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26th International Conference on Miniaturized systems for Chemistry and Life Sciences, MicroTAS 2022

作者： Childers, Katie Hupert, Mateusz L. Soper, Steven A. Bioengineering Program University of Kansas KS United States Center for BioModular Multiscale Systems for Precision Medicine KS United States Biofluidica Inc. CA United States

ISBN: (纸本)9781733419048

To integrate microfluidic devices into a single autonomous fluidic system, valves are used to connect different components, direct fluid, and control introduction of reagents. Microfluidic valves typically consist of thin elastomeric membranes bonded to a substrate layer containing fluidic networks. The elastomer commonly consists of PDMS. Here, we present elastomeric cyclic olefin copolymer (eCOC, TOPAS E-140) and its use as a membrane for microfluidic valves. We show a proof-of-concept in a system connecting two modules in series and allowing autonomous flow throughout the system for at-home testing of COVID-19 and other applications. © 2022 MicroTAS 2022 - 26th International Conference on Miniaturized systems for Chemistry and Life Sciences. All rights reserved.

关键词： COVID-19

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Microfluidic device for extraction of cell-free DNA from plasma 21

Microfluidic device for extraction of cell-free DNA from pla...

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21st International Conference on Miniaturized systems for Chemistry and Life Sciences, MicroTAS 2017

作者： Campos, Camila D.M. Witek, Malgorzata A. Soper, Steven A. University of Kansas LawrenceKS United States Center of BioModular Multiscale Systems for Precision Medicine LawrenceKS United States

ISBN: (纸本)9780692941836

We have fabricated a microfluidic device for the extraction of cell-free DNA (cfDNA) from blood plasma that is made from a plastic via replication. Efficient cfDNA extraction was accomplished from plasma when accompanied with enzymatic digestion of plasma proteins followed by solid-phase extraction of cfDNA in a high-surface area microfluidic channel. © 17CBMS-0001.

关键词： DNA

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Molecule dependenet time of flight identification of nucleotides: An approach for single-molecule DNA sequencing 21

Molecule dependenet time of flight identification of nucleot...

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21st International Conference on Miniaturized systems for Chemistry and Life Sciences, MicroTAS 2017

作者： Amarasekara, Charuni A. O'Neil, Colleen W-Ratnayake, Kumuditha M. Gross, Bethany Soper, Steven A. University of Kansas Lawrence United States Center of BioModular Multiscale Systems for Precision Medicine Lawrence United States University of North Carolina Chapel Hill Chapel Hill United States

ISBN: (纸本)9780692941836

We are developing a single molecule sequencing platform that utilizes the identification of nucleotides via molecular dependent time-of-flight (ToF), which uses nanochannels. To realize this, we are studying the differences in the migration properties of deoxynucleotide monophosphates (dNMPs) through polymer nanochannels driven electrokinetically. Migration differences for the dNMPs were observed by varying pH and buffer concentration to enhance the identification accuracy of single dNMPs to improve overall base calling accuracy. © 17CBMS-0001.

关键词： Nucleotides

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Automated microfluidic for the analysis of circulating multiple myeloma cells (CMMCs) using "fish" analysis 21

Automated microfluidic for the analysis of circulating multi...

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21st International Conference on Miniaturized systems for Chemistry and Life Sciences, MicroTAS 2017

作者： W-Ratnayake, K.M. Hupert, M.L. Witek, M.A. Kong, C. Hu, M. Kamande, J.W. Lindell, M. Vaidyanathan, S. Voorhees, P.M. Goodwin, A. August, K. Soper, S.A. University of Kansas United States Center of Biomodular Multiscale Systems for Precision Medicine United States Biofluidica Inc. BioFluidica Research Laboratory United States University of Kansas Medical Center United States University of Missouri United States University of North Carolina Chapel Hill United States

ISBN: (纸本)9780692941836

We demonstrate a novel fluorescence in-situ hybridization (FISH) imaging microchip with a home-built automated robotic microscope system capable of performing all FISH processing on-chip. Circulating multiple myeloma cells (CMMCs) were released from an isolation chip and directed to the imaging chip following impedance sensing for enumeration that generated a fully integrated microfluidic system. © 17CBMS-0001.

