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Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016

Human genomics 2016年第1期10 Suppl 1卷 12页

作者： A. K. Srivastava Y. Wang R. Huang C. Skinner T. Thompson L. Pollard T. Wood F. Luo R. Stevenson R. Polimanti J. Gelernter X. Lin I. Y. Lim Y. Wu A. L. Teh L. Chen I. M. Aris S. E. Soh M. T. Tint J. L. MacIsaac F. Yap K. Kwek S. M. Saw M. S. Kobor M. J. Meaney K. M. Godfrey Y. S. Chong J. D. Holbrook Y. S. Lee P. D. Gluckman N. Karnani A. Kapoor D. Lee A. Chakravarti C. Maercker F. Graf M. Boutros G. Stamoulis F. Santoni P. Makrythanasis A. Letourneau M. Guipponi N. Panousis M. Garieri P. Ribaux E. Falconnet C. Borel S. E. Antonarakis S. Kumar J. Curran J. Blangero S. Chatterjee J. Akiyama D. Auer C. Berrios L. Pennacchio T. R. Donti G. Cappuccio M. Miller P. Atwal A. Kennedy A. Cardon C. Bacino L. Emrick J. Hertecant F. Baumer B. Porter M. Bainbridge P. Bonnen B. Graham R. Sutton Q. Sun S. Elsea Z. Hu P. Wang Y. Zhu J. Zhao M. Xiong David A. Bennett A. Hidalgo-Miranda S. Romero-Cordoba S. Rodriguez-Cuevas R. Rebollar-Vega E. Tagliabue M. Iorio E. D’Ippolito S. Baroni B. Kaczkowski Y. Tanaka H. Kawaji A. Sandelin R. Andersson M. Itoh T. Lassmann Y. Hayashizaki P. Carninci A. R. R. Forrest C. A. Semple E. A. Rosenthal B. Shirts L. Amendola C. Gallego M. Horike-Pyne A. Burt P. Robertson P. Beyers C. Nefcy D. Veenstra F. Hisama R. Bennett M. Dorschner D. Nickerson J. Smith K. Patterson D. Crosslin R. Nassir N. Zubair T. Harrison U. Peters G. Jarvik F. Menghi K. Inaki X. Woo P. Kumar K. Grzeda A. Malhotra H. Kim D. Ucar P. Shreckengast K. Karuturi J. Keck J. Chuang E. T. Liu B. Ji A. Tyler G. Ananda G. Carter H. Nikbakht M. Montagne M. Zeinieh A. Harutyunyan M. Mcconechy N. Jabado P. Lavigne J. Majewski J. B. Goldstein M. Overman G. Varadhachary R. Shroff R. Wolff M. Javle A. Futreal D. Fogelman L. Bravo W. Fajardo H. Gomez C. Castaneda C. Rolfo J. A. Pinto K. C. Akdemir L. Chin S. Patterson C. Statz S. Mockus S. N. Nikolaev X. I. Bonilla L. Parmentier B. King F. Bezrukov G. Kaya V. Zoete V. Seplyarskiy H. Sharpe T. McKee K. Popadin N. Basset-Seguin R. Ben Chaabene M. Andrianova C. Verdan K. Grosdemange O. Sumara M. E JCSRI Greenwood Genetic Center Greenwood USA School of Computing Clemson University Clemson USA Biochemical Genetics Laboratory Greenwood Genetic Center Greenwood USA Department Psychiatry Yale Sch Med and VA CT Healthcare Center West Haven USA Department Genetics Yale Sch Med and VA CT Healthcare Center West Haven USA Department Neurobiology Yale Sch Med and VA CT Healthcare Center West Haven USA Singapore Institute for Clinical Sciences Singapore Singapore National University of Singapore Singapore Singapore University of British Columbia Vancouver Canada KK Women’s and Children’s Hospital Singapore Singapore University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK University of Auckland Auckland New Zealand McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore USA Esslingen University of Applied Sciences Esslingen Germany German Cancer Research Center Heidelberg Germany Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Geneva University Hospitals-HUG Service of Genetic Medicine Geneva Switzerland GE3 Institute of Genetics and Genomics of Geneva University of Geneva Medical School Geneva Switzerland South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Edinburg USA South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Brownsville USA Institute of Genetic Medicine Johns Hopkins University Baltimore USA Genomics Division Lawrence Berkeley National Laboratory Berkeley USA Molecular and Human Genetics Baylor College of Medicine Houston USA Department of Translational Medical Sciences Federico II University Naples Italy Metabolon Inc Durham USA Section of Pediatric Neurology and Neuroscience Baylor College of Medicine Houston USA Tawam Hospital Abu Dhabi United Arab Emirates Stanford Medical School Stanford USA Sch

