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Monocular meta-imaging camera sees depth

Light(Science & Applications) 2025年第1期14卷 8-9页

作者： Yujin Liu Xueli Chen nnovation Center for Advanced Medical Imaging and Intelligent Medicine Guangzhou Institute of TechnologyXidian UniversityGuangzhou510555GuangdongChina Center for Biomedical-photonics and Molecular Imaging Advanced Diagnostic-Therapy Technology and Equipment Key Laboratory of Higher Education Institutions in Shaanxi ProvinceSchool of Life Science and TechnologyXidian UniversityXi’an710126ShaanxiChina Engineering Research Center of Molecular and Neuro Imaging Ministry of Education&Xi’an Key Laboratory of Intelligent Sensing and Regulation of trans-Scale Life InformationSchool of Life Science and TechnologyXidian UniversityXi’an710126ShaanxiChina

A novel monocular depth-sensing camera based on meta-imaging sensor technology has been developed,offering more precise depth sensing with millimeter-level accuracy and enhanced robustness compared to conventional 2D ... 详细信息

关键词： offering precise millimeter

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Transducer design for high-efficient acoustic droplet ejection

Transducer design for high-efficient acoustic droplet ejecti...

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2023 IEEE International Ultrasonics Symposium, IUS 2023

作者： Huang, Youta Zhang, Yang Wu, Weichang Zheng, Hairong Qiu, Weibao Zhang, Zhiqiang Yu, Yanyan Shenzhen University School of Biomedical Engineering Shenzhen China University of South China School of Electrical Engineering Hengyang China Shenzhen Institute of Advanced Technology Paul C. Lauterbur Research Center for Biomedical Imaging Shenzhen China

ISBN: (纸本)9798350346459

Acoustic droplet ejection (ADE) has the advantage of mitigating cross-contamination and reducing cost for high-throughput liquid transfer. The ultrasound transducer design is important for the ADE systems. However, the commonly used systems with single-element focused transducer requires mechanical operation for focusing at different liquid surfaces positions, resulting into low liquid transfer efficiency. In this study, we designed a 15MHz annular array transducer enabling electronic focusing in axial direction, thereby allowing high efficient positioning of the liquid surfaces without mechanical operation. The proposed array element has a center frequency of 15.1MHz and a bandwidth of 88%. Transducer characterization results demonstrate the annular array has the ability of focusing at different depths, which enables high-efficient droplet ejection and liquid transfer. © 2023 IEEE.

关键词： Ultrasonic transducers

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NIR-Responsive Methotrexate-Modified Iron Selenide Nanorods for Synergistic Magnetic Hyperthermic, Photothermal, and Chemodynamic Therapy

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ACS Applied Materials and Interfaces 2024年第20期16卷 25622-25636页

作者： Thirumurugan, Senthilkumar Muthiah, Kayalvizhi Samuvel Lin, Yu-Chien Dhawan, Udesh Liu, Wai-Ching Wang, An-Ni Liu, Xinke Hsiao, Michael Tseng, Ching-Li Chung, Ren-Jei No. 1 Section 3 Zhongxiao East Road Taipei10608 Taiwan Centre for the Cellular Microenvironment Division of Biomedical Engineering James Watt School of Engineering Mazumdar-Shaw Advanced Research Centre University of Glasgow GlasgowG116EW United Kingdom Faculty of Science and Technology Technological and Higher Education Institute of Hong Kong Hong Kong New Territories999077 Hong Kong Scrona AG Grubenstrasse 9 Zürich8045 Switzerland College of Materials Science and Engineering Chinese Engineering and Research Institute of Microelectronics Shenzhen University Shenzhen518060 China Department of Electrical and Computer Engineering National University of Singapore Singapore117583 Singapore Genomics Research Center Academia Sinica Taipei115 Taiwan Department and Graduate Institute of Veterinary Medicine School of Veterinary Medicine National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Taipei10608 Taiwan

