检索结果-内蒙古大学图书馆

Aggregate 2023年第5期4卷 34-62页

作者： Peili Cen Jiani Huang Chentao Jin Jing Wang Yen Wei Hong Zhang Mei Tian Department of Nuclear Medicine and PET Center The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangChina Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University HangzhouZhejiangChina Key Laboratory of Medical Molecular Imaging of Zhejiang Province HangzhouZhejiangChina Department of Chemistry and the Tsinghua Center for Frontier Polymer Research Tsinghua UniversityBeijingChina College of Biomedical Engineering&Instrument Science Zhejiang UniversityHangzhouZhejiangChina Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhouZhejiangChina Human Phenome Institute Fudan UniversityShanghaiChina

Cancer is one of the most fatal diseases for ***-induced emission luminogens(AIEgens)have been recently used as molecular imaging or therapeutic agents in cancers,due to the advantages of large Stokes shift,high quantum yield,great biocompatibility,and strong *** can specifically target different types of cancer via diverse targeting ***-based fluorescence imaging,especially near-infrared imaging,demonstrated deep penetration and suitable signal-to-noise ratio,which allows reliable in vivo cancer *** with other imaging modalities,AIEgen-based multimodal imaging could provide multidimensional cancer hallmarks from different *** addition,AIEgenbased phototherapy can be used for photodynamic therapy and photothermal therapy,which facilitate ablation of cancer cells with good biosafety and high therapeutic effects in *** nanoparticles fabricated with some specific chemicals,drugs,or siRNA,could display synergistic therapeutic effects for *** paper comprehensively describes the current status and future perspectives of AIEgens,which have showed a great potential for the future preclinical and clinical translation on in vivo molecular imaging and theranostics in cancer.

关键词： aggregation-induced emission cancer near-infrared imaging phototherapy targeting strategy theranostics

来源：评论

学校读者我要写书评

暂无评论

A novel label-free electrochemical immunosensor for the detection of heat shock protein 70 of lung adenocarcinoma cell line following paclitaxel treatment using l-cysteine-functionalized Au@MnO2/MoO3 nanocomposites

引用

RSC Advances 2023年第43期13卷 29847-29861页

作者： Chen, Yi-An Shie, Ming-You Ho, Chia-Che Ye, Sheng-Wen Chen, I.-Wen Peter Shih, Yu-Yin Shen, Yu-Fang Chen, Yi-Wen x-Dimension Center for Medical Research and Translation China Medical University Hospital Taichung City404332 Taiwan The Master Program for Biomedical Engineering China Medical University Taichung City406040 Taiwan Department of Biomedical Engineering China Medical University Taichung City40447 Taiwan Department of Bioinformatics and Medical Engineering Asia University Taichung City41354 Taiwan Department of Chemistry National Cheng Kung University Tainan70101 Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung City40447 Taiwan

The future trend in achieving precision medicine involves the development of non-invasive cancer biomarker sensors that offer high accuracy, low cost, and time-saving benefits for risk clarification, early detection, disease detection, and therapeutic monitoring. A facile approach for the synthesis of MoO3 nanosheets was developed by thermally oxidizing MoS2 nanosheets in air followed by thermal annealing. Subsequently, Au@MnO2 nanocomposites were prepared using a combined hydrothermal process and in situ chemical synthesis. In this study, we present a novel immunosensor design strategy involving the immobilization of antiHSP70 antibodies on Au@MnO2/MoO3 nanocomposites modified on a screen-printed electrode (SPE) using EDC/NHS chemistry. This study establishes HSP70 as a potential biomarker for monitoring therapeutic response during anticancer therapy. Impedance measurements of HSP70 on the Au@MnO2/MoO3/SPE immunosensor using EIS showed an increase in impedance with an increase in HSP70 concentration. The electrochemical immunosensor demonstrated a good linear response in the range of 0.001 to 1000 ng mL−1 with a detection limit of 0.17 pg mL−1 under optimal conditions. Moreover, the immunosensor was effective in detecting HSP70 at low concentrations in a lung adenocarcinoma cell line following Paclitaxel treatment, indicating its potential for early detection of the HSP70 biomarker in organ-on-a-chip and clinical applications. © 2023 The Royal Society of Chemistry.