O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer’s

关键词： Pulmonary Arterial Hypertension Oral Squamous Cell Carcinoma Deep Neural Network Autosomal Recessive Polycystic Kidney Disease Whole Genome Bisulfite Sequencing

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Services-oriented URL filtering and verification

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International Journal of High Performance Systems Architecture 2013年第4期4卷 183-195页

作者： Wang, Aili Wang, Chao Li, Xi Zhou, Xuehai Nedjah, Nadia School of Software Engineering Suzhou Institute for Advanced Study University of Science and Technology of China Ren'ai Road No.166 Suzhou 215123 China School of Computer Science University of Science and Technology of China P.O. Box 4 Hefei 230027 China Department of Electronics Engineering and Telecommunications Center for Technology and Science State University of Rio de Janeiro Rua São Francisco Xavier 524 Rio de Janeiro RJ Brazil

Teenagers' online safety problem has become increasingly important. To tackle this problem, this paper proposes a services-oriented URL filtering and verification mechanism. A services-oriented browser architecture prototype has been implemented, named SOBA. SOBA is the first in literature that introduces SOA concepts into the web browser design paradigm. It contains a server cluster, which employs URL filter functions to verify the URL access, while whitelists and validation results are wrapped as services. Meanwhile, a customised SOBA client is in charge of data conversion and website navigation while verification workloads are deployed on the server side. Administrators can manage URL databases through back stage websites. A prototyping software browser of SOBA demonstrates that SOA concepts can greatly improve the online safety with high flexibility and *** © 2013 Inderscience Enterprises Ltd.

关键词： Websites

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Food Stamps:A Reminiscence Therapy Tablet Game for Chinese Seniors

Food Stamps:A Reminiscence Therapy Tablet Game for Chinese S...

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2013 ICME International Conference on Complex Medical engineering(2013 ICME复合医学工程国际会议)

作者： Kaige Chang Ning An Jian Qi Rongcan Li Sue Levkoff Hongtu Chen Peng Li Gerontechnology Group Lab for Advanced Computing School of Information Science and Engineering La School of Computer and Information Hefei University of Technology Hefei Gerontechnology Lab Hefe Institute of Computer Applications School of Information Science and Engineering Lanzhou Universit School of Computer and Information Hefei University of Technology Hefei Gerontechnology Lab Hefe University of South Carolina College of Social Work Columbia SC USA Global Initiative on Caregiving for the Elderly Asia Center Harvard University Cambridge USA Chengguan District Government Lanzhou China

ISBN: (纸本)9781467329705

During their aging process,many seniors are likely to develop mild cognitive impairment which could easily lead to Alzheimer's disease or *** medication treatment,various reminiscence therapy methods have been proven to be effective in terms of enhancing the cognitive capacities of seniors,as well as improving their capabilities to participate in daily *** paper describes our design and implementation a reminiscence therapy game on Android tablet for Chinese seniors to help them maintain their memory capacities as well as their calculating *** be more effective as a method of reminiscence therapy,we choose government food stamps that were mandated in China from 1960s to 1980s,as the backdrop of our *** our experiment and further studies in the future,we aim to prove that this type of reminiscence therapy games can help seniors to maintain their memory capacity and postpone the development of potential Alzheimer's disease,and eventually dementia.

关键词： Tablet game Reminiscences therapy Cognitive impairment Seniors

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Poster abstracts

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Sleep and Biological Rhythms 2016年第1期5卷 A1-A189页

