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arXiv 2023年

作者： Dalal, Roohi Li, Xiangchong Nicola, Andrina Zuntz, Joe Strauss, Michael A. Sugiyama, Sunao Zhang, Tianqing Rau, Markus M. Mandelbaum, Rachel Takada, Masahiro More, Surhud Miyatake, Hironao Kannawadi, Arun Shirasaki, Masato Taniguchi, Takanori Takahashi, Ryuichi Osato, Ken Hamana, Takashi Oguri, Masamune Nishizawa, Atsushi J. Plazas Malagón, Andrés A. Sunayama, Tomomi Alonso, David Slosar, Anže Armstrong, Robert Bosch, James Komiyama, Yutaka Lupton, Robert H. Lust, Nate B. MacArthur, Lauren A. Miyazaki, Satoshi Murayama, Hitoshi Nishimichi, Takahiro Okura, Yuki Price, Paul A. Tait, Philip J. Tanaka, Masayuki Wang, Shiang-Yu Department of Astrophysical Sciences Princeton University PrincetonNJ08544 United States McWilliams Center for Cosmology Department of Physics Carnegie Mellon University 5000 Forbes Ave PittsburghPA15213 United States The University of Tokyo Chiba277-8583 Japan Argelander Institut für Astronomie Universität Bonn Auf dem Hügel 71 Bonn53121 Germany Institute for Astronomy Royal Observatory Edinburgh University of Edinburgh EH9 3HJ United Kingdom Department of Physics The University of Tokyo Bunkyo Tokyo113-0031 Japan High Energy Physics Division Argonne National Laboratory LemontIL60439 United States The Inter-University Centre for Astronomy and Astrophysics Post bag 4 Ganeshkhind Pune411007 India Nagoya University Nagoya464-8602 Japan Institute for Advanced Research Nagoya University Nagoya464-8601 Japan National Astronomical Observatory of Japan National Institutes of Natural Sciences Tokyo Mitaka181-8588 Japan The Institute of Statistical Mathematics Tokyo Tachikawa190-8562 Japan Faculty of Science and Technology Hirosaki University 3 Bunkyo-cho Aomori Hirosaki036-8561 Japan Center for Frontier Science Chiba University Chiba263-8522 Japan Department of Physics Graduate School of Science Chiba University Chiba263-8522 Japan Gifu Shotoku Gakuen University 1-1 Takakuwanishi Gifu Yanaizu501-6194 Japan Kavli Institute for Particle Astrophysics and Cosmology P.O. Box 20450 MS29 StanfordCA94309 United States SLAC National Accelerator Laboratory 2575 Sand Hill Road MS29 Menlo ParkCA94025 United States Department of Astronomy Steward Observatory University of Arizona 933 N Cherry Ave TucsonAZ85719 United States Department of Physics University of Oxford Denys Wilkinson Building Keble Road OxfordOX1 3RH United Kingdom Brookhaven National Laboratory UptonNY11973 United States Lawrence Livermore National Laboratory LivermoreCA94551 United States Department of Advanced Sciences Faculty of Science and Engineering

We measure weak lensing cosmic shear power spectra from the three-year galaxy shear catalog of the Hyper Suprime-Cam (HSC) Subaru Strategic Program imaging survey. The shear catalog covers 416 deg2 of the northern sky, with a mean i-band seeing of 0.59 arcsec and an effective galaxy number density of 15 arcmin−2 within our adopted redshift range. With an i-band magnitude limit of 24.5 mag, and four tomographic redshift bins spanning 0.3 ≤ zph ≤ 1.5 based on photometric redshifts, we obtain a high-significance measurement of the cosmic shear power spectra, with a signal-to-noise ratio of approximately 26.4 in the multipole range 300 8 ≡ σ8(Ωm/0.3)0.5 = 0.776+0.032−0.033, which is in excellent agreement with the constraints from the other HSC Year 3 cosmology analyses, as well as those from a number of other cosmic shear experiments. This result implies a ∼2σ-level tension with the Planck 2018 cosmology [1]. We study the effect that various systematic errors and modeling choices could have on this value, and find that they can shift the best-fit value of S8 by no more than ∼0.5σ, indicating that our result is robust to such systematics. Copyright © 2023, The Authors. All rights reserved.

