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Gene expression of methylation cycle and related genes in lymphocytes and brain of patients with schizophrenia and non-psychotic controls

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Biomarkers in Neuropsychiatry 2021年 5卷 100038-100038页

作者： Sershen, Henry Guidotti, Alessandro Auta, James Drnevich, Jenny Grayson, Dennis R. Veldic, Marin Meyers, Jordan Youseff, Mary Zhubi, Adrian Faurot, Keturah Wu, Renrong Zhao, Jingping Jin, Hua Lajtha, Abel Davis, John M. Smith, Robert C. Nathan Kline Institute for Psychiatric Research Orangeburg NY United States NYU Langone Medical Center Department of Psychiatry New York NY United States Psychiatric Institute University of Illinois Department of Psychiatry Chicago IL United States High Performance Biological Computing Group and the Roy J. Carver Biotechnology Center University of Illinois Urbana United States Department of Psychiatry and Psychology Mayo Clinic Rochester MN United States Department of Psychiatry Vanderbilt University Nashville TN United States Harlem Hospital Department of Psychiatry New York NY United States Department of Physical Medicine & Rehabilitation University of North Carolina at Chapel Hill NC United States Department of Psychiatry The Second Xiangya Hospital Central South University Changsha Hunan China Mental Health Institute of the Second Xiangya Hospital Central South University Changsha Hunan China University of California San Diego Department of Psychiatry San Diego and VA San Diego Healthcare System San Diego CA United States

Some of the biochemical abnormalities underlying schizophrenia, involve differences in methylation and methylating enzymes, as well as other related target genes. We present results of a study of differences in mRNA expression in peripheral blood lymphocytes (PBLs) and post-mortem brains of chronic schizophrenics (CSZ) and non-psychotic controls (NPC), emphasizing the differential effects of sex and antipsychotic drug treatment on mRNA findings. We studied mRNA expression in lymphocytes of 61 CSZ and 49 NPC subjects using qPCR assays with TaqMan probes to assess levels of DNMT, TET, GABAergic, NR3C1, BDNF mRNAs, and several additional targets identified in a recent RNA sequence analysis. In parallel we studied DNMT1 and GAD67 in samples of brain tissues from 19 CSZ, 26 NPC. In PBLs DNMT1 and DNMT3A mRNA levels were significantly higher in male CSZ vs NPC No significant differences were detected in females. The GAD1, NR3C1 and CNTNAP2 mRNA levels were significantly higher in CSZ than NPC. In CSZ patients treated with clozapine, GAD-1 related, CNTNAP2, and IMPA2 mRNAs were significantly higher than in CSZ subjects not treated with clozapine. Differences between CSZ vs NPC in these mRNAs was primarily attributable to the clozapine treatment. In the brain samples, DNMT1 was significantly higher and GAD67 was significantly lower in CSZ than in NPC, but there were no significant sex differences in diagnostic effects. These findings highlight the importance of considering sex and drug treatment effects in assessing the substantive significance of differences in mRNAs between CSZ and NPC. © 2021 The Author(s)

关键词： DNMTs Epigenetics GABAergic Lymphocyte vs brain mRNA biomarkers Schizophrenia

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Multi-node big data VM platform and job submission Portlet 5

Multi-node big data VM platform and job submission Portlet

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5th International Conference on Applied computing and Information Technology, 2017 4th International Conference on Computational Science/Intelligence and Applied Informatics and 2017 1st International Conference on Big Data, Cloud computing, Data Science and Engineering, ACIT-CSII-BCD 2017

作者： Wu, Chien-Heng Chang, Wen-Yi Tsai, Whey-Fone Lin, Franco Lee, Ching-Fang Yang, Chao-Tung High Performance Computing and Applications National Center for High-Performance Computing National Applied Research Laboratories Hsinchu Science Park No. 7 R and D 6th Rd. Hsinchu30076 Taiwan Cloud Computing and System Integration National Center for High-Performance Computing National Applied Research Laboratories Hsinchu Science Park No. 7 R and D 6th Rd. Hsinchu30076 Taiwan Computer Science Department TungHai University Boulevard Xitun District Taichung40704 Taiwan

