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Deciphering the toxicity of polyhexamethylene guanidine phosphate in lung carcinogenesis: Mutational profiles and molecular mechanisms

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Chemosphere 2024年 368卷 143785页

作者： Lee, Hong Jeong, Sang Hoon Baek, Yong-Wook Lee, Hyejin Sa, Jason K. Lee, Ji Yoon Lee, Yu-Seon Nam, Yoon Jeong Kim, Jaeyoung Kim, Jonghoon Choi, Jin Young Park, Su A. Kim, Je Hyeong Park, Yoon Hee Lim, Jungyun Kim, Young-Hee Park, Eun-Kee Kim, Cherry Lee, Ju-Han Medical Science Research Center Korea University Ansan Hospital Korea University College of Medicine Gyeonggi Ansan15355 Korea Republic of Humidifier Disinfectant Health Center National Institute of Environmental Research Incheon22689 Korea Republic of Department of Biomedical Sciences Korea University College of Medicine Seoul02841 Korea Republic of Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology Sungkyunkwan University Seoul06531 Korea Republic of Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Korea University Ansan Hospital Korea University College of Medicine Gyeonggi Ansan15355 Korea Republic of Department of Medical Humanities and Social Medicine College of Medicine Kosin University Busan49267 Korea Republic of Department of Radiology Korea University Ansan Hospital Korea University College of Medicine Gyeonggi Ansan15355 Korea Republic of Department of Pathology Korea University Ansan Hospital Korea University College of Medicine Gyeonggi Ansan15355 Korea Republic of

Polyhexamethylene guanidine (PHMG) is widely utilized in personal hygiene products due to its bactericidal, non-volatile, and hydrophilic properties. However, the long-term toxic effects and underlying mechanisms associated with respiratory exposure to the commonly used form, PHMG phosphate (PHMG-p), are still insufficiently understood. This study aims to elucidate the types of pulmonary lesions and the incidence of lung cancer associated with varying concentrations of PHMG-p and observation periods, along with the molecular mechanisms underlying this relationship. To assess these effects, CT scans and pathological analyses were conducted for up to 54 weeks following initial exposure to PHMG-p. Furthermore, to investigate the underlying causes of pulmonary toxicity, TGF-beta-activated kinase 1 was identified as a PHMG-p-binding protein, and its associated signaling pathways, including necroptosis, apoptosis, and MKK7, were explored. Somatic mutational signature, and gene ontology (GO) analyses were performed to investigate the genetic characteristics of PHMG-p-induced lung carcinogenesis. PHMG-p exposure led to somatic mutations in lung cancer-related genes, including TP53, SOS1, KMT2D, MDM2, ERBB2, SETD2, MET, ARID1A, RBM10, and CDKN2A as well as in genes such as RAB31, WASHC1, DDX11, ECD, STAB2, MUC2, and MUC5AC. The mutated genes were primarily associated with impaired DNA repair mechanisms. GO analysis highlighted the activation of pathways related to cell cycle checkpoints, necroptosis, MAPK, and idiopathic pulmonary fibrosis, while also revealing the suppression of signaling pathways associated with natural killer cells, GADD45, LXR/RXR activation, and IL-15 production. Gain-of-function experiments confirmed the oncogenic roles of PLAU and HMGA2, as well as the tumor-suppressive functions of TBX4 and GPX3. These findings suggest that PHMG-p activates necroptosis and MAPK signaling, increases the frequency of somatic mutations, and inhibits apoptosis, thus fost

关键词： Cell signaling

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Factors influencing acceptability of final disposal of incinerated ash and decontaminated soil from TEPCO's Fukushima Daiichi nuclear power plant accident

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Journal of Environmental Management 2023年第1期345卷 118610页

