检索结果-内蒙古大学图书馆

GardnerNet: An Interpretable Deep Learning Model for Quantitative Human Blastocyst Evaluation - A Retrospective Model Development and Validation Study

学校读者我要写书评

暂无评论

SSRN

SSRN 2024年

作者： Liu, Hang Chen, Longbin Shan, Guanqiao Sun, Chen Liao, Hongqing Lu, Changfu Zhang, Shuoping Dong, Shaonan Xu, Xinxin Yan, Qiuyun Gong, Fei Zhang, Zhuoran Dai, Changsheng Chen, Wenyuan Song, Haocong Chen, Lei Sun, Haixiang Wang, Shanshan Lin, Ge Sun, Yu Gu, Yifan Department of Mechanical and Industrial Engineering University of Toronto 5 King’s College Road TorontoONM5S 3G8 Canada Institute of Reproductive and Stem Cell Engineering School of Basic Medical Science Central South University 172 Tongzipo Road Hunan Province Changsha China Hengyang Nanhua-Xinghui Reproductive Health Hospital 30 Jiefang Road Hunan Province Hengyang China The second Affiliated Hospital Hengyang Medical School University of South China 30 Jiefang Road Hunan Province Hengyang City China Reproductive & Genetic Hospital of CITIC-Xiangya 567 Tongzipo Road Hunan Province Changsha China NHC Key Laboratory of Human Stem Cell and Reproductive Engineering School of Basic Medical Science Central South University 172 Tongzipo Road Hunan Province Changsha China Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive & Genetic Hospital of CITIC-Xiangya 567 Tongzipo Road Hunan Province Changsha China School of Science and Engineering The Chinese University of Hong Kong-Shenzhen 2001 Longxiang Boulevard Longgang District Shenzhen China Institute of Robotics and Intelligent Systems Dalian University of Technolgy 2 Linggong Road Liaoning Province Dalian China Department of Computer Science University of Toronto 40 St George Street TorontoONM5S 2E4 Canada Center for Reproductive Medicine and Obstetrics and Gynecology Nanjing Drum Tower Hospital Nanjing University Medical School 321 Zhongshan Road Jiangsu Province Nanjing China National Engineering and Research Center of Human Stem Cell 8 Luyun Road Jiangsu Province Changsha China Department of Electrical and Computer Engineering 10 King’s College Road TorontoONM5S 3G8 Canada Institute of Biomedical Engineering University of Toronto 164 College Street TorontoONM5S 3G9 Canada

Background: Selecting the blastocyst with the highest potential for live birth from a cohort is crucial for the success of in vitro fertilization (IVF). While the Gardner and Schoolcraft morphological grading system, commonly known as the Gardner grading system, is widely used by embryologists worldwide, blastocysts having similar or the same inner cell mass (ICM) and trophectoderm (TE) grades cause challenges for embryologists in decision-making. Furthermore, human assessment is subjective and inconsistent in predicting which blastocysts have higher potential to result in live birth. This study aims to develop an interpretable, quantitative method aligned with the Gardner grading system, providing continuous scores that correlate with live birth outcomes, thereby assisting embryologists in improving blastocyst selection. Methods: In this retrospective study, we developed GardnerNet, an interpretable deep learning model that outputs expansion degree grade and continuous scores quantifying a blastocyst's ICM morphology and TE morphology, based on the Gardner grading system. The continuous ICM and TE scores were calculated by weighting each base grade's predicted probability and summing the predicted probabilities. To represent each blastocyst's overall potential for live birth, we combined the ICM and TE scores using their odds ratios (ORs) for live birth. We further assessed the correlation between the ICM score, TE score, and the OR-combined score (adjusted for expansion degree) with live birth rates by applying GardnerNet to blastocysts with known live birth outcomes. To test its generalizability, we also applied GardnerNet to an external IVF institution, accounting for variations in imaging conditions, live birth rates, and embryologists' experience levels. Findings: GardnerNet was developed using data from 2760 blastocysts with majority-voted grades for expansion degree, ICM, and TE. The model achieved mean area under the receiver operating characteristic curve

关键词： Risk assessment

Passive Quadrupedal Gait Synchronization for Extra Robotic Legs Using a Dynamically Coupled Double Rimless Wheel Model

学校读者我要写书评

暂无评论

arXiv 2020年

作者： Gonzalez, Daniel J. Harry Asada, H. Robotics Research Center Department of Electrical Engineering and Computer Science United States Military Academy West PointNY10996 United States d’Arbeloff Laboratory for Information Systems and Technology Department of Mechanical Engineering Massachusetts Institute of Technology CambridgeMA02139 United States

