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Cellulose Elementary Fibrils as deagglomerated Binder for High-Mass-Loading Lithium Battery Electrodes

Nano-Micro Letters 2025年第5期17卷 281-296页

作者： Young-Kuk Hong Jung-Hui Kim Nag-Young Kim Kyeong-Seok Oh Hong-I Kim Seokhyeon ryu Yumi Ko Ji-Young Kim Kwon-Hyung Lee Sang-Young Lee Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea Advanced Analysis and Data Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Ulsan Advanced Energy Technology R&D Center Korea Institute of Energy Research(KIER)Ulsan 44776Republic of Korea Department of Battery Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea

Amidst the ever-growing interest in high-mass-loading Li battery electrodes,a persistent challenge has been the insufficient continuity of their ion/electron conduction ***,we propose cellulose elementary fibrils(CEFs)as a class of deagglomerated binder for high-mass-loading *** from natural wood,CEF represents the most fundamental unit of cellulose with nanoscale *** preparation of the CEFs involves the modulation of intermolecular hydrogen bonding by the treatment with a proton acceptor and a hydrotropic *** elementary deagglomeration of the cellulose fibers increases surface area and anionic charge density,thus promoting uniform dispersion with carbon conductive additives and suppressing interfacial side reactions at ***,a homogeneous redox reaction is achieved throughout the *** resulting CEF-based cathode(overlithiated layered oxide(OLO)is chosen as a benchmark electrode active material)exhibits a high areal-mass-loading(50 mg cm^(-2),equivalent to an areal capacity of 12.5 mAh cm^(-2))and a high specific energy density(445.4 Wh kg–1)of a cell,which far exceeds those of previously reported OLO *** study highlights the viability of the deagglomerated binder in enabling sustainable high-mass-loading electrodes that are difficult to achieve with conventional synthetic polymer binders.

关键词： Cellulose elementary fibrils deagglomeration Electrode binders Lithium batteries High-mass-loading

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Clinical and Metabolic Signatures of FAM47E–SHrOOM3 Haplotypes in a General Population Sample

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Kidney International reports 2025年第5期10卷 1495-1508页

作者： Ghasemi-Semeskandeh, dariush König, Eva Foco, Luisa dordevic, Nikola Gögele, Martin rainer, Johannes ralser, Markus Acoba, dianne domingues, Francisco S. Peters, dorien J.M. Pramstaller, Peter P. Pattaro, Cristian Department of Human Genetics Leiden University Medical Center Leiden Netherlands Institute for Biomedicine Eurac Research Bolzano Italy Integrative Data Analysis Unit Health Data Science Centre Human Technopole Milan Italy Institute of Biochemistry Charité - Universitätsmedizin Berlin Berlin Germany Clinical Renal Late-stage Development Cardiovascular Renal and Metabolism Bio Pharmaceuticals R&D AstraZeneca Gothenburg Sweden Institut Necker Enfants-Malades Institut National de la Santé et de la Recherche Médicale U1151 Université Paris Cité Paris France

Introduction: Genome-wide association studies (GWAS) identified a locus on chromosome 4q21.1, spanning the Family With Sequence Similarity 47 Member E (FAM47E), Starch Binding domain 1 (STBd1), Coiled-Coil domain Containing 158 (CCdC158), and Shroom Family Member 3 (SHrOOM3) genes, to be associated with kidney function markers. Functional studies implicated SHrOOM3 as the effector gene, demonstrating its developmental role to guarantee podocyte barrier integrity. However, the locus has also been associated with other clinical traits, including electrolytes, hematological, cardiovascular, and neurological traits, not all of which can be easily traced to the regulation of kidney function. We therefore conducted a systematic analysis of the whole locus’ genetic profiles (haplotypes) to assess which phenotypic profiles they were associated with. Methods: For the 4 genes, we reconstructed haplotypes spanning 71 exonic and intronic variants for 12,834 participants in the Cooperative Health research in South Tyrol (CHrIS) study based on genotypes imputed on a local whole-exome sequencing (WES) reference panel. Haplotypes were tested for associations with 72 clinical traits, 170 serum metabolites, and 148 plasma protein concentrations, using linear regression models. results: We identified 11 haplotypes with a population frequency between 2% and 24%. Compared with the most common haplotype, most haplotypes were associated with higher creatinine-based estimated glomerular filtration rate (eGFr) and lower serum magnesium levels. In addition, specific haplotypes were also associated with biologically diverse groups of traits, including albuminuria, blood pressure, red blood cell traits, carnitines, and amino acids. Cluster analysis highlighted the existence of distinct genetic profiles in which individuals with specific haplotypes presented with specific phenotypic and metabolic signatures. Conclusion: The genetic variability of the FAM47E–SHrOOM3 locus indicates the existence