关键词： Nanosheets

来源：评论

学校读者我要写书评

暂无评论

Novel STING-targeted PET radiotracer for alert and therapeutic evaluation of acute lung injury

引用

Acta Pharmaceutica Sinica B 2023年第5期13卷 2124-2137页

作者： Duo Xu Fan Yang Jiayao Chen Tianxing Zhu Fen Wang Yitai Xiao Zibin Liang Lei Bi Guolong Huang Zebo Jiang Hong Shan Dan Li Center for Interventional Medicine the Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Nuclear Medicine the Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging the Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Pathology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China

Acute lung injury(ALI),as a common clinical emergency,is pulmonary edema and diffuse lung infiltration caused by *** lack of non-invasive alert strategy,resulting in failure to carry out preventive treatment,means high mortality and poor *** of interferon genes(STING)is a key molecular biomarker of innate immunity in response to inflammation,but there is still a lack of STING-targeted *** this study,a novel STING-targeted PET tracer,[~(18)F]FBTA,was labeled with high radiochemical yield(79.7±4.3%)and molar activity(32.5±2.9 GBq/μmol).We confirmed that[~(18)F]FBTA has a strong STING binding affinity(K_d=26.86±6.79 nmol/L)and can be used for PET imaging in ALI mice to alert early lung inflammation and to assess the efficacy of drug *** STING-targeted strategy also reveals that[~(18)F]FBTA can trace ALI before reaching the computed tomography(CT)diagnostic criteria,and demonstrates its better specificity and distribution than[~(18)F]fluorodeoxyglucose([~(18)F]FDG).

关键词： Acute lung injury(ALI) Stimulator of interferon genes(STING) PET imaging [~(18)F]FBTA

来源：评论

学校读者我要写书评

暂无评论

Fabricating 3-dimensional human brown adipose microtissues for transplantation studies

引用

Bioactive Materials 2023年第4期22卷 518-534页

作者： Ou Wang Li Han Haishuang Lin Mingmei Tian Shuyang Zhang Bin Duan Soonkyu Chung Chi Zhang Xiaojun Lian Yong Wang Yuguo Lei Department of Chemical and Biomolecular Engineering University of Nebraska-LincolnNEUSA Biomedical Engineering Program University of Nebraska-LincolnNEUSA Department of Biomedical Engineering Pennsylvania State UniversityPAUSA China Novartis Institutes for BioMedical Research Co. Ltd.BeijingChina Department of Chemistry University of Nebraska-LincolnNEUSA Mary&Dick Holland Regenerative Medicine Program and Division of Cardiology Department of Internal MedicineUniversity of Nebraska Medical CenterOmahaNEUSA Department of Nutrition University of MassachusettsAmherstMAUSA School of Biological Science University of Nebraska-LincolnNEUSA Huck Institutes of the Life Sciences Pennsylvania State UniversityPAUSA

Transplanting cell cultured brown adipocytes(BAs)represents a promising approach to prevent and treat obesity(OB)and its associated metabolic disorders,including type 2 diabetes mellitus(T2DM).However,transplanted BAs have a very low survival rate in *** enzymatic dissociation during the harvest of fully differentiated BAs also loses significant *** is a critical need for novel methods that can avoid cell death during cell preparation,transplantation,and in ***,we reported that preparing BAs as injectable microtissues could overcome the *** found that 3D culture promoted BA differentiation and UCP-1 expression,and the optimal initial cell aggregate size was 100μ*** microtissues could be produced at large scales via 3D suspension assisted with a PEG hydrogel and could be *** microtissues could survive in vivo for long *** alleviated body weight and fat gain and improved glucose tolerance and insulin sensitivity in high-fat diet(HFD)-induced OB and T2DM *** microtissues impacted multiple organs,secreted protein factors,and influenced the secretion of endogenous *** our best knowledge,this is the first report on fabricating human BA microtissues and showing their safety and efficacy in T2DM *** proposal of transplanting fabricated BA microtissues,the microtissue fabrication method,and the demonstration of efficacy in T2DM mice are all *** results show that engineered 3D human BA microtissues have considerable advantages in product scalability,storage,purity,safety,dosage,survival,and efficacy.

