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Role of pericytes in regulating penile angiogenesis and nerve regeneration

Asian Journal of Andrology 2025年第1期27卷 13-19页

作者： Guo Nan Yin Ji-Kan Ryu National Research Center for Sexual Medicine and Department of Urology Inha University School of MedicineIncheon 22332Korea Program in Biomedical Scienceand Engineering Inha UniversityIncheon 22212Korea

Pericytes are multifunctional mural cells that surround the abluminal wall of endothelial cells and are associated with vascular development,vascular permeability,and ***,pericytes demonstrate stem cell-like properties and contribute to neuroinflammatory *** have been extensively studied in the central nervous ***,specific mechanisms underlying its involvement in various physiological and pathological conditions,especially in erectile dysfunction(ED),remain poorly *** in in vitro and in vitro techniques,such as single-cell RNA sequencing,are expanding our understanding of *** studies have shown that pericyte dysfunction is considered an important factor in the pathogenesis of vascular and neurological ***,this study aims to analyze the specific role of pericytes in ED,focusing on diabetic and neurogenic *** article provides a comprehensive review of research findings on PubMed from 2000 to 2023,concerning pericyte dysfunction in the process of ED,offering valuable insights,and suggesting directions for further research.

关键词： angiogenesis blood-brain barrier erectile dysfunction nerve regeneration pericyte stem cell

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Editorial for “Collaborative Learning for Annotation-Efficient Volumetric MR Image Segmentation”

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Journal of Magnetic Resonance imaging 2024年第4期60卷 1615-1616页

作者： Sabati, Mohammad Yang, Mingrui Chauhan, Anil Hoglund Biomedical Imaging Center University of Kansas Medical Center Kansas City KS United States Bioengineering Program School of Engineering University of Kansas Lawrence KS United States Department of Biomedical Engineering Program of Advanced Musculoskeletal Imaging Cleveland Clinic Cleveland OH United States Department of Radiology University of Kansas Medical Center Kansas City KS United States

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Recent progress of ultrasound-responsive titanium dioxide sonosensitizers in cancer treatment

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Chinese Chemical Letters 2024年第10期35卷 63-72页

作者： Hajing Cui Weihao Zhu Chuning Yue Ming Yang Wenzhi Ren Aiguo Wu Cixi Biomedical Research Institute Wenzhou Medical UniversityNingbo 315300China Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of Sciences Ningbo315201China C Advanced Energy Science and Technology Guangdong LaboratoryHuizhou 516000China

Sonodynamic therapy(SDT)exhibits promising clinical applications in cancer treatment owing to its ad-vantages,including ultrasonic cavitation effect,mechanical effect,and deep tissue *** dioxide(TiO_(2))nanomaterials,recognized as excellent sonosensitizers,have been extensively studied in cancer *** review first outlines the mechanism of TiO_(2)-based SDT,then systematically discusses the regulation of TiO_(2) sonosensitivity,covering aspects such as morphology,particle size,element doping,defect engineering,heterojunction structure,and interactions with the tumor ***-more,the review generalizes ultrasound-responsive TiO_(2)-based therapeutic modalities for tumor treat-ment,including SDT,SDT combined with chemotherapy,chemodynamic therapy,photothermal therapy,immunotherapy,and treatment ***,the review navigates the ongoing challenges and prospects in TiO_(2)-based cancer SDT.

关键词： Titanium dioxide Sonodynamic therapy Reactive oxygen species Cavitation effects Combined therapy

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Nonlinearity of optoacoustic signals and a new contrast mechanism for imaging

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光：科学与应用（英文版） 2025年第5期14卷 1420-1432页

