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arXiv 2019年

作者： Sledge, Isaac J. Príncipe, José C. Advanced Signal Processing and Automated Target Recognition Branch US Naval Surface Warfare Center Panama CityFL32407 United States Department of Electrical and Computer Engineering University of Florida GainesvilleFL32611 United States University of Florida

Radial-basis-function networks are traditionally defined for sets of vector-based observations. In this short paper we reformulate such networks so that they can be applied to adjacency-matrix representations of weighted, directed graphs that represent the relationships between object *** restate the sum-of-squares objective function so that it is purely dependent on entries from the adjacency matrix. From this objective function, we derive a gradient descent update for the network *** also derive a gradient update that simulates the repositioning of the radial basis prototypes and changes in the radial basis prototype parameters. An important property of our radial basis function networks is that they are guaranteed to yield the same responses as conventional radial-basis networks trained on a corresponding vector realization of the relationships encoded by the adjacency-matrix. Such a vector realization only needs to provably exist for this property to hold, which occurs whenever the relationships correspond to distances from some arbitrary metric applied to a latent set of *** therefore completely avoid needing to actually construct vectorial realizations via multi-dimensional scaling, which ensures that the underlying relationships are totally preserved. Copyright © 2019, The Authors. All rights reserved.

关键词： Graphic methods

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Model-aided Deep Neural Network for Source Number Detection

arXiv

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arXiv 2019年

作者： Yang, Yuwen Gao, Feifei Qian, Cheng Liao, Guisheng Department of Automation Tsinghua University Beijing100084 China Department of Electrical and Computer Engineering University of Virginia CharlottesvilleVA22904 United States National Laboratory of Radar Signal Processing Collaborative Innovation Center of Information Sensing Understanding Xidian University Xi’an710071 China

—Source number detection is a critical problem in array signal processing. Conventional model-driven methods e.g., Akaikes information criterion (AIC) and minimum description length (MDL), suffer from severe performance degradation when the number of snapshots is small or the signal-to-noise ratio (SNR) is low. In this paper, we exploit the model-aided based deep neural network (DNN) to estimate the source number. Specifically, we first propose the eigenvalue based regression network (ERNet) and classification network (ECNet) to estimate the number of non-coherent sources, where the eigenvalues of the received signal covariance matrix and the source number are used as the input and the supervise label of the networks, respectively. Then, we extend the ERNet and ECNet for estimating the number of coherent sources, where the forward-backward spatial smoothing (FBSS) scheme is adopted to improve the performance of ERNet and ECNet. Numerical results demonstrate the outstanding performance of ERNet and ECNet over the conventional AIC and MDL methods as well as their excellent generalization capability, which also shows their great potentials for practical applications. Copyright © 2019, The Authors. All rights reserved.

关键词： Eigenvalues and eigenfunctions

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BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

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Nature methods 2023年第6期20卷 824-835页