关键词： Galaxies

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High-density implantable neural electrodes and chips for massive neural recordings

Brain-X

引用

Brain-X 2024年第2期2卷

作者： Wang, Longchun Suo, Yanxing Wang, Jiahao Wang, Xuanqi Xue, Kai An, Jingjing Sun, Xun Chen, Qinyu Tang, Xiaochen Zhao, Yang Ji, Bowen Liu, Jingquan Department of Micro/Nano Electronics Shanghai Jiao Tong University Shanghai China National Key Laboratory of Advanced Micro and Nano Manufacture Technology Shanghai Jiao Tong University Shanghai China DCI Joint Team Collaborative Innovation Center of IFSA Shanghai Jiao Tong University Shanghai China Unmanned System Research Institute Northwestern Polytechnical University Shaanxi Xi'an China National Key Laboratory of Unmanned Aerial Vehicle Technology Shaanxi Xi'an China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical Engineering Northwestern Polytechnical University Shaanxi Xi'an China Institute of Guizhou Aerospace Measuring and Testing Technology Guizhou Guiyang China Leiden Institute of Advanced Computer Science (LIACS) Leiden University Leiden Netherlands Klipsch School of Electrical and Computer Engineering New Mexico State University Las Cruces NM United States

High-density neural recordings with superior spatiotemporal resolution powerfully unveil cellular-scale neural communication, showing great promise in neural science, translational medicine, and clinical applications. To achieve such, many design and fabrication innovations enhanced the electrode, chip, or both for biocompatibility improvement, electrical performance upgrade, and size miniaturization, offering several thousands of recording sites. However, an enormous gap exists along the trajectory toward billions of recording sites for brain scale resolution, posing many more design challenges. This review tries to find possible insight into mitigating the gap by discussing the latest progress in high-density electrodes and chips for neural recordings. It emphasizes the design, fabrication, bonding techniques, and in vivo performance optimization of high-density electrodes. It discusses the promising opportunities for circuit-level and architecture-level multi-channel chip design innovations. We expect that joint effort and close collaboration between high-density electrodes and chips will pave the way to high-resolution neural recording tools supporting cutting-edge neuroscience discoveries and applications. © 2024 The Author(s). Brain-X published by John Wiley & Sons Australia, Ltd on behalf of Ainuohui Medical Technology.

关键词： brain-computer interface high density implantable chips implantable electrodes massive neural recording

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CHAPTER 9: Bijels the Easy Way

RSC Soft Matter

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RSC Soft Matter 2020年第10期2020-January卷 211-245页

作者： Forth, Joe Toor, Anju Chai, Yu Huang, Caili Liu, Xubo Feng, Wenqian Shi, Shaowei Wang, Dong Ashby, Paul D. Helms, Brett A. Russell, Thomas P. Materials Sciences Division Lawrence Berkeley National Laboratory BerkeleyCA94720 United States Department of Chemistry University College London LondonWC1H 0AJ United Kingdom School of Materials Science and Engineering University of California BerkeleyCA94720 United States Molecular Foundry Lawrence Berkeley National Laboratory BerkeleyCA94720 United States Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Wuhan430074 China Beijing Advanced Innovation Center for Soft MatterScience and Engineering Beijing University of Chemical Technology Beijing100029 China Max Planck Institute for Medical Research Heidelberg69120 Germany Tohoku University Aoba Sendai980-8577 Japan Polymer Science and Engineering Department University of Massachusetts Conte Center for Polymer Research MA01003 United States

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Higher-order nodal points in two dimensions

arXiv

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arXiv 2021年

作者： Wu, Weikang Liu, Ying Yu, Zhi-Ming Zhao, Y.X. Gao, Weibo Yang, Shengyuan A. Research Laboratory for Quantum Materials Singapore University of Technology and Design Singapore487372 Singapore Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore637371 Singapore School of Materials Science and Engineering Hebei University of Technology Tianjin300130 China Beijing Key Lab of Nanophotonics & Ultrafine Optoelectronic Systems School of Physics Beijing Institute of Technology Beijing100081 China National Laboratory of Solid State Microstructures Department of Physics Nanjing University Nanjing210093 China Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing210093 China

A two-dimensional (2D) topological semimetal is characterized by the nodal points in its low-energy band structure. While the linear nodal points have been extensively studied, especially in the context of graphene, the realm beyond linear nodal points remains largely unexplored. Here, we explore the possibility of higher-order nodal points, i.e., points with higher-order energy dispersions, in 2D systems. We perform an exhaustive search over all 80 layer groups both with and without spin-orbit coupling (SOC), and reveal all possible higher-order nodal points. We show that they can be classified into two categories: the quadratic nodal point (QNP) and the cubic nodal point (CNP). All the 2D higher-order nodal points have twofold degeneracy, and the order of dispersion cannot be higher than three. QNPs only exist in the absence of SOC, whereas CNPs only exist in the presence of SOC. Particularly, the CNPs represent a new topological state not known before. We show that they feature nontrivial topological charges, leading to extensive topological edge bands. Our work completely settles the problem of higher-order nodal points, discovers novel topological states in 2D, and provides detailed guidance to realize these states. Possible material candidates and experimental signatures are discussed. Copyright © 2021, The Authors. All rights reserved.