ISBN: (纸本)9781538633021

The present study utilizes VirtualBox virtual environment technology to develop the personal and compact size of multi-node big data VM platform with Spark and Hadoop cluster that can effectively replicate and provides an environment for developers to easily design and implement Spark and Hadoop Map/Reduce programming. By using the multi-node Hadoop VM system, developers can conduct Map/Reduce programing completely the same as that in the real multi-node Hadoop cluster. To demonstrate its capability and applicability, this study performs the benchmark by using the big data VM platform and a physical Multi-Node Hadoop Cluster. Based on the standard WordCount benchmarking, the computing time of the physical multi-node Hadoop cluster is 3.7 times faster than that of VM Hadoop cluster. The benchmark results show that the big data VM platform is an ideal platform for the portal and Map/Reduce programming, Spark programming and testing purposes, and the physical Hadoop cluster is the most appropriate for production runs. In addition, the big data VM platform contains a web portal development module designed to support applications that implement big data computing services for the engineering and science users. Such applications are inherently complex, potentially accessing data from a variety of sources and distributing applications to a variety of clients. This portal development module can act as multiple roles in many projects such as personal portals, small business portals, enterprise portals, educational portal, infrastructure portal, and other types of portals. Finally, the big data VM platform, in term of a big data development platform, is ready for users to download. The first author of this paper would like to give a demonstration for the proposed multi-node big data VM platform. © 2017 IEEE.

关键词： MapReduce

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Input optics systems of the KAGRA detector during O3GK (vol 2023, 023F01, 2023)

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PROGRESS OF THEORETICAL AND EXPERIMENTAL PHYSICS 2023年第5期2023卷