作者： Linus Manubens-Gil Zhi Zhou Hanbo Chen Arvind Ramanathan Xiaoxiao Liu Yufeng Liu Alessandro Bria Todd Gillette Zongcai Ruan Jian Yang Miroslav Radojević Ting Zhao Li Cheng Lei Qu Siqi Liu Kristofer E Bouchard Lin Gu Weidong Cai Shuiwang Ji Badrinath Roysam Ching-Wei Wang Hongchuan Yu Amos Sironi Daniel Maxim Iascone Jie Zhou Erhan Bas Eduardo Conde-Sousa Paulo Aguiar Xiang Li Yujie Li Sumit Nanda Yuan Wang Leila Muresan Pascal Fua Bing Ye Hai-Yan He Jochen F Staiger Manuel Peter Daniel N Cox Michel Simonneau Marcel Oberlaender Gregory Jefferis Kei Ito Paloma Gonzalez-Bellido Jinhyun Kim Edwin Rubel Hollis T Cline Hongkui Zeng Aljoscha Nern Ann-Shyn Chiang Jianhua Yao Jane Roskams Rick Livesey Janine Stevens Tianming Liu Chinh Dang Yike Guo Ning Zhong Georgia Tourassi Sean Hill Michael Hawrylycz Christof Koch Erik Meijering Giorgio A Ascoli Hanchuan Peng Institute for Brain and Intelligence Southeast University Nanjing China. Microsoft Corporation Redmond WA USA. Tencent AI Lab Bellevue WA USA. Computing Environment and Life Sciences Directorate Argonne National Laboratory Lemont IL USA. Kaya Medical Seattle WA USA. University of Cassino and Southern Lazio Cassino Italy. Center for Neural Informatics Structures and Plasticity Krasnow Institute for Advanced Study George Mason University Fairfax VA USA. Faculty of Information Technology Beijing University of Technology Beijing China. Beijing International Collaboration Base on Brain Informatics and Wisdom Services Beijing China. Nuctech Netherlands Rotterdam the Netherlands. Janelia Research Campus Howard Hughes Medical Institute Ashburn VA USA. Department of Electrical and Computer Engineering University of Alberta Edmonton Alberta Canada. Ministry of Education Key Laboratory of Intelligent Computation and Signal Processing Anhui University Hefei China. Paige AI New York NY USA. Scientific Data Division and Biological Systems and Engineering Division Lawrence Berkeley National Lab Berkeley CA USA. Helen Wills Neuroscience Institute and Redwood Center for Theoretical Neuroscience UC Berkeley Berkeley CA USA. RIKEN AIP Tokyo Japan. Research Center for Advanced Science and Technology (RCAST) The University of Tokyo Tokyo Japan. School of Computer Science University of Sydney Sydney New South Wales Australia. Texas A&M University College Station TX USA. Cullen College of Engineering University of Houston Houston TX USA. Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan. National Centre for Computer Animation Bournemouth University Poole UK. PROPHESEE Paris France. Department of Neuroscience Columbia University New York NY USA. Mortimer B. Zuckerman Mind Brain Behavior Institute Columbia University New York NY USA. Department of Computer Science Northern Illinois Universit

BigNeuron is an open community bench-testing platform with the goal of setting open standards for accurate and fast automatic neuron tracing. We gathered a diverse set of image volumes across several species that is representative of the data obtained in many neuroscience laboratories interested in neuron tracing. Here, we report generated gold standard manual annotations for a subset of the available imaging datasets and quantified tracing quality for 35 automatic tracing algorithms. The goal of generating such a hand-curated diverse dataset is to advance the development of tracing algorithms and enable generalizable benchmarking. Together with image quality features, we pooled the data in an interactive web application that enables users and developers to perform principal component analysis, t-distributed stochastic neighbor embedding, correlation and clustering, visualization of imaging and tracing data, and benchmarking of automatic tracing algorithms in user-defined data subsets. The image quality metrics explain most of the variance in the data, followed by neuromorphological features related to neuron size. We observed that diverse algorithms can provide complementary information to obtain accurate results and developed a method to iteratively combine methods and generate consensus reconstructions. The consensus trees obtained provide estimates of the neuron structure ground truth that typically outperform single algorithms in noisy datasets. However, specific algorithms may outperform the consensus tree strategy in specific imaging conditions. Finally, to aid users in predicting the most accurate automatic tracing results without manual annotations for comparison, we used support vector machine regression to predict reconstruction quality given an image volume and a set of automatic tracings.

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Computational Approaches to Explainable Artificial Intelligence: Advances Intheory, Applications and Trends

