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High-throughput 3D reconstruction of stochastic heterogeneous microstructures in energy storage materials

npj Computational Materials 2019年第1期5卷 1048-1055页

作者： Yanxiang Zhang Mufu Yan Yanhong Wan Zhenjun Jiao Yu Chen Fanglin Chen Changrong Xia Meng Ni National Key Laboratory for Precision Hot Processing of Metals MIIT Key Laboratory of Advanced Structure-Function Integrated Materials and Green Manufacturing TechnologySchool of Materials Science and EngineeringHarbin Institute of Technology150001 HarbinChina CAS Key Laboratory of Materials for Energy Conversion Department of Materials Science and EngineeringUniversity of Science and Technology of China230026 HefeiChina College of Science Harbin Institute of Technology518055 ShenzhenChina Center for Innovative Fuel Cell and Battery Technologies School of Materials Science and EngineeringGeorgia Institute of TechnologyGeorgiaGA 30332-0245USA Department of Mechanical Engineering University of South CarolinaCarolinaSC 29205USA Building Energy Research Group Department of Building and Real EstateThe Hong Kong Polytechnic UniversityHung HomKowloonHong Kong

Stochastic heterogeneous microstructures are widely applied in structural and functional materials,playing a crucial role in determining their performance.X-ray tomography and focused ion beam serial sectioning are frequently used methods to reconstruct three-dimensional(3D)microstructures,yet are demanding techniques and are ***,a highthroughput multi-stage 3D reconstruction method via distance correlation functions is developed using a single representatively large-sized 2D micrograph for stochastic microstructures,and verified by X-ray micro-tomography datasets of isotropic and anisotropic solid oxide fuel cell *** method provides an economic,easy-to-use and high-throughput approach for reconstructing stochastic heterogeneous microstructures for energy conversion and storage devices,and can readily be extended to other materials.

关键词： materials stochastic readily

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Oncoprotein LAMTOR5-mediated CHOP silence via DNA hypermethylation and miR-182/miR-769 in promotion of liver cancer growth

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中国药理学报（英文版） 2024年第12期45卷 2625-2645页

作者： Xue Wang Qian-qian Li Yan-xin Tang Ye Li Lu Zhang Fei-fei Xu Xue-li Fu Kai Ye Jia-qi Ma Shi-man Guo Fang-yuan Ma Zhi-yu Liu Xu-he Shi Xian-meng Li Hui-min Sun Yue Wu Wei-ying Zhang Li-hong Ye State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Protein SciencesDepartment of Biochemistry and Molecular BiologyCollege of Life SciencesNankai UniversityTianjin 300071China State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Protein SciencesDepartment of Biochemistry and Molecular BiologyCollege of Life SciencesNankai UniversityTianjin 300071China Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Biomedical Engineering Tianjin 300192China State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Protein SciencesDepartment of Biochemistry and Molecular BiologyCollege of Life SciencesNankai UniversityTianjin 300071China Institute of Radiation Medicine Peking Union Medical College & Chinese Academy of Medical SciencesTianjin 300192China State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Protein SciencesDepartment of Biochemistry and Molecular BiologyCollege of Life SciencesNankai UniversityTianjin 300071China Center for Cell Structure and Function Shandong Provincial Key Laboratory of Animal Resistance BiologyCollaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinan 250014China

C/EBP homologous protein(CHOP)triggers the death of multiple cancers via endoplasmic reticulum(ER)***,the function and regulatory mechanism of CHOP in liver cancer remain *** have reported that late endosomal/lysosomal adapter,mitogen-activated protein kinase and mTOR activator 5(LAMTOR5)suppresses apoptosis in various ***,we show that the transcriptional and posttranscriptional inactivation of CHOP mediated by LAMTOR5 accelerates liver cancer *** bioinformatic analysis revealed that the expression of CHOP was low in liver cancer tissues and that its increased expression predicted a good *** CHOP contributed to destruction of LAMTOR5-induced apoptotic suppression and ***,LAMTOR5-recruited DNA methyltransferase 1(DNMT1)to the CpG3 region(-559/-429)of the CHOP promoter and potentiated its hypermethylation to block its interaction with general transcription factor Ⅱi(TFⅡ-Ⅰ),resulting in its ***,LAMTOR5-enhanced miR-182/miR-769 reduced CHOP expression by targeting its 3'***,lenvatinib,a first-line targeted therapy for liver cancer,could target the LAMTOR5/CHOP axis to prevent liver cancer ***,LAMTOR5-mediated silencing of CHOP via the regulation of ER stress-related apoptosis promotes liver cancer growth,providing a theoretical basis for the use of lenvatinib for the treatment of liver cancer.

