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Identification of Cognitive Dysfunction in Patients with T2DM Using Whole Brain Functional Connectivity

Genomics, Proteomics & Bioinformatics 2019年第4期17卷 441-452页

作者： Zhenyu Liu Jiangang Liu Huijuan Yuan Taiyuan Liu Xingwei Cui Zhenchao Tang Yang Du Meiyun Wang Yusong Lin Jie Tian CAS Key Laboratory of Molecular Imaging Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Computer and Information Technology Beijing Jiaotong UniversityBeijing 100044China Department of Endocrinology and Metabolism Henan Provincial People’s Hospital&the People’s Hospital of Zhengzhou UniversityZhengzhou 450003China Department of Radiology Henan Provincial People’s Hospital&the People’s Hospital of Zhengzhou UniversityZhengzhou 450003China Cooperative Innovation Center for Internet Healthcare&School of Software Zhengzhou UniversityZhengzhou 450003China School of Mechanical Electrical&Information EngineeringShandong University(Weihai)Weihai 264209China University of Chinese Academy of Sciences Beijing 100080China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of MedicineBeihang UniversityBeijing 100191China Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education School of Life Science and TechnologyXidian UniversityXi’an 710126China

Majority of type 2 diabetes mellitus(T2DM)patients are highly susceptible to several forms of cognitive impairments,particularly ***,the underlying neural mechanism of these cognitive impairments remains *** aimed to investigate the correlation between whole brain resting state functional connections(RSFCs)and the cognitive status in 95 patients with *** constructed an elastic net model to estimate the Montreal Cognitive Assessment(MoCA)scores,which served as an index of the cognitive status of the patients,and to select the RSFCs for further ***,we utilized a machine learning technique to evaluate the discriminative ability of the connectivity pattern associated with the selected *** estimated and chronological MoCA scores were significantly correlated with R=0.81 and the mean absolute error(MAE)=***,cognitive impairments of patients with T2DM can be identified using the RSFC pattern with classification accuracy of 90.54%and the area under the receiver operating characteristic(ROC)curve(AUC)of *** connectivity pattern not only included the connections between regions within the default mode network(DMN),but also the functional connectivity between the task-positive networks and the DMN,as well as those within the task-positive *** results suggest that an RSFC pattern could be regarded as a potential biomarker to identify the cognitive status of patients with T2DM.

关键词： Type 2 diabetes mellitus Resting state functional connectivity Elastic net Support vector machines MoCA

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Quingo: A programming framework for heterogeneous quantum-classical computing with NISQ features

arXiv

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arXiv 2020年

作者： Fu, Xiang Yu, Jintao Su, Xing Jiang, Hanru Wu, Hua Cheng, Fucheng Deng, Xi Zhang, Jinrong Jin, Lei Yang, Yihang Xu, Le Hu, Chunchao Huang, Anqi Huang, Guangyao Qiang, Xiaogang Deng, Mingtang Xu, Ping Xu, Weixia Liu, Wanwei Zhang, Yu Deng, Yuxin Wu, Junjie Feng, Yuan Institute for Quantum Information & State Key Laboratory of High Performance Computing College of Computer National University of Defense Technology Changsha410073 China State Key Laboratory of Mathematical Engineering and Advanced Computing Zhengzhou450001 China College of Computer National University of Defense Technology Changsha410073 China Center for Quantum Computing Peng Cheng Laboratory Shenzhen518055 China Shanghai Key Laboratory of Trustworthy Computing East China Normal University Shanghai200062 China Center for Quantum Computing Peng Cheng Laboratory Shenzhen518055 China School of Information Engineering Zhengzhou University Zhengzhou450001 China Institute for Quantum Information & State Key Laboratory of High Performance Computing College of Computer National University of Defense Technology Changsha410073 China Department of Computing Science College of Computer National University of Defense Technology Changsha410073 China School of Computer Science and Technology University of Science and Technology of China Hefei230027 China Shanghai Key Laboratory of Trustworthy Computing East China Normal University Shanghai200062 China Institute for Quantum Information & State Key Laboratory of High Performance Computing College of Computer National University of Defense Technology Changsha410073 China Centre for Quantum Software and Information University of Technology Sydney Sydney2007 Australia