The Extra Robotic Legs (XRL) system is a robotic augmentation worn by a human operator consisting of two articulated robot legs that walk with the operator and help bear a heavy backpack payload. It is desirable for the Human-XRL quadruped system to walk with the rear legs lead the front by 25% of the gait period, minimizing the energy lost from foot impacts while maximizing balance stability. Unlike quadrupedal robots, the XRL cannot command the human’s limbs to coordinate quadrupedal locomotion. Using a pair of Rimless Wheel models, it is shown that the systems coupled with a spring and damper converge to the desired 25% phase difference. A Poincaré return map was generated using numerical simulation to examine the convergence properties to different coupler design parameters, and initial conditions. The Dynamically Coupled Double Rimless Wheel system was physically realized with a spring and dashpot chosen from the theoretical results, and initial experiments indicate that the desired synchronization properties may be achieved within several steps using this set of passive components alone. Copyright © 2020, The Authors. All rights reserved.

关键词： Exoskeleton (robotics)

3D Hierarchical Refinement and Augmentation for Unsupervised Learning of Depth and Pose from Monocular Video

学校读者我要写书评

暂无评论

arXiv 2021年

作者： Wang, Guangming Zhong, Jiquan Zhao, Shijie Wu, Wenhua Liu, Zhe Wang, Hesheng Department of Automation Institute of Medical Robotics Key Laboratory of System Control and Information Processing Ministry of Education Key Laboratory of Marine Intelligent Equipment and System of Ministry of Education Shanghai Engineering Research Center of Intelligent Control and Management Shanghai Jiao Tong University Shanghai200240 China Department of Engineering Mechanics Shanghai Jiao Tong University Shanghai200240 China Department of Computer Science and Technology University of Cambridge CambridgeCB2 1TN United Kingdom

Depth and ego-motion estimations are essential for the localization and navigation of autonomous robots and autonomous driving. Recent studies make it possible to learn the per-pixel depth and ego-motion from the unlabeled monocular video. A novel unsupervised training framework is proposed with 3D hierarchical refinement and augmentation using explicit 3D geometry. In this framework, the depth and pose estimations are hierarchically and mutually coupled to refine the estimated pose layer by layer. The intermediate view image is proposed and synthesized by warping the pixels in an image with the estimated depth and coarse pose. Then, the residual pose transformation can be estimated from the new view image and the image of the adjacent frame to refine the coarse pose. The iterative refinement is implemented in a differentiable manner in this paper, making the whole framework optimized uniformly. Meanwhile, a new image augmentation method is proposed for the pose estimation by synthesizing a new view image, which creatively augments the pose in 3D space but gets a new augmented 2D image. The experiments on KITTI demonstrate that our depth estimation achieves state-of-the-art performance and even surpasses recent approaches that utilize other auxiliary tasks. Our visual odometry outperforms all recent unsupervised monocular learning-based methods and achieves competitive performance to the geometry-based method, ORB-SLAM2 with back-end optimization. Copyright © 2021, The Authors. All rights reserved.

关键词： Robots

Assessing bone quality of spine on children with scoliosis using ultrasound reflection fai method - A preliminary study

学校读者我要写书评

暂无评论

arXiv 2021年

作者： Song, Sheng Chen, Hongbo Li, Conger Lou, Edmond Le, Lawrence H. Zheng, Rui School of Information Science and Technology ShanghaiTech University Shanghai201210 China Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai200050 China University of Chinese Academy of Sciences Beijing100049 China School of Physical Science and Technology ShanghaiTech University Shanghai201210 China Department of Electrical and Computer Engineering University of Alberta Edmonton Canada Department of Radiology and Diagnostic Imaging University of Alberta Edmonton Canada Shanghai Engineering Research Center of Intelligent Vision and Imaging ShanghaiTech University Shanghai201210 China

Osteopenia is indicated as a common phenomenon in patients who have scoliosis. Quantitative ultrasound (QUS) has been used to assess skeletal status for decades, and recently ultrasound imaging using reflection signals from vertebra were as well applied to measure spinal curvatures on children with scoliosis. The objectives of this study are to develop a new method which can robustly extract a parameter from ultrasound spinal data for estimating bone quality of scoliotic patients and to investigate the potential for the parameter on predicting curve progression. The frequency amplitude index (FAI) was calculated based on the spectrum of the original radio frequency (RF) signals reflected from the tissue-vertebra interface. The correlation between FAI and reflection coefficient was validated using decalcified bovine bone samples in vitro, and the FAIs of scoliotic subjects were investigated in vivo referring to BMI, Cobb angles and curve progression status. The results showed that the intra-rater measures were highly reliable between different trials (ICC=0.997). The FAI value was strongly correlated to the reflection coefficient of bone tissue (R2=0.824), and the lower FAI indicated the higher risk of curve progression for the non-mild cases. This preliminary study reported that the FAI method can provide a feasible and promising approach to assess bone quality and monitor curve progression of the patients who have AIS. Copyright © 2021, The Authors. All rights reserved.