关键词： liver cancer CHOP LAMTOR5 lenvatinib DNA methylation miR-182/miR-769

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The state of the nucleus, 1984. Higher order structure in the nucleus. Edited by P. B. COOKand R. A. LASKEY. Company of Biologists, Ltd, 1984. Pp. 234. £10.00

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BioEssays 1985年第6期3卷

作者： Barbara A. Zehnbauer Cell Structure and Function Laboratory Johns Hopkins Oncology Center 600 North Wolfe Street Baltimore Maryland 21205 USA

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Targeting protein aggregation for the treatment of neurodegenerative diseases

Medicine Plus

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Medicine Plus 2024年第1期1卷 3-7页

作者： Qingchao Li Wei Pan Jun Zhou Haiyang Yu Songbo Xie Center for Cell Structure and Function Shandong Provincial Key Laboratory of Animal Resistance BiologyCollege of Life SciencesShandong Normal UniversityJinan 250014China State Key Laboratory of Medicinal Chemical Biology Haihe Laboratory of Cell EcosystemCollege of Life SciencesNankai UniversityTianjin 300071China Department of Neuroscience GenentechSouth San FranciscoCA 94080USA Department of Ophthalmology Tianjin Key Laboratory of Ocular TraumaTianjin Medical University General HospitalTianjin 300052China

Pathological protein aggregation is a prevalent characteristic of major age-related neurodegenerative diseases,including Alzheimer's disease(AD),Huntington's disease(HD),amyotrophic lateral sclerosis(ALS),frontotemporal dementia(FTD),and Parkinson's disease(PD),and serves as a crucial biomarker for the diagnosis and *** the etiological role of protein aggregation in neurodegenerative diseases is under debate,it is believed to be associated with disease progression and clinical outcomes.1 Therefore,a comprehensive understanding of how protein aggregation forms and clears holds immense potential for discovering and developing therapeutic drugs against neurodegenerative diseases.

关键词： aggregation neurod protein degenerative diseases targeting treatment

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An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H hotspot mutant-driven cancer

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Science Bulletin 2024年第13期69卷 2122-2135页

作者： Lingping Kong Fanlu Meng Ping Zhou Ruixin Ge Xiaoshan Geng Zhihao Yang Guo Li Linlin Zhang Jing Wang Jinfeng Ma Cheng Dong Jun Zhou Sijin Wu Diansheng Zhong Songbo Xie Department of Medical Oncology Tianjin Medical University General HospitalTianjin 300052China Center for Cell Structure and Function Collaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinan 250014China The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease(Ministry of Education)School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Lung Cancer InstituteTianjin Medical University General HospitalTianjin 300052China Haihe Laboratory of Cell Ecosystem State Key Laboratory of Medicinal Chemical BiologyCollege of Life SciencesNankai UniversityTianjin 300071China Wisdom Lake Academy of Pharmacy Xi’an Jiaotong-Liverpool UniversitySuzhou 215028China Department of Ophthalmology Tianjin Medical University General HospitalLaboratory of Molecular OphthalmologyTianjin Key Laboratory of Ocular TraumaTianjin Medical UniversityTianjin 300052China