关键词： CCdC158 FAM47E haplotype kidney SHrOOM3 STBd1

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AZd2693, a PNPLA3 antisense oligonucleotide, for the treatment of MASH in 148M homozygous participants: Two randomized phase I trials

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Journal of Hepatology 2025年

作者： Armisen, Javier rauschecker, Mitra Sarv, Janeli Liljeblad, Mathias Wernevik, Linda Niazi, Mohammad Knöchel, Jane Eklund, Olof Sandell, Therése Sherwood, James Bergenholm, Linnéa Hallén, Stefan Wang, Shan Kamble, Prasad Bhat, Maria Maxvall, Ingela Wang, Yixin Lee, richard G. Bhanot, Sanjay Guo, Shuling romeo, Stefano Lawitz, Eric Fjellström, Ola Lindén, daniel Blau, Jenny E. Loomba, rohit Research and Early Development Cardiovascular Renal and Metabolism BioPharmaceuticals R&D AstraZeneca Cambridge United Kingdom Research and Early Development Cardiovascular Renal and Metabolism BioPharmaceuticals R&D AstraZeneca Gaithersburg MD United States Late Stage Development Cardiovascular Renal and Metabolism BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden Translational Science and Experimental Medicine Research and Early Development Cardiovascular Renal and Metabolism BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden Clinical Operations Cardiovascular Renal and Metabolism BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden Clinical Pharmacology and Quantitative Pharmacology Clinical Pharmacology & Safety Sciences R&D AstraZeneca Gothenburg Sweden Global Patient Safety Cardiovascular Renal and Metabolism BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden Precision Medicine and Biosamples Diagnostic and HBS Science Biopharma Diagnostics Oncology R&D AstraZeneca Cambridge United Kingdom Drug Metabolism and Pharmacokinetics Research and Early Development Cardiovascular Renal and Metabolism BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden Bioscience Metabolism Research and Early Development Cardiovascular Renal and Metabolism BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden Image Analysis & Platform Pathology Clinical Pharmacology and Safety Sciences BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden Ionis Pharmaceuticals Inc. Carlsbad CA United States Department of Molecular and Clinical Medicine Institute of Medicine The Sahlgrenska Academy Wallenberg Laboratory University of Gothenburg Gothenburg Sweden Department of Cardiology Sahlgrenska University Hospital Gothenburg Sweden Department of Medical and Surgical Sciences University Magna Graecia Catanzaro Italy Texas Liver Institute University of Texas Health San Antonio San Antonio TX United States Research and Early Development Cardiovascular

Background & Aims: A common genetic variant (rs738409) encoding an isoleucine to methionine substitution at position 148 in the PNPLA3 protein is a determinant of hepatic steatosis, inflammation, fibrosis, cirrhosis, and liver-related mortality. AZd2693 is a liver-targeted antisense oligonucleotide against PNPLA3 mrNA. We evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics in single and multiple ascending dose studies. Methods: AZd2693 was assessed in 3d cultures of homozygous PNPLA3 148M primary human hepatocytes and mice expressing human PNPLA3. The single ascending dose study investigated 2–110 mg doses in overweight/mildly obese but otherwise healthy volunteers. The multiple ascending dose study investigated three monthly doses (25 mg, 50 mg and 80 mg) in participants with MrI-proton density fat fraction (MrI-PdFF) ≥7%. Changes in liver fat content were assessed at baseline, weeks 8 and 12 by MrI-PdFF. PNPLA3 mrNA and protein knockdown levels were evaluated for the 80 mg dose. results: AZd2693 potently reduced PNPLA3 expression in human hepatocytes and livers of mice. Clinically, AZd2693 was generally well tolerated (no adverse events leading to discontinuation or treatment-related serious adverse events). Half-life was 14–33 days across investigated doses. A least-square mean liver PNPLA3 mrNA knockdown of 89% and reduction of protein levels demonstrated target engagement. Changes in hepatic steatosis at week 12 were −7.6% and −12.2% (placebo-corrected least-square means) for the 25 mg and 50 mg doses, respectively. There was a dose-dependent increase of polyunsaturated fatty acids in serum triglycerides and decreases vs. placebo in high-sensitivity C-reactive protein and interleukin 6. Conclusions: AZd2693 reduced liver PNPLA3 with an acceptable safety and tolerability profile. These findings support the continued development of AZd2693. Impact and implications: Clinical treatment options for metabolic dysfunction-associated steatohepati