关键词： Reflection

Understanding metric-related pitfalls in image analysis validation

学校读者我要写书评

暂无评论

arXiv 2023年

作者： Reinke, Annika Tizabi, Minu D. Baumgartner, Michael Eisenmann, Matthias Heckmann-Nötzel, Doreen Kavur, A. Emre Rädsch, Tim Sudre, Carole H. Acion, Laura Antonelli, Michela Arbel, Tal Bakas, Spyridon Benis, Arriel Blaschko, Matthew B. Buettner, Florian Cardoso, M. Jorge Cheplygina, Veronika Chen, Jianxu Christodoulou, Evangelia Cimini, Beth A. Collins, Gary S. Farahani, Keyvan Ferrer, Luciana Galdran, Adrian van Ginneken, Bram Glocker, Ben Godau, Patrick Haase, Robert Hashimoto, Daniel A. Hoffman, Michael M. Huisman, Merel Isensee, Fabian Jannin, Pierre Kahn, Charles E. Kainmueller, Dagmar Kainz, Bernhard Karargyris, Alexandros Karthikesalingam, Alan Kenngott, Hannes Kleesiek, Jens Kofler, Florian Kooi, Thijs Kopp-Schneider, Annette Kozubek, Michal Kreshuk, Anna Kurc, Tahsin Landman, Bennett A. Litjens, Geert Madani, Amin Maier-Hein, Klaus Martel, Anne L. Mattson, Peter Meijering, Erik Menze, Bjoern Moons, Karel G.M. Müller, Henning Nichyporuk, Brennan Nickel, Felix Petersen, Jens Rafelski, Susanne M. Rajpoot, Nasir Reyes, Mauricio Riegler, Michael A. Rieke, Nicola Saez-Rodriguez, Julio Sánchez, Clara I. Shetty, Shravya Summers, Ronald M. Taha, Abdel A. Tiulpin, Aleksei Tsaftaris, Sotirios A. van Calster, Ben Varoquaux, Gaël Yaniv, Ziv R. Jäger, Paul F. Maier-Hein, Lena Faculty of Mathematics and Computer Science Heidelberg University Heidelberg Germany Heidelberg Division of Intelligent Medical Systems Germany NCT Heidelberg A Partnership Between DKFZ University Medical Center Heidelberg Germany Heidelberg Division of Medical Image Computing Germany Heidelberg Division of Intelligent Medical Systems Germany MRC Unit for Lifelong Health and Ageing UCL Centre for Medical Image Computing Department of Computer Science University College London London United Kingdom School of Biomedical Engineering and Imaging Science King’s College London London United Kingdom Instituto de Cálculo CONICET – Universidad de Buenos Aires Buenos Aires Argentina Centre for Medical Image Computing University College London London United Kingdom McGill University Montreal Canada Division of Computational Pathology Dept of Pathology & Laboratory Medicine Indiana University School of Medicine IU Health Information and Translational Sciences Building Indianapolis United States University of Pennsylvania Richards Medical Research Laboratories FL7 PhiladelphiaPA United States Department of Digital Medical Technologies Holon Institute of Technology Holon Israel European Federation for Medical Informatics Le Mont-sur-Lausanne Switzerland Center for Processing Speech and Images Department of Electrical Engineering KU Leuven Leuven Belgium partner site Frankfurt/Mainz a partnership between DKFZ and UCT Frankfurt Marburg Germany Heidelberg Germany Goethe University Frankfurt Department of Medicine Germany Goethe University Frankfurt Department of Informatics Germany and Frankfurt Cancer Insititute Germany Department of Computer Science IT University of Copenhagen Copenhagen Denmark Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. Dortmund Germany Imaging Platform Broad Institute of MIT and Harvard CambridgeMA United States Centre for Statistics in Medicine University of Oxford Oxford United Kingdom Center for Biomedical In

Validation metrics are key for tracking scientific progress and bridging the current chasm between artificial intelligence (AI) research and its translation into practice. However, increasing evidence shows that particularly in image analysis, metrics are often chosen inadequately. While taking into account the individual strengths, weaknesses, and limitations of validation metrics is a critical prerequisite to making educated choices, the relevant knowledge is currently scattered and poorly accessible to individual researchers. Based on a multi-stage Delphi process conducted by a multidisciplinary expert consortium as well as extensive community feedback, the present work provides the first reliable and comprehensive common point of access to information on pitfalls related to validation metrics in image analysis. While focused on biomedical image analysis, the addressed pitfalls generalize across application domains and are categorized according to a newly created, domain-agnostic taxonomy. The work serves to enhance global comprehension of a key topic in image analysis validation. © 2023, CC BY.

