检索结果-内蒙古大学图书馆

HIV criminalisation laws and ending the US HIV epidemic

The lancet. HIV 2021年第1期8卷 e4-e6页

作者： Jonathan Mermin Sheila Salvant Valentine Eugene McCray National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta GA 30333 USA. Electronic address: jhm7@cdc.gov. Division of HIV/AIDS Prevention Atlanta GA 30333 USA.

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

引用

Nature communications 2024年第1期15卷 1054页

作者： Isabella C Young Ivana Massud Mackenzie L Cottrell Roopali Shrivastava Panita Maturavongsadit Alka Prasher Andres Wong-Sam Chuong Dinh Tiancheng Edwards Victoria Mrotz James Mitchell Josilene Nascimento Seixas Aryani Pallerla Allison Thorson Amanda Schauer Craig Sykes Gabriela De la Cruz Stephanie A Montgomery Angela D M Kashuba Walid Heneine Charles W Dobard Martina Kovarova J Victor Garcia J Gerardo Garcίa-Lerma S Rahima Benhabbour Division of Pharmacoengineering and Molecular Pharmaceutics Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC USA. Laboratory Branch Division of HIV Prevention National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta GA USA. Division of Pharmacotherapy and Experimental Therapeutics Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC USA. Joint Department of Biomedical Engineering North Carolina State University and The University of North Carolina at Chapel Hill Chapel Hill NC USA. Comparative Medicine Branch Division of Scientific Resources National Center for Emerging and Zoonotic Infection Diseases Centers for Disease Control and Prevention Atlanta GA USA. Infectious Diseases Pathology Branch Division of High-Consequence Pathogens and Pathology National Center for Emerging and Zoonotic Infection Diseases Centers for Disease Control and Prevention Atlanta GA USA. Department of Psychology and Neuroscience University of North Carolina at Chapel Hill Chapel Hill NC USA. Pathology Services Core Lineberger Comprehensive Cancer Center University of North Carolina School of Medicine Chapel Hill NC USA. International Center for the Advancement of Translational Science Division of Infectious Diseases Center for AIDS Research University of North Carolina at Chapel Hill Chapel Hill NC USA. Laboratory Branch Division of HIV Prevention National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta GA USA. jng5@cdc.gov. Division of Pharmacoengineering and Molecular Pharmaceutics Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC USA. benhabs@email.unc.edu. Joint Department of Biomedical Engineering North Carolina State University and The University of North Carolina at Chapel Hill Chapel Hill NC USA. benhabs@email.unc.edu.

来源：评论

学校读者我要写书评

暂无评论

Real-time digital intervention on oral pre-exposure prophylaxis adherence among MSM: randomized controlled trial

引用

npj Digital Medicine 2025年第1期8卷 1-8页

作者： Zhen-Xing Chu Yan-Yan Zhu Yu-Jing An Zhen-Hao Wu Yong-Jun Jiang Qing-Hai Hu Hong Shang Xia Jin Ze-Hao Ye Xiao-Jie Huang Hui Wang Yao-Kai Chen State Key Laboratory for Diagnosis and Treatment of Infectious Diseases NHC Key Laboratory of AIDS Prevention and Treatment National Clinical Research Centre for Laboratory Medicine The First Hospital of China Medical University China Medical University Shenyang 110001 China Key Laboratory of AIDS Immunology Chinese Academy of Medical Sciences Shenyang 110001 China Key Laboratory of AIDS Immunology of Liaoning Province Shenyang 110001 China Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases 79 Qingchun Street Hangzhou 310003 China Parexel International Real World Research 100020 Beijing China Department of STD and HIV/AIDS Control and Prevention Ningbo Municipal Centre for Disease Control and Prevention Ningbo 315010 China Centre for Infectious Diseases Beijing Youan Hospital Capital Medical University 100069 Beijing China Department of Infectious Diseases National Clinical Centre for Infectious Diseases Third People’s Hospital of Shenzhen (Second Affiliated Hospital of Southern University of Science and Technology) Shenzhen 518112 China Department of Infectious Diseases Chongqing Public Health Medical Center Chongqing 400036 China