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GIScience in the Era of Artificial Intelligence: A Research Agenda Towards Autonomous GIS

arXiv

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arXiv 2025年

作者： Li, Zhenlong Ning, Huan Gao, Song Janowicz, Krzysztof Li, Wenwen Arundel, Samantha T. Yang, Chaowei Bhaduri, Budhendra Wang, Shaowen Zhu, A. Xing Gahegan, Mark Shekhar, Shashi Ye, Xinyue McKenzie, Grant Cervone, Guido Hodgson, Michael E. Geoinformation and Big Data Research Lab Department of Geography The Pennsylvania State University University ParkPA United States Department of Geography University of Wisconsin – Madison WI United States STKO Lab Department of Geography and Regional Research University of Vienna Vienna Austria Spatial Analysis Research Center School of Geographical Sciences and Urban Planning Arizona State University AZ United States Center of Excellence for Geospatial Information Science U.S. Geological Survey VA United States NSF Spatiotemporal Innovation Center Department of Geography & Geoinformation Science George Mason University VA United States TN United States CyberGIS Center for Advanced Digital and Spatial Studies Department of Geography and Geographic Information Science University of Illinois Urbana-Champaign IL United States School of Computer Science University of Auckland New Zealand Department of Computer Science & Engineering University of Minnesota MN United States Department of Landscape Architecture & Urban Planning Center for Geospatial Sciences Applications & Technology Texas A&M University TX United States Platial Analysis Lab Department of Geography McGill University Quebec Canada Institute for Computational and Data Sciences Department of Geography The Pennsylvania State University University ParkPA United States Department of Geography University of South Carolina SC United States

The advent of generative AI exemplified by large language models (LLMs) opens new ways to represent and compute geographic information and transcends the process of geographic knowledge production, driving geographic information systems (GIS) towards autonomous GIS. Leveraging LLMs as the decision core, autonomous GIS can independently generate and execute geoprocessing workflows to perform spatial analysis. In this vision paper, we further elaborate on the concept of autonomous GIS and present a conceptual framework that defines its five autonomous goals, five autonomous levels, five core functions, and three operational scales. We demonstrate how autonomous GIS could perform geospatial data retrieval, spatial analysis, and map making with four proof-of-concept GIS agents. We conclude by identifying critical challenges and future research directions, including fine-tuning and self-growing decision-cores, autonomous modeling, and examining the societal and practical implications of autonomous GIS. By establishing the groundwork for a paradigm shift in GIScience, this paper envisions a future where GIS moves beyond traditional workflows to autonomously reason, derive, innovate, and advance geospatial solutions to pressing global challenges. Meanwhile, as we design and deploy increasingly intelligent geospatial systems, we carry a responsibility to ensure they are developed in socially responsible ways, serve the public good, and support the continued value of human geographic insight in an AI-augmented future. © 2025, CC BY.

关键词： Image retrieval

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Structural vulnerability of complex networks under multiple edge-based attacks 3

Structural vulnerability of complex networks under multiple ...

引用

3rd IEEE International Conference on Data Science in Cyberspace, DSC 2018

作者： Wu, Xiaobo Li, Shudong Li, Aiping Zhou, Bin Tian, Zhihong Zhao, Dawei School of Software Engineering Yantai Vocational College Shandong Yantai264003 China Cyberspace Institute of Advanced Technology Guangzhou University Guangzhou510006 China School of Computer Science National University of Defense Technology Hunan Changsha410073 China Shandong Provincial Key Laboratory of Computer Network Shandong Computer Science Center Jinan250014 China

ISBN: (纸本)9781538642108

We investigate the structural vulnerability of complex networks under different edge-based attacks. The attacks are induced by removing a certain ratio of edges according to four kinds of weighting methods strategies introduced, which also can describe the characteristics of links. Two metrics (the relative size of the giant component in network, the average length of shortest path) are measured. The simulations demonstrate that, the edges with higher product of betweenness centrality of the two endpoints of one edge connected are more important for SF network, ER random network, autonomous system network(AS), Italy power grid and US airport networks, but the edges with higher edge betweenness centrality are more important for WS networks. Moreover, the edges with higher edge betweenness centrality for SF network and those with higher k-shell index for AS networks are also important. The findings highlight the identification of structural key links for protecting real-world networks. © 2018 IEEE.