关键词： antisense oligonucleotide (ASO) clinical trial Liver disease metabolic dysfunction-associated steatohepatitis (MASH) metabolic dysfunction-associated steatotic liver disease (MASLd) non-alcoholic fatty liver disease (NAFLd) non-alcoholic steatohepatitis (NASH) patatin-like phospholipase domain-containing protein 3 (PNPLA3) precision medicine

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Human tau promotes Warburg effect–like glycolytic metabolism under acute hyperglycemia conditions

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Journal of Biological Chemistry 2025年第4期301卷 108376页

作者： Yao, Jinyi Li, Keying Fu, Zhenli Zheng, Jingjing Chen, Zicong Xu, Jiahao Lai, Guoqing Huang, Yaomin Huang, Jinsheng You, Guanying Han, Shuangxue He, Zhijun Liu, Qiong Li, Nan Shenzhen Key Laboratory of Marine Biotechnology and Ecology Brain Disease and Big Data Research Institute College of Life Sciences and Oceanography Shenzhen University Shenzhen China National R&D Center for Se-rich Agricultural Products Processing Hubei Engineering Research Center for Deep Processing of Green Se-rich Agricultural Products School of Modern Industry for Selenium Science and Engineering Wuhan Polytechnic University Wuhan China Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Shenzhen China Instrumental Analysis Center of Shenzhen University Shenzhen University Shenzhen China Shenzhen Bay Laboratory Shenzhen China

The neurofilaments formed by hyperphosphorylated tau is a hallmark of tauopathies. However, the biological functions of tau and the physiological significance of its phosphorylation are still not fully understood. By using human tau (441 a.a.) transgenic (hTau) mice, murine tau KO mice, and C57BL/6J (C57) mice, unexpectedly, we found that under acute hyperglycemia conditions, JNK but not previously reported GSK3β mediated tau phosphorylation. Moreover, Akt, the inhibitory kinase upstream of GSK3β, was activated in a tau-dependent manner. Furthermore, under acute high glucose conditions, the presence of human tau significantly augmented Akt activation but inhibited 4E-BP1 phosphorylation simultaneously, indicating that human tau is also involved in regulating the alternative activation of mTOrC1/2. By comparing the hippocampal membrane-associated proteome, we found that human tau influenced the homeostasis of protein-membrane association under acute hyperglycemia conditions. Of note, with respect to C57 and Tau KO mice, the membrane association of oxidative phosphorylation–related proteins was impeded by human tau in the hippocampus. In vitro study consistently showed that aerobic glycolysis was promoted in the presence of human tau under high glucose conditions, which maintained the ratio of NAd+/NAdH. On the other hand, human tau restricted the level of oxidative phosphorylation, modulated the activity of SdH, and reduced rOS production upon high glucose challenging. In summary, the current study revealed that human tau played an important role in regulating glycolytic metabolism under acute hyperglycemia conditions, which is similar with the Warburg effect, through influencing the homeostasis of protein-membrane association. © 2025 The Authors

关键词： Mammals

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analysis OF global r&d TrENdS IN NATUrAL COSMETICS BASEd ON PATENT BIBLIOMETrICS 21

ANALYSIS OF GLOBAL R&D TRENDS IN NATURAL COSMETICS BASED ON ...