Breast cancer is a malignant tumor with a high mortality rate among women. Therefore, it is necessary to develop novel therapies to effectively treat this disease. In this study, iron selenide nanorods (FeSe2 NRs) were designed for use in magnetic hyperthermic, photothermal, and chemodynamic therapy (MHT/PTT/CDT) for breast cancer. To illustrate their efficacy, FeSe2 NRs were modified with the chemotherapeutic agent methotrexate (MTX). MTX-modified FeSe2 (FeSe2-MTX) exhibited excellent controlled drug release properties. Fe2+ released from FeSe2 NRs induced the release of •OH from H2O2 via a Fenton/Fenton-like reaction, enhancing the efficacy of CDT. Under alternating magnetic field (AMF) stimulation and 808 nm laser irradiation, FeSe2-MTX exerted potent hyperthermic and photothermal effects by suppressing tumor growth in a breast cancer nude mouse model. In addition, FeSe2 NRs can be used for magnetic resonance imaging in vivo by incorporating their superparamagnetic characteristics into a single nanomaterial. Overall, we presented a novel technique for the precise delivery of functional nanosystems to tumors that can enhance the efficacy of breast cancer treatment. © 2024 The Authors. Published by American Chemical Society

关键词： Magnetic resonance imaging

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High-quality endoscopic laser speckle contrast imaging with conical fiber illumination

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Photonics research 2025年第3期13卷 583-592页

作者： JUNSHUAI YAN QINXIN HAN LIANGWEI MENG TINGYU SUN YAN YAN SHIJIE FENG SHAOMIN YUAN JINLING LU PENGCHENG LI Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics Advanced Biomedical Imaging Facility-Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China Research Unit of Multimodal Cross Scale Neural Signal Detection and Imaging Chinese Academy of Medical ScienceHUST-Suzhou Institute for BrainsmaticsJITRISuzhou 215100China State Key Laboratory of Digital Medical Engineering Key Laboratory of Biomedical Engineering of Hainan ProvinceSchool of Biomedical EngineeringHainan UniversitySanya 572025China

Blood flow is essential for maintaining normal physiological functions of the human *** laser speckle contrast imaging(LSCI)can achieve rapid,high-resolution,label-free,and long-term blood flow perfusion velocity monitoring in minimally invasive ***,conventional endoscopic LSCI uses a lowcoherence laser illumination scheme,leading to restricted angles of illumination,compromised laser coherence,uneven laser illumination distribution,and low coupling efficiency,all of which degrade the quality of LSCI in the *** this paper,we propose that conical fiber(CF)-coupled high-coherence laser can be used to achieve large-angle,high-coherence,high-uniformity,and high coupling efficiency laser illumination in the ***,we establish an effective model for calculating the divergence angle of *** phantom and animal experiments,we reveal that laser illumination based on CF markedly enhances endoscopic LSCI *** technology broadens the imaging field of view,enhances the signal-to-noise ratio,enables more sensitive detection of minute blood flow changes,expands the detectable flow range,and improves signal-to-background ratio of endoscopic *** findings suggest that CF-based laser illumination stands as a highly promising advancement in endoscopic LSCI.

关键词： conical fiber maintaining normal physiological functions lowcoherence laser illumination schemeleading laser speckle contrast imaging lsci can endoscopic laser speckle contrast imaging blood flow blood flow perfusion velocity monitoring high coherence laser

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Raster-scanning Donut simplifies MINFLUX and provides alternative implement on other scanning-based microscopes

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Light(Science & Applications) 2022年第10期11卷 2271-2275页

作者： Xinzhu Xu Shu Jia Peng Xi Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing 100871China Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlantaGeorgia 30332USA UTS-SUStech Joint Research Centre for Bio-medical Materials&Devices Department of Biomedical EngineeringCollege of EngineeringSouthern University of Science and TechnologyShenzhenGuangdong 518055China National Biomedical Imaging Center Peking UniversityBeijing 100871China

A donut excitation moves around a single molecule with a zigzag configuration lattice by *** a method implemented in scanning fluorescence microscopy simplifies the conventional MINFLUX *** of hollow zero-intensity excitation,single-pixel detection,time-correlated single photon counting,and drift stabilization,the system achieves localization precision and resolution very close to conventional MINFLUX theoretically and *** averaged high-SNR reference,and pixel-registered intensity from a single molecule is essential to reconstruct localization in maximum likelihood *** performance reaching nearly conventional MINFLUX's,the proposed raster-scanning MINFLUX can inspire researchers expertized in STED or confocal setup to quickly transform to MINFLUX and develop for further exploring on bio-specimens or optical applications.