关键词： Microfluidics

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Design and fabrication of a multi-scale fluidic motherboard for a universal molecular processing system (UMPS)

Design and fabrication of a multi-scale fluidic motherboard ...

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ASME 2019 International Mechanical Engineering Congress and Exposition, IMECE 2019

作者： Park, D.S. Witek, M. Zhao, X. Kang, Y. Dathathreya, K. You, B.H. Soper, S.A. Murphy, M.C. Center for BioModular Multiscale Systems Department of Mechanical and Industrial Engineering Louisiana State University Baton RougeLA United States Center for BioModular Multiscale Systems Department of Chemistry University of Kansas LawrenceKS United States Department of Engineering Technology Texas State University San MarcosTX United States

ISBN: (纸本)9780791859476

A multi-scale fluidic motherboard, which can be used in a universal molecular processing system (uMPS) integrated with task-specific processing modules, was designed and fabricated in thermoplastics. The motherboard consists of a coverplate and a substrate. The coverplate included fluidic interconnects and thermal grooves on the top side, and the corresponding interconnects on the bottom side. The substrate was comprised of cell lysis microchannels, micromixers, and flow-connecting microchannels on the top side, and reservoirs for sample inputs and waste output, thermal grooves, and valve seats for flow control on the bottom side. The coverplates and substrates were fabricated with double-sided hot embossing of polycarbonate (PC) using four micromilled brass molds, two for the coverplate and another two for the substrate. Evaluation of the relative front-to-backside alignment for the double-sided hot embossing yielded an accuracy of 25 µm ± 14 µm (average ± standard deviation) for the coverplates and 30 µm ± 20 µm for the substrates. Thermal fusion bonding (TFB) of the coverplate and substrate was done using a spring plunger bonding setup with a range of temperatures and pressures. The motherboard bonded at 154oC and 12.0 psi for 2 hours in a convection oven produced complete bonding with a little deformation of the valve seats. The complete motherboard will be integrated with the task-specific processing modules in the uMPS for investigating circulating markers from whole blood for precision molecular diagnosis of disease at low cost and with high fidelity. Copyright © 2019 ASME.

关键词： Substrates

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Scalable fabrication of sub-10 nm polymernanopores for DNA analysis

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Microsystems & Nanoengineering 2019年第1期5卷 532-541页

作者： Junseo Choi Charles C.Lee Sunggook Park Department of Mechanical&Industrial Engineering and Center for BioModular Multiscale Systems for Precision Medicine Louisiana State UniversityBaton RougeLA 70803USA Department of Comparative Biomedical Sciences School of Veterinary MedicineLouisiana State UniversityBaton RougeLA 70803USA

We present the first fabrication of sub-10 nm nanopores in freestanding polymer membranes via a simple,costeffective,high-throughput but deterministic fabrication *** in the range of 10 nm were initially produced via a single-step nanoimprinting process,which was further reduced to sub-10 nm pores via a post-NIL polymer reflow *** low shrinkage rate of 2.7 nm/min obtained under the conditions used for the reflow process was the key to achieving sub-10 nm pores with a controllable pore *** fabricated SU-8 nanopore membranes were successfully employed for transient current measurements during the translocation of DNA molecules through the nanopores.

关键词： process. polymer pores

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Summer research experience for high school students and teachers: A pilot program

Summer research experience for high school students and teac...

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114th Annual ASEE Conference and Exposition, 2007

作者： Dann, Summer Nixon, Brenda Waggenspack, Warren Craft, Daivon Peters, Cheryle CBM2 Center for BioModular MultiScale Systems United States Louisiana State University United States Gordon A. Cain Center for Scientific Technological Engineering and Mathematical Literacy Mechanical Engineering Louisiana State University United States NSBE Minority Engineering Program College of Engineering

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A novel biosensor system on microfluidic platform for early diagnosis of breast cancer

A novel biosensor system on microfluidic platform for early ...

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2006 AIChE Annual Meeting

作者： Wei, Suying Soper, Steven A. McCarley, Robin L. Chemistry Department Louisiana State University Baton Rouge LA 70803 United States Center for Biomodular Multiscale Systems (CBM2) Louisiana State University Baton Rouqe LA 70803 United States

No abstract available

ISBN: (纸本)081691012X

No abstract available

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