SSRN

引用

SSRN 2023年

作者： Górriz, Juan Manuel Álvarez-Illán, I. Álvarez-Marquina, A. Arco, J.E. Atzmueller, M. Ballarini, F. Barakova, E. Bologna, G. Bonomini, P. Castellanos-Dominguez, G. Castillo-Barnes, D. Cho, S.B. Contreras, R. Cuadra, J.M. Domínguez, E. Domínguez-Mateos, F. Duro, R.J. Elizondo, D. Fernández-Caballero, A. Fernandez-Jover, E. Formoso, M.A. Gallego-Molina, N.J. Gamazo, J. García González, J. Garcia-Rodriguez, J. Garre, C. Garrigós, J. Gómez-Rodellar, A. Gómez-Vilda, P. Graña, M. Guerrero-Rodriguez, B. Hendrikse, S.C.F. Jimenez-Mesa, C. Jodra-Chuan, M. Julian, V. Kotz, G. Kutt, K. Leming, M. de Lope, J. Macas, B. Marrero-Aguiar, V. Martinez, J.J. Martinez-Murcia, F.J. Martínez-Tomás, R. Mekyska, J. Nalepa, G.J. Novais, P. Orellana, D. Ortiz, A. Palacios-Alonso, D. Palma, J. Pereira, A. Pinacho-Davidson, P. Pinninghoff, M.A. Ponticorvo, M. Psarrou, A. Ramírez, J. Rincón, M. Rodellar-Biarge, V. Rodríguez-Rodríguez, I. Roelofsma, P.H.M.P. Santos, J. Salas-Gonzalez, D. Salcedo-Lagos, P. Segovia, F. Shoeibi, A. Silva, M. Simic, D. Suckling, J. Treur, J. Tsanas, A. Varela, R. Wang, S.H. Wang, W. Zhang, Y.D. Zhu, H. Zhu, Z. Ferrández-Vicente, J.M. SiPBA at Data Science and Computational Intelligence Institute University of Granada Granada Spain University of Granada Granada Spain Dept. of Psychiatry University of Cambridge Cambridge United Kingdom Dept. of Communications Engineering University of Malaga Malaga Spain School of Computing and Mathematical Sciences University of Leicester Leicester United Kingdom Semantic Information Systems Group Osnabrück University Osnabrück Germany Osnabrück Germany Dept. of Electronics Computer Technology and Projects Universidad Politécnica de Cartagena Cartagena Spain Universitat Politècnica de València València Spain Institute of Applied Computer Science Jagiellonian University Kraków Poland Dept. of Information and Communication Engineering University of Murcia Murcia Spain Dept. of Computer Science and Information Technologies University of A Coruña A Coruña Spain Dept. of Computer Science University of Oviedo Oviedo Spain Buenos Aires Argentina Buenos Aires Argentina Eindhoven University of Technology Eindhoven5612 AZ Netherlands Dept. of Computer Science University of Malaga Malaga Spain De Montfort University Leicester United Kingdom Dept. of Computer Science Faculty of Engineering Universidad de Concepción Concepción Chile Neurocognition and Emotion Research Unit Albacete Research Institute of Informatics University of Castilla-La Mancha Albacete Spain Dept. of Educational Informatics Universidad de Concepción Concepción Chile Madrid Spain Dept. of Humanistic Studies University of Naples Federico II Napoli Italy Escuela Técnica Superior de Ingeniería Informática Universidad Rey Juan Carlos Campus de Móstoles Móstoles Madrid28933 Spain Neuromorphic Speech Processing Lab Center for Biomedical Technology Universidad Politécnica de Madrid Campus de Montegancedo Pozuelo de Alarcón Madrid28223 Spain Biomedical Research Networking Center in Mental Health Instituto de Salud Carlos III Madrid28016 Spain Usher Institute Faculty o

Groundbreaking advances in theoretical and applied Artificial Intelligence (AI). DL algorithms are groundedin non-linear and complex artificial neural systems that progressively extract higher-level features from *** is frequently compared with human-level performance in real-world tasks, such as clinical diagnostics. Itis also a turning point in solving otherwise intractable problems in the design of virtual agents or robotics;orin providing novel insight into disease progress in genomics and Neuroimaging (NI), understanding humanbrain function, the automation of industrial processes based on computer vision, and so on. In this paper, themost relevant advances from the last few years in AI and several applications to neuroscience, neuroimaging,computer vision, and robotics are presented, reviewed and discussed. In this way, we summarize the state-ofthe-art in AI methods, models and applications within a collection of works presented at the 9th InternationalConference on the Interplay between Natural and Artificial Computation (IWINAC). The works presentedin this paper are excellent examples of new scientific discoveries made in laboratories that are successfullytransferred to real-life applications. © 2023, The Authors. All rights reserved.