作者： Shirai, Kosuke Takada, Momo Murakami, Michio Ohnuma, Susumu Yamada, Kazuo Osako, Masahiro Yasutaka, Tetsuo Research Institute for Geo-Resources and Environment Geological Survey of Japan National Institute of Advanced Industrial Science and Technology 1-1-1 Higashi Ibaraki Tsukuba305-8567 Japan Social Safety and Industrial Innovation Division Mitsubishi Research Institute Inc. 10-3 Nagatacho 2-chome Chiyoda-ku Tokyo100-8141 Japan Center for Infectious Disease Education and Research Osaka University 2-8 Yamada-oka Suita Osaka565-0871 Japan Department of Behavioral Science Faculty of Humanities and Human Sciences Hokkaido University Kita 10 Nishi 7 Kita-ku Hokkaido Sapporo060-0810 Japan Fukushima Regional Collaborative Research Center National Institute for Environmental Studies 10-2 Fukasaku Miharu Tamura District Fukushima963-7700 Japan Material Cycles Division National Institute for Environmental Studies 16-2 Onogawa Ibaraki Tsukuba305-8506 Japan

TEPCO's Fukushima Daiichi nuclear power plant accident prompted extensive decontamination work. The decontaminated soil and incinerated ash generated by the process are scheduled for final disposal by March 2045 outside Fukushima Prefecture. The final disposal is unprecedented worldwide. Clarifying their acceptability will contribute to the final disposal of decontaminated soil and incinerated ash, as well as add knowledge about the perceived risk of low-concentration radioactive waste. A questionnaire survey was conducted to assess the psychological factors influencing final disposal acceptability. The results of the structural equation modeling demonstrated stable results, with risk perception decreasing acceptability, social benefits increasing acceptability, and personal benefits having limited impact. The initiative for the final disposal of decontaminated soil and incinerated ash can facilitate the reconstruction of Fukushima Prefecture after the disaster. Trust and intergenerational expectations are critical factors influencing the acceptability of this disposal. The responses were classified based on the relevance of moral norms using cluster analysis and moral foundations. The influence of each element on acceptability varied depending on the cluster. Trust was identified as the most influential factor in acceptability, regardless of the level of importance placed on moral norms. © 2023 The Authors

关键词： Risk perception

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Enhanced redox kinetics and capacitance in ceria doped cobalt metal organic framework derived mesoporous carbon electrodes for supercapacitors

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Journal of Industrial and Engineering Chemistry 2025年

作者： Ayesha Israr Rabia Ahmad Khadija Tul Kubra Zeeshan Ali Faiza Jan Iftikhar Ghulam Ali U.S.-Pakistan Center for Advanced Studies in Energy (USPCAS–E) National University of Sciences and Technology (NUST) Islamabad 44000 Pakistan Interdisciplinary Research Center for Advanced Materials King Fahd University of Petroleum & Minerals (KFUPM) Dhahran 31261 Saudi Arabia Department of Physics University of Engineering and Technology Lahore Pakistan School of Chemical and Materials Engineering (SCME) National University of Sciences and Technology (NUST) H-12 Islamabad 44000 Pakistan NUTECH School of Applied Science & Humanities National University of Technology Islamabad 44000 Pakistan

In this study, a series of ceria-doped cobalt-based composites were synthesized via the incorporation of cobalt and cerium precursors into trimesic acid-based metal–organic frameworks (MOFs), followed by pyrolysis to obtain Co–CeO 2 /C hybrid materials. The thermal decomposition of the MOF structure facilitated the in-situ formation of a conductive carbon matrix comprising carbon nanotubes (CNTs) and carbon nanospheres, catalyzed by cobalt nanoparticles. Among the prepared composites, the 5Co-5Ce/C sample exhibited the most promising electrochemical performance, delivering a high specific capacitance of 839F g −1 at a current density of 0.1 A g −1 and demonstrating excellent cycling stability, with 97% capacitance retention after 6000 charge- discharge cycles at 10 A g −1 . The superior performance is attributed to the synergistic effect between cobalt and cerium oxide, wherein CeO 2 not only enhances faradic charge storage through reversible redox reactions but also promotes the development of a mesoporous structure. Cerium was found to influence the crystallization behavior of cobalt during pyrolysis, thereby regulating the growth and distribution of CNTs and nanospheres. This structural refinement contributes to an increased electrochemically active surface area and improved ion transport kinetics, leading to enhanced overall capacitive behavior. These results highlight the potential of Co–CeO 2 /C composites as promising electrode materials for high-performance supercapacitor applications.