作者： Akutsu, T. Ando, M. Arai, K. Arai, Y. Araki, S. Araya, A. Aritomi, N. Asada, H. Aso, Y. Bae, S. Bae, Y. Baiotti, L. Bajpai, R. Barton, M. A. Cannon, K. Cao, Z. Capocasa, E. Chan, M. Chen, C. Chen, K. Chen, Y. Chiang, C-I Chu, H. Chu, Y-K Eguchi, S. Enomoto, Y. Flaminio, R. Fujii, Y. Fujikawa, Y. Fukunaga, M. Fukushima, M. Furuhata, T. Gao, D. Ge, G-G Ha, S. Hagiwara, A. Haino, S. Han, W-B Hasegawa, K. Hattori, K. Hayakawa, H. Hayama, K. Himemoto, Y. Hiranuma, Y. Hirata, N. Hirose, E. Hong, Z. Hsieh, B-H Huang, G-Z Huang, H-Y Huang, P. Huang, Y-C Huang, Y-J Hui, D. C. Y. Ide, S. Ikenoue, B. Imam, S. Inayoshi, K. Inoue, Y. Ioka, K. Ito, K. Itoh, Y. Izumi, K. Jeon, C. Jin, H-B Jung, K. Jung, P. Kaihotsu, K. Kajita, T. Kakizaki, M. Kamiizumi, M. Kanbara, S. Kanda, N. Kang, G. Kataoka, Y. Kawaguchi, K. Kawai, N. Kawasaki, T. Kim, C. Kim, J. Kim, J. C. Kim, Ws Kim, Y-M Kimura, N. Kita, N. Kitazawa, H. Kojima, Y. Kokeyama, K. Komori, K. Kong, A. K. H. Kotake, K. Kozakai, C. Kozu, R. Kumar, R. Kume, J. Kuo, C. Kuo, H-S Kuromiya, Y. Kuroyanagi, S. Kusayanagi, K. Kwak, K. Lee, H. K. Lee, H. W. Lee, R. Leonardi, M. Li, K. L. Lin, L. C-C Lin, C-Y Lin, F-K Lin, F-L Lin, H. L. Liu, G. C. Luo, L-W Majorana, E. Marchio, M. Michimura, Y. Mio, N. Miyakawa, O. Miyamoto, A. Miyazaki, Y. Miyo, K. Miyoki, S. Mori, Y. Morisaki, S. Moriwaki, Y. Nagano, K. Nagano, S. Nakamura, K. Nakano, H. Nakano, M. Nakashima, R. Nakayama, Y. Narikawa, T. Naticchioni, L. Negishi, R. Quynh, L. Nguyen Ni, W-T Nishizawa, A. Nozaki, S. Obuchi, Y. Ogaki, W. Oh, J. J. Oh, S. H. Ohashi, M. Ohishi, N. Ohkawa, M. Ohta, H. Okutani, Y. Okutomi, K. Oohara, K. Ooi, C. Oshino, S. Otabe, S. Pan, K-C Pang, H. Parisi, A. Park, J. Arellano, F. E. Pena Pinto, I. Sago, N. Saito, S. Saito, Y. Sakai, K. Sakai, Y. Sakuno, Y. Sato, S. Sato, T. Sawada, T. Sekiguchi, T. Sekiguchi, Y. Shao, L. Shibagaki, S. Shimizu, R. Shimoda, T. Shimode, K. Shinkai, H. Shishido, T. Shoda, A. Somiya, K. Son, E. J. Sotani, H. Sugimoto, R. Suresh, J. Suzuki, T. Suzuki, T. Tagoshi, H. Takahashi, H Gravitational Wave Science Project National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka City Tokyo 181-8588 Japan Department of Physics The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Research Center for the Early Universe The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Institute for Cosmic Ray Research KAGRA Observatory The University of Tokyo 5-1-5 Kashiwa-no-Ha Kashiwa City Chiba 277-8582 Japan Accelerator Laboratory High Energy Accelerator Research Organization (KEK) 1-1 Oho Tsukuba City Ibaraki 305-0801 Japan Earthquake Research Institute The University of Tokyo 1-1-1 Yayoi Bunkyo-ku Tokyo 113-0032 Japan Department of Mathematics and Physics Graduate School of Science and Technology Hirosaki University 3 Bunkyo-cho Hirosaki Aomori 036-8561 Japan Kamioka Branch National Astronomical Observatory of Japan 238 Higashi-Mozumi Kamioka-cho Hida City Gifu 506-1205 Japan The Graduate University for Advanced Studies (SOKENDAI) 2-21-1 Osawa Mitaka City Tokyo 181-8588 Japan Korea Institute of Science and Technology Information 245 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea National Institute for Mathematical Sciences 70 Yuseong-daero 1689 Beon-gil Yuseong-gu Daejeon 34047 Republic of Korea International College Osaka University 1-1 Machikaneyama-cho Toyonaka City Osaka 560-0043 Japan School of High Energy Accelerator Science The Graduate University for Advanced Studies (SOKENDAI) 1-1 Oho Tsukuba City Ibaraki 305-0801 Japan Department of Astronomy Beijing Normal University Xinjiekouwai Street 19 Haidian District Beijing 100875 China Department of Applied Physics Fukuoka University 8-19-1 Nanakuma Jonan Fukuoka City Fukuoka 814-0180 Japan Department of Physics Tamkang University No. 151 Yingzhuan Road Danshui Dist. New Taipei City 25137 Taiwan Department of Physics

KAGRA, the underground and cryogenic gravitational-wave detector, was operated for its solo observation from February 25 to March 10, 2020, and its first joint observation with the GEO 600 detector from April 7 to April 21, 2020 (O3GK). This study presents an overview of the input optics systems of the KAGRA detector, which consist of various optical systems, such as a laser source, its intensity and frequency stabilization systems, modulators, a Faraday isolator, mode-matching telescopes, and a high-power beam dump. These optics were successfully delivered to the KAGRA interferometer and operated stably during the observations. The laser frequency noise was observed to limit the detector sensitivity above a few kilohertz, whereas the laser intensity did not significantly limit the detector sensitivity.

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Raptor: A Five-Safes Approach to a Secure, Cloud Native and Serverless Genomics Data Repository