关键词： Neuroimaging

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Detection of Fusarium wilt on Phalaenopsis stem base region using band selection techniques 38

Detection of Fusarium wilt on Phalaenopsis stem base region ...

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38th Annual IEEE International Geoscience and Remote Sensing Symposium, IGARSS 2018

作者： Lee, Meng-Chueh Ma, Kenneth-Yeonkong Ouyang, Yen-Chieh Ou-Yang, Mang Guo, Horng-Yuh Liu, Tsang-Sen Chen, Hsian-Min Wu, Chao-Cheng Chang, Chgein-I Department of Communications Engineering National Chung Hsing University Taichung Taiwan Department of Electrical Engineering National Chung Hsing University Taichung Taiwan National Chiao-Tung University Department of Electrical and Computer Engineering Hsinchu City Taiwan Taiwan Agriculture Research Institute Nan-Tou Taiwan Center for Quantitative Imaging in Medicine Taichung Veterans General Hospital Taichung Taiwan Department of Electrical Engineering National Taipei University of Technology Taipei Taiwan Remote Sensing Signal and Image Processing Laboratory Department of Computer Science and Electrical Engineering University of Maryland Baltimore County BaltimoreMD21250 United States

ISBN: (纸本)9781538671504

Phalaenopsis is a significant agriculture product with high economic value in Taiwan. However, the fusarium wilt causes Phalaenopsis leaves turning yellow, thinning, water loss, and finally died. This paper presents an emerging method to detect fusarium wilt on Phalaenopsis stem base. In order to build the detection models, the hyperspectral databases are generated form two statues of Phalaenopsis samples, which are health and disease sample. We applied band selection (BS) processing base on band prioritization (BP) and band de-correlation (BD) to extract the significant bands and eliminate the redundant bands. Then, three algorithms were used, orthogonal subspace projection (OSP), constrain energy minimization (CEM), and support vector machine (SVM) to detect the fusarium wilt. © 2018 IEEE

关键词： Diseases Hyperspectral imaging Support vector machines Agriculture Databases Entropy

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Reduced Dimension Minimum BER PSK Precoding for Constrained Transmit signals in Massive MIMO

Reduced Dimension Minimum BER PSK Precoding for Constrained ...

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2018 IEEE International Conference on Acoustics, Speech, and signal processing, ICASSP 2018

作者： Lee Swindlehurst, A. Jedda, Hela Fijalkowt, Inbar Center for Pervasive Communications and Computing University of California Irvine IrvineCA92697 United States Department of Signal Processing Dept. of Electrical Computer Engineering Technical University of Munich Munich80290 Germany ETIS ENSEA CNRS Universitc Paris-Seine Universite Cergy-Pontoise CergyF-95000 France

ISBN: (纸本)9781538646588

Recently a number of nonlinear precoding algorithms have been developed for designing a downlink transmit signal that is constrained by some nonlinearity, such as one-bit quantization, power-amplifier saturation or constant modulus. These methods use iterative search algorithms to directly design the signal that is transmitted from each antenna. Since the dimension of the search space equals the number of antennas, the computational complexity of these approaches can be high for massive MIMO scenarios. Thus, in this paper we pose the problem in a smaller dimensional space by constraining the signal prior to the nonlinearity to be the output of a linear precoder. The search is then over the vector of predistorted symbols at the input to the linear precoder, which is typically much smaller than the number of antennas. We focus on algorithms that minimize the bit error rate at the receivers, and show that performance can be obtained that is similar to algorithms that operate directly in the antenna domain. © 2018 IEEE.

关键词： Precoding Transmitting antennas MIMO communication Phase shift keying Downlink Predistortion"

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Proof-of-Principle Experimental Demonstration of Twin-Field Type Quantum Key Distribution

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Physical Review Letters 2019年第10期123卷 100506-100506页

作者： Xiaoqing Zhong Jianyong Hu Marcos Curty Li Qian Hoi-Kwong Lo Center for Quantum Information and Quantum Control Department of Physics University of Toronto Toronto Ontario M5S 1A7 Canada Center for Quantum Information and Quantum Control Department of Electrical and Computer Engineering University of Toronto Toronto Ontario M5S 3G4 Canada EI Telecomunicación Department of Signal Theory and Communications University of Vigo E-36310 Vigo Spain