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Field-Induced Criticality in YbCu4Au

arXiv

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arXiv 2024年

作者： Taniguchi, Takanori Osato, Kotaro Okabe, Hirotaka Kitazawa, Takafumi Kawamata, Masahiro Hashimoto, Shota Ikeda, Yoichi Nambu, Yusuke Sari, Dita Puspita Watanabe, Isao Nakamura, Jumpei G. Koda, Akihiro Gouchi, Jun Uwatoko, Yoshiya Kittaka, Shunichiro Sakakibara, Toshiro Mizumaki, Masaichiro Kawamura, Naomi Yamanaka, Takayoshi Hiraki, Koichi Sasaki, Takahiko Fujita, Masaki Institute for Materials Research Tohoku University Sendai980-8577 Japan Department of Physics Tohoku University Sendai980-8578 Japan Organization for Advanced Studies Tohoku University Sendai980-8577 Japan FOREST Japan Science and Technology Agency Kawaguchi Saitama332-0012 Japan Innovative Global Program College of Engineering Shibaura Institute of Technology Saitama337-8570 Japan Nuclear Structure Research Group Nishina Center for Accelerator-Based Science RIKEN Wako Saitama351-0198 Japan Institute of Materials Structure Science High-Energy Accelerator Research Organization Tsukuba305-0801 Japan The Institute for Solid State Physics The University of Tokyo Kashiwa Chiba277-8581 Japan Department of Physics Faculty of Science and Engineering Chuo University Tokyo112-8551 Japan Faculty of Science Kumamoto University 2-39-1 Kurokami Chuou-ku Kumamoto860-8555 Japan Japan Synchrotron Radiation Research Institute Sayo Hyogo679-5148 Japan Integrated Center for Science and Humanities Fukushima Medical University Fukushima960-1295 Japan

YbCu4Au is a unique material exhibiting multiple quantum fluctuations simultaneously. In this study, we investigated the field-induced criticality in YbCu4Au, based on comprehensive micro and macro measurements, including powder Xray diffraction (XRD), neutron powder diffraction (NPD), nuclear magnetic resonance, magnetization, resistivity, specific heat, muon spin rotation relaxation (μSR), and X-ray absorption spectroscopy (XAS). Single crystals of YbCu4Au were grown, and their crystal structure was determined using XRD, and NPD measurements. Magnetic successive transitions were observed below 1 T by specific heat, resistivity, NPD, and μSR measurements. XAS measurements further indicate that the valence of Yb ions (+2.93) remained unchanged above 2 T. Moreover, the change in quadrupole frequency observed in the previous study is attributable to the electric quadrupole, as the expected value of the electric quadrupole was finite under magnetic fields [S. Wada et al., Journal o f Physics: Condensed Matter, 20, 175201 (2008).]. These experimental results suggest that YbCu4Au exhibited bicritical behavior near 1 T, arising from the competition between RKKY interaction, accounting for the magnetic phases, and the Zeeman effect. © 2024, CC BY-NC-SA.

关键词： X ray absorption spectroscopy

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A dulcimer keys positioning method based on improved Roberts operator

A dulcimer keys positioning method based on improved Roberts...

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Chinese Automation Congress (CAC)

作者： De Tang Ziying Zhang Xin Chen Zhe Xiao Mengxi Qin School of Automation China University of Geosciences Wuhan China Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Ministry of Education Engineering Research Center of Intelligent Technology for Geo-Exploration School of Arts and Communication China University of Geosciences Wuhan China

ISBN: (纸本)9781665426480

It is important for the dulcimer robot to obtain the spatial coordinates of the dulcimer phonemes. However, the traditional manual positioning method is both inefficient and does not meet the intelligence requirements of modern robot. A visual positioning method based on improved Roberts operator is proposed in this paper on account of solving these problems, which can obtain the 3D coordinates of the dulcimer keys in a short time. First, an improved Roberts edge detection operator is designed, which fully detects the edge information of the target by transforming the scale. Further, this paper proposes a dulcimer keys positioning method by fusing RGB and depth image information. This method has a better positioning effect for dulcimer keys with complex background and small size. The experimental results show that the visual positioning method proposed in this paper can effectively identify and locate the dulcimer keys, and it has better robustness to the lighting environment.