关键词： computer vision

Multiplicative modulations in hue-selective cells enhance unique hue representation

学校读者我要写书评

暂无评论

arXiv 2019年

作者： Mehrani, Paria Mouraviev, Andrei Tsotsos, John K. Department of Electrical Engineering and Computer Science York University Toronto Canada Center for Vision Research York University Toronto Canada

There is still much to understand about the color processing mechanisms in the brain and the transformation from cone-opponent representations to perceptual hues. Moreover, it is unclear which areas(s) in the brain represent unique hues. We propose a hierarchical model inspired by the neuronal mechanisms in the brain for local hue representation, which reveals the contributions of each visual cortical area in hue representation. Local hue encoding is achieved through incrementally increasing processing nonlinearities beginning with cone input. Besides employing nonlinear rectifications, we propose multiplicative modulations as a form of nonlinearity. Our simulation results indicate that multiplicative modulations have significant contributions in encoding of hues along intermediate directions in the MacLeod-Boynton diagram and that model V4 neurons have the capacity to encode unique hues. Additionally, responses of our model neurons resemble those of biological color cells, suggesting that our model provides a novel formulation of the brain's color processing pathway. Copyright © 2019, The Authors. All rights reserved.

关键词： Brain

Quantitative susceptibility atlas construction in montreal neurological institute space: Towards histological-consistent Iron-rich deep brain nucleus sub-region identification

学校读者我要写书评

暂无评论

Research Square

research Square 2021年

作者： He, Chenyu Guan, Xiaojun Zhang, Weimin Li, Jun Liu, Chunlei Wei, Hongjiang Xu, Xiaojun Zhang, Yuyao School of Information Science and Technology ShanghaiTech University 393 Huaxia Road Shanghai201210 China Department of Radiology Second Affiliated Hospital Zhejiang University School of Medicine 88 Jiefang Road Hangzhou Zhejiang 310009 China Electrical Engineering and Computer Science University of California at Berkeley BerkeleyCA94720 United States School of Biomedical Engineering Shanghai Jiao Tong University 800 Dongchuan Road Shanghai200030 China Institute of Medical Robotics Shanghai Jiao Tong University 800 Dongchuan Road Shanghai200030 China Shanghai Engineering Research Center of Intelligent Vision and Imaging ShanghaiTech University 393 Huaxia Road Shanghai201210 China

Iron-rich deep brain nuclei (DBN) of the human brain are involved in various motoric, emotional and cognitive brain functions. The abnormal iron alterations in the DBN are closely associated with multiple neurological and psychiatric diseases. Quantitative susceptibility mapping (QSM) provides the spatial distribution of tissue magnetic susceptibility in the human brain. Compared to traditional structural imaging, QSM has superiority for imaging the iron-rich DBN owing to the susceptibility difference existing between brain tissues. In this study, we construct a Montreal Neurological Institute (MNI) space unbiased QSM human brain atlas via group-wise registration from 100 healthy subjects aged 19-29 years. The atlas construction process is guided by hybrid images that fused from multi-modal Magnetic Resonance Images (MRI), thus named as Multi-modal-fused magnetic Susceptibility (MuSus-100) atlas. The high-quality susceptibility atlas provides extraordinary image contrast between iron-rich DBN with their surroundings. Parcellation maps of DBN and their sub-regions that are highly related to neurological and psychiatric pathology are then manually labeled based on the atlas set with the assistance of an image border-enhancement process. Especially, the bilateral thalamus is delineated into 64 detailed sub-regions referring to the Schaltenbrand and Wahren stereotactic atlas. To our best knowledge, the histological-consistent thalamic nucleus parcellation map is well defined for the first time in MNI space. Comparing with existing atlases emphasized on DBN parcellation, the newly proposed atlas outperforms on atlas-guided individual brain image DBN segmentation accuracy and robustness. Moreover, we apply the proposed DBN parcellation map to conduct detailed identification of the pathology-related iron content alterations in subcortical nuclei for Parkinson Disease (PD) patients. We envision that the MuSus-100 atlas could play a crucial role in improving the accuracy of