Targeting oncogenic mutant p53 represents an attractive strategy for cancer treatment due to the high frequency of gain-of-function mutations and ectopic expression in various cancer *** extensive efforts,the absence of a druggable active site for small molecules has rendered these mutants therapeutically *** we develop a selective and effective proteolysis-targeting chimera(PROTAC)for p53-R175H,a common hotspot mutant with dominant-negative and oncogenic *** a novel iterative molecular docking-guided post-SELEX(systematic evolution of ligands by exponential enrichment)approach,we rationally engineer a high-performance DNA aptamer with improved affinity and specificity for *** this resulting aptamer as a binder for PROTACs,we successfully developed a selective p53-R175H degrader,named ***53m induces the ubiquitin–protea some-dependent degradation of p53-R175H while sparing wildtype ***,dp53m demonstrates significant antitumor efficacy in p53-R175H-driven cancer cells both in vitro and in vivo,without ***,dp53m significantly and synergistically improves the sensitivity of these cells to cisplatin,a commonly used chemotherapy *** findings provide evidence of the potential therapeutic value of dp53m in p53-R175H-driven cancers.

关键词： P53 Aptamer PROTAC Cancer Drug resistance

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Proteomic profiling of the extracellular matrix in the human adrenal cortex

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Matrix Biology Plus 2024年 23卷 100158页

作者： Kremer, Jean Lucas Sanchez Ortega, Henrique Souza-Siqueira, Talita Blanes Angeli, Claudia Kei Iwai, Leo Palmisano, Giuseppe Ferini Pacicco Lotfi, Claudimara Laboratory of Cellular Structure and Function Department of Anatomy Institute of Biomedical Sciences University of São Paulo Glycoproteomics Laboratory Department of Parasitology ICB University of São Paulo Department of Clinical Medicine Laboratory of Cellular Genetic and Molecular Nephrology University of São Paulo School of Medicine Laboratory of Applied Toxicology Center of Toxins Immune-response and Cell Signaling LETA/CeTICS Laboratory Butantan Institute School of Natural Science Macquarie University

The extracellular matrix (ECM) comprises macromolecules that shape a complex three-dimensional network. Filling the intercellular space and playing a crucial role in the structure and function of tissues, ECM regulates essential cellular processes such as adhesion, differentiation, and cell signaling. In the human adrenal gland, composed of cortex and medulla surrounded by a capsule, the ECM has not yet been directly described, although its impact on the processes of proliferation and steroidogenesis of the adrenal cortex is recognized. This study analyzes the ECM of the adult human adrenal cortex, which was separated into outer fraction (OF) and inner fraction (IF), by comparing their proteomic profiles. The study discusses the composition, spatial distribution, and relevance of differentially expressed ECM signatures of the adrenal cortex matrisome on adrenal structure and function. The findings were validated through database analysis (cross-validation), histochemical, and immunohistochemical approaches. A total of 121 ECM proteins were identified and categorized into glycoproteins, collagens, ECM regulators, proteoglycans, ECM-affiliated proteins, and secreted factors. Thirty-one ECM proteins were identified only in OF, nine only in IF, and 81 were identified in common with both fractions. Additionally, 106 ECM proteins were reported in the Human matrisome DB 2.0, and the proteins differentially expressed in OF and IF, were identified. This study provides significant insights into the composition and regulation of the ECM in the human adrenal cortex, shedding light on the adrenal microenvironment and its role in the functioning, maintenance, and renewal of the adrenal gland. © 2024 The Author(s)

关键词： Cortex Extracellular matrix Human adrenal gland Matrisome

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Disruption of photoreceptor cilia is a critical event in the pathogenesis of retinal degeneration—Insights from N-methyl-N-nitrosourea-induced mouse model

Medicine Plus

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Medicine Plus 2024年第3期1卷 25-29页

作者： Guizhi Guo Runa Wang Yufei Zhang Zhiyi Wang Lin Li Miaoyuan Liu Jun Zhou Jie Ran Center for Cell Structure and Function Shandong Provincial Key Laboratory of Animal Resistance Biology College of Life Sciences Shandong Normal University Department of Genetics and Cell Biology College of Life Sciences State Key Laboratory of Medicinal Chemical Biology Haihe Laboratory of Cell Ecosystem Nankai University

Retinal degeneration (RD) encompasses a diverse range of disorders and is one of the leading causes of blindness worldwide.1 Patients with RD share a common feature:extensive loss of photoreceptors, which leads to a deafferented neural retina and subsequent neurodegeneration. Currently, clinical therapeutic options for RD are limited, as is the case for many neurodegenerative diseases, although new therapeutic approaches, including gene therapy, stem cell therapy, optogenetics, and retinal prostheses are on the horizon.