关键词： Visualization Three-dimensional displays Robot kinematics Image edge detection Measurement uncertainty Lighting Manuals

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Crystalline carbon nitride derived self-assembly composite membranes with enhanced self-cleaning performance toward dye/salt separation

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Journal of Environmental Management 2025年 388卷 125943页

作者： Qiu, Yujing Xu, Haochen Zhou, Ying Chen, Beizhao Wang, Zhongying Yang, Yi Fang, Qile Mei, Ying Research and Development Center for Watershed Environmental Eco-Engineering Advanced Institute of Natural Sciences Beijing Normal University Zhuhai519087 China School of Environment Beijing Normal University Beijing100875 China Faculty of Arts and Sciences Beijing Normal University Zhuhai519087 China Center for Water Research Advanced Institute of Natural Sciences Beijing Normal University Zhuhai519087 China School of Environmental Science and Engineering Southern University of Science and Technology Shenzhen518055 China

Membrane technology can realize the sustainable management of textile wastewater through dye/salt separation, but its practical implementation has long been hampered by membrane fouling. This work was to develop a novel carbon nitride based two-dimensional (2D) self-assembled membrane for efficient dye/salt separation with excellent photocatalytic self-cleaning performance toward azo dyes (e.g., methyl blue), anthraquinone dyes (e.g., reactive blue 19) and natural organic matters (e.g., humic acid). Specifically, conventional graphite carbon nitride (g-C3N4), poly triazine imide (PTI) and the composites of iron oxide doped PTI (PTI-Fe2O3) were comparatively investigated for manipulating the lamellar self-catalytic membrane through facile vacuum filtration. The considerable separation factors of sodium chloride to methyl blue (Ssalt/dye) of 76.97, 80.72, and 74.33 were obtained by g-C3N4, PTI, and PTI-Fe2O3, respectively. The generation of radicals and non-radicals were triggered by light irradiation and was accelerated by PTI compared to g-C3N4, resulting in the better flux recovery rate (FRR) of 95.7 % for PTI membrane than that of g-C3N4 membrane (74.4 %). Besides, the introduction of iron oxide enables the enhanced self-cleaning performance by coupling photocatalytic and Fenton-like process, leading to the highest FRR value of 99.4 %. Meanwhile, the fabricated membranes demonstrate remarkable stability (FRR ≥ 80 %) during prolonged operation (64 h) to both simulated and real textile wastewater, indicating that it can a promising alternative membrane material for textile wastewater management. © 2025 Elsevier Ltd

关键词： Membrane technology

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Evaluation of IoT-Setting Method Among Senior Citizens in Japan 7th

Evaluation of IoT-Setting Method Among Senior Citizens in Ja...

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7th International Conference on Human Aspects of IT for the Aged Population, ITAP 2021, held as part of the 23rd International Conference, HCI International 2021

作者： Yoshioka, Daisuke Kogami, Hiroki Kang, SooIn Yoshizaki, Reina Sakurai, Yuriki Nakano, Koki Wu, Jiang Fujisaki-Sueda-Sakai, Mahiro Sugawara, Ikuko Miura, Takahiro Yabu, Ken-ichiro Ito, Kenichiro Ifukube, Tohru Graduate School of Frontier Sciences The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-8656 Japan Graduate School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-8656 Japan Graduate School of Interdisciplinary Information Studies The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-8656 Japan Graduate School of Humanities and Sociology The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-8656 Japan School of Medicine Tohoku University Sendai Japan Institute of Gerontology The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-8656 Japan Human Augmentation Research Center National Institute of Advanced Industrial Science and Technology Kashiwa Japan Research Center for Advanced Science and Technology The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-8656 Japan Virtual Reality Educational Research Center The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-8656 Japan