SSRN

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SSRN 2022年

作者： Shih, Chih Chuan Chen, Jieqi Lee, Ai Shan Bertin, Nicolas Hebrard, Maxime Khor, Chiea Chuen Li, Zheng Tan, Joanna Hui Juan Meah, Wee Yang Peh, Su Qin Mok, Shi Qi Sim, Kar Seng Liu, Jianjun Wang, Ling Wong, Eleanor Li, Jingmei Tin, Aung Cheng, Ching-Yu Heng, Chew-Kiat Yuan, Jian-Min Koh, Woon-Puay Saw, Seang Mei Friedlander, Yechiel Sim, Xueling Chai, Jin Fang Chong, Yap Seng Davila, Sonia Goh, Liuh Ling Lee, Eng Sing Wong, Tien Yin Karnani, Neerja Leong, Khai Pang Yeo, Khung Keong Chambers, John C. Lim, Su Chi Goh, Rick Siow Mong Tan, Patrick Dorajoo, Rajkumar Genome Institute of Singapore Agency for Science Technology and Research Singapore Singapore Eye Research institute Singapore National Eye Centre Singapore Yong Loo Lin School of Medicine National University of Singapore Singapore Duke-NUS Medical School Singapore Singapore National Eye Centre Singapore Department of Paediatrics Yong Loo Lin School of Medicine National University of Singapore Singapore Khoo Teck Puat - National University Children's Medical Institute National University Health System Singapore Department of Epidemiology Graduate School of Public Health University of Pittsburgh PittsburghPA United States UPMC Hillman Cancer Center University of Pittsburgh PittsburghPA United States Healthy Longevity Translational Research Programme Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Institute for Clinical Sciences Agency for Science Technology and Research Singapore Saw Swee Hock School of Public Health National University of Singapore Singapore Braun School of Public Health Hebrew University of Jerusalem Jerusalem Israel Precision Health Research Singapore SingHealth Duke-NUS Institute of Precision Medicine Singapore Molecular Diagnostic Laboratory Tan Tock Seng Hospital Singapore Clinical Research Unit National Healthcare Group Polyclinics Singapore Lee Kong Chian School of Medicine Nanyang Technological University Singapore Bioinformatics Institute Agency for Science Technology and Research Singapore Personalised Medicine Service Tan Tock Seng Hospital Singapore Department of Cardiology National Heart Centre Singapore Singapore School of Public Health Imperial College London United Kingdom Clinical Research Unit Khoo Teck Puat Hospital Singapore Diabetes Centre Admiralty Medical Centre Singapore Institute of High Performance Computing Agency for Science Technology and Research Singapore Cancer Science Institute of Singapore National University of Singapore Singapore

Genomic researchers are increasingly utilizing commercial cloud platforms (CCPs) to manage their data and analytics needs. Commercial clouds allow researchers to grow their storage and analytics capacity on demand, keeping pace with expanding project data footprints and enabling researchers to avoid large capital expenditures while paying only for IT capacity consumed by their project. Cloud computing also allows researchers to overcome common network and storage bottlenecks encountered when combining or re-analysing large datasets. However, cloud computing presents a new set of challenges. Without adequate security controls, the risk of unauthorised access may be higher for data stored on the cloud. In addition, regulators are increasingly mandating data access patterns and specific security protocols on the storage and use of genomic data to safeguard rights of the study participants. While CCPs provide tools for security and regulatory compliance, utilising these tools to build the necessary controls required for cloud solutions is not trivial as such skill sets are not commonly found in a genomics lab. The Research Assets Provisioning and Tracking Online Repository (RAPTOR) by the Genome Institute of Singapore is a cloud native genomics data repository and analytics platform focusing on security and regulatory compliance. Using a "five-safes" framework (Safe Purpose, Safe People, Safe Settings, Safe Data and Safe Output), RAPTOR provides security and governance controls to data contributors and users leveraging cloud computing for sharing and analysis of large genomic datasets without the risk of security breaches or running afoul of regulations. RAPTOR can also enable data federation with other genomic data repositories using GA4GH community-defined standards, allowing researchers to boost the statistical power of their work and overcome geographic and ancestry limitations of data sets © 2022, The Authors. All rights reserved.

关键词： Genome

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Charge-symmetry breaking in light hypernuclei based on chiral and similarity renormalization group-evolved interactions

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AIP Conference Proceedings 2019年第1期2130卷

作者： Andreas Nogga 1Institut für Kernphysik Institute for Advanced Simulation and Jülich Center for Hadron Physics Forschungszentrum Jülich D-52425 Jülich Germany 2JARA-High Performance Computing Forschungszentrum Jülich D-52425 Jülich Germany

We present Λ separation energies for light hypernuclei based on chiral hyperon-nucleon interactions at leading and next-to-leading order. For the very light systems, the problem can be directly solved using Faddeev-Yakubovsky equations. For systems with A > 4, we employ the Jacobi no-core shell model. In this case, the hyperon-nucleon and nucleon-nucleon interactions are evolved using the similarity renormalization group (SRG). We discuss the SRG parameter dependence in some detail. The results are used to study the charge-symmetry breaking of A = 4 and 6 hypernuclei.

