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In situ forming oxygen/ROS-responsive niche-like hydrogel enabling gelation-triggered chemotherapy and inhibition of metastasis

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Bioactive Materials 2023年第3期21卷 86-96页

作者： Shi-Xiong Chen Ji Zhang Fengfeng Xue Wei Liu Yichen Kuang Bingxin Gu Shaoli Song Hangrong Chen State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049PR China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesSub-lane Xiangshan Road 1Hangzhou310024PR China Department of Nuclear Medicine Fudan University Shanghai Cancer CenterShanghai200032PR China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai200032PR China Center for Biomedical Imaging Fudan UniversityShanghai200032PR China Shanghai Engineering Research Center of Molecular Imaging Probes Shanghai200032PR China

Though the development of the diverse hypoxia-activated prodrugs(HAPs)has made great progresses in the last several decades,current cancer therapy based on HAPs still suffers many obstacles,e.g.,poor therapeutic outcome owing to hard deep reaching to hypoxic region,and the occurrence of metastasis due to *** by engineered niches,a novel functional chitosan polymer(CS-FTP)is synthesized for construction of a hydrogel-based bio-niche(CS-FTP-gel)in aiming at remodeling tumor hypoxic *** CS-FTP polymers are crosslinked to form a niche-like hydrogel via enzyme-mediated oxygen-consumable dimerization after injected into tumor,in which a HAP(i.e.,AQ4N)could be physically encapsulated,resulting in enhanced tumor hypoxia to facilitate AQ4N-AQ4 toxic transformation for maximizing efficacy of ***,Pazopanib(PAZ)conjugated onto the CS backbone via ROS-sensitive linker undergoes a stimuli-responsive release behavior to promote antiangiogenesis for tumor starvation,eventually contributing to the inhibition of lung metastasis and synergistic action with AQ4N-based chemotherapy for an orthotopic 4T1 breast tumor *** study provides a promising strategy for hypoxia-based chemotherapy and demonstrates an encouraging clinical potential for multifunctional hydrogel applicable for antitumor treatment.

关键词： Hypoxia-activated prodrugs Bio-niches Hypoxia-inducible hydrogels Antimetastases

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Fucoxanthin induces human melanoma cytotoxicity by thwarting the JAK2/STAT3/BCL-xL signaling axis

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Environmental Toxicology 2024年第6期39卷 3356-3366页

作者： Kuo, Min-Yung Dai, Wen-Chyi Chang, Jie-Li Chang, Jo-Shu Lee, Tse-Min Chang, Chia-Che Pediatric Surgery Division Department of Surgery Tungs' Taichung MetroHarbor Hospital Taichung Taiwan Doctoral Program in Biotechnology Industrial Innovation and Management National Chung Hsing University Taichung Taiwan Taichung Municipal Taichung First Senior High School Taichung Taiwan Department of Chemical and Materials Engineering Research Center for Smart Sustainable Circular Economy Tunghai University Taichung Taiwan Department of Life Sciences National Chung Hsing University Taichung Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung Taiwan Graduate Institute of Biomedical Sciences Master Program in Precision Health Doctoral Program in Translational Medicine Rong Hsing Research Center for Translational Medicine The iEGG and Animal Biotechnology Research Center National Chung Hsing University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan Department of Medical Research China Medical University Hospital Taichung Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei Taiwan

