard, Jessica T., MD Rosko, Ashley, MD Bayer, Ruthee-Lu, MD Krishnan, Amrita, MD Stadtmauer, Edward A., MD Maziarz, Richard T., MD McCarthy, Phillip L, MD Hahn, Theresa E., PhD Biostatistics & Bioinformatics Roswell Park Comprehensive Cancer Center Buffalo NY Department of Medicine Roswell Park Comprehensive Cancer Center Buffalo NY Cancer Genetics & Genomics Roswell Park Comprehensive Cancer Center Buffalo NY Center for International Blood and Marrow Transplant Research Medical College of Wisconsin Milwaukee WI Center for Hematologic Malignancies - Knight Cancer Institute Oregon Health & Science University Portland OR The Ohio State University Columbus OH Hematology/Oncology North Shore University Hospital Northwell Health Lake Success NY City of Hope Duarte CA Blood and Marrow Transplantation Program Abramson Cancer Center and the Division of Hematology and Oncology Hospital of the University of Pennsylvania Philadelphia PA Cancer Prevention & Control Roswell Park Comprehensive Cancer Center Buffalo NY

An increased risk of ALL second primary malignancy (SPM) has been observed with lenalidomide maintenance therapy after autologous HCT (len-post-autoHCT) for MM. Lenalidomide exerts its therapeutic effects via cereblon-mediated downregulation of the transcription factors Ikaros ( IKZF1) and Aiolos ( IKZF3). Inherited susceptibility variants in IKZF1 have been described for de novo ALL. We performed a case-control germline targeted sequencing study of the entire IKZF1 and IKZF3 genes with mean coverage ∼2,200X to investigate inherited susceptibility to ALL SPM risk. All cases and controls had a primary diagnosis of MM and received len-post-autoHCT with melphalan; sequencing was performed on an aliquot of the apheresis product or peripheral blood sample that was collected before autoHCT for MM. Cases of ALL SPMs were contributed by 4 individual centers and one national trial (BMT CTN 0702); each case had a maximum of 4 controls per case, sampled with replacement and matched on age, sex, race/ethnicity and duration of lenalidomide exposure (controls had longer duration of lenalidomide maintenance than cases). An additional control group of Acute Myeloid Leukemia/Myelodysplastic Syndrome (AML/MDS) SPMs after len-post-autoHCT were contributed by one center (Table). Multivariate logistic regression of case-control status, adjusted by age at HCT, sex, race/ethnicity, duration of lenalidomide maintenance, was performed for: 1) ALL SPM, 2) AML/MDS SPM, 3) ALL and AML/MDS SPM. We found the risk allele A of rs62447181 in IKZF1 had an OR=2.51 P=9.53 × 10 −3 for ALL SPM, OR=4.18 P=0.09 for AML/MDS SPM and OR=2.57 P=4.98 × 10 −3 for ALL&AML/MDS SPM. rs62447181 is a cis-expression quantitative trait loci (eQTL) of IKZF1 in blood (p=3.88 × 10 −55 in eQTLGen Consortium data) and resides in a promoter-proximal enhancer predicted by the ENCODE project (Figure A). Our in silico analysis of transcription factor binding sites showed that rs62447181 disrupts the binding site of PLAGL2, a k

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