关键词： insights mouse event model from cilia critical degeneration disruption induced

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Cryo-EM structure of human rhodopsin bound to an inhibitory G protein (vol 558, pg 553, 2018)

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NATURE 2018年第7724期561卷 E44-E44页

作者： Kang, Yanyong Kuybeda, Oleg de Waal, Parker W. Mukherjee, Somnath Van Eps, Ned Dutka, Przemyslaw Zhou, X. Edward Bartesaghi, Alberto Erramilli, Satchal Morizumi, Takefumi Gu, Xin Yin, Yanting Liu, Ping Jiang, Yi Meng, Xing Zhao, Gongpu Melcher, Karsten Ernst, Oliver P. Kossiakoff, Anthony A. Subramaniam, Sriram Xu, H. Eric Center for Cancer and Cell Biology Innovation and Integration Program Van Andel Research Institute Grand Rapids USA Cancer Research Technology Program Frederick National Laboratory for Cancer Research Frederick USA Department of Biochemistry and Molecular Biology University of Chicago Chicago USA Department of Biochemistry University of Toronto Toronto Canada Faculty of Biochemistry Biophysics and Biotechnology Jagiellonian University Krakow Poland University of Chinese Academy of Sciences Beijing China Key Laboratory of Receptor Research VARI-SIMM Center Center for Structure and Function of Drug Targets Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China David Van Andel Advanced Cryo-Electron Microscopy Suite Van Andel Research Institute Grand Rapids USA Department of Molecular Genetics University of Toronto Toronto Canada Institute for Biophysical Dynamics University of Chicago Chicago USA Center for Cancer Research National Cancer Institute NIH Bethesda USA

In the PDF version of this Article, owing to a typesetting error, an incorrect figure was used for Extended Data Fig. 5; the correct figure was used in the HTML version. This has been corrected online.

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Erratum: Discovery of a highly potent glucocorticoid for asthma treatment

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cell discovery 2016年第1期2卷 15051页

作者： Yuanzheng He Jingjing Shi Wei Yi Xin Ren Xiang Gao Jianshuang Li Nanyan Wu Kevin Weaver Qian Xie Sok Kean Khoo Tao Yang Xiaozhu Huang Karsten Melcher H Eric Xu Laboratory of Structural Sciences Van Andel Research Institute 333 Bostwick Avenue Northeast Grand Rapids MI USA. VARI-SIMM Center Center for Structure and Function of Drug Targets Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China. Department of Medicine Lung Biology Center University of California San Francisco San Francisco CA USA. Laboratory of Skeletal Biology Van Andel Research Institute Grand Rapids MI USA College of Life Sciences Wuhan University Wuhan Hubei China. Laboratory of Skeletal Biology Van Andel Research Institute Grand Rapids MI USA. Molecular Oncogenesis and Targeted Therapy Laboratory of Molecular Oncology Center of Cancer and Cell Biology Van Andel Research Institute Grand Rapids MI USA. Department of Cell and Molecular Biology Grand Valley State University Grand Rapids MI USA. Laboratory of Structural Sciences Van Andel Research Institute 333 Bostwick Avenue Northeast Grand Rapids MI USA VARI-SIMM Center Center for Structure and Function of Drug Targets Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China.

[This corrects the article DOI: 10.1038/celldisc.2015.35.].

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25th Annual Computational Neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts

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BMC NEUROSCIENCE 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1 functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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