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作者： SHAO, Yiming ZHU, Jiang LI, Yuxing WILSON, Ian A. KONG, Leopold JU, Bin HE, Linling REN, Li CHEN, Yajing LIU, Jiandong

Broadly neutralizing antibodies against HIV-1 which specifically bind to gp120 of HIV-1, a method of preparing such antibodies and the use thereof are provided.

标准号: EP3414266(A1)

Broadly neutralizing antibodies against HIV-1 which specifically bind to gp120 of HIV-1, a method of preparing such antibodies and the use thereof are provided.

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Reply to Pan et al

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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018年第4期67卷 644-645页

作者： Yan Zhao Zunyou Wu Jennifer M McGoogan National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing China. Department of Epidemiology UCLA Fielding School of Public Health Los Angeles California.

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Author Correction: HIV-1 Transmissions Among Recently Infected Individuals in Southwest China are Predominantly Derived from Circulating Local Strains

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Scientific reports 2018年第1期8卷 17478页

作者： Jianjun Li Yi Feng Zhiyong Shen Yingxin Li Zhenzhu Tang Runsong Xiong Hongman Zhang Jing Wei Xinjuan Zhou Yueqin Deng Ningye Fang Guanghua Lan Shujia Liang Qiuying Zhu Hui Xing Yuhua Ruan Yiming Shao Institute of HIV/AIDS Prevention and Control Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning China. State Key Laboratory of Infectious Disease Prevention and Control (SKLID) National Center for AIDS/STD Control (NCAIDS) and Prevention Chinese Center for Disease Control and Prevention (China CDC) Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Beijing China. College of Pharmacy Guangxi Medical University Nanning China. Institute of HIV/AIDS Prevention and Control Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning China. tangzhzh@***.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

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Epidemiology of HIV/aids in China: recent trends

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Global Health Journal 2017年第1期1卷 26-32页

作者： Yan Cui Cynthia X.Shi Zunyou Wu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Epidemiology of Microbial Diseases and Center for Interdisciplinary Research on AIDS Yale School of Public Health135 College StreetNew HavenCT 06520USA

We used nationally reported cases (NCaids/China CDC,2016) and published literature to summarize up-to the end of 2015 epidemiologic trends in the HIV/aids epidemic in ***-positive cases are distributed unevenly with most infections found in southwest China and the most affected population being men who have sex with *** mode of HIV infection has shifted from drug injection to sexual contact,which accounts for 95% of total reported *** thirds of cases are from heterosexual *** pattern varies greatly throughout *** provinces in China reported heterosexual transmission accounted for over 90% of cases while other provinces reported homosexual transmission accounted for over 80% of *** of heterosexually acquired HIV also vary widely,with 80% of cases attributed to commercial sex in some provinces,while in other provinces non-commercial extramarital sex accounted for over 70% of *** increase in HIV infection was observed among young students aged *** has successfully controlled blood transfusion-and injecting drug-related transmissions of *** and non-commercial extramarital heterosexual transmissions have become new challenges for China's HIV/aids *** adoption of the UNaids/WHO 90-90-90 target will help overcome these new challenges.

关键词： HIV aids epidemiology China

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In vitro inhibition of HIV-1 replication in autologous CD4*T cells indicates viral containment by multifactorial mechanisms

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Virologica Sinica 2017年第6期32卷 485-494页

作者： Ting Tu Jianbo Zhan Danlei Mou Wei Li Bin Su Tong Zhang Tao Li Ning Li Hao Wu Cong Jin Huabiao Chen Jiangsu Key Laboratory of Clinical Laboratory Medicine Jiangsu University School of MedicineZhenjiang 212013China National HIV/HCV Reference Laboratory National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Hubei Provincial Center for Disease Control and Prevention Wuhan 430079China Beijing You'an Hospital Capital Medical UniversityBeijing 100069China

HIV-1-specific cytotoxic T lymphocytes(CTLs) and neutralizing antibodies(NAbs) are present during chronic infection, but the relative contributions of these effector mechanisms to viral containment remain unclear. Here, using an in vitro model involving autologous CD4+ T cells,primary HIV-1 isolates, HIV-1-specific CTLs, and neutralizing monoclonal antibodies, we show that b12, a potent and broadly neutralizing monoclonal antibody to HIV-1, was able to block viral infection when preincubated with virus prior to infection, but was much less effective than CTLs at limiting virus replication when added to infected cell cultures. However, the same neutralizing antibody was able to contain viruses by antibody-dependent cell-mediated virus inhibition in vitro,which was mediated by natural killer cells(NKs) and dependent on an Fc-Fc receptor ***, bulk CTLs from HIV-1 controllers were more effective in suppression of virus replication than those from progressors. These findings indicate that control of HIV-1 replication in activated CD4^+ T cells is ineffectively mediated by neutralizing antibodies alone, but that both CTLs and antibody-dependent NK-mediated immune mechanisms contribute to viral containment. Our study systemically compared three major players in controlling HIV-1 infection, CTLs, NAbs, and NKs, in an autologous system and highlighted the multifactorial mechanisms for viral containment and vaccine success.

