Over past three decades,many prevention strategies have been proven effective in reducing human immunodeficiency virus (HIV) ***,none of these strategies alone are effective to stop the spread of *** review discusses ...
详细信息
Over past three decades,many prevention strategies have been proven effective in reducing human immunodeficiency virus (HIV) ***,none of these strategies alone are effective to stop the spread of *** review discusses a few key prevention strategies,including testing,harm reduction,prevention,prophylaxis,and modern communication *** argue that although there are great challenges remaining to stop HIV transmission via sexual contact and injecting drug use routes,the combination of these effective strategies,control HIV epidemic can be achieved.
Provided are antigenic polypeptides of HIV envelope glycoproteins which are constructed based on amino acid mutation of attenuated live vaccine of Equine Infectious Anemia Virus, DNA constructions and recombinant viru...
标准号:
US10251948(B2)
Provided are antigenic polypeptides of HIV envelope glycoproteins which are constructed based on amino acid mutation of attenuated live vaccine of Equine Infectious Anemia Virus, DNA constructions and recombinant virus vectors comprising polynucleotides encoding said polypeptides, antibodies against said polypeptides as well as uses thereof in preventing and treating HIV infection. Said antigenic polypeptides and vaccines can induce high titer neutralization antibodies against HIV in organism.
Promoting biosafety regulations and techniques supports human health and protects individuals and groups from harmful *** attention should be paid to those potential infectious hazards associated with blood and other ...
详细信息
Promoting biosafety regulations and techniques supports human health and protects individuals and groups from harmful *** attention should be paid to those potential infectious hazards associated with blood and other bodily fluids,especially those highly transmitted infectious diseases,such as human immunodeficiency virus(HIV),one of the largest global health *** innovative and adaptive screening and laboratory techniques to reduce the possibility of HIV transmission are integral to managing the *** review here the evolution and success of blood screening techniques for HIV,along with current issues that still need to be *** academic articles and media reports about nosocomial HIV transmission events since 1981 were reviewed to identify current blood screening and transfusion safety trends across the globe,along with specific recommendations from the Chinese *** most initial screening was limited only to antibody and antigen testing,newer screening tests(such as nucleic acid testing),coupled with risk-based screening of donors,have led to reduced risk of HIV transmission and continues to reduce the“window period,”when an HIV-positive individual may test negative though they have been *** examination of current guidelines and regulations across the globe are discussed,in order to understand where critical gaps in screening may *** examination of this data,it is evident that huge strides have been made since the beginning of the epidemic;however improved technical training of staff and streamlined testing guidelines could help promote efficient screening of HIV,while also supporting those providing care.
Broadly neutralizing antibodies against HIV-1 which specifically bind to gp120 of HIV-1, a method of preparing such antibodies and the use thereof are provided.
标准号:
US2019002539(A1)
Broadly neutralizing antibodies against HIV-1 which specifically bind to gp120 of HIV-1, a method of preparing such antibodies and the use thereof are provided.
作者：
Tao, GuoyuDivision of STD Prevention
National Center for HIV/AIDS Viral Hepatitis STD TB Prevention Centers for Disease Control and Prevention Atlanta GA United States
Annual wellness visit (AWV) was introduced for Medicare patients in 2011 to help patients stay healthy. The object of this study is to assess whether AWV have an impact on the use of other preventive services in the e...
Background. Sexual health education plays a vital role in preventing adverse consequences of sexual behavior. Data are limited on how professional development (PD) for teachers is associated with teaching sexual healt...
详细信息
Ebola virus(EBOV)is one of the most pathogenic viruses in humans which can cause a lethal hemorrhagic *** the cellular entry mechanisms of EBOV can promote the development of new therapeutic strategies to control viru...
详细信息
Ebola virus(EBOV)is one of the most pathogenic viruses in humans which can cause a lethal hemorrhagic *** the cellular entry mechanisms of EBOV can promote the development of new therapeutic strategies to control virus replication and *** has been known that EBOV virions bind to factors expressed at the host cell ***,the virions are internalized by a macropinocytosis-like process,followed by being trafficked through early and late *** researches indicate that the entry of EBOV into cells requires integrated and functional lipid *** lipid rafts have been hypothesized to play a role in virus entry,there is a current lack of supporting *** major technical hurdle is the lack of effective approaches for observing viral *** provide evidence on the involvement of lipid rafts in the entry process of EBOV,we generated the fluorescently labeled Ebola virus like particles(VLPs),and utilized single-particle tracking(SPT)to visualize the entry of fluorescent Ebola VLPs in live cells and the interaction of Ebola VLPs with lipid *** this study,we demonstrate the compartmentalization of Ebola VLPs in lipid rafts during entry process,and inform the essential function of lipid rafts for the entry of Ebola *** such,our study provides evidence to show that the raft integrity is critical for Ebola virus pathogenesis and that lipid rafts can serve as potential targets for the development of novel therapeutic strategies.
暂无评论