Oral pre-exposure prophylaxis (PrEP) effectively prevents HIV among men who have sex with men, but its adherence faces significant hindrances. We evaluated the effectiveness of real-time digital intervention in promoting oral PrEP adherence through a randomized controlled trial using electronic medication monitors. The trial was registered on the Chinese Clinical Trial Registry (ChiCTR1900025604) and randomized 442 MSM to intervention (247) or control group (195). At the 6-month follow-up, the intervention group exhibited significantly higher oral PrEP adherence than the control (83.1% vs. 59.8%; adjusted net difference: 21.0%, 95% confidence interval: 12.9–29.2%,p< 0.001), while no differences were detected in the number of male sexual partners, condomless anal intercourse prevalence, or substance use disorder, with consistent results across both daily and event-driven oral PrEP regimens. Therefore, digital intervention significantly increased oral PrEP adherence over 6 months in the daily and event-driven subgroups but demonstrated no effect on high-risk behaviors.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Consensus statement on human immunodeficiency virus pre-exposure prophylaxis in China

引用

Chinese Medical Journal 2020年第23期133卷 2840-2846页

作者： Jun-Jie Xu Xiao-Jie Huang Xin-Chao Liu Li-Ming Wang Yao-Kai Chen Hui Wang Fu-Jie Zhang Hao Wu Tai-Sheng Li Meng-Jie Han Fang Zhao Hai-Bo Ding Jun-Yi Duan Gen-Shen Sheng Hong Shang National Health Commission(NHC)Key Laboratory of AIDS Immunology(China Medical University) National Clinical Research Center for Laboratory MedicineThe First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China Key Laboratory of AIDS Immunology Chinese Academy of Medical SciencesShenyangLiaoning 110001China Key Laboratory of AIDS Immunology of Liaoning Province ShenyangLiaoning 110001China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases HangzhouZhejiang 310003China Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Department of Infection Peking Union Medical College HospitalBeijing 100730China Beijing Ditan Hospital Capital Medical UniversityBeijing 100015China Chongqing Public Health Medical Center Chongqing 400036China Department of Infectious Diseases National Clinical Center for Infectious DiseasesThird People’s Hospital of Shenzhen(Second Affiliated Hospital of Southern University of Science and Technology)ShenzhenGuangdong 518112China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Shenzhen Rainbow 258 Centre For Men ShenzhenGuangdong 518001China

Introduction Although the global human immunodeficiency virus(HIV)epidemic has been effectively curbed,preventing and managing HIV infection in high-risk populations remains challenging.[1]In China,HIV is primarily transmitted through sexual contact.[1,2]Pre-exposure prophylaxis(PrEP)is a new and effective method for preventing HIV infection using antiretroviral drugs[3];data from multiple clinical trials worldwide have shown that using antiretroviral drugs for PrEP can limit HIV transmission.[4,5,6,7]The World Health Organization(WHO)issued guidelines in 2015 recommending PrEP in populations with an HIV incidence above 3/100 person-years(PY)and in individuals engaging in high-risk behaviors.[3]According to existing studies,the HIV incidence among key populations in China was 5.6/100 PY for men who have sex with men(MSM),[8]1.6/100 PY for intravenous drug users(IDUs),[9]and 1.4/100 PY for female sex workers.[10,11]As of July 2020,54 countries and regions have issued PrEP guidelines for adults to prevent HIV infection,and 36 of these have also published guidelines for children and ***,there are no PrEP guidelines or related consensus statement in *** such,there is a strong need for standardized guidance on the implementation of PrEP pertaining to medical selection criteria,PrEP timing,drug safety,and consultation and testing *** we present the consensus statement on the implementation of PrEP in China based on the opinions and suggestions of health policy-makers,scientists,clinical experts,community-based organizations of key populations,and the latest reports in PrEP researches.