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21st International Conference on Applied Computing 2024, AC 2024 and 23rd International Conference on WWW/Internet 2024, ICWI 2024

作者： Sohn, Eunsoo Seo, Jinny Lee, Chang-Hoan Center for Global R&D Data Analysis Korea Institute of Science and Technology Information 66 Hoegi-ro Dongdaemun-gu Seoul Korea Republic of

ISBN: (纸本)9789898704627

Natural cosmetics including nature-derived cosmetic materials, are growing significantly in line with global S&T trends such as eco-friendliness, sustainability, and technology convergence. In particular, due to concerns about air pollution and the rapid increase in skin disease patients such as allergies and atopy, the demand for natural cosmetics known to be safe and cause little skin irritation is increasing. In this study, through bibliometric analysis of 233,281 patent literature data we analyzed the global technology trends in natural cosmetics and the r&d level and competitiveness of Korean natural cosmetics leading the Korean Wave (Hallyu) and K-beauty. Network analysis, text mining, and machine learning using large language model were used to extract, cleaning, and analyze keyword from big text documents. These bibliometric big data analysis can help identifying development trends in natural cosmetics and provide important insights for establishing patent or r&d strategies. © 2024 Proceedings of the International Conferences on Applied Computing and WWW/Internet 2024. All rights reserved.

关键词： Cosmetics

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Washing Machine's Working States recognition Based on Audio Fusion Feature 7

Washing Machine's Working States Recognition Based on Audio ...

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7th International Conference on Advanced Algorithms and Control Engineering, ICAACE 2024

作者： Xu, Siqiang Gao, Cuiyun Zhao, Yang Wu, Zengyuan du, Fei Wang, Hongqiang Anhui Jianzhu University Power Quality Analysis And Load Detection Technology Laboratory Hefei China Corporation Global R&d Center Hefei China

ISBN: (纸本)9798350361445

In order to effectively determine the normal working status of smart home appliances, this paper realizes the recognition of washing machine's working states based on audio signals of microphone array (6 sensors). The paper proposes a fusion classification method combining optimizing STFT features and LSTM, and compares multi-channel feature fusion and voting classification methods. determine the relatively optimal frequency resolution feature by changing the frequency resolution of STFT. The multi-channel feature fusion classification method is to concatenate the features of six different channels, input them into the LSTM network model for training, and obtain a comprehensive LSTM classifier. Voting fusion classification method: Train a LSTM network model independently for each channel's feature, and obtain 6 corresponding LSTM sub-classifiers, and then vote for the predicted classes of 6 channels corresponding to the same sample to obtain the fusion classification result. A vertical axis washing machine is taken to verify the proposed method, the experiment results show that both fusion classification methods have better performance than single channel methods. Compared with the multi-channel feature fusion method, the recognition rate of the multi-channel feature fusion method is slightly higher than that of the voting classification method, with a maximum of 99.7%. © 2024 IEEE.

关键词： Classification (of information)

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The dehydration rotation Speed Curve Extraction based on 3d Vibration Signals for drum Washing Machine 5

The Dehydration Rotation Speed Curve Extraction based on 3D ...

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5th International Conference on Intelligent Control, Measurement and Signal Processing, ICMSP 2023

作者： Zhang, Yuqing Gao, Cuiyun du, Fei Liu, Qingshan Wang, Hongqiang Wang, Zihan Anhui Jianzhu University Power Quality Analysis and Load Detection Technology Laboratory Hefei China Corporation Global R&D Center Hefei China

ISBN: (纸本)9798350336030

GB/T 4288-2018 requires that the sensors be installed on the shell of the washing machine to measure the vibration and displacement, and requires the sensor be installed on the drum to measure the speed. This measurement method is inefficient and has the risk of causing fault due to the second unpacking. To solve the above problem, an 3d acceleration sensor on the shell of a washing machine is used to extract the dehydration rotation speed, and a novel method, named as CSdS-AMdF, is proposed in this paper. Firstly, the desired speed curve of the drum is extracted from the STFT-based maximum harmonic value of the motor current. Secondly, the speed curve is segmented by the adaptive first-order-difference-threshold method. Finally, the segmented-Average Magnitude difference Function (AMdF) is used to extract the rotation speed from the vibration signals of shell and outer tub according to the five segments. Taking six target speeds of a certain type of drum washing machine in the dehydration stage as the experimental object, set the sampling rates as 10kHz, 1kHz and 500Hz respectively to verify the method in this paper. The experiment shows that: The method proposed in this paper has universality for different sampling rates and robustness for 3d, and is suitable for the automatic manufacturing process of washing machines. © 2023 IEEE.