ISBN: (纸本)9783030781071

To develop methods for supporting senior citizens is critical because the number of senior citizens is growing globally. Recently, the focus is on supporting senior citizens using information technology (IT), including the Internet of Things (IoT). In the IoT system, IoT tools such as cameras and sensors are connected and interacted by the Internet. Furthermore, we can customize their function easily using smartphones to modulate the function we want. Therefore, senior citizens should customize IoT products and help themselves. However, it is challenging to customize IoT product functions for senior citizens because they had fewer chances to use smartphones or computers than young people. Therefore, other customizing methods for IoT products are needed for senior citizens. In this study, we design a workshop to test, where the setting of the user interface (UI) is suitable for senior citizens. We develop three UIs, namely, voice, touch, and camera. To explore which method is suitable for senior citizens, we evaluate the setting time for each method. Consequently, the setting time of the voice interface is shorter than the others. Furthermore, the system usability scale (SUS) score was higher than 68, indicating that the setting method using the voice interface is acceptable for senior citizens. These results indicate that the voice interface is a suitable setting method for senior citizens. © 2021, Springer Nature Switzerland AG.

关键词： User interfaces

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DEEP2: Deep Learning Powered De-scattering with Excitation Patterning

arXiv

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arXiv 2022年

作者： Wijethilake, Navodini Anandakumar, Mithunjha Zheng, Cheng So, Peter T.C. Yildirim, Murat Wadduwage, Dushan N. Center for Advanced Imaging Faculty of Arts and Sciences Harvard University Cambridge United States Department of Electronic and Telecommunication Engineering University of Moratuwa Sri Lanka Department of Mechanical Engineering Massachusetts Institute of Technology 77 Massachusetts Ave. CambridgeMA02139 United States Laser Biomedical Research Center Massachusetts Institute of Technology 77 Massachusetts Ave. CambridgeMA02139 United States Picower Institute for Learning and Memory Massachusetts Institute of Technology 77 Massachusetts Ave. CambridgeMA02139 United States Department of Biological Engineering Massachusetts Institute of Technology 77 Massachusetts Ave. CambridgeMA02139 United States Department of Neuroscience Cleveland Clinic Lerner Research Institute ClevelandOH44195 United States

Limited throughput is a key challenge in in-vivo deep-tissue imaging using nonlinear optical microscopy. Point scanning multiphoton microscopy, the current gold standard, is slow especially compared to the wide-field imaging modalities used for optically cleared or thin specimens. We recently introduced "De-scattering with Excitation Patterning or DEEP", as a widefield alternative to point-scanning geometries. Using patterned multiphoton excitation, DEEP encodes spatial information inside tissue before scattering. However, to de-scatter at typical depths, hundreds of such patterned excitations are needed. In this work, we present DEEP2, a deep learning based model, that can de-scatter images from just tens of patterned excitations instead of hundreds. Consequently, we improve DEEP's throughput by almost an order of magnitude. We demonstrate our method in multiple numerical and physical experiments including in-vivo cortical vasculature imaging up to four scattering lengths deep, in alive mice. © 2022, CC BY.

关键词： Tissue

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NiO-YSZ anode composite material derived from mechano-chemical for solid oxide fuel cells application

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Case Studies in Chemical and Environmental Engineering 2025年 11卷

