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Hierarchically structured conductive hydrogels for electrically programmable drug delivery in a diabetic wound healing electronic patch

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Journal of controlled Release 2025年 383卷

作者： Lin, Zhe-Wei Chen, Yo-Lin Lei, Wan-Lou Ku, Chi-Yao Su, Pin-Yu Tai, Li-Chia Tsai, Tsung-Heng Liao, Yu-Te Chuang, Andrew E.-Y. Huang, Wei-Chen Institute of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Institute of Electrical and Control Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Department of Material Science and Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University New Taipei City235603 Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan Department of Electronics and Electrical Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei11031 Taiwan

Smart wound dressings that integrate advanced drug delivery strategies and electrical stimulation (ES) represent a revolutionary approach for improving diabetic wound healing. However, limited drug loading efficiency and delayed reactivity to electrical inputs make it difficult to practically implement ES-controlled drug release in hydrogel-coated electrodes. In order to address these limitations, we developed a hydrogel-based electronic wound dressing patch that enables highly programmable, ES-triggered drug delivery. In particular, a hierarchically architectrual conductive polymer hydrogel composed of PEDOT: CHC/silk was designed to be used as an electroresponsive matrix and a drug reservoir. This hydrogel exhibited a high encapsulation efficiency (>90 %) for the hydrophobic drug ibuprofen and demonstrated exceptional mechanical resilience and electrochemical stability. Through systematic optimization of ES parameters such as voltage, frequency, and waveform, the system achieved precise spatiotemporal modulation of drug release. Notably, the integration of the hydrogel into interdigitated electrode arrays significantly enhanced delivery performance through improved field distribution and release control. In addition, the multifunctional patch also exhibited intrinsic antibacterial activity and biocompatibility, making it well-suited for clinical application. This work cumulatively introduces a wearable, electroceutical, and long-term active wound dressing system that is integratively assembled with wound protection, electrical treatment, and stimulus-sensitive drug delivery, hence being a promising approach to enhance diabetic wound healing through intelligent bioelectric treatment. © 2025 Elsevier B.V.

关键词： controlled drug delivery

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Switching Multiplicative Watermark Design Against Covert Attacks

arXiv

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arXiv 2025年

作者： Gallo, Alexander J. Anand, Sribalaji C. Teixeira, Andre M.H. Ferrari, Riccardo M.G. Department of Electronics Information and Bioengineering Politecnico di Milano Milano Italy School of Electrical Engineering and Computer Science and Digital Futures KTH Royal Institute of Technology Sweden Department of Information Technology Uppsala University PO Box 337 UppsalaSE-75105 Sweden Delft Center for Systems and Control Mechanical Engineering TU Delft Delft Netherlands

Active techniques have been introduced to give better detectability performance for cyber-attack diagnosis in cyber-physical systems (CPS). In this paper, switching multiplicative watermarking is considered, whereby we propose an optimal design strategy to define switching filter parameters. Optimality is evaluated exploiting the so-called output-to-output gain of the closed loop system, including some supposed attack dynamics. A worst-case scenario of a matched covert attack is assumed, presuming that an attacker with full knowledge of the closed-loop system injects a stealthy attack of bounded energy. Our algorithm, given watermark filter parameters at some time instant, provides optimal next-step parameters. Analysis of the algorithm is given, demonstrating its features, and demonstrating that through initialization of certain parameters outside of the algorithm, the parameters of the multiplicative watermarking can be randomized. Simulation shows how, by adopting our method for parameter design, the attacker’s impact on performance diminishes. © 2025, CC BY-NC-ND.

关键词： Networked control systems

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A Hybrid Data-Driven Granular Model for Battery Remaining Useful Life Prediction

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IEEE Transactions on Instrumentation and Measurement 2025年 74卷

作者： Jing, TaiLong Du, Sheng Wang, Cong Wu, Chao Pedrycz, Witold Sharaf, Mohamed Li, ZhiWu Luoyang Institute of Science and Technology School of Electrical Engineering and Automation Luoyang471023 China China University of Geosciences School of Automation Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education Wuhan430074 China Xi’an710072 China University of Alberta Department of Electrical and Computer Engineering EdmontonABT6G 2R3 Canada Systems Research Institute Polish Academy of Sciences Warsaw00-901 Poland King Saud University College of Engineering Department of Industrial Engineering Riyadh11421 Saudi Arabia Institute of Systems Engineering Macau University of Science and Technology Macau China