关键词： risk assessment

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regional profile of questionable publishing

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Journal of Informetrics 2025年第3期19卷

作者： Taekho You Jinseo Park June Young Lee Jinhyuk Yun Institute for Social Data Science Pohang University of Science and Technology 77 Cheongam-ro Pohang 37673 Gyeongsangbukdo Republic of Korea Center for Digital Humanities & Computational Social Sciences Korea Advanced Institute of Science and Technology 192 Daehak-ro Yuseong-gu 34141 Daejeon Republic of Korea Center for Global R&D Data Analysis Korea Institute of Science and Technology Information 66 Heogi-ro Dongdaemun-gu 02456 Seoul Republic of Korea School of AI Convergence Soongsil University 369 Sangdo-ro Dongjak-gu 06978 Seoul Republic of Korea

Countries and authors in the academic periphery have occasionally been criticized for contributing to the expansion of questionable publishing, because they share a major fraction of papers in questionable journals. On the other side, both quantitative evaluation systems and social stratification in academic publishing drive authors toward questionable journals rather than legitimate publications. Questionable journals are sometimes perceived as serving local academia, a function considered essential for regional scientific development in certain countries. However, this requires rigorous examination. In this study, we performed an in-depth analysis of the distribution of questionable publications and journals along with their interplay with countries, quantifying the influence of questionable publications on academic inequality. We found that low-impact journals play a vital role in the regional academic environment, whereas questionable journals with equivalent impacts publish papers globally, both geographically and academically. The business model of questionable journals differs from that of regional journals, and may thus be detrimental to the broader academic community.

关键词： Questionable publishing Country-wise analysis dominance of journal

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Using Trac for Empirical data Collection and analysis in developing Small and Medium-Sized Enterprise Systems

Using Trac for Empirical Data Collection and Analysis in Dev...

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International Symposium on Empirical Software Engineering and Measurement, ESEM

作者： Naoki Ohsugi Kyohei Fushida Nobuto Inoguchi Hiroyuki Arai Hiroyuki Yamanaka Takashi Niwa Misa Fujinuki Motohisa Tomura Tuyoshi Kitani Global Business Sector NTT DATA Corporation Toyosu Center Tokyo Japan R&D Headquarters NTT DATA Corporation Toyosu Center Tokyo Japan R&D Headquarters NTT DATA Corp. Toyosu Center Tokyo Japan

This paper describes practical case studies of using Trac as a platform for collecting empirical data in the development of small and medium-sized enterprise systems. Project managers have been using various empirical data such as size, development efforts and number of bugs found. These data are vital for management, although the cost entailed is not small in preparing an effective combination of measurement tools, procedures and continuous monitoring to collect reliable data, and many small and medium-sized projects are constrained by budget limitations. This paper describes practical examples of data collection at low cost in the development of two enterprise systems. The examples consist of a small project (5 development personnel at the peak period, down to 3 during the maintenance) and a medium-sized project (80 personnel at the peak, down to 28), used to develop two different enterprise systems. Over 29 months, ten basic metrics and seven derived metrics were collected regarding effort, size and quality, and were used for progress management, estimation, and quality assurance.

关键词： Measurement data collection Personnel Monitoring reliability Maintenance engineering Estimation

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Auditing citation polarization during the early COVId-19 pandemic

arXiv

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arXiv 2023年

作者： You, Taekho Lee, June Young Park, Jinseo Yun, Jinhyuk Institute for Social Data Science Pohang University of Science and Technology Korea Republic of Center for Global R&D Data Analysis Korea Institute of Science and Technology Information Korea Republic of School of AI Convergence Soongsil University Korea Republic of

The recent pandemic stimulated scientists to publish a significant amount of research that created a surge of citations of COVId-19-related publications in a short time, leading to an abrupt inflation of the journal impact factor (IF). By auditing the complete set of COVId-19-related publications in the Web of Science, we reveal here that COVId-19-related research worsened the polarization of academic journals: the IF before the pandemic was proportional to the increment of IF, which had the effect of increasing inequality while retaining the journal rankings. We also found that the most highly cited studies related to COVId-19 were published in prestigious journals at the onset of the epidemic. Through the present quantitative investigation, our findings caution against the belief that quantitative metrics, particularly IF, can indicate the significance of individual papers. rather, such metrics reflect the social attention given to a particular study. © 2023, CC BY.

关键词： COVId-19

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