The twin-field (TF) quantum key distribution (QKD) protocol and its variants are highly attractive because they can beat the well-known fundamental limit of the secret key rate for point-to-point QKD without quantum repeaters (repeaterless bound). In this Letter, we perform a proof-of-principle experimental demonstration of TFQKD based on the protocol proposed by Curty, Azuma, and Lo, which removes the need for postselection on the matching of a global phase from the original TFQKD scheme and can deliver a high secret key rate. Furthermore, we employ a Sagnac loop structure to help overcome the major difficulty in the practical implementation of TFQKD, namely, the need to stabilize the phase of the quantum state over kilometers of fiber. As a proof-of-principle demonstration, the estimated secure key rate from our experimental TFQKD data at the high loss region surpasses the repeaterless bound of QKD with current technology.

关键词： Optical quantum information processing Quantum cryptography Quantum optics

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Metrics Reloaded: Recommendations for image analysis validation

arXiv

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arXiv 2022年

作者： Maier-Hein, Lena Reinke, Annika Godau, Patrick Tizabi, Minu D. Buettner, Florian Christodoulou, Evangelia Glocker, Ben Isensee, Fabian Kleesiek, Jens Kozubek, Michal Reyes, Mauricio Riegler, Michael A. Wiesenfarth, Manuel Emre Kavur, A. Sudre, Carole H. Baumgartner, Michael Eisenmann, Matthias Heckmann-Nötzel, Doreen Rädsch, Tim Acion, Laura Antonelli, Michela Arbel, Tal Bakas, Spyridon Benis, Arriel Blaschko, Matthew B. Jorge Cardoso, M. Cheplygina, Veronika Cimini, Beth A. Collins, Gary S. Farahani, Keyvan Ferrer, Luciana Galdran, Adrian Ginneken, Bram Van Haase, Robert Hashimoto, Daniel A. Hoffman, Michael M. Huisman, Merel Jannin, Pierre Kahn, Charles E. Kainmueller, Dagmar Kainz, Bernhard Karargyris, Alexandros Karthikesalingam, Alan Kenngott, Hannes Kofler, Florian Kopp-Schneider, Annette Kreshuk, Anna Kurc, Tahsin Landman, Bennett A. Litjens, Geert Madani, Amin Maier-Hein, Klaus Martel, Anne L. Mattson, Peter Meijering, Erik Menze, Bjoern Moons, Karel G.M. Müller, Henning Nichyporuk, Brennan Nickel, Felix Petersen, Jens Rajpoot, Nasir Rieke, Nicola Saez-Rodriguez, Julio Sánchez, Clara I. Shetty, Shravya Smeden, Maarten Van Summers, Ronald M. Taha, Abdel A. Tiulpin, Aleksei Tsaftaris, Sotirios A. Calster, Ben Van Varoquaux, Gaël Jäger, Paul F. Heidelberg Division of Intelligent Medical Systems and HI Helmholtz Imaging Germany Faculty of Mathematics and Computer Science and Medical Faculty Heidelberg University Heidelberg Germany NCT Heidelberg a partnership between DKFZ University Medical Center Heidelberg Germany Faculty of Mathematics and Computer Science Heidelberg University Heidelberg Germany Heidelberg Division of Intelligent Medical Systems Germany partner site Frankfurt/Mainz a partnership between DKFZ and UCT Frankfurt-Marburg Germany Heidelberg Goethe University Frankfurt Germany Department of Medicine Goethe University Frankfurt Germany Department of Informatics Frankfurt Cancer Insititute Germany Department of Computing Imperial College London London United Kingdom Heidelberg Division of Medical Image Computing and HI Applied Computer Vision Lab Germany Institute for AI in Medicine University Medicine Essen Essen Germany Centre for Biomedical Image Analysis Faculty of Informatics Masaryk University Brno Czech Republic ARTORG Center for Biomedical Engineering Research University of Bern Bern Switzerland Department of Radiation Oncology University Hospital Bern University of Bern Bern Switzerland Simula Metropolitan Center for Digital Engineering Oslo Norway UiT The Arctic University of Norway Romsø Norway Heidelberg Division of Biostatistics Germany Heidelberg Division of Intelligent Medical Systems Division of Medical Image Computing HI Applied Computer Vision Lab Germany MRC Unit for Lifelong Health and Ageing UCL Centre for Medical Image Computing Department of Computer Science University College London London United Kingdom School of Biomedical Engineering and Imaging Science King’s College London London United Kingdom Heidelberg Division of Medical Image Computing Germany Instituto de Cálculo CONICET – Universidad de Buenos Aires Buenos Aires Argentina Centre for Medical Image Computing University College London London United Kingdom McGill University Montréal