Accurate and meaningful prediction of the remaining useful life (RUL) of lithium-ion batteries (LIBs) provides a significant guide for the maintenance and management of these LIBs. A singular numerical predictive result by numerous conventional models is insufficient to furnish decision-makers with comprehensive or nuanced insights. To address this issue, predictive RUL results in the form of information granules are essential. In this study, a hybrid data-driven granular model is established for battery RUL prediction with granular (interval-based) quantification for LIBs. This granular model is designed and formulated in a way that it produces comprehensive prediction outcomes realized as information granules, which are expressed in a more descriptive and comprehensive manner. Thus, the resulting information granules can effectively reflect and communicate the confidence associated with the predictions. The granular model is realized in two steps: 1) probabilistic prediction results are produced by a hybrid numeric predictive model and 2) a comprehensive granulation of the probabilistic results is achieved under the principle of information granularity. The granular predictive results are holistically evaluated and optimized by the two associated criteria of granularity (coverage and specificity). This transformation of information granules provides an intuitive and interpretable display for battery maintenance and safe work. The proposed granular model is verified by using an open-access LIBs dataset, and the experimental results demonstrate that the proposed granular model outperforms other comparative methods. © 2025 IEEE. All rights reserved.

关键词： Prediction models

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Extended Dissipativity Analysis and Synthesis for Discrete-Time Lur'e Delayed Systems: Matrix-Separation-Based Lyapunov Functional Method

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IET control Theory and Applications 2025年第1期19卷

作者： Xie, Ke-You Lee, Sangmoon Zhang, Chuan-Ke Jin, Li Liu, Yajuan He, Yong School of Automation China University of Geosciences Wuhan China Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Wuhan China Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education Wuhan China School of Electronic and Electrical Engineering Kyungpook National University Daegu Korea Republic of School of Control and Computer Engineering North China Electric Power University Beijing China

This paper develops a matrix-separation-based Lyapunov functional method to study the extended dissipativity analysis and synthesis issue of discrete-time Lur'e-type delayed systems. The advanced idea of matrix-separation is reflected in Lyapunov functional candidates and estimates summation terms as precisely as feasible. First, we introduce a novel summation inequality based on the matrix-separation method to provide a bound for the augmented summation that involves common state variables. An improved delay-product-type Lyapunov functional is devised by extending non-positive definite summations as separate subblocks of the state-augmented summation. Then, by using the matrix injection method to handle the cubic delay term in the functional forward difference, a delay-variation-dependent stability criterion and an extended dissipativity criterion are developed under the matrix-separation-based method. Subsequently, sufficient conditions for the control design of Lur'e-type systems are derived. Finally, the effectiveness and superiority of the proposed method are verified through its application to Chua's circuits, neural networks, and a stochastic numerical example. © 2025 The Author(s). IET control Theory & Applications published by John Wiley & Sons Ltd on behalf of The Institution of engineering and Technology.

关键词： Stability criteria

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3D printing of self-powered triboelectric intelligent system with enhanced output performance for material identification via machine learning

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Chemical engineering Journal 2025年 515卷

作者： Huang, Bingyu Xu, Kailong Zhang, Xiaofei Zhang, Yongcheng Long, Yun-Ze Ge, Shuzhi Sam Wei, Xiangxia School of Automation Shandong Key Laboratory of Industrial Control Technology Qingdao University Qingdao266071 China College of Materials Science and Engineering Qingdao University Qingdao266071 China Collaborative Innovation Center for Nanomaterials & Devices College of Physics Qingdao University Qingdao266071 China College of Physics Qingdao University Qingdao266071 China Department of Electrical & Computer Engineering National University of Singapore 117576 Singapore

Triboelectric nanogenerators (TENGs) have attracted global attention for energy conversion from various types of mechanical energy into electricity. Traditional approaches for improving triboelectric conversion efficiency generally involved complicated preparation methods and strict structural design, which cannot fulfill the stringent requirements of material adaptability and application scenarios. In this work, a flexible TENG was developed based on zirconium-doped barium titanate (BaZrxTi1−xO3, BZT) particles in polydimethylsiloxane (PDMS) matrix. Subsequently, BZT/PDMS composites with patterned structures were fabricated by direct ink writing (DIW) based three-dimensional (3D) printing to significantly enhance the electrical performance. It was demonstrated that the TENG could deliver a maximum open-circuit voltage (VOC) of 350 V and a short-circuit current (ISC) of 4.9 µA with a maximum power density of 2.4 W m−2. Moreover, an effective utilization of the TENG was designed to detect the presence of humans, saving a huge amount of electrical energy. Finally, a TENG-based tactile sensor was integrated with machine learning to construct a material identification system, which was capable of recognizing different materials with a high accuracy of 98.54 %. The TENG-based tactile sensor with machine learning demonstrated a tremendous application in material perception, promoting the development of versatile sensors in the field of machine intelligence. © 2025 Elsevier B.V.