Melanoma is the most lethal skin malignancy. Fucoxanthin is a marine carotenoid with significant anticancer activities. Intriguingly, Fucoxanthin's impact on human melanoma remains elusive. Signal Transducer and Activator of Transcription 3 (STAT3) represents a promising target in cancer therapy due to its persistent activation in various cancers, including melanoma. Herein, we revealed that Fucoxanthin is cytotoxic to human melanoma cell lines A2758 and A375 while showing limited cytotoxicity to normal human melanocytes. Apoptosis is a primary reason for Fucoxanthin's melanoma cytotoxicity, as the pan-caspase inhibitor z-VAD-fmk drastically abrogated Fucoxanthin-elicited clonogenicity blockage. Besides, Fucoxanthin downregulated tyrosine 705-phosphorylated STAT3 (p-STAT3 (Y705)), either inherently present in melanoma cells or inducible by interleukin 6 (IL-6) stimulation. Notably, ectopic expression of STAT3-C, a dominant-active STAT3 mutant, abolished Fucoxanthin-elicited melanoma cell apoptosis and clonogenicity inhibition, supporting the pivotal role of STAT3 blockage in Fucoxanthin's melanoma cytotoxicity. Moreover, Fucoxanthin lowered BCL-xL levels by blocking STAT3 activation, while ectopic BCL-xL expression rescued melanoma cells from Fucoxanthin-induced killing. Lastly, Fucoxanthin was found to diminish the levels of JAK2 with dual phosphorylation at tyrosine residues 1007 and 1008 in melanoma cells, suggesting that Fucoxanthin impairs STAT3 signaling by blocking JAK2 activation. Collectively, we present the first evidence that Fucoxanthin is cytotoxic selectively against human melanoma cells while sparing normal melanocytes. Mechanistically, Fucoxanthin targets the JAK2/STAT3/BCL-xL antiapoptotic axis to provoke melanoma cell death. This discovery implicates the potential application of Fucoxanthin as a chemopreventive or therapeutic strategy for melanoma management. © 2024 Wiley Periodicals LLC.

关键词： Carotenoids

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CellPilot: A Unified Approach to Automatic and Interactive Segmentation in Histopathology 22

CellPilot: A Unified Approach to Automatic and Interactive S...

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22nd IEEE International Symposium on biomedical imaging, ISBI 2025

作者： Endres, Philipp Koch, Valentin Schnabel, Julia A. Marr, Carsten School of Computation and Information Technology Technical University of Munich Germany Helmholtz Zentrum München German Research Center for Environmental Health Germany School of Biomedical Engineering and Imaging Sciences King's College London United Kingdom

ISBN: (纸本)9798331520526

Histopathology, the microscopic study of diseased tissue, is increasingly digitized, enabling improved visualization and streamlined workflows. An important task in histopathology is the segmentation of cells and glands, essential for determining shape and frequencies that can serve as indicators of disease. Deep learning tools are widely used in histopathology. However, variability in tissue appearance and cell morphology presents challenges for achieving reliable segmentation, often requiring manual correction to improve accuracy. This work introduces CellPilot, a framework that bridges the gap between automatic and interactive segmentation by providing initial automatic segmentation as well as guided interactive refinement. Our model was trained on over 675,000 masks of nine diverse cell and gland segmentation datasets, spanning 16 organs. CellPilot demonstrates superior performance compared to other interactive tools on three held-out histopathological datasets while enabling automatic segmentation. We make the model and a graphical user interface designed to assist practitioners in creating large-scale annotated datasets available as open-source, fostering the development of more robust and generalized diagnostic models. 11https://***/philippendres/CellPilot. © 2025 IEEE.

关键词： Graphical user interfaces

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Remote control of the recruitment and capture of endogenous stem cells by ultrasound for in situ repair of bone defects

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Bioactive Materials 2023年第3期21卷 223-238页

作者： Yanni He Fei Li Peng Jiang Feiyan Cai Qin Lin Meijun Zhou Hongmei Liu Fei Yan Department of Ultrasound Institute of Ultrasound in Musculoskeletal Sports MedicineGuangdong Second Provincial General HospitalGuangzhou510317PR China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510515China Paul C.Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055People’s Republic of China Center for Cell and Gene Circuit Design CAS Key Laboratory of Quantitative Engineering BiologyShenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055People’s Republic of China