关键词： drugs statement exposure

来源：评论

学校读者我要写书评

暂无评论

Assessment of trends in cervical cancer screening rates using healthcare claims data: United States, 2003–2014

引用

Preventive Medicine Reports 2018年 9卷 124-130页

作者： Watson, Meg Benard, Vicki Flagg, Elaine W. Division of Cancer Prevention and Control National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention Atlanta GA United States Division of Sexually Transmitted Disease Prevention National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta GA United States

Improved understanding of the natural history of cervical cancer has led to changes in screening recommendations, including the addition of the human papillomavirus (HPV) testing as an option in routine screening. Most studies of screening trends have used national self-reported survey data. To better understand recent trends in cervical cancer screening, including cytology (Papanicolaou, or Pap, tests) and human papillomavirus co-tests (HPV + Pap test), we used healthcare claims data to examine screening practices and trends. We analyzed screening among commercially-insured females ages 18–65 during 2005–2014 who were continuously enrolled during three or more contiguous calendar years, to identify those who received cervical cancer screening with a Pap test or co-test. We examined screening prevalence by age group and year. During the latter years of our study period, screening prevalence (regardless of screening method) declined significantly for women in all age groups examined. Despite declines in overall screening, the prevalence of co-testing increased in all age groups except those aged 18–20. In 2014, women aged 30–39 had the highest overall screening uptake (77.5%) and the highest use of co-testing (44.4%);this group also had the lowest overall declines in screening over the time period (−4.5%). These screening measures from healthcare claims were lower than self-reported screening from national surveys of the general population. More research to explore the reasons for these differences is needed to ensure that women are receiving appropriate screening, and to better understand why screening prevalence is declining among this population of commercially insured women. © 2018

关键词： Cervical cancer Cervical cancer screening Claims data HPV test

来源：评论

学校读者我要写书评

暂无评论

Uptake of HIV Self-testing among Men Who have Sex with Men in Beijing, China： a Cross-sectional Study

引用

Biomedical and Environmental Sciences 2017年第6期30卷 407-417页

作者： REN Xian Long WU Zun You MI Guo Dong MCGOOGAN Jennifer ROU Ke Ming ZHAO Yan Division of Prevention Intervention National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Office of the Director National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Division of Treatment and Care National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China

Objective To examine HIV self-testing uptake and its determinates among men who have sex with men （MSM） in Beijing, China. Methods A cross-sectional online survey was conducted in Beijing, China in 2016. Participants were users of a popular Chinese gay networking application and had an unknown or negative HIV status. Univariate and multivariate logistic regression analyses were conducted to examine factors associated with HIV self-testing based on adjusted odds ratio （AOR） and 95% confidence interval （CI）. Results Among the 5,996 MSM included in the study, 2,383 （39.7%） reported to have used HIV self-testing kits. Willingness to use an HIV self-test kit in the future was expressed by 92% of the participants. High monthly income （AOR = 1.49; CI = 1.10-2.02; P = 0.010）, large number of male sex partners （≥2： AOR = 1.24; CI = 2.09-1.43; P = 0.002）, sexual activity with commercial male sex partners （〉 2： AOR = 1.94; CI = 1.34 -2.82; P = 0.001）, long-term drug use （AOR = 1.42; CI = 1.23-1.62; P 〈 0.001）, and long-term HIV voluntary counseling and testing （VCT） attendance （AOR = 3.62; CI = 3.11-4.22; P 〈 0.001） were all associated with increased odds of HIV self-testing uptake. Conclusion The nearly 40% rate of HIV self-testing uptake among MSM in our sample was high. In addition, an over 90% willingness to use kits in the future was encouraging. HIV self-testing could be an important solution to help China achieve the global target of having 90% of all people living with HIV diagnosed by 2020.