作者： J. Ferrie M. Shipley F. Cappuccio E. Brunner M. Miller M. Kumari M. Marmot A. Coenen J. L. Castillo F. Araya G. Bustamante L. Montecino C. Torres S. Oporto J. Gronli E. Fiske R. Murison B. Bjorvatn E. Sorensen R. Ursin C. M. Portas S. Rajaraman A. Gribok N. Wesensten T. Balkin J. Reifman N. Dursunoglu S. Ozkurt S. Baser O. Delen S. Sarikaya P. Sadler P. Mitchell D. Françon M. Decobert B. Herve A. Richard G. Griebel P. Avenet B. Scatton G. L. Fur D. Eckert A. Jordan A. Wellman S. Smith A. Malhotra D. White D. Bruck I. Thomas A. Kritikos W. Oertel K. Stiasny-Kolster D. Garcia-Borreguero W. Poewe B. Hoegl R. Kohnen E. Schollmayer J. Keffel C. Trenkwalder A. Valle S. Roizenblatt F. Fregni P. Boggio S. Tufik K. Ward L. Robertson L. Palmer P. Eastwood D. Hillman J. Lee S. Mukherjee V. de Padova G. Barbato G. Ficca I. Zilli P. Salzarulo M. Veldi T. Hion V. Vasar M. Kull L. Nowak J. Davis Y. Latzer O. Tzischinsky S. Crowley M. Carskadon M. Anca-Herschkovitsch D. Frey J. Ortega C. Wiseman C. Farley K. Wright A. Campbell A. Neill K. Spiegel R. Leproult E. Tasali N. Scherberg E. van Cauter A. T. Noradina N. A. Karim I. Norlinah A. A. Raymond R. Sahathevan B. Hamidon E. Werth R. Poryazova R. Khatami C. Bassetti R. G. Beran L. Ainley G. Holand J. Duncan H. Kinney B. Davis B. Hood S. Frey C. Schmidt M. Hofstetter P. Peigneux C. Cajochen W.-P. Hu J.-D. Li C. Zhang L. Boehmer J. Siegel Q.-Y. Zhou Y. Sagawa H. Kondo T. Takemura H. Kanayama Y. Kaneko M. Sato T. Kanbayashi Y. Hishikawa T. Shimizu A. Viola L. James L. Schlangen D.-J. Dijk R. Andretic Y.-C. Kim K.-A. Han F. Jones R. Greenspan L. Sanford L. Yang X. Tang K. Dieter E. Uta H. Sven M. Richard N. Oyane S. Pallesen F. Holsten Y. Inoue M. Fujita N. Emura K. Kuroda N. Uchimura A. Johnston J. Astbury G. Kennedy K. Hoedlmoser M. Schabus T. Pecherstorfer S. Moser G. Gruber P. Anderer W. Klimesch N. Naidoo M. Ferber A. Pack D. Neu O. Mairesse G. Hoffmann A. Dris L. Lambrecht P. Linkowski P. Verbanck O. Le Bon N. Matsuura M. Yamao N. Adachi R. Aritomi Y. Komada H. Tanaka S. Shirak University College London London UK University College London London USA Warwick Medical School London UK Warwick Medical School Coventry USA Radboud University Nijmegen Nijmegen Netherlands Department of Neurology University of Chile Santiago Chile Neurology Service Hospital del Salvador Santiago Chile Family Health Center Juan Pablo II Santiago Chile Department of Biomedicine Section on Physiology Univeristy of Bergen Bergen Norway Department of Public Health and Primary Health Care Univeristy of Bergen Bergen Norway Department of Public Health and Primary Health Care University of Bergen Bergen Norway Norwegian Competence Center for Sleep Disorders Haukeland University Hospital Bergen Norway Department of Child and Adolescent Psychiatry Haukeland University Hospital Univeristy of Bergen Bergen Norway Department of Biomedicine University of Bergen Bergen Norway US Army Medical Research and Materiel Command Fort Detrick Frederick USA Walter Reed Army Institute of Research Silver Spring USA Department of Behavioral Biology Walter Reed Army Institute of Research Silver Spring USA Faculty Department of Pulmonology Pamukkale University Medical Denizli Turkey University of Ballarat Ballarat Australia Sanofi-Aventis Recherche et Developpement Paris France Brigham and Women’s Hospital Harvard Medical School Boston USA The University of Queensland Adelaide Australia School of Psychology University of Queensland Brisbane Australia The University of Queensland Brisbane Australia Victoria University Melbourne Australia Department of Psychology Victoria University Melbourne Australia School of Psychology Victoria University Melbourne Australia Philips-Universität Marburg Germany Philips-Universitaet-Marburg Marburg Germany Instituto de Investigaciones del Sueno Madrid Spain Universitätsklinik für Neurologie Innsbruck Austria Universitaetsklinik fuer Neurologie Innsbruck Austria IMEREM GmbH Nuernberg Germany Schwarz Pharma AG Monheim Germany

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Generation of discrete frequency and wavelength for secured computer networks system using integrated ring resonators

Generation of discrete frequency and wavelength for secured ...