作者： Srisuwan, Thanakorn Puengjinda, Pramote Kaewtrakulchai, Napat Chanpee, Sirayu Jadsadajerm, Supachai Panomsuwan, Gasidit Ruttanadech, Nuttapong Wongrekdee, Sutthipoj Chollacoop, Nuwong Faungnawakij, Kajornsak Fuji, Masayoshi Eiad-ua, Apiluck College of Materials Innovation and Technology King Mongkut's Institute of Technology Ladkrabang Bangkok 10520 Thailand Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) Bangkok 10110 Thailand Kasetsart Agricultural and Agro-Industrial Product Improvement Institute Kasetsart University Bangkok 10900 Thailand Department of Chemical Engineering School of Engineering King Mongkut's Institute of Technology Ladkrabang Bangkok 10520 Thailand Department of Industrial Chemistry Faculty of Applied Science King Mongkut's University of Technology North Bangkok Bangkok 10800 Thailand Department of Materials Engineering Faculty of Engineering Kasetsart University Bangkok 10900 Thailand Department of Engineering King Mongkut's Institute of Technology Ladkrabang Prince of Chumphon Campus Chumphon 86000 Thailand Department of Physical and Material Sciences Faculty of Liberal Arts and Science Kasetsart University Khamphaeng Saen Campus Nakhon Pathom 73140 Thailand Renewable Energy and Energy Efficiency Research Team National Energy Technology Center (ENTEC) National Science and Technology Development Agency (NSTDA) Pathumthani 12120 Thailand National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA) 111 Thailand Science Park Pathum Thani 12120 Thailand Advanced Ceramic Center Nagoya Institute of Technology Tajimi 507-0033 Japan

This study investigates the effects of calcination time, milling duration, and sintering temperature on the properties of Nickel oxide and Yttria-stabilized zirconia (NiO-YSZ) anode composite materials for solid oxide fuel cell (SOFC) applications. NiO nanoparticles were synthesized from nickel (II) sulfate (Ni(II)SO₄), with X-ray diffraction (XRD) confirming a face-centered cubic (FCC) structure. The crystallite size (21 nm) was achieved after 8 hours of calcination, while prolonged durations caused particle agglomeration. Ball-milling for 12 hours produced comparatively fine particles with an average of 706 nm, though extended milling led to grain growth and aggregation. Scanning electron microscopy (SEM) revealed nano aggregation. Sintering at 1200 °C improved the densification of the NiO-YSZ layer while increasing its porosity, which enhanced the reduction of NiO to metallic nickel (Ni). Electrochemical Impedance Spectroscopy (EIS) demonstrated lower impedance and improved electrochemical performance for cells cold-sintered at 1200 °C. These findings show the importance of optimizing processing conditions to enhance the performance of NiO-YSZ anode for SOFCs, offering valuable insights for advanced energy conversion technologies. © 2025

关键词： Cold-sintering Mechano-chemical reaction Nickel oxide Solid oxide fuel cell Yttria-stabilized zirconia

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Microplasma Synthesized Gold Nanoparticle/TEMPO Cellulose Nanocomposites for Potential SERS Sensing Applications

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Vacuum 2025年

作者： Jie Zhu Zhenxing Wang Ciaran Duffy Zhehong Lu Dan Sun Advanced Composite Research Group (ACRG) School of Mechanical & Aerospace Engineering Queen's University Belfast Belfast BT9 5AH UK School of Materials and Environmental Engineering Hunan University of Humanities Science and Technology Loudi 417000 China Key Laboratory of Advanced Marine Materials Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo 315201 China National Special Superfine Powder Engineering Research Center of China Nanjing University ofScience and Technology Nanjing 210014 China

This is a study reporting the one-pot synthesis of gold nanoparticles/TEMPO (2,2,6,6-Tetramethylpiperidine-1-oxyl) cellulose nanofibers (CNF) nanocomposites through facile direct current atmospheric pressure microplasma (APM) technology. Compared to conventional synthetic approaches, the APM process is fast (within minutes), energy-efficient and eliminates the use of harsh chemicals. To reveal the impact of APM processing and effect of gold salt precursor concentration on the resulting materials structures and properties, comprehensive characterization (such as ultraviolet-visible (UV-vis) spectroscopy, XRD, XPS, and TEM) has been carried out. In addition, density functional theory (DFT) calculation was carried out to reveal the interfacial interaction mechanism between gold nanoparticles and the TEMPO-cellulose nanofibers. Finally, the potential of the resulting nanocomposite as SERS substrates was demonstrated using methylene blue as model analyte.

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