关键词： Dispersions

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Inference of Antimicrobial Resistance (AMR) from a Whole Genome Database Outperforming AMR Gene Detection

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iscience 2025年

作者： Pornsawan Cholsaktrakool Kornthara Kawang Nicha Sangpiromapichai Pannaporn Thongsuk Songtham Anuntakarun Pattapon Kunadirek Natthaya Chuaypen Sumanee Nilgate Naris Kueakulpattana Ubolrat Rirerm Tanittha Chatsuwan Elita Jauneikaite Frances Davies Ploy N. Pratanwanich Sira Sriswasdi Voraphoj Nilaratanakul Program in Bioinformatics and Computational Biology Graduate School Chulalongkorn University Bangkok Thailand Division of Infectious Diseases Department of Medicine Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand Excellence Center for Infectious Diseases King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand Master of Science Program in Medical Sciences Faculty of Medicine Chulalongkorn University Bangkok Thailand Center of Excellence in Hepatitis and Liver Cancer Department of Biochemistry Faculty of Medicine Chulalongkorn University Bangkok Thailand Bumrungrad International Hospital Bangkok Thailand Metabolic Diseases in Gut and Urinary System Research Unit (MeDGURU) Department of Biochemistry Faculty of Medicine Chulalongkorn University Bangkok Thailand Department of Microbiology Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand Center of Excellence in Antimicrobial Resistance and Stewardship Faculty of Medicine Chulalongkorn University Bangkok Thailand NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance Department of Infectious Disease Imperial College London London United Kingdom Imperial College Healthcare NHS Trust London United Kingdom Department of Microbiology North West London Pathology London United Kingdom Department of Mathematics and Computer Science Faculty of Science Chulalongkorn University Bangkok Thailand Center of Excellence in Computational Molecular Biology Faculty of Medicine Chulalongkorn University Bangkok Thailand Center for Artificial Intelligence in Medicine Research Affairs Faculty of Medicine Chulalongkorn University Bangkok Thailand Healthcare-associated Infection Research Group STAR (Special Task Force for Activating Research) Chulalongkorn University Bangkok Thailand

This study focuses on the rapid detection of antimicrobial resistance (AMR) in Klebsiella pneumoniae . The "Align-Search-Infer" pipeline aligned query sequences from 24 urine samples against a curated genome database of 40 Klebsiella isolates, searched for the best matches, and inferred their antimicrobial susceptibility. Carbapenem resistance inference achieved 77.3% accuracy (95%CI: 59.8–94.8%) within 10 minutes using whole-genome matching, and 85.7% accuracy (95%CI: 70.7–100.0%) within 1 hour using plasmid matching—both surpassing the 54.2% accuracy (95%CI: 34.2–74.1%) of AMR gene detection at 6 hours. The proposed method requires less bacterial DNA and is suitable for low-load clinical samples. Our small local database performed comparably to large public databases. This study supports the integration of pathogen-specific genome databases into clinical workflows to enable rapid and accurate antimicrobial susceptibility prediction. Further research is needed to validate and refine the method using larger genomic-phenotypic datasets across diverse pathogens and sample types.

关键词： antimicrobial resistance Klebsiella pneumoniae nanopore sequencing de novo whole genome assembly database

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Prevent pandemics and halt climate change? Strengthen land rights for Indigenous peoples

引用

The Lancet. Planetary health 2022年第5期6卷 e381-e382页

作者： Jessica Hernandez Julianne Meisner Kevin Bardosh Peter Rabinowitz Center for One Health Research Department of Environmental and Occupational Health Sciences University of Washington Seattle WA 98195 USA Division of Physical Sciences School of Science Technology Engineering and Mathematics University of Washington Bothell Bothell WA USA. Center for One Health Research Department of Environmental and Occupational Health Sciences University of Washington Seattle WA 98195 USA. Electronic address: meisnerj@uw.edu. Center for One Health Research Department of Environmental and Occupational Health Sciences University of Washington Seattle WA 98195 USA.