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2012 International Conference on computer and Communication engineering, ICCCE 2012

作者： Amiri, I.S. Sarkhanlou, K. Nikoukar, A. Shahidinejad, A. Ali, J. Yupapin, P.P. 81310 Johor Bahru Malaysia Department of Computer Software Engineering Comprehensive University of Applied and Practical Sciences Ardebil Iran 81300 Johor Bahru Malaysia Advanced Research Center for Photonics Faculty of Science King Mongkut's Institute of Technology Ladkrabang Bangkok 10520 Thailand

ISBN: (纸本)9781467304788

In this study, a system of discrete optical pulse generation via a series of microring resonator (MRR) is presented. Chaotic signals can be generated by an optical soliton or a Gaussian pulse within a MRR system. Large bandwidth signals of optical soliton are generated by input pulse propagating within the MRRs, which can be used to form continuous wavelength or frequency with large tunable channel capacity. Therefore, distinguished discrete wavelength or frequency pulses can be generated by using localized spatial pulses via a networks communication system. Selected discrete pulses are more suitable to generate high-secured quantum codes because of the large free spectral range (FSR). Quantum codes can be generated by using a polarization control unit and a beam splitter, incorporating to the MRRs. In this work, frequency band of 10.7 MHz and 16 MHz and wavelengths of 206.9 nm, 1448 nm, 2169 nm and 2489 nm are localized and obtained which can be used for quantum codes generation applicable for secured networks communication. © 2012 IEEE.

关键词： Optical resonators

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Generation of discrete frequency and wavelength for secured computer networks system using integrated ring resonators

Generation of discrete frequency and wavelength for secured ...

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International Conference on computer and Communication engineering, ICCCE

作者： I. S. Amiri k. Sarkhanlou A. Nikoukar A. Shahidinejad J. Ali P. P. Yupapin Institute of Advanced Photonics Science Nanotechnology Research Alliance Universiti Teknologi Malaysia (UTM) Johor Bahru Malaysia Department of Computer Software Engineering Comprehensive University of Applied and Practical Sciences Ardebil Iran Faculty of Computer Science & Information Systems (FCSIS) Universiti Teknologi Malaysia (UTM) Johor Bahru Malaysia Advanced Research Center for Photonics Faculty of Science King Mongkut's Institute of Technology Ladkrabang Bangkok Thailand

关键词： Optical solitons Optical filters Optical pulses Optical ring resonators Nonlinear optics Optical polarization

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Towards modeling and validating analysis processes for software adaptation

Towards modeling and validating analysis processes for softw...

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SEKE 2011 - Proceedings of the 23rd International Conference on software engineering and Knowledge engineering

作者： Chen, Xiangping Huang, Gang Shao, Lingshuang National Engineering Research Center of Digital Life Institute of Advanced Technology Sun Yat-sen University Guangzhou 510006 China Key Laboratory of High Confidence Software Technologies Peking University Ministry of Education Beijing 100871 China Computer School of Wuhan University Wuhan 430072 China

ISBN: (纸本)1891706292

With the complexity and the dynamic analysis requirements during software adaptation for software in the open and dynamic environment, the software analysis requires integrating multiple analysis methods and controlling the execution of analysis methods in specific sequence. As a result, the analysis process is hard to be communicated to its designers, implementers and users without an explicit model. In addition, if dependent methods are not included or encounter runtime failure, the data dependency and control dependency between analysis methods may cause correctness problem. In this paper, we proposed a domain-specific language for modeling the analysis process using subset of notations from BPMN. In order to cope with the dependency problem in model and implementation level, the dependency relationships are divided into static dependency and dynamic dependency. Dependency identification and matching algorithm is provided to assure the static dependency in the analysis process model. For the dynamic dependency, we provide a service to detect the analysis failure caused by dynamic dependency. We model and validate two analysis processes supporting software adaptation with performance and reliability concerns, and apply the analysis processes in analyzing a running system ECPerf.