作者： Jaber Malekzadeh-Najafabadi Jaya Prakash Daniel Razansky Jorge Ripoll Vipul Gujrati Vasilis Ntziachristos Biological Imaging Central Institute for Translational Cancer Research(TranslaTUM)School of Medicine and Health & School of ComputationInformation and TechnologyTechnical University of MunichMunichGermany Institute of Biological and Medical Imaging Bioengineering CenterHelmholtz Zentrum MünchenNeuherbergGermany Institute for Biomedical Engineering Department of Information Technology and Electrical EngineeringETH ZurichZurichSwitzerland Biological Imaging Central Institute for Translational Cancer Research(TranslaTUM)School of Medicine and Health & School of ComputationInformation and TechnologyTechnical University of MunichMunichGermany Institute of Biological and Medical Imaging Bioengineering CenterHelmholtz Zentrum MünchenNeuherbergGermany Department of Instrumentation and Applied Physics Indian Institute of ScienceBengaluruIndia Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology Faculty of MedicineUniversity of ZurichZurichSwitzerland Institute for Biomedical Engineering Department of Information Technology and Electrical EngineeringETH ZurichZurichSwitzerland Department of Bioengineering and Aerospace Engineering Universidad Carlos Ⅲ de MadridMadridSpain Biological Imaging Central Institute for Translational Cancer Research(TranslaTUM)School of Medicine and Health & School of ComputationInformation and TechnologyTechnical University of MunichMunichGermany Institute of Biological and Medical Imaging Bioengineering CenterHelmholtz Zentrum MünchenNeuherbergGermany Biological Imaging Central Institute for Translational Cancer Research(TranslaTUM)School of Medicine and Health & School of ComputationInformation and TechnologyTechnical University of MunichMunichGermany Institute of Biological and Medical Imaging Bioengineering CenterHelmholtz Zentrum MünchenNeuherbergGermany Munich Institute of Robotics and Machine Intelligence(MIRMI) Technical University of MunichMunichGermany

Optoacoustic signals behave nonlinearly at light fluences above a few mJ/cm2,which may affect the interpretation and quantification of *** has been proposed that optoacoustic nonlinearity arises from the heat-induced formation of nanobubbles or changes in local thermo-physical ***,such explanations are only valid at much higher fluences than typically used in biomedical optoacoustic imaging(＞20 mJ/cm2)or in the presence of materials with high absorption coefficients such as gold *** propose herein that electromagnetic permittivity changes in response to photon absorption are major source of optoacoustic signal nonlinearity at low *** provide theoretical and experimental evidence that supports this postulation and show that optoacoustic pressure responses due to permittivity changes,which are function of thermally excited third-order nonlinear susceptibility,can explain the nonlinear behavior of the optoacoustic *** different materials exhibit different thermally excited third-order nonlinear susceptibility,this property could function as a new contrast mechanism that can identify the sensitivity of a substance's dielectric constant to photon-induced temperature ***,we propose an imaging method based on nonlinear optoacoustic signals that exploits this newly identified contrast *** findings may have far-reaching implications for improving the accuracy of optoacoustics and utilizing the proposed new contrast mechanism would advance our understanding of cellular and tissue functionality.

关键词： mechanism contrast imaging nonlinearity optoacoustic signals

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MMP-9-responsive probe for fiuorescence-magnetic resonance dual-mode imaging of hepatocellular carcinoma models with different metastatic capacities

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Chinese Chemical Letters 2025年第4期36卷 351-356页

作者： Qiuye Wang Yabing Sun Liangxue Lai Haijing Cui Yonglong Ye Ming Yang Weihao Zhu Bo Yuan Quanliang Mao Wenzhi Ren Aiguo Wu Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Cixi Biomedical Research Institute Wenzhou Medical UniversityNingbo 315300China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Department of Radiology First Affiliated Hospital of Ningbo UniversityNingbo 315010China

Visual assessment of tumor metastatic capacity is crucial for predicting hepatocellular carcinoma(HCC)prognosis and guiding clinical therapeutic *** this study,we developed an enzyme-responsive probe based on the peptide GK10,which is selectively cleaved by matrix metalloproteinase-9(MMP-9),a critical marker for metastasis in *** GK10 peptide was conjugated with near-infrared fiuorescent molecule IR783,fiuorescent quencher black hole quencher 3(BHQ3),and magnetic resonance(MR)contrast agent DOTA-Gd,forming the IR783-GK10-BHQ3-Gd *** MMP-9 cleavage of GK10,BHQ3 is released from the probe,thereby amplifying the previously quenched IR783 fiuorescence *** vitro experiments demonstrate the probe's impressive detection limit for MMP-9,as low as 1.84 ng/m ***,in vivo imaging results reveal that the probe can differentiate liver cancers with varying metastatic *** fiuorescence and MR imaging signal intensity of high metastatic HCC are approximately1.2 times greater than that of low metastatic ***,this engineered probe holds promise as a valuable tool for evaluating HCC metastatic capacity through fiuorescence-MR dual-mode imaging.