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ITRI Biofilm Prevented Thoracic Adhesion in Pigs That Received Myocardial Ischemic Induction Treated by Myocardial Implantation of EPCs and ECSW Treatment

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Cell transplantation 2024年 33卷

作者： Jiunn-Jye Sheu Jui-Ning Yeh Pei-Hsun Sung John Y Chiang Yi-Ling Chen Yi-Ting Wang Hon-Kan Yip Jun Guo Division of Thoracic and Cardiovascular Surgery Department of Surgery Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung. Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial Hospital Kaohsiung. Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial Hospital Kaohsiung. Department of Cardiology The First Affiliated Hospital Jinan University Guangzhou China. Division of Cardiology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung. Department of Computer Science and Engineering National Sun Yat-Sen University Kaohsiung. Department of Nursing Asia University Taichung. Department of Medical Research China Medical University Hospital China Medical University Taichung.

This study tested the hypothesis that ITRI Biofilm prevents adhesion of the chest cavity. Combined extracorporeal shock wave (ECSW) + bone marrow-derived autologous endothelial progenitor cell (EPC) therapy was superior to monotherapy for improving heart function (left ventricular ejection fraction [LVEF]) in minipigs with ischemic cardiomyopathy (IC) induced by an ameroid constrictor applied to the mid-left anterior descending artery. The minipigs ( = 30) were equally designed into group 1 (sham-operated control), group 2 (IC), group 3 (IC + EPCs/by directly implanted into the left ventricular [LV] myocardium; 3 [+]/3[-] ITRI Biofilm), group 4 (IC + ECSW; 3 [+]/[3] - ITRI Biofilm), and group 5 (IC + EPCs-ECSW; 3 [+]/[3] - ITRI Biofilm). EPC/ECSW therapy was administered by day 90, and the animals were euthanized, followed by heart harvesting by day 180. studies demonstrated that cell viability/angiogenesis/cell migratory abilities/mitochondrial concentrations were upregulated in EPCs treated with ECSW compared with those in EPCs only (all s < 0.001). The LVEF was highest in group 1/lowest in group 2/significantly higher in group 5 than in groups 3/4 (all s < 0.0001) by day 180, but there was no difference in groups 3/4. The adhesion score was remarkably lower in patients who received ITRI Biofilm treatment than in those who did not (all s <0.01). The protein expressions of oxidative stress (NOX-1/NOX-2/oxidized protein)/apoptotic (mitochondrial-Bax/caspase3/PARP)/fibrotic (TGF-β/Smad3)/DNA/mitochondria-damaged (γ-H2AX/cytosolic-cytochrome-C/p-DRP1), and heart failure/pressure-overload (BNP [brain natriuretic peptide]/β-MHC [beta myosin heavy chain]) biomarkers displayed a contradictory manner of LVEF among the groups (all s < 0.0001). The protein expression of endothelial biomarkers (CD31/vWF)/small-vessel density revealed a similar LVEF within the groups (all s < 0.0001). ITRI Biofilm treatment prevented chest cavity adhesion and was superior in restoring IC-rela

关键词： ITRI Biofilm angiogenesis endothelial progenitor cells extracorporeal shock wave ischemic cardiomyopathy

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Subaru high-z exploration of low-luminosity quasars (SHELLQs) XII. extended [C II] structure (merger or outflow) in a z = 6.72 red quasar