关键词： Liquid crystals

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Hand Gesture Recognition from an Open-Set Perspective

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IEEE Transactions on Multimedia 2025年

作者： Zhou, Jun Xu, Chi Cheng, Li China University of Geosciences School of Automation Wuhan430074 China Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems China Ministry of Education Engineering Research Center of Intelligent Technology for Geo-Exploration Wuhan430074 China University of Alberta Vision and Learning Laboratory Department of Electrical and Computer Engineering EdmontonABT6G 2R3 Canada

Existing hand gesture recognition methods predominantly rely on a close-set assumption, which in essence limits the viewpoints, gesture categories, and hand shapes at test time to closely resemble those seen during training. This requirement is however rarely met in practice, as images are often captured from unconstrained viewpoints, with novel gestures and unseen hand shapes that can differ significantly from the training data. This motivates us to investigate an open-set hand gesture recognition problem, where hand gestures are still recognizable from unconstrained viewpoints, and novel gesture classes and hand shapes can be incrementally learned with just a few examples. To address this, we propose a viewpoint influence elimination network that extracts view-independent features, significantly improving performance in scenarios with unconstrained viewpoints. Moreover, a joint-weighted classification scheme is introduced to augment the cosine similarity metric for evaluating few-shot incremental learning of novel gestures and shapes. Finally, as existing hand gesture recognition datasets primarily adhere to the close-set assumption, a new hand gesture recognition dataset, OHG, is introduced in this paper, that includes a wide range of viewpoints, diverse gesture classes, and distinct hand shapes. Experimental hand gesture recognition results demonstrate the superior performance of our approach in both unconstrained viewpoint and few-shot incremental learning scenarios. The source code and the OHG dataset are to be made available at https://***/zhoujun-7/OSHGR. © 1999-2012 IEEE.

关键词： Palmprint recognition

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Sensing With Random Communication Signals

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IEEE Network 2025年

作者： Lu, Shihang Liu, Fan Xiong, Yifeng Du, Zhen Cui, Yuanhao Li, Shuangyang Yuan, Weijie Yang, Jie Jin, Shi Southeast University National Mobile Communications Research Laboratory Nanjing210096 China Beijing University of Posts and Telecommunications School of Information and Communication Engineering Beijing100876 China Nanjing University of Information Science and Technology School of Electronic and Information Engineering Nanjing210044 China Technical University of Berlin Faculty of Electrical Engineering and Computer Science Berlin10587 Germany Shenzhen518055 China Frontiers Science Center for Mobile Information Communication and Security China Southeast University MOE Key Laboratory of Measurement and Control of Complex Systems of Engineering Nanjing211189 China

Communication-centric Integrated Sensing and Communication (ISAC) has been recognized as a promising methodology to implement wireless sensing functionality over existing network architectures, due to its cost-effectiveness and backward compatibility to legacy cellular systems. However, the inherent randomness of the communication signal may incur huge fluctuations in sensing capabilities, leading to unfavorable detection and estimation performance. To address this issue, we elaborate on random ISAC signal processing methods in this article, aiming at improving the sensing performance without unduly deteriorating the communication functionality. Specifically, we commence by discussing the fundamentals of sensing with random communication signals, including the performance metrics and optimal ranging waveforms. Building on these concepts, we then present a general framework for random ISAC signal transmission, followed by an in-depth exploration of time-domain pulse shaping, frequency-domain constellation shaping, and spatial-domain precoding methods. We provide a comprehensive overview of each of these topics, including models, results, and design guidelines. Finally, we conclude this article by identifying several promising research directions for random ISAC signal transmission. © 2025 IEEE.

关键词： Mobile telecommunication systems

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Multimodal Emotion Recognition Based on Multi-Scale Facial Features and Cross-Modal Attention 26

Multimodal Emotion Recognition Based on Multi-Scale Facial F...

引用

26th International Conference on Industrial Technology, ICIT 2025

作者： Bao, Chengao Chen, Luefeng Li, Min Wu, Min Pedrycz, Witold Hirota, Kaoru School of Automation China University of Geosciences Wuhan430074 China School of Automation Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education China University of Geosciences Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Wuhan430074 China University of Alberta Department of Electrical and Computer Engineering EdmontonABT6R 2G7 Canada Tokyo Institute of Technology Yokohama226-8502 Japan Tokyo Institute of Technology Tokyo226-8502 Japan

ISBN: (纸本)9798331521950

A multi-modal emotion recognition method based on facial multi-scale features and cross-modal attention (MS-FCA) network is proposed. The MSFCA model improves the traditional single-branch ViT network into a two-branch ViT architecture by using classification tokens in each branch to interact with picture embeddings in the other branch, which facilitates effective interactions between different scales of information. Subsequently, audio features are extracted using ResNet18 network. The cross-modal attention mechanism is used to obtain the weight matrices between different modal features, making full use of inter-modal correlation and effectively fusing visual and audio features for more accurate emotion recognition. Two datasets are used for the experiments: eNTERFACE'05 and REDVESS dataset. The experimental results show that the accuracy of the proposed method on the eNTERFACE'05 and REDVESS datasets is 85.42% and 83.84% respectively, which proves the effectiveness of the proposed method. © 2025 IEEE.