关键词： Men who have sex with men HIV self-testing Associated factors Beijing

来源：评论

学校读者我要写书评

暂无评论

MicroRNA 31 inhibits CD8^(+) T-cell function by increasing its sensitivity to type I interferon signaling in chronic viral infection

引用

Cellular & Molecular Immunology 2018年第5期15卷 533-535页

作者： Mingming Jia Yiming Shao Kunxue Hong Division of Research on Virology and Immunology State Key Laboratory for Infectious Disease Prevention and ControlNational Center for AIDS/STD Control and PreventionChina CDCCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijing 102206China Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Chronic viral infections and malignant tumors can cause T cells to become dysfunctional and exhausted through two different associated immune statuses:inflammation and *** immunity is a necessary step for the establishment of the immune response to control infection and ***,once a pathogen cannot be cleared in time or a tumor continues to progress,an immunosuppressive environment involving various immune cells and cytokines may form,thereby promoting the persistence of the pathogen or *** those immune factors,type I interferons play a dual role by driving inflammation and inducing a variety of suppressive factors that limit immune responses in chronic infection and cancer.

关键词： inflammation infection immunity

来源：评论

学校读者我要写书评

暂无评论

Antiretroviral regimen change among people infected with HIV:evidence from a crosssectional study in China

引用

Global Health Journal 2018年第3期2卷 21-30页

作者： Junfang Xu Peicheng Wang Liangmin Gao Xinyu Peng Feng Cheng Research Center for Public Health School of MedicineTsinghua UniversityBeijing 100084China Institute for International and Area Studies Tsinghua UniversityBeijing 100084China National Center for AIDS/STD Control and Prevention China Center for Disease Control and PreventionBeijing 102206China

Background:The rate of death among people living with HIV/aids has decreased significantly as a result of treatment with highly active antiretroviral therapy(HAART).However,the issues of drug induced toxicities and complexity of current HAART regimens has remained of great *** aim of this study was to determine factors in uencing antiretroviral regimen changes among people living with HIV/aids in ***:This retrospective study collected data through face-to-face interviews with people living with HIV/aids who were receiving HAART,and gathered relevant information from infectious disease *** following information were collected:social-demographic characteristics,antiretroviral therapies,CD4 cell counts,virus loads,reasons for changing medication and other related *** and percentages were used to describe the frequency of regimen change among patients,and binary logistic regression was employed to test the factors in uencing regimen ***:1,123 people who had experienced regimen change were included in the *** average,patients remained on HAART for 10.2 months before changing regimen,and the average CD4 cell count and viral load(VL)were 383.1 cells/ l and 28,132.4 copies/mL respectively when changing *** reasons for modi cation were determined as treatment failure(52.5%),adverse reactions(32.3%),and other reasons including pregnancy(15.2%).There are significant differences in regimen change among people with different genders(P<0.001),modes of transmission(P<0.001),duration of HAART(P<0.001)and initial CD4 cell counts(P=0.0024).Males,drug users,people taking long-term medication,and those with lower initial CD4 counts when starting HAART tend to change ***:Treatment failure was the main reason for the change of HAART ***,drug users,people on longterm medication and those with lower initial CD4 cell counts when starting HAART were most likely to change regimen.

关键词： antiretroviral therapy regimen change HIV China

来源：评论

学校读者我要写书评

暂无评论

2007-17年美国儿童和青少年结核病流行病学:国家监测数据分析

2007-17年美国儿童和青少年结核病流行病学:国家监测数据分析

引用

作者： Tori L Cowger Jonathan M Wortham Deron C Burton 许磊 Division of Tuberculosis Elimination National Center for HIV/AIDSViral HepatitisSTDand TB PreventionUS Centers for Disease Control and Prevention Department of Epidemiology Harvard T H Chan School of Public Health

背景:在2018年期间,全球15岁以下的儿童中约有100万例结核病病例和233000例与结核相关的死亡。儿童和青少年的结核病在临床和流行病学上存在差异,给护理和预防带来了挑战。对儿童和青少年结核病流行病学的了解有助于治疗和预防工作,以... 详细信息