关键词： Complex networks

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swTVM: Towards Optimized Tensor Code Generation for Deep Learning on Sunway Many-Core Processor

arXiv

引用

arXiv 2019年

作者： Li, Mingzhen Liu, Changxi Liao, Jianjin Zheng, Xuegui Yang, Hailong Sun, Rujun Xu, Jun Gan, Lin Yang, Guangwen Luan, Zhongzhi Qian, Depei School of Computer Science and Engineering Beihang University Beijing China State Key Laboratory of Software Development Environment Beijing China National University of Singapore Singapore Singapore State Key Laboratory of Mathematical Engineering and Advanced Computing Wuxi China Science and Technology on Special System Simulation Laboratory Beijing Simulation Center Beijing China Department of Computer Science and Technology Tsinghua University Beijing China

The flourish of deep learning frameworks and hardware platforms has been demanding an efficient compiler that can shield the diversity in both software and hardware in order to provide application portability. Among the existing deep learning compilers, TVM is well known for its efficiency in code generation and optimization across diverse hardware devices. In the meanwhile, the Sunway many-core processor renders itself as a competitive candidate for its attractive computational power in both scientific computing and deep learning workloads. This paper combines the trends in these two directions. Specifically, we propose swTVM that extends the original TVM to support ahead-of-time compilation for architecture requiring cross-compilation such as Sunway. In addition, we leverage the architecture features during the compilation such as core group for massive parallelism, DMA for high bandwidth memory transfer and local device memory for data locality, in order to generate efficient codes for deep learning workloads on Sunway. The experiment results show that the codes generated by swTVM achieves 1.79× on average compared to the state-of-the-art deep learning framework on Sunway, across six representative benchmarks. This work is the first attempt from the compiler perspective to bridge the gap of deep learning and Sunway processor particularly with productivity and efficiency in mind. We believe this work will encourage more people to embrace the power of deep learning and Sunway many-core processor. Copyright © 2019, The Authors. All rights reserved.

关键词： Program compilers

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Associations between Aβ deposition and neurometabolic alterations in Alzheimer's disease: Insights from hybrid 3D MRSI-PET imaging

引用

Alzheimer's & dementia : the journal of the Alzheimer's Association 2025年第6期21卷 e70332页

作者： Miao Zhang Jialin Hu Yaoyu Zhang Ziyu Meng Yibo Zhao Yudu Li Wen Jin Xiao-Hang Qian Lijun Wang Guanyu Ye Xu-Feng Jiang Ya-Dong Li Jian Ye Huidong Tang Jun Liu Parashkev Nachev Zhi-Pei Liang Biao Li Yao Li Department of Nuclear Medicine Ruijin Hospital School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China. National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy Shanghai Jiao Tong University Shanghai China. Institute of Medical Robotics Shanghai Jiao Tong University Shanghai China. Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign Urbana Illinois USA. Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign Urbana Illinois USA. National Center for Supercomputing Applications University of Illinois at Urbana-Champaign Urbana Illinois USA. Department of Geriatrics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China. Medical Center on Aging of Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China. Department of Neurology and Institute of Neurology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China. Department of Neurovascular Center Changhai Hospital Naval Medical University Shanghai China. Department of Gastroenterology Songjiang Hospital and Songjiang Research Institute Shanghai Key Laboratory of Emotions and Affective Disorders State Key Laboratory of Eye Health Shanghai Jiao Tong University School of Medicine Shanghai China. Shanghai Key Laboratory of Gynecologic Oncology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China. High-Dimensional Neurology Group Institute of Neurology University College London London UK.