关键词： scanning excitation stabilization

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Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer’s disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assay

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Nano research 2023年第5期16卷 7459-7469页

作者： Liding Zhang Ying Su Xiaohan Liang Kai Cao Qingming Luo Haiming Luo Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology(HUST)Wuhan 430074China MoE Key Laboratory for Biomedical Photonics School of Engineering SciencesHuazhong University of Science and TechnologyWuhan 430074China Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Biomedical Engineering of Hainan Province School of Biomedical EngineeringHainan UniversityHaikou 570228China Research Unit of Multimodal Cross Scale Neural Signal Detection and Imaging Chinese Academy of Medical SciencesHUST-Suzhou Institute for BrainsmaticsJiangsu Industrial Technology Research Institute(JITRI)Suzhou 215123China

Phosphorylation of tau at Ser(396,404)(p-tau^(396,404))is one of the earliest phosphorylation events,plasma p-tau^(396,404) level appears to be a potentially promising biomarker of Alzheimer’s disease(AD).The low abundance and easy degradation of p-tau in the plasma make the lateral flow assay(LFA)a suitable choice for point-of-care detection of plasma p-tau^(396,404) ***,based on our screening of a pair of p-tau^(396,404)-specific antibodies,we developed a colorimetric and surface-enhanced Raman scattering(SERS)dual-readout LFA for the rapid,highly sensitive,robust detection of plasma p-tau^(396,404) *** LFA realized a detection limit of 60 pg/mL by the naked eye or 3.8 pg/mL by SERS without cross-reacting with other tau *** importantly,LFA rapidly and accurately differentiated AD patients from healthy controls,suggesting that it has the potential for clinical point-of-care application in AD *** dual-readout LFA has the advantages of simple operation,rapid,ultra-sensitive detection,providing a new way for early AD diagnosis and intervention,especially in primary and community AD screening.

关键词： Alzheimer’s disease p-tau^(396,404) plasma detection surface-enhanced Raman scattering lateral flow assay

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Hyperspectral Time-Resolved Compressive Sensing Spectroscopy for Monitoring Cytochrome-c-Oxidase and Blood Oxygenation 15

Hyperspectral Time-Resolved Compressive Sensing Spectroscopy...

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Optical Tomography and Spectroscopy of Tissue XV 2023

作者： Li, Natalie C. Ioussoufovitch, Seva Diop, Mamadou School of Biomedical Engineering Western University London Canada Dept. of Medical Biophysics Western University London Canada Imaging Program Lawson Health Research Institute London Canada

ISBN: (纸本)9781510658578

Time-resolved (TR) near-infrared spectroscopy (NIRS) is a promising technique for neuromonitoring, but there are currently very few TR-NIRS devices with the spectral range and resolution needed for accurate monitoring of cerebral blood oxygenation (StO2) and metabolism (cytochrome-c-oxidase;oxCCO). Here we present a hyperspectral TR compressive sensing spectrometer with a wide spectral range, high spectral resolution, and no afterpulsing. A homogeneous blood-yeast phantom experiment was performed to evaluate the spectrometer’s ability to monitor StO2 and oxCCO with and without compression. The effect of using a 90% compression rate on the recovered changes in deoxyhemoglobin (Hb), oxyhemoglobin (HbO), and oxCCO concentrations was investigated. No meaningful differences were found between concentration changes recovered from uncompressed and compressed data, with mean differences of 0.16 ± 0.20 µM, -0.25 ± 0.21 µM, and -0.04 ± 0.10 µM for Hb, HbO, and oxCCO, respectively. The results show that changes in oxCCO and StO2 can be reliably monitored with a high compression rate. Future work will compare the performance of the TR spectrometer with that of a continuous-wave spectrometer to assess accuracy and will investigate the sensitivity of the device to oxCCO and StO2 changes in the bottom compartment of a 2-layer tissue-mimicking phantom. © 2023 SPIE.

关键词： Near infrared spectroscopy

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Atrophy of the cholinergic regions advances from early to late mild cognitive impairment

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Neuroradiology 2024年第4期66卷 543-556页

作者： Lai, Ying-Liang Larry Hsu, Fei-Ting Yeh, Shu-Yi Kuo, Yu-Tzu Lin, Hui-Hsien Lin, Yi-Chun Kuo, Li-Wei Chen, Cheng-Yu Liu, Hua-Shan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei Taiwan Department of Biological Science and Technology China Medical University Taichung Taiwan School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan CT/MR Division Rotary Trading CO. LTD Taipei Taiwan Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli Taiwan Institute of Medical Device and Imaging National Taiwan University College of Medicine Taipei Taiwan Department of Radiology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Medical Imaging Taipei Medical University Hospital Medical University Taipei Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan

Purpose: We investigated the volumetric changes in the components of the cholinergic pathway for patients with early mild cognitive impairment (EMCI) and those with late mild cognitive impairment (LMCI). The effect of patients’ apolipoprotein 4 (APOE-ε4) allele status on the structural changes were analyzed. Methods: Structural magnetic resonance imaging data were collected. Patients’ demographic information, plasma data, and validated global cognitive composite scores were included. Relevant features were extracted for constructing machine learning models to differentiate between EMCI (n = 312) and LMCI (n = 541) and predict patients’ neurocognitive function. The data were analyzed primarily through one-way analysis of variance and two-way analysis of covariance. Results: Considerable differences were observed in cholinergic structural changes between patients with EMCI and LMCI. Cholinergic atrophy was more prominent in the LMCI cohort than in the EMCI cohort (P < 0.05 family-wise error corrected). APOE-ε4 differentially affected cholinergic atrophy in the LMCI and EMCI cohorts. For LMCI cohort, APOE-ε4 carriers exhibited increased brain atrophy (left amygdala: P = 0.001;right amygdala: P = 0.006, and right Ch123, P = 0.032). EMCI and LCMI patients showed distinctive associations of gray matter volumes in cholinergic regions with executive (R² = 0.063 and 0.030 for EMCI and LMCI, respectively) and language (R² = 0.095 and 0.042 for EMCI and LMCI, respectively) function. Conclusions: Our data confirmed significant cholinergic atrophy differences between early and late stages of mild cognitive impairment. The impact of the APOE-ε4 allele on cholinergic atrophy varied between the LMCI and EMCI groups. © 2024, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： APOE-ε4 allele cholinergic pathway Early mild cognitive impairment (EMCI) mild cognitive impairment (MCI) nucleus basalis of Meynert

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Rydberg-Induced Topological Solitons in Three-Dimensional Rotation Spin–Orbit-Coupled Bose–Einstein Condensates

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Chinese Physics Letters 2024年第9期41卷 9-14页

作者： Yang Wang Jinlong Cui Hongkai Zhang Yuan Zhao Siliu Xu Qin Zhou Key Laboratory of Optoelectronic Sensing and Intelligent Control Hubei University of Science and TechnologyXianning 437100China School of Electronic and Information Engineering Hubei University of Science and TechnologyXianning 437100China School of Biomedical Engineering and Imaging Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Research Center of Nonlinear Science School of Mathematics and Physical SciencesWuhan Textile UniversityWuhan 430200China

We present a novel approach for generating stable three-dimensional(3D)spatiotemporal solitons(SSs)within a rotating Bose–Einstein condensate,incorporating spin–orbit coupling(SOC),a weakly anharmonic potential and cold Rydberg *** intricate system facilitates the emergence of quasi-stable 3D SSs with topological charges|m|≤3 in two spinor components,potentially exhibiting diverse spatial *** findings reveal that the Rydberg long-range interaction,spin–orbit coupling,and rotational angular frequency exert significant influence on the domains of existence and stability of these ***,the Rydberg interaction contributes to a reduction in the norm of topological solitons,while the SOC plays a key role in stabilizing the SSs with finite topological *** research of SSs exhibits potential applications in precision measurement,quantum information processing,and other advanced technologies.

关键词： Rydberg topological Einstein

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Enhancing Scene Simplification and Optimization for Retinal Prosthesis Platform 5

Enhancing Scene Simplification and Optimization for Retinal ...

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5th International IEEE Novel Intelligent and Leading Emerging Sciences Conference, NILES 2023

作者： Holiel, Heidi Ahmed Fawzi, Sahar Ali Al-Atabany, Walid Nile University Medical Imaging and Image Processing Research Group Center for Informatics Science Sheikh Zayed City Egypt Cairo University Systems and Biomedical Engineering Department Giza Egypt Helwan University Biomedical Engineering Department Helwan Egypt

ISBN: (纸本)9798350381030

Retinal prostheses are designed to aid individuals with retinal degenerative conditions such as Retinitis Pigmentosa (RP) and Age-related Macular Degeneration (AMD). These prostheses seek to restore vision and improve the perceived scene by stimulating degenerated retinal cells using retinal stimulating electrodes. While these electrodes allow more efficient interaction with the surroundings, they offer limited *** paper presents an innovative approach to revolutionize the visual perception of retinal prosthesis users. The key idea behind the proposed approach is to fuse information extracted from advanced Meanshift and saliency detection algorithms. This proposed approach aims to improve the perceived scene for users, leading to enhanced visual perception and increased efficiency of retinal prostheses. © 2023 IEEE.

关键词： Computer vision

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