关键词： Reliability analysis

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2D Simulator for Eddy Current Field Filters

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Procedia engineering 2011年 25卷 427-430页

作者： F. Liakou P. Dimitropoulos G. Stamoulis Center For Research and Technology Thessaly Technology Park Volos 38500 Greece SENSAP Microsystems Electronic Systems and Software Applications SA Ydras 2 Athens 18346 Greece University of Thessaly Computer & Communications Engineering DepartmentGlavani 37 Volos 38221 Greece

Hall devices are magnetic field current sensors based on the Hall effect. A bias current is applied via contacts through the Hall plates which are placed along magnetic field. High frequency components affect the Hall plates in a non- linear manner, disturbing the uniform biasing current flow. This problem can be alleviated by the development of a flux shaping device. A CAD tool is presented here, which can simulate the behavior of shields with different shape in order to choose the one that may be optimally used.

关键词： Eddy Current Hall Plate Magnetic Field Simulator

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Examining OSGi from an ideal enterprise software component model

Examining OSGi from an ideal enterprise software component m...

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2010 IEEE International Conference on software engineering and Service Sciences, ICSESS 2010

作者： Zhou, Jingang Zhao, Dazhe Ji, Yong Liu, Jiren National Engineering Research Center for Computer Software Northeastern University 110004 Shenyang China State Key Laboratory of Advanced Software Architecture Neusoft Corporation 110179 Shenyang China School of Management Dalian University of Technology 116023 Dalian China

ISBN: (纸本)9781424460526

Component-based software development is becoming a discipline in software engineering community, but it still immature in enterprise application development. OSGi gives some insights for component-based development (CBD). By proposing an ideal component model for enterprise applications, we analyze the performance of OSGi against such a model. The result shows that OSGi is still lack of some advanced component features for CBD, although it provides a modular solution superior to plain Java. The result also contributes both to the decision making for the software developers who want to select the OSGi component technology and to the improvements to be made to OSGi. © 2010 IEEE.

关键词： Enterprise software

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Individual vs. combinatorial effect of elevated CO₂conditions and salinity stress on Arabidopsis thaliana liquid cultures: Comparing the early molecular response using time-series transcriptomic and metabolomic analyses

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BMC Systems Biology 2010年第1期4卷 1-15页

作者： Kanani, Harin Dutta, Bhaskar Klapa, Maria I. Metabolic Engineering and Systems Biology Laboratory Department of Chemical and Biomolecular Engineering University of Maryland College Park MD 20742 United States Metabolic Engineering and Systems Biology Laboratory Institute of Chemical Engineering and High Temperature Chemical Processes (ICE-HT) Foundation for Research and Technology-Hellas (FORTH) GR-265 04 Patras Greece Neogen Chemicals Limited Thane MH 400601 India Biotechnology HPC Software Applications Institute Telemedicine and Advanced Technology Research Center U.S. Army Medical Research and Materiel Command Ft. Detrick MD United States

Background: In this study, we investigated the individual and combinatorial effect of elevated CO2 conditions and salinity stress on the dynamics of both the transcriptional and metabolic physiology of Arabidopsis tha...

Background: In this study, we investigated the individual and combinatorial effect of elevated CO₂conditions and salinity stress on the dynamics of both the transcriptional and metabolic physiology of Arabidopsis thaliana liquid hydroponic cultures over the first 30 hours of continuous treatment. Both perturbations are of particular interest in plant and agro-biotechnological applications. Moreover, within the timeframe of this experiment, they are expected to affect plant growth to opposite directions. Thus, a major objective was to investigate whether this expected "divergence" was valid for the individual perturbations and to study how it is manifested under the combined stress at two molecular levels of cellular function, using high-throughput ***: We observed that a) high salinity has stronger effect than elevated CO₂at both the transcriptional and metabolic levels, b) the transcriptional responses to the salinity and combined stresses exhibit strong similarity, implying a robust transcriptional machinery acting to the salinity stress independent of the co-occurrence of elevated CO₂, c) the combinatorial effect of the two perturbations on the metabolic physiology is milder than of the salinity stress alone. Metabolomic analysis suggested that the beneficial role of elevated CO₂on salt-stressed plants within the timeframe of this study should be attributed to the provided additional resources;these allow the plants to respond to high salinity without having to forfeit other major metabolic functions, and d) 9 h-12 h and 24 h of treatment coincide with significant changes in the metabolic physiology under any of the investigated stresses. Significant differences between the acute and longer term responses were observed at both molecular ***: This study contributes large-scale dynamic omic data from two levels of cellular function for a plant system under various stresses. It provides an ad

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