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IEEE Symposium (IUS) Ultrasonics

作者： Youta Huang Yang Zhang Weibao Qiu Hairong Zheng Zhiqiang Zhang Yanyan Yu School of Biomedical Engineering Shenzhen University Shenzhen China School of Electrical Engineering University of South China Hengyang China Paul C. Lauterbur Research Center for Biomedical Imaging Shenzhen Institute of Advanced Technology Shenzhen China

Acoustic droplet ejection (ADE) has the advantage of mitigating cross-contamination and reducing cost for high-throughput liquid transfer. The ultrasound transducer design is important for the ADE systems. However, the commonly used systems with single-element focused transducer requires mechanical operation for focusing at different liquid surfaces positions, resulting into low liquid transfer efficiency. In this study, we designed a 15MHz annular array transducer enabling electronic focusing in axial direction, thereby allowing high efficient positioning of the liquid surfaces without mechanical operation. The proposed array element has a center frequency of 15.1MHz and a bandwidth of 88%. Transducer characterization results demonstrate the annular array has the ability of focusing at different depths, which enables high-efficient droplet ejection and liquid transfer.

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Histopathological diagnosis of microvascular invasion in hepatocellular carcinoma:Is it reliable?

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World Journal of Gastroenterology 2025年第5期31卷 105-116页

作者： Liu-Jun Li Chao-Qun Wu Fei-Le Ye Zhou Xuan Xiao-Li Zhang Jian-Ping Li Jia Zhou Zhong-Zhen Su Department of Ultrasound The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina Department of Ultrasound The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Pathology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Pathology The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina

BACKGROUND Microvascular invasion(MVI)is a critical prognostic factor for postoperative hepatocellular carcinoma recurrence,but the reliability of its current pathological diagnosis remains *** To evaluate the accuracy of current 7-point sampling methods and propose an optimal pathological protocol using whole-mount slide imaging(WSI)for better MVI *** We utilized 40 New Zealand white rabbits to establish VX2 liver tumor *** entire tumor-containing liver lobe was subsequently obtained,following which five different sampling protocols(A-E)were employed to evaluate the detection rate,accuracy,quantity,and distribution of MVI,with the aim of identifying the optimal sampling *** VX2 liver tumor models were successfully established in 37 rabbits,with an incidence of MVI of 81.1%(30/37).The detection rates[27%(10/37),43%(16/37),62%(23/37),68%(25/37),and 93%(14/15)]and quantity(15,36,107,125,and 395)of MVI increased significantly from protocols A to *** distribution of MVI showed fewer MVIs farther away from the tumor,but the percentage of MVI detected quantity gradually increased from 6.7%to 48.3%in the distant nonneoplastic liver tissue from protocols A to *** C was identified as the optimal sampling method by comparing them in *** sampling protocol of three consecutive interval WSIs at the tumor center(WSI3)was further screened to determine the optimal number of *** A(7-point sampling method)exhibited only 46%accuracy and a high false-negative rate of 67%.Notably,the WSI3 protocol improved the accuracy to 78%and decreased the false-negative rate to 27%.CONCLUSION The current 7-point sampling method has a high false-negative rate in MVI *** contrast,the WSI3 protocol provides a practical and effective approach to improve MVI diagnostic accuracy,which is crucial for hepatocellular carcinoma diagnosis and treatment planning.

关键词： Hepatocellular carcinoma Microvascular invasion Histopathological diagnosis Whole-mount slide imaging Sampling protocol

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Electronic Preresonance Stimulated Raman Scattering Spectromicroscopy Using Multiple-Plate Continuum

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Journal of Physical Chemistry B 2023年第31期127卷 6896-6902页

作者： Huang, Guan-Jie Li, Cheng-Wei Lee, Po-Yi Su, Jia-Xuan Chao, Kuo-Chuan Chu, Li-An Chiang, Ann-Shyn Cheng, Ji-Xin Chen, Bo-Han Lu, Chih-Hsuan Chu, Shi-Wei Yang, Shang-Da Department of Physics National Taiwan University Taipei10617 Taiwan Institute of Photonics Technologies National Tsing Hua University Hsinchu300044 Taiwan Brain Research Center National Tsing Hua University Hsinchu300044 Taiwan Department of Biomedical Engineering & Environmental Sciences National Tsing Hua University Hsinchu30044 Taiwan Institute of Systems Neuroscience and Department of Life Science National Tsing Hua University Hsinchu30044 Taiwan Department of Electrical and Computer Engineering Boston University BostonMA02215 United States Molecular Imaging Center National Taiwan University Taipei10617 Taiwan