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Multi-node Big Data VM Platform and Job Submission Portlet

Multi-node Big Data VM Platform and Job Submission Portlet

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International Conference on Applied computing and Information Technology/International Conference on Computational Science and Intelligence (ACIT-CSI)

作者： Chien-Heng Wu Wen-Yi Chang Whey-Fone Tsai Franco Lin Ching-Fang Lee Chao-Tung Yang High Performance Computing and Applications National Applied Research Laboratories Hsinchu Taiwan Cloud Computing and System Integration National Center for High-Performance Computing National Applied Research Laboratories Hsinchu Taiwan Computer Science Department TungHai University Taichung Taiwan

ISBN: (纸本)9781538633038

关键词： Big Data Portals Sparks Programming Benchmark testing Microsoft Windows Java

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An implicit lie-group iterative scheme for solving the sinh-Gordon equation

An implicit lie-group iterative scheme for solving the sinh-...

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International Conference on Applied system Innovation, ICASI 2015

作者： Chang, C.-W. Cloud Computing and System Integration Division National Center for High-Performance Computing Taichung Taiwan

ISBN: (纸本)9781138028937

In this article, the sinh-Gordon equations are coped with by contemplating the semidiscretization method and then, the resulting ordinary differential equations at the discretized spaces are numerically integrated towards the time direction by utilizing the proposed scheme to find the unknown wave quantity. When the numerical experiment is examined, we reveal that the present implicit Lie-group iterative scheme is applicable to the sinh-Gordon equation and convergent fast at each time step;moreover, we can attain the accurate, stable and effective results. © 2016 Taylor & Francis Group.

关键词： Lie groups

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Few- and many-nucleon systems with semilocal coordinate-space regularized chiral two- and three-body forces

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Physical Review C 2019年第2期99卷 024313-024313页

作者： E. Epelbaum J. Golak K. Hebeler T. Hüther H. Kamada H. Krebs P. Maris Ulf-G. Meißner A. Nogga R. Roth R. Skibiński K. Topolnicki J. P. Vary K. Vobig H. Witała Ruhr-Universität Bochum Fakultät für Physik und Astronomie Institut für Theoretische Physik II D-44780 Bochum Germany M. Smoluchowski Institute of Physics Jagiellonian University PL-30348 Kraków Poland Institut für Kernphysik Technische Universität Darmstadt 64289 Darmstadt Germany Department of Physics Faculty of Engineering Kyushu Institute of Technology Kitakyushu 804-8550 Japan Department of Physics and Astronomy Iowa State University Ames Iowa 50011 USA Helmholtz-Institut für Strahlen- und Kernphysik and Bethe Center for Theoretical Physics Universität Bonn D-53115 Bonn Germany Institut für Kernphysik Institute for Advanced Simulation and Jülich Center for Hadron Physics Forschungszentrum Jülich D-52425 Jülich Germany JARA - High Performance Computing Forschungszentrum Jülich D-52425 Jülich Germany

We present calculations of nucleon-deuteron scattering as well as ground and low-lying excited states of light nuclei in the mass range A=3–16 up through next-to-next-to-leading order in chiral effective field theory using semilocal coordinate-space regularized two- and three-nucleon forces. It is shown that both of the low-energy constants entering the three-nucleon force at this order can be determined from the triton binding energy and the differential cross section minimum in elastic nucleon-deuteron scattering. From all considered nucleon-deuteron scattering observables, the strongest constraint on these low-energy constants emerges from the precisely measured cross section minimum at EN=70 MeV. The inclusion of the three-nucleon force is found to improve the agreement with the data for most of the considered observables.