关键词： HIV-1 infection viral replication cytotoxic T lymphocyte(CTL) natural killer cells neutralizing antibody

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Drivers of Patient Costs in Accessing HIV/aids Services in Tanzania

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Journal of the International Association of Providers of aids Care 2018年 17卷 2325958218774775-2325958218774775页

作者： Mnzava, Thomas Mmari, Eunice Berruti, Andres Division of Global HIV and TB Center for Global Health US Centers for Disease Control and Prevention Dar es Salaam Tanzania Division of STD Prevention National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention US Centers for Disease Control and Prevention Atlanta GA United States

Background: Patient costs pose a challenge in accessing antiretroviral therapy for people living with HIV in sub-Saharan Africa. The study aimed at identifying drivers for out-of-pocket (OOP) costs in Tanzania. Methods: In 2009, 500 adult patients who attended 10 HIV clinics across 7 regions of Tanzania were asked about time and resources consumed to access HIV services. Bivariate and multivariate median regression models were used to determine the main drivers for OOP costs. Results: Male and female patients have a median OOP costs of $40.37 and $28.01 per year, respectively (P =.01). Males spend significantly more on travel ($26.51) than females ($19.68;P =.02). Living in rural areas and poor social economic status (SES) are associated with greater OOP costs (P =.001) for both sexes. Conclusion: Poor SES and rural residence are main drivers of OOP costs. Patients are less likely to seek health care unless they are in dire need, leading to expensive services. © The Author(s) 2018.

关键词： HIV care and treatment out-of-pocket costs PLHIV SES

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Monocyte activation and cardiovascular disease in HIV infection

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Cellular & Molecular Immunology 2017年第12期14卷 960-962页

作者： Hua Liang Zhe Xie Tao Shen State Key Laboratory of Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChina CDCCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina Department of Microbiology and Center of Infectious Diseases School of Basic Medical SciencesPeking UniversityBeijingChina

Antiretroviral therapy(ART)has increased the lifespan of HIVinfected individuals,which is now approaching that of the general ***,cardiovascular disease(CVD),including myocardial infarction,stroke,heart failure,and arrhythmia,is still a main cause of mortality in HIVpositive *** risk of CVD in people living with HIV is about 1.5–2-fold higher than that in the general population.1 Even in those successfully treated with ART,the incidence of CVD is still higher than that in uninfected individuals.2 Thus,in addition to the traditional risk factors associated with CVD,other factors(such as ART per se,inflammation,and immune activation caused by HIV infection)may be involved in CVD development.

关键词： cardiovascular mortality inflammation

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Impact of Antiretroviral Therapy on the Spread of Human Immunodeficiency Virus in Chaoyang District, Beijing, China： Using the Asian Epidemic Model

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Chinese Medical Journal 2017年第1期130卷 32-38页

作者： Li-Li Tao Min Liu Shu-Ming Li Jue Liu Shu-Lin Jiang Li-Juan Wang Feng-Ji Luo Ning Wang Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China Department of STD and AIDS Prevention and Control Beijing Chaoyang District Centre for Disease Control and Prevention Beijing 100021 China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China

Background： Successful antiretroviral therapy （ART） has been demonstrated to be effective in reducing the infectivity of human immunodeficiency virus （HIV）. We conducted a study to predict the potential effect of ART on the spread of HIV in Chaoyang District, Beijing, China, using the Asian Epidemic Model （AEM）. Methods： The AEM baseline workbook was used to determine the current infection status and to project the future spread of HIV under current conditions. We changed the input on the ART coverage from 2014 to 2025 and also modified the treatment eligibility in the AEM intervention workbook, in order to allow for analysis of the projected downstream impact of ART. Results： By gradually increasing the ART coverage rate from 29.7% （rate of 2013） to 40.0%, 50.0%, 60.0%, 70.0%, 80.0%, and 90.0% （at CD4＋ ≤350 cells/μl）, and by changing the dates of coverage from 2014 to 2020, the number of new infections showed a cumulative decline of 0.60%, 1.59%, 2.94%, 5.33%, 9.32%, and 14.98%, respectively. After 2020, the projected rates of infection rebounded slightly, so with the exception of the years with very high coverage （90.0%）, new infections continued to decrease. When we changed the initial threshold of therapy to CD4＋ cell counts ≤500 cells/μl, new infections decreased 6.00%, 11.64%, 15.92%, 21.11%, 26.92%, 33.05%, and 38.75%, respectively, under varying ART coverages. Conclusion： Our study demonstrates that the early initiation of ART for people living with HIV/acquired immune deficiency syndrome （aids） has a positive effect in slowing the spread of HIV.