关键词： Brain

Deep learning - A first meta-survey of selected reviews across scientific disciplines, their commonalities, challenges and research impact

学校读者我要写书评

暂无评论

arXiv 2020年

作者： Egger, Jan Pepe, Antonio Gsaxner, Christina Jin, Yuan Li, Jianning Kern, Roman Institute of Computer Graphics and Vision Faculty of Computer Science and Biomedical Engineering Graz University of Technology Graz Austria Computer Algorithms for Medicine Laboratory Graz Austria Department of Oral and Maxillofacial Surgery Medical University of Graz Graz Austria University Medicine Essen Essen Germany Research Center for Connected Healthcare Big Data Zhejiang Lab Zhejiang Hangzhou China Research Unit Experimental Neurotraumatology Department of Neurosurgery Medical University of Graz Graz Austria Knowledge Discovery Know-Center Graz Austria Institute of Interactive Systems and Data Science Graz University of Technology Graz Austria

Deep learning belongs to the field of artificial intelligence, where machines perform tasks that typically require some kind of human intelligence. Deep learning tries to achieve this by drawing inspiration from the learning of a human brain. Similar to the basic structure of a brain, which consists of (billions of) neurons and connections between them, a deep learning algorithm consists of an artificial neural network, which resembles the biological brain structure. Mimicking the learning process of humans with their senses, deep learning networks are fed with (sensory) data, like texts, images, videos or sounds. These networks outperform the state-of-the-art methods in different tasks and, because of this, the whole field saw an exponential growth during the last years. This growth resulted in way over 10,000 publications per year in the last years. For example, the search engine PubMed alone, which covers only a sub-set of all publications in the medical field, provides already over 11,000 results in Q3 2020 for the search term 'deep learning', and around 90% of these results are from the last three years. Consequently, a complete overview over the field of deep learning is already impossible to obtain and, in the near future, it will potentially become difficult to obtain an overview over a subfield. However, there are several review articles about deep learning, which are focused on specific scientific fields or applications, for example deep learning advances in computer vision or in specific tasks like object detection. With these surveys as a foundation, the aim of this contribution is to provide a first high-level, categorized meta-survey of selected reviews on deep learning across different scientific disciplines and outline the research impact that they already have during a short period of time. The categories (computer vision, language processing, medical informatics and additional works) have been chosen according to the underlying data sources (image,

关键词： Surveys

Walking-in-Place Characteristics-Based Geriatric Assessment Using Deep Convolutional Neural Networks

学校读者我要写书评

暂无评论

Walking-in-Place Characteristics-Based Geriatric Assessment ...

Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Dawoon Jung Mau Dung Nguyen Mina Park Miji Kim Chang Won Won Jinwook Kim Kyung-Ryoul Mun Center for Imaging Media Research KIST Seoul South Korea Department of Human Computer Interface & Robotics Engineering University of Science and Technology Daejeon South Korea Department of Biomedical Science and Technology College of Medicine East-West Medical Research Institute Kyung Hee University Seoul South Korea Department of Family Medicine College of Medicine Kyung Hee University Seoul South Korea

ISBN: (数字)9781728119908

ISBN: (纸本)9781728119915

The world population is aging, and this phenomenon is expected to continue for the next decades. This study aimed to propose a simple and reliable method that can be used for daily in-home monitoring of frailty and cognitive dysfunction in the elderly based on their walking-in-place characteristics. Fifty-four community-dwelling elderly people aged 65 years or older participated in this study. The participants were categorized into the robust and the non-robust groups according to the FRAIL scale. The mini-mental state examination was used to classify the cognitive impairment and the non-cognitive impairment groups. The 3-axis acceleration and the 3-axis angular velocity signals were measured using the inertial measurement units attached to the foot, shank, thigh, and posterior pelvis while each participant was walking in place for 20 seconds. The walking-in-place spectrograms were acquired by applying time-frequency analysis to the lower body movement signals measured in one stride. Four-fold cross-validation was applied to 80% of the total samples and the remaining 20% were used as test data. The deep convolutional neural network-based classifiers trained with the walking-in-place spectrograms enabled to categorize the robust and the non-robust groups with 94.63% accuracy and classify the cognitive impairment and the non-cognitive impairment groups with 97.59% accuracy. This study suggests that the walking-in-place spectrograms, which can be obtained without spacious experimental space, cumbersome equipment, and laborious processes, are effective indicators of frailty and cognitive dysfunction in the elderly.

关键词： Spectrogram Foot Acceleration Angular velocity Atmospheric measurements Particle measurements Senior citizens