关键词： Few-body systems Nuclear binding Nuclear forces Nuclear many-body theory

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Calibration of the gravitational wave telescope KAGRA 38

Calibration of the gravitational wave telescope KAGRA

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38th International Cosmic Ray Conference, ICRC 2023

作者： Chen, Dan Abe, H. Akutsu, T. Ando, M. Aoumi, M. Araya, A. Aritomi, N. Aso, Y. Bae, S. Bajpai, R. Cannon, K. Cao, Z. Chang, R.-J. Chen, A.H.-Y. Chen, D. Chen, H. Chen, Y. Chiba, A. Chiba, R. Chou, C. Eisenmann, M. Fujii, S. Fukunaga, I. Haba, D. Haino, S. Han, W.-B. Hayakawa, H. Hayama, K. Himemoto, Y. Hirata, N. Hirose, C. Hoshino, S. Hsieh, H.-F. Hsiung, C. Hsu, S.-C. Hui, D.C.Y. Inayoshi, K. Itoh, Y. Iwaya, M. Jin, H.B. Jung, K. Kajita, T. Kamiizumi, M. Kanda, N. Kato, J. Kato, T. Kim, S. Kimura, N. Kiyota, T. Kohri, K. Kokeyama, K. Komori, K. Kong, A.K.H. Koyama, N. Kume, J. Kuroyanagi, S. Kuwahara, S. Kwak, K. Lai, S. Lee, H.W. Lee, R. Lee, S. Leonardi, M. Li, K.L. Lin, L.C.-C. Lin, C.-Y. Lin, E.T. Liu, G.C. Ma, L.-T. Maeda, K. Matsuyama, M. Meyer-Conde, M. Michimura, Y. Mio, N. Miyakawa, O. Miyamoto, S. Miyoki, S. Morisaki, S. Moriwaki, Y. Murakoshi, M. Nakamura, K. Nakano, H. Narikawa, T. Nguyen Quynh, L. Nishino, Y. Nishizawa, A. Obayashi, K. Oh, J.J. Oh, K. Ohashi, M. Ohkawa, M. Oohara, K. Oshima, Y. Oshino, S. Page, M.A. Pan, K.-C. Park, J. Peña Arellano, F.E. Saha, S. Sakai, K. Sako, T. Sato, R. Sato, S. Sato, Y. Sawada, T. Sekiguchi, Y. Shao, L. Shikano, Y. Shimode, K. Shinkai, H. Shiota, J. Somiya, K. Suzuki, T. Suzuki, T. Tagoshi, H. Takahashi, H. Takahashi, R. Takamori, A. Takatani, K. Takeda, H. Takeda, M. Tamaki, M. Tanaka, K. Tanaka, S.J. Tanaka, T. Taruya, A. Tomaru, T. Tomita, K. Tomura, T. Toriyama, A. Trani, A.A. Tsuchida, S. Uchikata, N. Uchiyama, T. Uehara, T. Ueno, K. Ushiba, T. van Putten, M.H.P.M. Wang, H. Washimi, T. Wu, C. Wu, H. Yamamoto, K. Yamamoto, M. Yamamoto, T. Yamamoto, T.S. Yamamura, S. Yamazaki, R. Yang, L.-C. Yang, Y. Yeh, S.-W. Yokoyama, J. Yokozawa, T. Yuzurihara, H. Zhao, Y. Zhu, Z.-H. Kamioka Branch National Astronomical Observatory of Japan 238 Higashi-Mozumi Kamioka-cho Hida City Gifu506-1205 Japan Graduate School of Science Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo152-8551 Japan Gravitational Wave Science Project National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka City Tokyo181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka City Tokyo181-8588 Japan Department of Physics The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan Institute for Cosmic Ray Research KAGRA Observatory The University of Tokyo 238 Higashi-Mozumi Kamioka-cho Hida City Gifu506-1205 Japan Earthquake Research Institute The University of Tokyo 1-1-1 Yayoi Bunkyo-ku Tokyo113-0032 Japan LIGO Hanford Observatory RichlandWA99352 United States 2-21-1 Osawa Mitaka City Tokyo181-8588 Japan 245 Daehak-ro Yuseong-gu Daejeon34141 Korea Republic of Department of Astronomy Beijing Normal University Xinjiekouwai Street 19 Haidian District Beijing100875 China Department of Physics National Cheng Kung University No.1 University Road Tainan City701 Taiwan Institute of Physics National Yang Ming Chiao Tung University 101 Univ. Street Hsinchu Taiwan Department of Physics National Tsing Hua University No. 101 Section 2 Kuang-Fu Road Hsinchu30013 Taiwan Faculty of Science University of Toyama 3190 Gofuku Toyama City Toyama930-8555 Japan Institute for Cosmic Ray Research KAGRA Observatory The University of Tokyo 5-1-5 Kashiwa-no-Ha Chiba Kashiwa City277-8582 Japan Department of Electrophysics National Yang Ming Chiao Tung University 101 Univ. Street Hsinchu Taiwan Department of Physics Graduate School of Science Osaka Metropolitan University 3-3-138 Sugimoto-cho Sumiyoshi-ku Osaka City Osaka558-8585 Japan Institute of Physics Academia Sinica 128 Sec. 2 Academia Rd. Na