Increasing evidence shows that flaws in machine learning (ML) algorithm validation are an underestimated global problem. Particularly in automatic biomedical image analysis, chosen performance metrics often do not reflect the domain interest, thus failing to adequately measure scientific progress and hindering translation of ML techniques into practice. To overcome this, we created Metrics Reloaded, a comprehensive framework guiding researchers in the problem-aware selection of metrics. It was developed by a large international consortium in a multi-stage Delphi process and is based on the novel concept of a problem fingerprint – a structured representation of the given problem that captures all aspects that are relevant for metric selection, from the domain interest to the properties of the target structure(s), data set and algorithm output. Based on the problem fingerprint, users are guided through the process of choosing and applying appropriate validation metrics while being made aware of potential pitfalls. Metrics Reloaded targets image analysis problems that can be interpreted as a classification task at image, object or pixel level, namely image-level classification, object detection, semantic segmentation, and instance segmentation tasks. To improve the user experience, we implemented the framework in the Metrics Reloaded online tool. Following the convergence of ML methodology across application domains, Metrics Reloaded fosters the convergence of validation methodology. Its applicability is demonstrated for various biomedical use cases. © 2022, CC BY.

关键词： Semantic Segmentation

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OCTAVA: An open-source toolbox for quantitative analysis of optical coherence tomography angiography images

arXiv

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arXiv 2021年

作者： Untracht, Gavrielle R. Matos, Rolando Dikaios, Nikolaos Bapir, Mariam Durrani, Abdullah K. Butsabong, Teemapron Campagnolo, Paola Sampson, David D. Heiss, Christian Sampson, Danuta M. Optical+Biomedical Engineering Laboratory School of Electrical Electronic and Computer Engineering The University of Western Australia 35 Stirling Highway PerthWA6009 Australia Surrey Biophotonics Advanced Technology Institute School of Physics School of Biosciences and Medicine University of Surrey Surrey GuildfordGU2 7XH United Kingdom Department of Biochemical Sciences Department of Clinical and Experimental Medicine School of Biosciences and Medicine University of Surrey Surrey GuildfordGU2 7XH United Kingdom Mathematics Research Center Academy of Athens Athens106 79 Greece Surrey and Sussex Healthcare NHS Trust East Surrey Hospital Surrey RedhillRH1 5RH United Kingdom Surrey Biophotonics Centre for Vision Speech and Signal Processing School of Biosciences and Medicine The University of Surrey GuildfordGU2 7XH United Kingdom

Optical coherence tomography angiography (OCTA) performs non-invasive visualization and characterization of microvasculature in research and clinical applications mainly in ophthalmology and dermatology. A wide variety of instruments, imaging protocols, processing methods and metrics have been used to describe the microvasculature, such that comparing different study outcomes is currently not feasible. With the goal of contributing to standardization of OCTA data analysis, we report a user-friendly, open-source toolbox, OCTAVA (OCTA Vascular Analyzer), to automate the pre-processing, segmentation, and quantitative analysis of en face OCTA maximum intensity projection images in a standardized workflow. We present each analysis step, including optimization of filtering and choice of segmentation algorithm, and definition of metrics. We perform quantitative analysis of OCTA images from different commercial and non-commercial instruments and samples and show OCTAVA can accurately and reproducibly determine metrics for characterization of microvasculature. Wide adoption could enable studies and aggregation of data on a scale sufficient to develop reliable microvascular biomarkers for early detection, and to guide treatment, of microvascular disease. © 2021, CC BY-NC-SA.