Stem cell-based tissue engineering has provided a promising platform for repairing of bone ***,the use of exogenous bone marrow mesenchymal stem cells(BMSCs)still faces many challenges such as limited sources and potential *** is important to develop new approach to effectively recruit endogenous BMSCs and capture them for in situ bone ***,we designed an acoustically responsive scaffold(ARS)and embedded it into SDF-1/BMP-2 loaded hydrogel to obtain biomimetic hydrogel scaffold complexes(BSC).The SDF-1/BMP-2 cytokines can be released on demand from the BSC implanted into the defected bone via pulsed ultrasound(p-US)irradiation at optimized acoustic parameters,recruiting the endogenous BMSCs to the bone defected or BSC *** by the daily p-US irradiation for 14 days,the alginate hydrogel was degraded,resulting in the exposure of ARS to these recruited host stem *** another set of sinusoidal continuous wave ultrasound(s-US)irradiation was applied to excite the ARS intrinsic resonance,forming highly localized acoustic field around its surface and generating enhanced acoustic trapping force,by which these recruited endogenous stem cells would be captured on the scaffold,greatly promoting them to adhesively grow for in situ bone tissue *** study provides a novel and effective strategy for in situ bone defect repairing through acoustically manipulating endogenous BMSCs.

关键词： Acoustically responsive scaffolds Biomimetic hydrogel scaffold complexes Endogenous stem cells Acoustic radiation force Bone defect repairing

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Open-source algorithm and software for computed tomography-based virtual pancreatoscopy and other applications

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 239-249页

作者： Haofan Huang Xiaxia Yu Mu Tian Weizhen He Shawn Xiang Li Zhengrong Liang Yi Gao School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen 518060China Laboratory for Imaging Research and Informatics State University of New YorkStony BrookNY 11794USA Shenzhen Key Laboratory of Precision Medicine for Hematological Malignancies Shenzhen 518060China Marshall Laboratory of Biomedical Engineering Shenzhen 518060China Peng Cheng Laboratory Shenzhen 518066China

Pancreatoscopy plays a significant role in the diagnosis and treatment of pancreatic ***,the risk of pancreatoscopy is remarkably greater than that of other endoscopic procedures,such as gastroscopy and bronchoscopy,owing to its severe *** comparison,virtual pancreatoscopy(VP)has shown notable ***,because of the low resolution of current computed tomography(CT)technology and the small diameter of the pancreatic duct,VP has limited clinical *** this study,an optimal path algorithm and super-resolution technique are investigated for the development of an open-source software platform for VP based on 3D *** proposed segmentation of the pancreatic duct from the abdominal CT images reached an average Dice coefficient of 0.85 with a standard deviation of *** to the excellent segmentation performance,a fly-through visualization of both the inside and outside of the duct was successfully reconstructed,thereby demonstrating the feasibility of *** addition,a quantitative analysis of the wall thickness and topology of the duct provides more insight into pancreatic diseases than a fly-through *** entire VP system developed in this study is available at https://***/gaoyi/***.

关键词： Pancreatic cancer Pancreatic duct segmentation Virtual pancreatoscopy 3D Slicer

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Physical and Biological Investigation of Injectable Thai Silk Fibroin/Hyaluronic Acid Hydrogel Sustained-Releasing Dexamethasone

Physical and Biological Investigation of Injectable Thai Sil...

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biomedical engineering International Conference (BMEiCON)

作者： Thapakorn Pankoh Rath Itthipanichpong Juthamas Ratanavaraporn Biomedical Engineering Program Faculty of Engineering Chulalongkorn University Bangkok Thailand Department of Ophthalmology Faculty of Medicine Chulalongkorn University Bangkok Thailand Biomedical Engineering Program Biomedical Engineering Research Center Biomaterial Engineering for Medical and Health Research Unit Faculty of Engineering Chulalongkorn University Bangkok Thailand