INTRODUCTION:Understanding the neurometabolic changes associated with amyloid-β (Aβ) deposition is important for early Alzheimer's disease (AD) diagnosis, but their spatial relationships remained unexplored due to technical limitations. METHODS:We investigated the relationship between Aβ deposition and neuronal and glial metabolites using high-resolution 3D magnetic resonance spectroscopic imaging (MRSI) (8-min scan, 2 × 3 × 3 mm resolution) and Aβ-positron emission tomography (Aβ-PET) imaging. N-acetylaspartate, myo-inositol, and creatine maps were obtained from 174 participants: 39 controls, 65 mild cognitive impairment (MCI), and 70 AD patients. RESULTS:N-Acetylaspartate levels were negatively correlated with Aβ, while myo-inositol levels were positively correlated globally. Regional associations with Aβ include N-acetylaspartate reductions in frontal cortex, anterior cingulate cortex, and precuneus, and myo-inositol increases in precuneus, lateral temporal, and lateral parietal cortices. Combined MRSI and PET biomarkers achieved the highest diagnostic accuracy for MCI and AD . DISCUSSION:Hybrid high-resolution 3D MRSI and Aβ-PET imaging provides valuable insights into Aβ's impact on neurometabolic changes, improving early AD diagnosis. HIGHLIGHTS:Hybrid 3D magnetic resonance spectroscopic imaging-positron emission tomography (MRSI-PET) imaging reveals Aβ deposition impact on neurometabolism in Alzheimer's disease (AD). N-acetylaspartate (NAA) as a neuronal metabolic marker is negatively associated with Aβ globally and locally. Myo-inositol (mI) as a glial metabolic marker is positively associated with Aβ globally and locally. Combining 3D magnetic resonance spectroscopic imaging (MRSI) and PET biomarkers improves diagnostic accuracy for mild cognitive impairment (MCI) and AD.

关键词： alzheimer's disease amyloid‐β magnetic resonance spectroscopic imaging myo‐inositol n‐acetylaspartate

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Atomic structure of the continuous random network of amorphous C[(C6H4)2]2, PAF-1

arXiv

引用

arXiv 2021年

作者： Cai, Guanqun Lin, He Zhao, Ziqiang Liu, Jiaxun Phillips, Anthony E. Headen, Thomas F. Youngs, Tristan G.A. Hai, Yang Tian, Haolai He, Chunyong Ke, Yubin Tao, Juzhou Ben, Teng Dove, Martin T. College of Computer Science Sichuan University Sichuan Chengdu610065 China Department of Physics School of Sciences Wuhan University of Technology 205 Luoshi Road Hubei Hong-shan district Wuhan430070 China School of Mechanical Engineering Dongguan University of Technology Guangdong Dongguan523830 China School of Physical and Chemical Sciences Queen Mary University of London Mile End Road LondonE1 4NS United Kingdom Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences 99 Haike Road Shanghai201210 China Institute of Molecules Plus Tianjin University Tianjin300072 China ISIS Neutron and Muon Facility Rutherford Appleton Laboratory Harwell Campus Oxfordshire DidcotOX11 0QX United Kingdom Spallation Neutron Source Science Center Guangdong Dongguan523803 China Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China University of Chinese Academy of Sciences Beijing100049 China Zhejiang Eng. Lab. for Green Syntheses and Applications of Fluorine-Containing Specialty Chemicals Institute of Advanced Fluorine-Containing Materials Zhejiang Normal University Jinhua321004 China Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Institute of Physical Chemistry Zhejiang Normal University Jinhua321004 China

We demonstrate that the amorphous material PAF-1, C[(C6H4)2]2forms a continuous random network in which tetrahedral carbon sites are connected by 4,4'-biphenyl linkers. Experimental neutron total scattering measurements on deuterated, hydrogenous, and null-scattering samples agree with molecular dynamics simulations based on this model. From the MD model, we are able for the first time to interrogate the atomistic structure. The small-angle scattering is consistent with Porod scattering from particle surfaces, of the form Q-4, where Q is the scattering vector. There We measure a distinct peak in the scattering at Q = 0:45 Å-1, corresponding to the first sharp diffraction peak in amorphous silica, which indicates the structural analogy between these two amorphous tetrahedral networks. Copyright © 2021, The Authors. All rights reserved.