arXiv

引用

arXiv 2021年

作者： Izumi, Takuma Onoue, Masafusa Matsuoka, Yoshiki Strauss, Michael A. Fujimoto, Seiji Umehata, Hideki Imanishi, Masatoshi Kawamuro, Taiki Nagao, Tohru Toba, Yoshiki Kohno, Kotaro Kashikawa, Nobunari Inayoshi, Kohei Kawaguchi, Toshihiro Iwasawa, Kazushi Inoue, Akio K. Goto, Tomotsugu Baba, Shunsuke Schram, Malte Suh, Hyewon Harikane, Yuichi Ueda, Yoshihiro Silverman, John D. Hashimoto, Takuya Hashimoto, Yasuhiro Ikarashi, Soh Iono, Daisuke Lee, Chien-Hsiu Lee, Kianhong Minezaki, Takeo Nakanishi, Kouichiro Nakano, Suzuka Tamura, Yoichi Tang, Ji-Jia National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Department of Astronomical Science The Graduate University for Advanced Studies SOKENDAI 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Max-Planck-Institut für Astronomie Königstuhl 17 HeidelbergD-69117 Germany Research Center for Space and Cosmic Evolution Ehime University 2-5 Bunkyo-cho MatsuyamaEhime790-8577 Japan Princeton University Observatory Peyton Hall PrincetonNJ08544 United States Copenhagen Denmark Niels Bohr Institute University of Copenhagen Jagtvej 128 Copenhagen N2200 Denmark RIKEN Cluster for Pioneering Research 2-1 Hirosawa Wako Saitama351-0198 Japan Institute of Astronomy Graduate School of Science The University of Tokyo 2-21-1 Osawa Mitaka Tokyo181-0015 Japan Department of Astronomy Kyoto University Kitashirakawa-Oiwake-cho Sakyo-ku Kyoto606-8502 Japan Academia Sinica Institute of Astronomy and Astrophysics 11F of Astronomy-Mathematics Building AS/NTU No.1 Section 4 Roosevelt Road Taipei10617 Taiwan Research Center for the Early Universe Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan Department of Astronomy School of Science The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan Kavli Institute for Astronomy and Astrophysics Peking University Beijing100871 China Department of Economics Management and Information Science Onomichi City University 1600-2 Hisayamada Onomichi Hiroshima722-8506 Japan ICREA and Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Martí i Franquès 1 BarcelonaE-08028 Spain Department of Physics School of Advanced Science and Engineering Faculty of Science and Engineering Waseda University 3-4-1 Okubo Shinjuku Tokyo169-8555 Japan Waseda Research Institute for Science and Engineering Faculty of Science and Engineering Waseda University 3-4-1 Okubo Shinjuku Tokyo169-8555 Japan Institute of Astronomy Department of Physi

We present ALMA [C II] 158 µm line and far-infrared (FIR) continuum emission observations toward HSC J120505.09−000027.9 (J1205−0000) at z = 6.72 with the beam size of ∼ 0′′.8 × 0′′.5 (or 4.1 kpc × 2.6 kpc), the most distant red quasar known to date. Red quasars are modestly reddened by dust, and are thought to be in rapid transition from an obscured starburst to an unobscured normal quasar, driven by powerful active galactic nucleus (AGN) feedback which blows out a cocoon of interstellar medium (ISM). The FIR continuum of J1205−0000 is bright, with an estimated luminosity of LFIR ∼ 3×1012 L☉. The [C II] line emission is extended on scales of r ∼ 5 kpc, greater than the FIR continuum. The line profiles at the extended regions are complex and broad (FWHM ∼ 630 − 780 km s−1). Although it is not practical to identify the nature of this extended structure, possible explanations include (i) companion/merging galaxies and (ii) massive AGN-driven outflows. For the case of (i), the companions are modestly star-forming (∼ 10 M☉ yr−1), but are not detected by our Subaru optical observations (yAB,5σ = 24.4 mag). For the case of (ii), our lower-limit to the cold neutral outflow rate is ∼ 100 M☉ yr−1. The outflow kinetic energy and momentum are both much smaller than what predicted in energy-conserving wind models, suggesting that the AGN feedback in this quasar is not capable of completely suppressing its star formation. Copyright © 2021, The Authors. All rights reserved.

关键词： Galaxies

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Porous Organic Polymers for Efficient and Selective SO2Capture from CO2-rich Flue Gas

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Angewandte Chemie 2024年第26期136卷

作者： Dr. Jiangtao Jia Prashant M. Bhatt Dr. Sergio R. Tavares Dr. Edy Abou-Hamad Youssef Belmabkhout Hao Jiang Arijit Mallick Prakash T. Parvatkar Dr. Guillaume Maurin Mohamed Eddaoudi Functional Materials Design Discovery and Development Research Group (FMD3) Advanced Membranes and Porous Materials Center (AMPMC) Division of Physical Sciences and Engineering (PSE) King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Saudi Arabia Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Faculty of Chemistry Northeast Normal University Changchun 130024 China ICGM Univ. Montpellier CNRS ENSCM Montpellier France Instituto de Pesquisas de Produtos Naturais Walter Mors Universidade Federal do Rio de Janeiro Rio de Janeiro RJ 21941-599 Brasil King Abdullah University of Science and Technology (KAUST) Core Labs Thuwal 23955-6900 Saudi Arabia