关键词： Brown adipocyte Microtissue Transplantation Obesity Type 2 diabetes

来源：评论

学校读者我要写书评

暂无评论

Coevolution of Myoelectric Hand Control under the Tactile Interaction among Fingers and Objects

引用

Cyborg and Bionic Systems 2022年第1期2022卷 285-302页

作者： Yuki Kuroda Yusuke Yamanoi Shunta Togo Yinlai Jiang Hiroshi Yokoi Joint Doctoral Program for Sustainability Research Graduate School of Informatics and Engineering The University of Electro-CommunicationsTokyoJapan Department of Mechan ical and Intelligent System Engineering Graduate School of Informatics and Engineering The University of Electro Communications TokyoJapan Center for Neuroscience and Biomedical Engineering The University of Electro Communications TokyoJapan Bejing Innovation Center for Inelligent Robots and Systems BeijingChina

The usability of a prosthetic hand difers significantly from that of a real ***,the complexity of manipulation increases as the number of degrees of freedom to be controlled increases,making manipulation with biological signals extremely *** overcome this problem,users need to select a grasping posture that is adaptive to the object and a stable grasping method that prevents the object from *** previous studies,these have been left to the operating skills of the user,which is extremely difficult to *** this study,we demonstrate how stable and adaptive grasping can be achieved according to the object regardless of the user's operation *** required grasping technique is achieved by determining the correlation bet ween the motor output and each sensor through the interaction between the prosthetic hand and the surrounding stimuli,such as myoelectricity,sense of touch,and grasping *** agents of the 16 DOF robot hand were trained with the myoelectric signals of six participants,including one child with a congenital forearm ***,each agent could open and close the hand in response to the myoeletric stimuli and could accomplish the object pickup *** the tasks,the agents successfully identified grasping patterns suitable for practical and stable positioning of the *** addition,the agents were able to pick up the object in a similar posture regardless of the partiipant,suggesting that the hand was optimized by evolutionary computation to a posture that prevents the object from being dropped.

关键词： robot Objects overcome

来源：评论

学校读者我要写书评

暂无评论

Biomimetic nanoparticles directly remodel immunosuppressive microenvironment for boosting glioblastoma immunotherapy

引用

Bioactive Materials 2022年第10期7卷 418-432页

作者： Tingting Wang Hao Zhang Weibao Qiu Yaobao Han Hanghang Liu Zhen Li Center for Molecular Imaging and Nuclear Medicine State Key Laboratory of Radiation Medicine and ProtectionSchool for Radiological and Interdisciplinary Sciences(RAD-X)Soochow UniversityCollaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSuzhou215123PR China Paul C.Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055PR China

Glioblastoma(GBM),as a very aggressive cancer of central nervous system,is very challenging to completely cure by the conventional combination of surgical resection with radiotherapy and *** success of emerging immunotherapy in hot tumors has attracted considerable interest for the treatment of GBM,but the unique tumor immunosuppressive microenvironment(TIME)of GBM leads to the failure of ***,we show the significant improvement of the immunotherapy efficacy of GBM by modulating the TIME through novel all-in-one biomimetic nanoparticles(***-I/J@CM NPs).The nanoparticles consist of utrasmall Cu2-xSe nanoparticles(NPs)with outstanding intrinsic properties(e.g.,photo-responsive Fenton-like catalytic property for inducing immunogenic cell death(ICD)and alleviating the hypoxia of tumor),indoximod(IND,an inhibitor of indoleamine-2,3-dioxygenease in tumor),JQ1(an inhibitor for reducing the expression of PD-L1 by tumor cells),and tumor cell membrane for improving the targeting capability and accumulation of nanoparticles in *** reveal that these smart CS-I/J@CM NPs could drastically activate the immune responses through remodeling TIME of GBM by multiple *** could(1)increase M1-phenotype macrophages at tumor site by promoting the polarization of tumor-associated macrophages through the reactive oxygen species(ROS)and oxygen generated from the Fenton-like reaction between nanoparticles and H2O2 within tumor under NIR II irradiation;(2)decrease the infiltration of Tregs cells at tumor site through the release of IND;(3)decrease the expression of PD-L1 on tumor cells through *** notable increments of anti-tumor CD8+T cells in the tumor and memory T cells(TEM)in the spleen show excellent therapy efficacy and effectively prevent the recurrence of GBM after modulation of the *** work demonstrates the modulation of TIME could be a significant strategy to improve the immunotherapy of GBM and other cold tumors.