Stimulated Raman scattering (SRS) spectromicroscopy is a powerful technique that enables label-free detection of chemical bonds with high specificity. However, the low Raman cross section due to typical far-electronic resonance excitation seriously restricts the sensitivity and undermines its application to bio-imaging. To address this bottleneck, the electronic preresonance (EPR) SRS technique has been developed to enhance the Raman signals by shifting the excitation frequency toward the molecular absorption. A fundamental weakness of the previous demonstration is the lack of dual-wavelength tunability, making EPR-SRS only applicable to a limited number of species in the proof-of-concept experiment. Here, we demonstrate the EPR-SRS spectromicroscopy using a multiple-plate continuum (MPC) light source able to examine a single vibration mode with independently adjustable pump and Stokes wavelengths. In our experiments, the C═C vibration mode of Alexa 635 is interrogated by continuously scanning the pump-to-absorption frequency detuning throughout the entire EPR region enabled by MPC. The results exhibit 150-fold SRS signal enhancement and good agreement with the Albrecht A-term preresonance model. Signal enhancement is also observed in EPR-SRS images of the whole Drosophila brain stained with Alexa 635. With the improved sensitivity and potential to implement hyperspectral measurement, we envision that MPC-EPR-SRS spectromicroscopy can bring the Raman techniques closer to a routine in bio-imaging. © 2023 American Chemical Society.

关键词： Stimulated Raman scattering

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Multi-task Learning Graph Neural Networks for Cancer Prognosis Prediction with Genomic Data

Multi-task Learning Graph Neural Networks for Cancer Prognos...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Tsung-Wei Lin Sofia Ormazabal Arriagada Che Lin Graduate Institute of Communication Engineering National Taiwan University (NTU) Taiwan International Graduate Program AIoT NTU Research Center for Information Technology Innovation Academia Sinica Department of Electrical Engineering NTU Center for Advanced Computing and Imaging in Biomedicine NTU Smart Medicine and Health Informatics Program NTU

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

Providing robust prognosis predictions for cancers with limited data samples remains a challenge for precision oncology. In this study, we propose a novel approach that combines multi-task learning (MTL) and graph neural networks (GNNs) to address this issue. By representing gene-gene interactions as a graph network, our approach leverages multi-task learning to effectively capture the relationships of genes relevant to the oncogenesis and progression of breast, lung, and colon cancer. We demonstrate that our approach improves the cancer prognosis prediction for cancers with fewer samples, such as colon adenocarcinoma, by leveraging the shared gene-gene interactions across different cancer types, obtaining increases in the area under the precision-recall curve (AUPRC) of 24%. Our work contributes to the field of smart healthcare by demonstrating the potential of MTL and GNNs for enhancing cancer prognosis prediction, even with limited data samples.

关键词： Lungs Genomics Medical services Colorectal cancer Breast Multitasking Oncology Graph neural networks Prognostics and health management Cancer

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Self-Assembly of Iron Oxide Nanoparticles for Microvascular Magnetic Resonance imaging

SSRN

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SSRN 2024年

作者： Soni, Raghav Tian, Xin Mahara, Atsushi National Cerebral and Cardiovascular Center Research Institute Kishibe Shimmachi Osaka Suita564-8565 Japan Department of Medical Imaging The Second Hospital of Hebei Medical University China Department of Biomedical Engineering

Iron-oxide nanoparticles (IONPs) are clinically used as stable contrast agents for magnetic resonance imaging. However, their application in microvascular imaging is limited because of their rapid diffusion across soft tissues and high accumulation in the liver. In this study, we present a self-assembled IONPs based contrast agent for cerebrovascular imaging. The IONPs were modified with fluorescein-conjugated 4-arm polyethylene glycol to prepare 4P-F-IONPs. Light-scattering analysis revealed that 4P-F-IONPs formed fiber-like structures through self-assembly via fluorescein conjugation. Pharmacokinetic studies indicated longer blood circulation and reduced organ diffusion for the self-assembled fiber contrast agent compared with pristine IONPs. Furthermore, microvasculature as small as 400 µm in diameter was clearly visualized after intravenous injection in a rat model. In contrast, the signals were not enhanced when 4P-IONPs (without fluorescein conjugation) were injected. These results suggest that fluorescein conjugation induces a structural transition in IONPs, which reduces contrast diffusion across micro-vessels and enhances the MR signals in the microvasculature. © 2024, The Authors. All rights reserved.