KAGRA is a laser interferometric gravitational wave (GW) telescope in Japan. It joined O4, the fourth international GW observation run, with other telescopes, namely, Laser Interferometer Gravitational Wave Observatory (LIGO) and Virgo. In the previous GW observation runs: O1, O2, and O3, 90 events were reported, and many more events are expected to be observed in O4. With the beginning of GW astronomy, the calibration of observed GW signals is becoming more important than ever before. The main calibration system used in KAGRA, LIGO, and Virgo is a photon calibration system (Pcal), which injects reference signals into a telescope by the radiation pressure of a laser. On the basis of the preparation and operation of KAGRA Pcals in O3, we prepared an upgrading plan for O4. This plan includes three main improvements: improving the Pcal laser beam alignment system, reducing noise, and dereasing uncertainty. Improvement works were conducted between the end of O3 and the start of O4 in accordance with this plan. The following results were obtained: first, precise remote alignment was enabled in the critical Pcal laser path region. Second, a Pcal noise source was identified and noise was significantly improved, resulting in a remarkable 50 dB reduction and sufficient reduction of the Pcal noise below the design sensitivity of KAGRA. Third, studies on the temperature dependence and laser incidence state dependence of the integrating sphere-type power meter were conducted to reduce the uncertainty of the Pcal, which is directly related to the uncertainty of the telescope signal. The details of the KAGRA Pcal and the improvements made between O3 and O4 are reported in this study. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Laser interferometry

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Development of Gravity Field Calibrator for KAGRA 38

Development of Gravity Field Calibrator for KAGRA

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38th International Cosmic Ray Conference, ICRC 2023