关键词： Molecular dynamics

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Deep learning enabled strain mapping of single-atom defects in 2D transition metal dichalcogenides with sub-picometer precision

arXiv

引用

arXiv 2020年

作者： Lee, Chia-Hao Khan, Abid Luo, Di Santos, Tatiane P. Shi, Chuqiao Janicek, Blanka E. Kang, Sangmin Zhu, Wenjuan Sobh, Nahil A. Schleife, André Clark, Bryan K. Huang, Pinshane Y. Department of Materials Science and Engineering University of Illinois Urbana-Champaign UrbanaIL61801 United States Department of Physics University of Illinois Urbana-Champaign UrbanaIL61801 United States Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign UrbanaIL61801 United States Beckman Institute for Advanced Science and Technology University of Illinois Urbana-Champaign UrbanaIL61801 United States Materials Research Laboratory University of Illinois at Urbana-Champaign UrbanaIL61801 United States National Center for Supercomputing Applications University of Illinois at Urbana-Champaign UrbanaIL61801 United States

2D materials offer an ideal platform to study the strain fields induced by individual atomic defects, yet challenges associated with radiation damage have so-far limited electron microscopy methods to probe these atomic-scale strain fields. Here, we demonstrate an approach to probe single-atom defects with sub-picometer precision in a monolayer 2D transition metal dichalcogenide, WSe2-2xTe2x. We utilize deep learning to mine large datasets of aberration-corrected scanning transmission electron microscopy images to locate and classify point defects. By combining hundreds of images of nominally identical defects, we generate high signal-to-noise class-averages which allow us to measure 2D atomic coordinates with up to 0.3 pm precision. Our methods reveal that Se vacancies introduce complex, oscillating strain fields in the WSe2-2xTe2xlattice which cannot be explained by continuum elastic theory. These results indicate the potential impact of computer vision for the development of high-precision electron microscopy methods for beam-sensitive materials. Copyright © 2020, The Authors. All rights reserved.

关键词： Transition metals

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Fine-grained event categorization with heterogeneous graph convolutional networks

arXiv

引用

arXiv 2019年

作者： Peng, Hao Li, Jianxin Gong, Qiran Song, Yangqiu Ning, Yuanxing Lai, Kunfeng Yu, Philip S. Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang University State Key Laboratory of Software Development Environment Beihang University Department of Computer Science and Engineering Hong Kong University of Science and Technology Platform and Content Group Tencent Institute for Data Science Tsinghua University Department of Computer Science University of Illinois Chicago United States

Events are happening in real-world and real-time, which can be planned and organized occasions involving multiple people and objects. Social media platforms publish a lot of text messages containing public events with comprehensive topics. However, mining social events is challenging due to the heterogeneous event elements in texts and explicit and implicit social network structures. In this paper, we design an event meta-schema to characterize the semantic relatedness of social events and build an event-based heterogeneous information network (HIN) integrating information from external knowledge base, and propose a novel Pairwise Popularity Graph Convolutional Network (PP-GCN) based fine-grained social event categorization model. We propose a Knowledgeable meta-paths Instances based social Event Similarity (KIES) between events and build a weighted adjacent matrix as input to the PP-GCN model. Comprehensive experiments on real data collections are conducted to compare various social event detection and clustering tasks. Experimental results demonstrate that our proposed framework outperforms other alternative social event categorization techniques. Copyright © 2019, The Authors. All rights reserved.

关键词： Information services

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Residual Networks for Light Field Image Super-Resolution

Residual Networks for Light Field Image Super-Resolution

引用

IEEE/CVF Conference on computer Vision and Pattern Recognition

作者： Shuo Zhang Youfang Lin Hao Sheng Beijing Key Lab of Traffic Data Analysis and Mining School of Computer and Information Technology Beijing Jiaotong University Key Laboratory of Intelligent Passenger Service of Civil Aviation CAAC State Key Laboratory of Software Development Environment School of Computer Science and Engineering Beihang University Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang University

Light field cameras are considered to have many potential applications since angular and spatial information is captured simultaneously. However, the limited spatial resolution has brought lots of difficulties in developing related applications and becomes the main bottleneck of light field cameras. In this paper, a learning-based method using residual convolutional networks is proposed to reconstruct light fields with higher spatial resolution. The view images in one light field are first grouped into different image stacks with consistent sub-pixel offsets and fed into different network branches to implicitly learn inherent corresponding relations. The residual information in different spatial directions is then calculated from each branch and further integrated to supplement high-frequency details for the view image. Finally, a flexible solution is proposed to super-resolve entire light field images with various angular resolutions. Experimental results on synthetic and real-world datasets demonstrate that the proposed method outperforms other state-of-the-art methods by a large margin in both visual and numerical evaluations. Furthermore, the proposed method shows good performances in preserving the inherent epipolar property in light field images.

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