关键词： Light scattering

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Benefits and drawbacks of radiofrequency ablation via percutaneous or minimally invasive surgery for treating hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第11期16卷 3400-3407页

作者： Ching-Lung Hsieh Cheng-Ming Peng Chun-Wen Chen Chang-Hsien Liu Chih-Tao Teng Yi-Jui Liu Department of Computer Science and Information Engineering Feng Chia UniversityTaichung 40724Taiwan Department of Surgery Chung Shan Medical University HospitalTaichung 40201Taiwan School of Medicine Chung Shan Medical UniversityTaichung 40201Taiwan Department of Radiology Taichung Armed Forces General HospitalTaichung 406Taiwan Department of Medical Imaging and Radiological Sciences Central Taiwan University of Science and TechnologyTaichung 406Taiwan Department of Radiology School of MedicineNational Defense Medical CenterTaipei 11490Taiwan Department of Medical Imaging China Medical University Hsinchu Hospital and China Medical UniversityHsinchu 302Taiwan Institute of Nuclear Engineering and Science National Tsing Hua UniversityHsinchu 300Taiwan Department of Radiology Nantou Hospital of the Ministry of Health and WelfareNantou 540Taiwan Master’s Program of Biomedical Informatics and Biomedical Engineering Feng Chia UniversityTaichung 407Taiwan Department of Automatic Control Engineering Feng Chia UniversityTaichung 407Taiwan

The management of early stage hepatocellular carcinoma(HCC)presents significant *** radiofrequency ablation(RFA)has shown safety and effectiveness in treating HCC,with lower mortality rates and shorter hospital stays,its high recurrence rate remains a significant ***,achieving improved survival solely through RFA is challenging,particularly in retrospective studies with inherent *** is commonly used for guiding percutaneous RFA,but its low contrast can lead to missed tumors and the risk of HCC *** enhance the efficiency of ultrasound-guided percutaneous RFA,various techniques such as artificial ascites and contrast-enhanced ultrasound have been developed to facilitate complete tumor *** invasive surgery(MIS)offers advantages over open surgery and has gained traction in various surgical *** studies suggest that laparoscopic intraoperative RFA(IORFA)may be more effective than percutaneous RFA in terms of survival for HCC patients unsuitable for surgery,highlighting its ***,combining MIS-IORFA with these enhanced percutaneous RFA techniques may hold greater significance for HCC treatment using the MIS-IORFA *** article reviews liver resection and RFA in HCC treatment,comparing their merits and proposing a trajectory involving their combination in future therapy.

关键词： Percutaneous radiofrequency ablation Minimally invasive surgery Hepatocellular carcinoma Intraoperative radiofrequency ablation Contrast-enhanced ultrasound

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Causal-IQA: Towards the Generalization of Image Quality Assessment Based on Causal Inference 41

Causal-IQA: Towards the Generalization of Image Quality Asse...

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41st International Conference on Machine Learning, ICML 2024

作者： Zhong, Yan Wu, Xingyu Zhang, Li Yang, Chenxi Jiang, Tingting School of Mathematical Sciences Peking University Beijing China National Engineering Research Center of Visual Technology National Key Laboratory for Multimedia Information Processing School of Computer Science Peking University Beijing China Department of Computing The Hong Kong Polytechnic University Hong Kong Hefei Institute of Physical Science Chinese Academy of Sciences University of Science and Technology of China Hefei China National Biomedical Imaging Center Peking University Beijing China

Due to the high cost of Image Quality Assessment (IQA) datasets, achieving robust generalization remains challenging for prevalent deep learning-based IQA *** address this, this paper proposes a novel end-to-end blind IQA method: ***, we first analyze the causal mechanisms in IQA tasks and construct a causal graph to understand the interplay and confounding effects between distortion types, image contents, and subjective human ***, through shifting the focus from correlations to causality, Causal-IQA aims to improve the estimation accuracy of image quality scores by mitigating the confounding effects using a causality-based optimization *** optimization strategy is implemented on the sample subsets constructed by a Counterfactual Division process based on the Backdoor *** experiments illustrate the superiority of Causal-IQA. Copyright 2024 by the author(s)

关键词： Image correlation

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Comparison Between Dielectric Resonators and a High-Permittivity Helmet to Improve the Transmit Efficiency in the Brain

Comparison Between Dielectric Resonators and a High-Permitti...

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USNC-URSI Radio Science Meeting (Joint with AP-S Symposium)

作者： Giuseppe Carluccio Christopher M. Collins Daniele Riccio Giuseppe Ruello Department of Electrical Engineering and Information Technology University of Napoli Federico II Italy Department of Radiology Center for Advanced Imaging Innovation and Research (CAI2R) and Bernard and Irene Schwartz Center for Biomedical Imaging New York University School of Medicine New York NY USA

ISBN: (数字)9789463968119

ISBN: (纸本)9798350359497

In Magnetic Resonance imaging, it is becoming common to use High-Permittivity Materials to enhance SNR and transmit efficiency. In this work we are going to compare the efficacy of two different solutions to enhance transmit efficiency, one based on an HPM helmet, and another based on dielectric resonators. These solutions have been tested when 4 dipoles are used to generate the fields. Our simulations show an increase of the transmit efficiency in the center of the brain of 23.8 % when the HPM helmet is used, while no improvement was observed for the dielectric resonators.