关键词： Hepatocellular carcinoma Matrix metalloproteinase-9 Fluorescence imaging Magneticresonance imaging F?rster resonance energy transfer

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Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition

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Chinese Chemical Letters 2024年第4期35卷 292-297页

作者： Yi Cao Xiaojiao Ge Yuanyuan Wei Lulu He Aiguo Wu Juan Li Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China

Peptide-drug conjugates have achieved considerable development and application as a novel strategy for targeted delivery of anticancer drugs. Bioactive peptides induced calcium deposition can irreversibly assist inhibition of tumors. However, active regulation of calcium level through signal transduction of bioactive substances has not been reported yet. In this study, novel neuropeptide-doxorubicin conjugates(NP-DOX) with lysosome-specific acid response were described for neuropeptide Y_1 receptor(Y_1R)-overexpressed triple-negative breast cancer. The delivery mechanism of NP-DOX was clarified that diverse pathways were involved, including intracellular and intercellular transport. Importantly, up-regulation of Y_1 R-mediated intracellular calcium level via second messenger inositol triphosphate was presented in NP-DOX treated MDA-MB-231 cells. In vivo antitumor efficacy demonstrated that NP-DOX showed less organ toxicity and enhanced tumor inhibition benefited from its controlled release and Y_1R-mediated calcium deposition, compared with free DOX. This bioconjugate is a proof-of-concept confirming that neuropeptide-mediated control of signaling responses in neuropeptide-drug conjugates enables great potential for further applications in tumor chemotherapy.

关键词： Neuropeptide-drug conjugate Tumor penetration Calcium deposition Tumor inhibition Triple-negative breast cancer

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An olsalazine nanoneedle-embedded inulin hydrogel reshapes intestinal homeostasis in inflammatory bowel disease

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Bioactive Materials 2024年第3期33卷 71-84页

作者： Zhuangzhuang Zhang Yang Pan Zhaoyuan Guo Xi Fan Qingqing Pan Wenxia Gao Kui Luo Yuji Pu Bin He National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengdu610064China School of Preclinical Medicine Chengdu UniversityChengdu610106China College of Chemistry&Materials Engineering Wenzhou UniversityWenzhou325027China Huaxi MR Research Center(HMRRC) Department of RadiologyWest China HospitalFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceSichuan UniversityChina

Inflammatory bowel disease(IBD)is a chronic and refractory condition characterized by disrupted epithelial barrier,dysregulated immune balance,and altered gut ***-enabled interventions for restoring gut homeostasis have the potential to alleviate inflammation in ***,we developed a combination of olsalazine(Olsa)-based nanoneedles and microbiota-regulating inulin gel to reshape intestinal homeostasis and relieve *** Olsa-derived nanoneedles exhibited reactive oxygen species scavenging ability and anti-inflammatory effects in lipopolysaccharide-simulated *** composite of nanoneedles and inulin gel(Cu2(Olsa)/Gel)displayed a macroporous structure,improved bio-adhesion,and enhanced colon retention after oral ***,the composite effectively downregulated pro-inflammatory cytokine levels and promoted epithelial barrier repair through anti-inflammatory and antioxidant therapies,resulting in significant alleviation of colitis in three animal models of ***,analysis of gut microbiota revealed that Cu2(Olsa)/Gel treatment increased the diversity of intestinal microflora and decreased the relative abundance of pathogenic bacteria such as ***,this study provides a self-delivering nanodrug and dietary fiber hydrogel composite for IBD therapy,offering an efficient approach to restore intestinal homeostasis.

关键词： Inflammatory bowel disease Intestinal homeostasis Olsalazine Hydrogel Nanoneedle

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Minimum spectral resolution for continuous-wave hyperspectral near-infrared tissue spectroscopy

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Journal of biomedical Optics 2025年第4期30卷 047002-047002页

作者： Ping, Ann Haque, Redwan Li, Natalie C. Eskandari, Rasa Diop, Mamadou University of Toronto Department of Mechanical and Industrial Engineering TorontoON Canada Western University Department of Medical Biophysics LondonON Canada Western University School of Biomedical Engineering LondonON Canada Imaging Program Lawson Research Institute LondonON Canada