关键词： Modal analysis

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Prescribed Performance control for a Nonlinear System With Actuator Saturation via Anti-Windup Design

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IEEE Transactions on Circuits and Systems I: Regular Papers 2025年

作者： Lai, Wenxin Li, Yuanlong Lin, Zongli Shanghai Jiao Tong University Department of Automation Shanghai 200240 China Ministry of Education of China Key Laboratory of System Control and Information Processing Shanghai 200240 China Shanghai Engineering Research Center of Intelligent Control and Management Shanghai 200240 China University of Virginia Charles L. Brown Department of Electrical and Computer Engineering Charlottesville 22904 VA United States

In this paper, within the prescribed performance control framework, we revisit the output tracking problem of a nonlinear system with input saturation, user-specified performance and external disturbances. To handle the intrinsic conflict between actuator saturation and performance requirements, we introduce a novel auxiliary system, which is driven by an artificial saturation nonlinearity, to generate modification signals for relaxing the prescribed performance functions. To further alleviate the adverse effects caused by actuator saturation, we incorporate a new performance-based anti-windup compensator into the control framework. In particular, the auxiliary system is designed to adjust the external performance requirements, and the anti-windup compensator is used for improving the internal saturation handling capability. Moreover, we employ a predetermined weighting coefficient to balance between the auxiliary system and the anti-windup compensator for better control performance. To deal with external disturbances, we construct a series of disturbance observers. With the help of dynamic surface control strategies, we develop a state-feedback control law. Theoretical analysis establishes the boundedness of all signals. Finally, an academic example and a tunnel diode circuit system are provided to demonstrate the effectiveness of our control strategy. © 2004-2012 IEEE.

关键词： activation mechanism Actuator saturation anti-windup disturbance observers prescribed performance reference tracking

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Exploiting the Intrinsic Neighborhood Semantic Structure for Domain Adaptation in EEG-based Emotion Recognition

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IEEE Transactions on Affective Computing 2025年

作者： Yang, Yi Wang, Ze Song, Yu Jia, Ziyu Wang, Boyu Jung, Tzyy-Ping Wan, Feng Macau University of Science and Technology Macao Centre for Mathematical Sciences Respiratory Disease AI Laboratory on Epidemic Intelligence and Medical Big Data Instrument Applications Faculty of Innovation Engineering 999078 China Tianjin University of Technology School of Electrical Engineering and Automation Tianjin Key Laboratory of New Energy Power Conversion Transmission and Intelligent Control Tianjin300384 China Chinese Academy of Sciences Beijing Key Laboratory of Brainnetome and Brain-Computer Interface and Brainnetome Center Institute of Automation Beijing100045 China Western University Department of Computer Science Brain Mind Institute LondonONN6A 3K7 Canada University of California at San Diego Swartz Center for Computational Neuroscience Institute for Neural Computation La Jolla CA92093 United States University of Macau Department of Electrical and Computer Engineering Faculty of Science and Technology China University of Macau Centre for Cognitive and Brain Sciences Centre for Artificial Intelligence and Robotics Institute of Collaborative Innovation 999078 China

Due to the inherent non-stationarity and individual differences present in electroencephalogram (EEG) signals, developing a generalizable model that performs well on new subjects is challenging in EEG-based emotion recognition. Most existing domain adaptation (DA) methods typically mitigate these discrepancies by aligning the marginal distributions of domain feature representations. However, when there is a significant difference in the class-conditional distribution between domain features and labels, the domain-invariant features learned by aligning marginal distributions may have limited discriminative ability for unlabeled target instances or even prove counterproductive. To address this issue, we propose a Neighborhood Semantic Aware Learning-based Dynamic Graph Attention Convolution (NSAL-DGAT) approach that learns target semantic information by considering the inter-domain semantic topological structure, thereby improving classifier adaptation for target instances. Specifically, the proposed NSAL framework is designed to capitalize on the insight that after domain feature alignment, some target samples and their neighboring source samples exhibit similar semantics. By leveraging the neighborhood topological structure, we extract and incorporate semantic target features to train a more transferable classifier. Besides, we implement an entropy weighting mechanism to emphasize representative target semantic information, encouraging target instances to prioritize high-confidence individuals within the source neighborhood. We have conducted extensive experiments on the public SEED dataset and our collected the Hearing-Impaired EEG Dataset (HIED). The experimental results underscore the efficacy of our proposed NSAL-DGAT approach, showcasing state-of-the-art accuracy in subject-dependent as well as subject-independent scenarios. The source code is available at https://***/YYingDL/NSAL-DGAT. © 2010-2012 IEEE.

关键词： Speech analysis

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