关键词： Head Magnetic resonance imaging Conferences Brain modeling Safety Dielectrics Resonators

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Borosilicate bioactive glass synergizing low-dose antibiotic loaded implants to combat bacteria through ATP disruption and oxidative stress to sequentially achieve osseointegration

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Bioactive Materials 2025年第2期44卷 184-204页

作者： Mengke Fan Youliang Ren Yanbin Zhu Hao Zhang Shuaijie Li Chunyu Liu Hongzhi Lv Lei Chu Zhiyong Hou Yingze Zhang Haobo Pan Xu Cui Wei Chen Department of Orthopaedic Surgery the Hebei Medical University Third Hospital Orthopaedic Research Institution of Hebei ProvinceNHC Key Laboratory of Intelligent Orthopaedic EquipmentEngineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment of Ministry of EducationKey Laboratory of Biomechanics of Hebei ProvinceNo.139 Ziqiang RoadShijiazhuang050051PR China Shenzhen Key Laboratory of Marine Biomedical Materials CAS-HK Joint Lab of BiomaterialsThe Key Laboratory of Biomedical Imaging Science and SystemShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055PR China Department of Orthopaedics Second Affiliated Hospital of Chongqing Medical University76 Linjiang RoadYuzhong DistinctChongqing400010PR China Department of Orthopaedics Guizhou Provincial People’s HospitalGuiyang550000PR China Shenzhen Healthemes Biotechnology Co. Ltd.ShenzhenPR China

Bone infection is a catastrophe in clinical *** being the standard therapy for osteomyelitis,antibiotic-loaded polymethyl methacrylate(PMMA)cement has low efficiency against bacteria in ***,high-dose antibiotic-loaded implants carry risks of bacterial resistance,tissue toxicity,and impairment of local tissue *** incorporating borosilicate bioactive glass(BSG)into low-dose gentamicin sulfate(GS)-loaded PMMA cement,an intelligent strategy that synergistically eradicates bacteria and sequen-tially promotes osseointegration,was *** showed that BSG did not compromises the handling properties of the cement,but actually endowed it with an ionic and alkaline microenvironment,thereby damaging the integrity of bacterial cell walls and membranes,inhibiting ATP synthesis by disrupting the res-piratory chain in cell membranes and glycogen metabolism,and elevating reactive oxygen species(ROS)levels by weakening antioxidant components(peroxisomes and carotenoids).These antibacterial characteristics of BSG synergistically reinforced the effectiveness of GS,which was far below the actual clinical dosage,achieving efficient bacterial killing and biofilm clearance by binding to the 30S subunit of ***,the released GS and the ionic and alkaline microenvironment from the implants fostered the osteogenic activity of hBMSCs in vitro and coordinately enhanced osseointegration in ***,this study underscores that BSG incorporation offers a promising strategy for reducing antibiotic dosage while simultaneously enhancing the antibacterial activity and osteogenesis of *** approach holds potential for resolving the conflict be-tween bacterial resistance and bone infection.

关键词： Staphylococcus aureus Biofilm Osteomyelitis Borosilicate bioactive glass Polymethyl methacrylate

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Impact of Multiple Layers of High-Permittivity Materials on the EM Fields Transmission for Magnetic Resonance imaging Applications

Impact of Multiple Layers of High-Permittivity Materials on ...

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USNC-URSI Radio Science Meeting (Joint with AP-S Symposium)

作者： Giuseppe Carluccio Daniele Riccio Giuseppe Ruelle Department of Radiology Center for Advanced Imaging Innovation and Research (CAI2R) and Bernard and Irene Schwartz Center for Biomedical Imaging New York University School of Medicine New York NY USA Department of Electrical Engineering and Information Technology University of Napoli Federico II Italy

ISBN: (数字)9789463968119

ISBN: (纸本)9798350359497

High-Permittivity Materials have been used to increase and manipulate the radiofrequency field $\mathrm{B}_{1}$ in Magnetic Resonance imaging scans. In this work we have explored the possibility to enhance the $\mathrm{B}_{1}$ field even more by using High-Permittivity Pads with different permittivities positioned at different distance from the sample. We have tested this hypothesis by optimizing the permittivity of three layers of a 2D analytical solution, where infinitely long concentric cylinders are excited by a conducting wire. As a result, we have found an increase of the $\mathrm{B}_{1}$ field of about 8% in the center of symmetry of the cylinders.

关键词： Radio frequency Geometry Analytical models Magnetic resonance imaging Conferences Numerical models Wire

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