Failure of glaucoma surgery occurred due to fibrosis formation. To prevent fibrosis formation, an anti-inflammation agent, such as dexamethasone (DEX), was utilized to inhibit inflammation during the wound healing process, leading to fibrosis reduction. In the present study, DEX is loaded into an ultrasonication-induced silk fibroin/hyaluronic acid (SF/HA) hydrogel as a sustained-release drug delivery system. The SF/HA hydrogel can be fabricated using ultrasonic induction resulting to homogeneous gel within 1 day after incubation at 37°C. For injectability test, the results confirmed that the hydrogel could be easily injected through the 30-gauge needle, particularly for hydrogel containing less concentration and higher HA content. Furthermore, The SF/HA hydrogel showed non-swelling ability, released DEX up to 60% along 30 days of incubation in balanced salt solution, and non-cytotoxic to fibroblasts. However, these properties of the SF/HA hydrogels are independent of their concentrations and SF/HA ratios. As aforementioned, the ultrasonication-induced SF/HA hydrogel could be utilized as an injected carrier of DEX for incorporation with postoperative glaucoma surgery to reduce inflammation and fibrosis formation.

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Natural Frequency Dependency of Magneto-Mechanical Resonators on Magnet Distance

arXiv

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arXiv 2025年

作者： Faltinath, Jonas Mohn, Fabian Foerger, Fynn Möddel, Martin Knopp, Tobias Section for Biomedical Imaging University Medical Center Hamburg-Eppendorf Hamburg Germany Institute for Biomedical Imaging Hamburg University of Technology Hamburg Germany Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE Lübeck Germany

The precise derivation of physical quantities like temperature or pressure at arbitrary locations is useful in numerous contexts, e.g. medical procedures or industrial process engineering. The novel sensor technology of magneto-mechanical resonators (MMR), based on the interaction of a rotor and stator permanent magnet, allows for the combined tracking of the sensor position and orientation while simultaneously sensing an external measurand. Thereby, the quantity is coupled to the torsional oscillation frequency, e.g. by varying the magnet distance. In this paper, we analyze the (deflection angle-independent) natural frequency dependency of MMR sensors on the rotor-stator distance, and evaluate the performance of theoretical models. The presented sensors incorporate magnets of spherical and/or cylindrical geometry. We find the distance-frequency relationship to be well described by an adapted dipole model accounting for material and manufacturing uncertainties. Their combined effect can be compensated by an adjustment of a single parameter which drives the median model deviation generally below 0.2 %. Our depicted methods and results are important for the design and calibration process of new sensor types utilizing the MMR technique. © 2025, CC BY.

关键词： Permanent magnets

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Low-cost analog signal chain for transmit-receive circuits of passive induction-based resonators

arXiv

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arXiv 2025年

作者： Mohn, Fabian Thieben, Florian Knopp, Tobias Institute for Biomedical Imaging Hamburg University of Technology Hamburg Germany Section for Biomedical Imaging University Medical Center Hamburg-Eppendorf Hamburg Germany Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE Lübeck Germany

Passive wireless sensors are crucial in modern medical and industrial settings to monitor procedures and conditions. We demonstrate a circuit to inductively excite passive resonators and to conduct their decaying signal response to a low noise amplifier. Two design variations of a generic transmit-receive signal chain are proposed, measured, and described in detail for the purpose of facilitating replication. Instrumentation and design aim to be scalable for multi-channel array configurations, using either off-the-shelf class-D audio amplifiers or a custom full H-bridge. Measurements are conducted on miniature magneto-mechanical resonators in the ultra low frequency range to enable sensing and tracking applications of such devices in different environments. © 2025, CC BY.