Significance: Continuous-wave hyperspectral near-infrared spectroscopy (h-NIRS) is a reliable and cost-effective technique for noninvasive monitoring of tissue blood content and oxygenation at the point-of-care;however, most h-NIRS devices are based on expensive custom-built spectrometers. For widespread adoption, lowcost, miniature, off-the-shelf spectrometers are needed. To guide the development of such spectrometers, a standard for spectral resolution must first be defined. Aim: We aim to identify the minimum spectral resolution needed for h-NIRS devices to accurately measure oxy- and deoxy-hemoglobin (HbO and Hb) concentrations in tissue. Approach: h-NIRS measurements were acquired from fully oxygenated and deoxygenated blood-lipid phantoms at 13 spectral resolutions. Data for other oxygenation levels were simulated using NIRFAST. HbO and Hb concentrations were estimated at each resolution and compared with the ground truth hemoglobin concentration. Results: The concentration of Hb was estimated with high accuracy for resolutions up to 10 nm, whereas HbO estimates were more variable. For both chromophores, the accuracy of the estimation gradually decreased with resolutions beyond 10 nm. Conclusions: Spectral resolutions up to 10 nm can be used for h-NIRS without compromising the accuracy of estimating tissue blood content and oxygenation. © 2025 SPIE. All rights reserved.

关键词： Near infrared spectroscopy

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Intravoxel Incoherent Motion Quantification Dependent on Measurement SNR and Tissue Perfusion: A Simulation Study

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Journal of biomedical Physics and engineering 2023年第6期13卷 555-562页

作者： Javidi, Sam Sharifzadeh Shirazinodeh, Alireza Rad, Hamidreza Saligheh Department of Medical Physics and Biomedical Engineering Medicine School Tehran University of Medical Sciences Tehran Iran Quantitative Medical Imaging Systems Group Research Center for Molecular and Cellular Imaging Tehran University of Medical Sciences Tehran Iran

Background: The intravoxel incoherent motion (IVIM) model extracts both functional and structural information of a tissue using motion-sensitizing gradients. Objective: The Objective of the present work is to investigate the impact of signal to noise ratio (SNR) and physiologic conditions on the validity of IVIM parameters. Material and Methods: This study is a simulation study, modeling IVIM at a voxel, and also done 10,000 times for every single simulation. Complex noises with various standard deviations were added to signal in-silico to investigate SNR effects on output validity. Besides, some blood perfusion situations for different tissues were considered based on their physiological range to explore the impacts of blood fraction at each voxel on the validity of the IVIM outputs. Coefficient variation (CV) and bias of the estimations were computed to assess the validity of the IVIM parameters. Results: This study has shown that the validity of IVIM output parameters highly depends on measurement SNR and physiologic characteristics of the studied organ. Conclusion: IVIM imaging could be useful if imaging parameters are correctly selected for each specific organ, considering hardware limitations. © Journal of biomedical Physics and engineering.

关键词： Magnetic resonance imaging

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Main Paths of Brain Fibers in Diffusion Images Mixed with a Noise to Improve Performance of Tractography Algorithm-Evaluation in Phantom

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Journal of biomedical Physics and engineering 2024年第4期14卷 357-364页

作者： Shirazinodeh, Alireza Faraji, Hadis Sharifzadeh Javidi, Sam Jafari, Amir Homayoun Nazemzadeh, Mohammadreza Rad, Hamidreza Saligheh Department of Medical Physics and Biomedical Engineering Medicine School Tehran University of Medical Sciences Tehran Iran Research Center for Molecular and Cellular Imaging Advanced Medical Technologies and Equip-ment Tehran University of Medical Sciences Tehran Iran Tehran University of Medical Sciences Teh-ran Iran Quantitative Medical Imaging Systems Group Research Center for Molecular and Cellular Imaging Tehran University of Medical Sciences Tehran Iran

Background: Some voxels may alter the tractography results due to unintentional alteration of noises and other unwanted factors. Objective: This study aimed to investigate the effect of local phase features on tractography results providing data are mixed by a Gaussian or random distribution noise. Material and Methods: In this simulation study, a mask was firstly designed based on the local phase features to decrease false-negative and-positive tractography results. The local phase features are calculated according to the local structures of im-ages, which can be zero-dimensional, meaning just one point (equivalent to noise in tractography algorithm), a line (equivalent to a simple fiber), or an edge (equivalent to structures more complex than a simple fiber). A digital phantom evaluated the feasibility current model with the maximum complexities of configurations in fibers, including crossing fibers. In this paper, the diffusion images were mixed separately by a Gaussian or random distribution noise in 2 forms: a zero-mean noise and a noise with a mean of data. Results: The local mask eliminates the pixels of unfitted values with the main structures of images, due to noise or other interferer factors. Conclusion: The local phase features of diffusion images are an innovative solution to determine principal diffusion directions. © Journal of biomedical Physics and engineering.

关键词： Phantoms

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