关键词： Optical tomography

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AI-based volumetric six-tissue body composition quantification from CT cardiac attenuation scans for mortality prediction: a multicentre study

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The Lancet. Digital health 2025年第5期7卷 100862页

作者： Jirong Yi Anna M Marcinkiewicz Aakash Shanbhag Robert J H Miller Jolien Geers Wenhao Zhang Aditya Killekar Nipun Manral Mark Lemley Mikolaj Buchwald Jacek Kwiecinski Jianhang Zhou Paul B Kavanagh Joanna X Liang Valerie Builoff Terrence D Ruddy Andrew J Einstein Attila Feher Edward J Miller Albert J Sinusas Daniel S Berman Damini Dey Piotr J Slomka Departments of Medicine (Division of Artificial Intelligence in Medicine) Biomedical Sciences and Imaging Cedars-Sinai Medical Center Los Angeles CA USA. Departments of Medicine (Division of Artificial Intelligence in Medicine) Biomedical Sciences and Imaging Cedars-Sinai Medical Center Los Angeles CA USA Center of Radiological Diagnostics National Medical Institute of the Ministry of the Interior and Administration Warsaw Poland. Signal and Image Processing Institute Ming Hsieh Department of Electrical and Computer Engineering University of Southern California Los Angeles CA USA. Department of Cardiac Sciences University of Calgary Calgary AB Canada. Department of Cardiology Centrum voor Hart-en Vaatziekten (CHVZ) Universitair Ziekenhuis Brussel (UZ Brussel) Vrije Universiteit Brussel (VUB) Brussels Belgium. Department of Interventional Cardiology and Angiology Institute of Cardiology Warsaw Poland. Division of Cardiology University of Ottawa Heart Institute Ottawa ON Canada. Division of Cardiology Department of Medicine and Department of Radiology Columbia University Irving Medical Center and New York-Presbyterian Hospital New York NY USA. Section of Cardiovascular Medicine Department of Internal Medicine Yale University School of Medicine New Haven CT USA. Departments of Medicine (Division of Artificial Intelligence in Medicine) Biomedical Sciences and Imaging Cedars-Sinai Medical Center Los Angeles CA USA. Electronic address: piotr.slomka@***.

BACKGROUND:CT attenuation correction (CTAC) scans are routinely obtained during cardiac perfusion imaging, but currently only used for attenuation correction and visual calcium estimation. We aimed to develop a novel artificial intelligence (AI)-based approach to obtain volumetric measurements of chest body composition from CTAC scans and to evaluate these measures for all-cause mortality risk stratification. METHODS:We applied AI-based segmentation and image-processing techniques on CTAC scans from a large international image-based registry at four sites (Yale University, University of Calgary, Columbia University, and University of Ottawa), to define the chest rib cage and multiple tissues. Volumetric measures of bone, skeletal muscle, subcutaneous adipose tissue, intramuscular adipose tissue (IMAT), visceral adipose tissue (VAT), and epicardial adipose tissue (EAT) were quantified between automatically identified T5 and T11 vertebrae. The independent prognostic value of volumetric attenuation and indexed volumes were evaluated for predicting all-cause mortality, adjusting for established risk factors and 18 other body composition measures via Cox regression models and Kaplan-Meier curves. FINDINGS:The end-to-end processing time was less than 2 min per scan with no user interaction. Between 2009 and 2021, we included 11 305 participants from four sites participating in the REFINE SPECT registry, who underwent single-photon emission computed tomography cardiac scans. After excluding patients who had incomplete T5-T11 scan coverage, missing clinical data, or who had been used for EAT model training, the final study group comprised 9918 patients. 5451 (55%) of 9918 participants were male and 4467 (45%) of 9918 participants were female. Median follow-up time was 2·48 years (IQR 1·46-3·65), during which 610 (6%) patients died. High VAT, EAT, and IMAT attenuation were associated with an increased all-cause mortality risk (adjusted hazard ratio 2·39, 95% CI 1·92-2·96; p<

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