关键词： Low noise amplifiers

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Achieving high surface bioactivity and adhesion in Ti-6Al-4V alloy via anodic oxidation and electrophoretic deposition

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Ceramics International 2025年第16期51卷 22755-22765页

作者： Wu, Yu-Jie Wang, Chi-Yun Mana-ay, Haidee Tu, Chi-Shun Lai, Po-Liang Chen, Pin-Yi International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Physics Fu Jen Catholic University New Taipei City24205 Taiwan Bone and Joint Research Center Department of Orthopedic Surgery Chang Gung Memorial Hospital Taoyuan City33305 Taiwan Department of Mechanical Engineering Chang Gung University Taoyuan City33302 Taiwan Department of Physics Silliman University Dumaguete City6200 Philippines

This study combines 3D printing, anodic oxidation (AO), and electrophoretic deposition (ED) technologies to develop Ti-6Al-4V alloy (abbreviated as Ti64) with high hydrophilicity, adhesion, and bioactivity. Titanium oxide nanotubes formed by AO treatment on the Ti64 surface exhibited reduced contact angles from 53 ° to 10 °. The adhesion of the calcium (Ca) layer through the integrated technology of the AO and ED treatments (herein abbreviated as AED) displays an optimal adhesive force of over 30 N on the Ti64 surface, which is attributed to the stable chemical bond due to the formation of OH− ions on the substrate after the AO treatment and the subsequent oxidation reaction of the Ca2+ ions to form a predominantly Ca(OH)2 layer after the ED treatment. Moreover, the AED treatment forms tiny needle-like structures that can effectively promote osteogenic differentiation. The expressions of the osteocyte marker genes (i.e., OCN, OPN, and DMP1) were improved after the AED treatment, showing increased osteogenic differentiation into mature bone tissue. This work presents the AED treatment as a valuable surface modification technique to boost the surface bioactivity of Ti64 for clinical orthopedic applications. © 2025

关键词： Anodic oxidation

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Recent advances in CRISPR/Cas systems-associated surface enhanced Raman spectroscopy biosensor towards nucleic acid detection

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Medicine in Novel Technology and Devices 2024年第4期24卷 137-145页

作者： Dongjie Zhang Siyuan He Zixu Wang Peirao Yan Huandi Li Xinyi Xu Qi Zeng Nan Wang Xueli Chen Biomedical Photonics and Molecular Imaging Laboratory School of Life Science and TechnologyXidian University and Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life InformationXi'anShaanxi710126China Engineering Research Center of Molecular and Neuro Imaging Ministry of Education&Advanced Diagnostic-Therapy Technology and Equipment Key Laboratory of Higher Education Institutions in Shaanxi ProvinceXidian UniversityXi'anShaanxi710126China Innovation Center for Advanced Medical Imaging and Intelligent Medicine Guangzhou Institute of TechnologyXidian UniversityGuangzhouGuangdong51055China

Nucleic acids play a decisive role in vital life processes,such as growth,heredity,and evolution,and exploring different types of nucleic acid detection techniques has always been a research hotspot *** to traditional nucleic acid analysis methods,surface-enhanced Raman spectroscopy(SERS)detection has advantages,such as high sensitivity,good specificity,narrow spectral bands,minimal sample requirement,simple operation,and resistance to interference from autofluorescence and water in biological *** clustered regularly interspaced short palindromic repeats(CRISPR)/Cas system has gained widespread attention in the fields of gene editing and *** the sequence-specific recognition capability of the CRISPR/Cas system with the high sensitivity fingerprinting properties of SERS technology offers a simple,rapid,and sensitive method towards nucleic acid ***,common SERS Nanotags methods for nucleic acid detection are introduced,including“sandwich assay”,“signal switch assay”and HCR signal ***,the building mechanism of CRISPR-associated SERS detection is ***/Cas12a activated by crRNA can recognize and lock the complementary target double-stranded DNA(dsDNA),followed by ciscleavage of the dsDNA and trans-cleavage of the adjacent linker *** loss of SERS signal based on aggregation is finally used for highly sensitive detection of the target ***,some typical applications through the integration of CRISPR/Cas and SERS technology are introduced,such as HIV-1 dsDNA,HBV DNA and AFB1 etc.

关键词： spectroscopy sandwich gained

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