背景:在2018年期间,全球15岁以下的儿童中约有100万例结核病病例和233000例与结核相关的死亡。儿童和青少年的结核病在临床和流行病学上存在差异,给护理和预防带来了挑战。对儿童和青少年结核病流行病学的了解有助于治疗和预防工作,以及消除结核病发病率和死亡率差异。目的:我们试图描述美国患有结核病的儿童和青少年的流行病学,包括按父母出生国和美国领土及自由联系的州分列的结核病发病率,这些情况以前没有描述过。方法:我们分析了2007-17年期间向国家结核病监测系统报告的15岁以下儿童和15-17岁青少年的数据,并使用美国人口普查局的人口估计数计算了结核病发病率。结果:在2010至2017年间,有6072例肺结核病例发生在儿童和青少年中,其中5175例(85%)发生在美国50个州或哥伦比亚特区,6072例中有897例(15%)发生在美国附属岛屿。在美国各州,5175例中有3520例(68%)发生在美国出生的人群中,包括3896名儿童中的2977名(76%)和1279名青少年中的543名(42%)。2007-2017年儿童和青少年发病率为1.0/10万人,同期下降47.8%(95%CI-51.4～44.1)。我们观察到,在所有非白人种族或族裔群体的儿童和青少年中,生活在美国附属岛屿的人,以及出生在结核病流行国家或与其父母一起出生的儿童中,结核病发病率过高。讨论:在对国家监测数据的审查中,我们观察到所有非白种人种族或族裔群体的儿童和青少年、生活在美国附属岛屿的儿童和青少年、出生在结核病流行国家或其父母来自于结核病流行国家的儿童和青少年中结核病发病率过高。此外,我们观察到,与美国各州相比,美国附属岛屿的儿童和青少年患结核病的死亡率高得不成比例。这些广泛和普遍的差距可能反映了结构性的不平等,造成了不成比例的接触、感染和疾病的脆弱性以及不平等的迅速诊断和治疗机会。我们的研究结果表明,美国的结核病护理和预防策略正在成功地降低儿童和青少年的总体结核病负担,但需要更多的关注和可能的新方法来解决这些年龄组结核病发病率和死亡率的差异。我们观察到儿童和青少年的结核病发病率和死亡率存在普遍的种族或民族和地理差异。与非西班牙裔白人儿童和青少年相比,每一个被调查的种族或族裔群体的结核病发病率都显著增加,这表明健康的结构性和社会决定因素可能具有广泛的影响,导致历史上边缘化的儿童和青少年接触结核病、感染或疾病进展的风险增加。尽管我们强调了结核病的差异可能会被种族,民族,地理位置和出生地等影响,但我们注意到这种异质性可能归因于基本的社会,政策和环境条件。此外,通过对各种健康结果的研究确定了有助于人口水平的其他因素健康差距,这些因素可能包括粮食安全和营养,获得经济和营养物质资源,住宅隔离,接触二手烟,室内外空气质量,持久历史创伤的影响(例如奴隶制,殖民,流离失所),医疗政策,获取和基础设施。所以除了努力预防和治疗高危儿童和青少年中的结核病外,还应努力阐明和改善风险增加的潜在社会和结构驱动因素。结论:总体而言,美国儿童和青少年中的结核病发病率较低,而且稳步下降,但仍需作出更多努力,以消除发病率和死亡率方面的差异。

关键词：肺结核儿童青少年流行病学

来源：评论

学校读者我要写书评

暂无评论

Reply to Sayed

引用

The Journal of infectious diseases 2019年第6期220卷 1083-1084页

作者： Youkyung Choi Xiugen Zhang Brianna Skinner Laboratory Branch Division of Viral Hepatitis National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention. Comparative Medicine Branch Division of Scientific Resources National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Atlanta Georgia.

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：