The quest for effective technologies to reduce SO 2 pollution is crucial due to its adverse effects on the environment and human health. Markedly, removing a ppm level of SO 2 from CO 2 -containing waste gas is a persistent challenge, and current technologies suffer from low SO 2 /CO 2 selectivity and energy-intensive regeneration processes. Here using the molecular building blocks approach and theoretical calculation, we constructed two porous organic polymers (POPs) encompassing pocket-like structures with exposed imidazole groups, promoting preferential interactions with SO 2 from CO 2 -containing streams. Markedly, the evaluated POPs offer outstanding SO 2 /CO 2 selectivity, high SO 2 capacity, and an easy regeneration process, making it one of the best materials for SO 2 capture. To gain better structural insights into the notable SO 2 selectivity of the POPs, we used dynamic nuclear polarization NMR spectroscopy (DNP) and molecular modelling to probe the interactions between SO 2 and POP adsorbents. The newly developed materials are poised to offer an energy-efficient and environment-friendly SO 2 separation process while we are obliged to use fossil fuels for our energy needs.

关键词： SO2 capture porous organic polymer gas separation acs topology desulfurization solution

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Diversity in women and their vaginal microbiota

引用

Trends in Microbiology 2025年

作者： Condori-Catachura, Sandra Ahannach, Sarah Ticlla, Monica Kenfack, Josiane Livo, Esemu Anukam, Kingsley C. Pinedo-Cancino, Viviana Collado, Maria Carmen Dominguez-Bello, Maria Gloria Miller, Corrie Vinderola, Gabriel Merten, Sonja Donders, Gilbert G.G. Gehrmann, Thies Lebeer, Sarah Laboratory of Applied Microbiology and Biotechnology Department of Bioscience Engineering University of Antwerp Groenenborgerlaan 171 Antwerp 2020 Belgium U-MaMi Centre of Excellence University of Antwerp Antwerp Belgium Unit Society Gender and Health – Department of Epidemiology and Public Health Swiss Tropical and Public Health Institute Allschwil Switzerland Department of Biochemistry Faculty of Science University of Yaounde I Yaounde Cameroon Centre for Research on Emerging and Reemerging Diseases Institute of Medical Research and Medicinal Plant Studies Yaounde Cameroon The Biotechnology Center University of Yaounde I Yaounde Cameroon Department of Biomedical Sciences Faculty of Health Sciences University of Buea Buea Cameroon Strengthening Health and Applied Research Yaounde Cameroon Department of Medical Microbiology and Public Health Faculty of Medical Laboratory Science Nnamdi Azikiwe University Nigeria Laboratorio de Investigación de Productos Naturales Antiparasitarios de la Amazonía (LIPNAA) Centro de Investigaciones de Recursos Naturales de la UNAP (CIRNA) Universidad Nacional de la Amazonía Peruana (UNAP) Iquitos Peru Facultad de Medicina Humana Universidad Nacional de la Amazonía Peruana (UNAP) Iquitos Peru Department of Biotechnology Institute of Agrochemistry and Food Technology – National Research Council (IATA-CSIC) Valencia Paterna Spain Department of Biochemistry and Microbiology Rutgers University New Brunswick NJ United States Department of Anthropology Rutgers University New Brunswick NJ United States Humans and the Microbiome Program Canadian Institute for Advanced Research Toronto ON Canada Department of Obstetrics Gynecology and Women's Health Division of Maternal Fetal Medicine John A. Burns School of Medicine University of Hawaii at Manoa Honolulu 96813 HI United States Instituto de Lactología Industrial (INLAIN CONICET-UNL) Facultad de Ingeniería Química Universidad Nacional del Litoral Santa Fe Argentina Department

Women's health is essential to global societal and economic wellbeing, yet health disparities remain prevalent. The vaginal microbiota plays a critical role in health, with research indicating that reduced levels of core bacteria, such as lactobacilli, are associated with conditions like bacterial vaginosis (BV) and increased infection susceptibility. Lower levels of vaginal lactobacilli are reported more frequently in women of African and Latin American descent compared with women of European and Asian descent. However, geographical and other study inclusion and analysis biases influence current research. This opinion highlights the need for a more comprehensive understanding of a ‘healthy’ vaginal microbiome. It underscores efforts to broaden global research on microbiome diversity in socially relevant contexts, avoiding inappropriate applications of terms such as race and ethnicity. © 2025 The Authors

关键词： capacity building citizen science community outreach health equity internationalization open science and transparency taboo breaking vaginal microbiome women empowerment women's health

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