作者： Bajpai, Rishabh Abe, H. Akutsu, T. Ando, M. Aoumi, M. Araya, A. Aritomi, N. Aso, Y. Bae, S. Bajpai, R. Cannon, K. Cao, Z. Chang, R.-J. Chen, A.H.-Y. Chen, D. Chen, H. Chen, Y. Chiba, A. Chiba, R. Chou, C. Eisenmann, M. Fujii, S. Fukunaga, I. Haba, D. Haino, S. Han, W.-B. Hayakawa, H. Hayama, K. Himemoto, Y. Hirata, N. Hirose, C. Hoshino, S. Hsieh, H.-F. Hsiung, C. Hsu, S.-C. Hui, D.C.Y. Inayoshi, K. Itoh, Y. Iwaya, M. Jin, H.-B. Jung, K. Kajita, T. Kamiizumi, M. Kanda, N. Kato, J. Kato, T. Kim, S. Kimura, N. Kiyota, T. Kohri, K. Kokeyama, K. Komori, K. Kong, A.K.H. Koyama, N. Kume, J. Kuroyanagi, S. Kuwahara, S. Kwak, K. Lai, S. Lee, H.W. Lee, R. Lee, S. Leonardi, M. Li, K.L. Lin, L.C.-C. Lin, C.-Y. Lin, E.T. Liu, G.C. Ma, L.-T. Maeda, K. Matsuyama, M. Meyer-Conde, M. Michimura, Y. Mio, N. Miyakawa, O. Miyamoto, S. Miyoki, S. Morisaki, S. Moriwaki, Y. Murakoshi, M. Nakamura, K. Nakano, H. Narikawa, T. Nguyen Quynh, L. Nishino, Y. Nishizawa, A. Obayashi, K. Oh, J.J. Oh, K. Ohashi, M. Ohkawa, M. Oohara, K. Oshima, Y. Oshino, S. Page, M.A. Pan, K.-C. Park, J. Peña Arellano, F.E. Saha, S. Sakai, K. Sako, T. Sato, R. Sato, S. Sato, Y. Sawada, T. Sekiguchi, Y. Shao, L. Shikano, Y. Shimode, K. Shinkai, H. Shiota, J. Somiya, K. Suzuki, T. Suzuki, T. Tagoshi, H. Takahashi, H. Takahashi, R. Takamori, A. Takatani, K. Takeda, H. Takeda, M. Tamaki, M. Tanaka, K. Tanaka, S.J. Tanaka, T. Taruya, A. Tomaru, T. Tomita, K. Tomura, T. Toriyama, A. Trani, A.A. Tsuchida, S. Uchikata, N. Uchiyama, T. Uehara, T. Ueno, K. Ushiba, T. van Putten, M.H.P.M. Wang, H. Washimi, T. Wu, C. Wu, H. Yamamoto, K. Yamamoto, M. Yamamoto, T. Yamamoto, T.S. Yamamura, S. Yamazaki, R. Yang, L.-C. Yang, Y. Yeh, S.-W. Yokoyama, J. Yokozawa, T. Yuzurihara, H. Zhao, Y. Zhu, Z.-H. National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo Japan Graduate School of Science Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo152-8551 Japan Gravitational Wave Science Project National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka City Tokyo181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka City Tokyo181-8588 Japan Department of Physics The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan Institute for Cosmic Ray Research KAGRA Observatory The University of Tokyo 238 Higashi-Mozumi Kamioka-cho Hida City Gifu506-1205 Japan Earthquake Research Institute The University of Tokyo 1-1-1 Yayoi Bunkyo-ku Tokyo113-0032 Japan LIGO Hanford Observatory RichlandWA99352 United States 2-21-1 Osawa Mitaka City Tokyo181-8588 Japan 245 Daehak-ro Yuseong-gu Daejeon34141 Korea Republic of Department of Astronomy Beijing Normal University Xinjiekouwai Street 19 Haidian District Beijing100875 China Department of Physics National Cheng Kung University No.1 University Road Tainan City701 Taiwan Institute of Physics National Yang Ming Chiao Tung University 101 Univ. Street Hsinchu Taiwan Kamioka Branch National Astronomical Observatory of Japan 238 Higashi-Mozumi Kamioka-cho Hida City Gifu506-1205 Japan Department of Physics National Tsing Hua University No. 101 Section 2 Kuang-Fu Road Hsinchu30013 Taiwan Faculty of Science University of Toyama 3190 Gofuku Toyama City Toyama930-8555 Japan Institute for Cosmic Ray Research KAGRA Observatory The University of Tokyo 5-1-5 Kashiwa-no-Ha Chiba Kashiwa City277-8582 Japan Department of Electrophysics National Yang Ming Chiao Tung University 101 Univ. Street Hsinchu Taiwan Department of Physics Graduate School of Science Osaka Metropolitan University 3-3-138 Sugimoto-cho Sumiyoshi-ku Osaka City Osaka558-

The output of a gravitational wave telescope is a voltage signal which needs to be calibrated to get the strain signal h(t). This signal h(t) can then be used to derive various parameters of the gravitational wave sources. Any uncertainty in the calibration is directly transferred to these parameters. Therefore, absolute calibration of gravitation wave detectors using a precise reference (known) signal is essential. Currently, KAGRA uses Photon Calibrator (PCAL) to generate reference signals for calibration. PCAL injects a power-modulated laser onto the test mass to calibrate the absolute displacement of the mirror using radiation pressure. Hence, the absolute calibration of KAGRA is limited to 3% by the absolute laser power measurement uncertainty due to the deviation in the laser power standards. KAGRA proposed a new method combining PCAL with Gravity Field Calibrator (GCAL) to reduce the calibration uncertainty. GCAL modulates the test mass using a dynamic gravitational field generated by rotating multipole masses. Since the injected force by GCAL depends on the gravitational constant, mass, distance, rotation frequency, and radius, calibration uncertainty in the sub-percent region can be achieved. In this paper, we will report on the progress of the development of the gravity field calibrator and our future plans. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Laser mirrors

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