关键词： Antiretroviral Therapy Asian Epidemic Model Human Immunodeficiency Virus Impact Transmission

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Antiviral Activity of Dual-acting Hydrocarbon-stapled Peptides against HIV-1 Predominantly Circulating in China

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Biomedical and Environmental Sciences 2017年第6期30卷 398-406页

作者： WANG Yan CURRELI Francesca XU Wei Si LI Zhen Peng KONG De Sheng REN Li HONG Kun Xue JIANG Shi Bo SHAO Yi Ming DEBNATH Asim K MA Li Ying State Key Laboratory of Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesChinese Center for Disease Control and PreventionBeijing 102206China State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesChinese Center for Disease Control and PreventionBeuhing 102206China Laboratory of Molecular Modeling and Drug Design Lindsley F.Kimball Research Institute of the New York Blood CenterNew York 10065USA Key Laboratory of Medical Molecular Virology of Ministries of Education and Health Shanghai Medical College and Institute of Medical MicrobiologyFudan UniversityShanghai 200032China

Objective New rationally designed i,i＋7-hydrocarbon-stapled peptides that target both HIV-1 assembly and entry have been shown to have antiviral activity against HIV-1 subtypes circulating in Europe and North America. Here, we aimed to evaluate the antiviral activity of these peptides against HIV-1 subtypes predominantly circulating in China. Methods The antiviral activity of three i,i＋7-hydrocarbon-stapled peptides, NYAD-36, NYAD-67, and NYAD-66, against primary HIV-1 CRF07_BC and CRFOI_AE isolates was evaluated in peripheral blood mononuclear cells （PI3MCs）. The activity against the CRF07_BC and CRF01_AE Env-pseudotyped viruses was analyzed in TZM-bl cells. Results We found that all the stapled peptides were effective in inhibiting infection by all the primary HIV-1 isolates tested, with 50% inhibitory concentration toward viral replication （ICso） in the low micromolar range. NYAD-36 and NYAD-67 showed better antiviral activity than NYAD-66 did. We further evaluated the sensitivity of CRF01_AE and CRF07_BC Env-pseudotyped viruses to these stapled peptides in a single-cycle virus infectivity assay. As observed with the primary isolates, the ICs0s were in the low micromolar range, and NYAD-66 was less effective than NYAD-36 and NYAD-67. Conclusion Hydrocarbon-stapled peptides appear to have broad antiviral activity against the predominant HIV-1 viruses in China. This finding may provide the impetus to the rational design of peptides for future antiviral therapy.

关键词： Hydrocarbon-stapled peptide HIV-1 CRF07 BC CRFOI_AE Antiviral activity

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Erratum for Oladeinde et al., "Horizontal Gene Transfer Is the Main Driver of Antimicrobial Resistance in Broiler Chicks Infected with Salmonella enterica Serovar Heidelberg"

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mSystems 2021年第5期6卷 e0114721页

作者： Adelumola Oladeinde Zaid Abdo Maximilian O Press Kimberly Cook Nelson A Cox Benjamin Zwirzitz Reed Woyda Steven M Lakin Jesse C Thomas Torey Looft Douglas E Cosby Arthur Hinton Jean Guard Eric Line Michael J Rothrock Mark E Berrang Kyler Herrington Gregory Zock Jodie Plumblee Lawrence Denice Cudnik Sandra House Kimberly Ingram Leah Lariscy Martin Wagner Samuel E Aggrey Lilong Chai Casey Ritz U.S. National Poultry Research Center USDA-ARS Athens Georgia USA. Department of Microbiology Immunology and Pathology Colorado State Universitygrid.47894.36 Fort Collins Colorado USA. Phase Genomics Inc. Seattle Washington USA. Office of National Programs USDA-ARS Beltsville Maryland USA. Institute of Food Safety Food Technology and Veterinary Public Health University of Veterinary Medicine Vienna Austria. Austrian Competence Centre for Feed and Food Quality Safety and Innovation FFoQSI GmbH Tulln Austria. Division of STD Prevention National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta Georgia USA. National Animal Disease Center USDA-ARS Ames Iowa USA. Medical College of Georgia Augusta Georgia USA. Poultry Science Department University of Georgia Athens Georgia USA.

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