关键词： Glioblastoma Immunotherapy Ultrasmall copper selenide nanoparticles Tumor immune microenvironment Immune checkpoint blockade therapy

来源：评论

学校读者我要写书评

暂无评论

Realization of NIR-II 3D whole-body contour and tumor blood vessels imaging in small animals using rotational stereo vision technique

引用

Journal of biomedical Optics 2023年第9期28卷

作者： Su, Shih-Po Lee, Yun-Chen Lin, Syue-Liang Li, Yi-Xuan Lin, Min-Ying Chan, Yang-Hsiang Lee, Yi-Jang Yang, Muh-Hwa Chiang, Huihua Kenny National Yang Ming Chiao Tung University Department of Biomedical Engineering Taipei Taiwan National Yang Ming Chiao Tung University Biomedical Engineering Research and Development Center Taipei Taiwan National Yang Ming Chiao Tung University Department of Applied Chemistry Hsinchu Taiwan National Yang Ming Chiao Tung University Department of Biomedical Imaging and Radiological Sciences Taipei Taiwan National Yang Ming Chiao Tung University Institute of Clinical Medicine Taipei Taiwan

Significance: Optical imaging in the second near-infrared (NIR-II, 1000 to 1700 nm) region is capable of deep tumor vascular imaging due to low light scattering and low autofluorescence. Non-invasive real-time NIR-II fluorescence imaging is instrumental in monitoring tumor status. Aim: Our aim is to develop an NIR-II fluorescence rotational stereo imaging system for 360-deg three-dimensional (3D) imaging of whole-body blood vessels, tumor vessels, and 3D contour of mice. Approach: Our study combined an NIR-II camera with a 360-deg rotational stereovision technique for tumor vascular imaging and 3D surface contour for mice. Moreover, self-made NIR-II fluorescent polymer dots were applied in high-contrast NIR-II vascular imaging, along with a 3D blood vessel enhancement algorithm for acquiring high-resolution 3D blood vessel images. The system was validated with a custom-made 3D printing phantom and in vivo experiments of 4T1 tumor-bearing mice. Results: The results showed that the NIR-II 3D 360-deg tumor blood vessels and mice contour could be reconstructed with 0.15 mm spatial resolution, 0.3 mm depth resolution, and 5 mm imaging depth in an ex vivo experiment. Conclusions: The pioneering development of an NIR-II 3D 360-deg rotational stereo imaging system was first applied in small animal tumor blood vessel imaging and 3D surface contour imaging, demonstrating its capability of reconstructing tumor blood vessels and mice contour. Therefore, the 3D imaging system can be instrumental in monitoring tumor therapy effects. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License.

关键词： Blood vessels

来源：评论

学校读者我要写书评

暂无评论

Age-Dependent Spatial Patterns of Brain Noise in fMRI Series 46

Age-Dependent Spatial Patterns of Brain Noise in fMRI Series

引用

46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Scarciglia, Andrea Catrambone, Vincenzo Bianco, Martina Bonanno, Claudio Toschi, Nicola Valenza, Gaetano University of Pisa School of Engineering Bioengineering and Robotics Research Center E.Piaggio Department of Information Engineering Italy University of Pisa Department of Mathematics Italy University of Rome 'Tor Vergata' Department of Biomedicine and Prevention Rome Italy Mgh and Harvard Medical School A.A. Martinos Center for Biomedical Imaging BostonMA United States

ISBN: (纸本)9798350371499

Functional Magnetic Resonance imaging (fMRI) serves as a unique non-invasive tool for investigating brain function by analyzing blood oxygenation level-dependent (BOLD) series. These signals result from the complex interplay between deterministic and stochastic components underpinning biological brain activity. In this context, the quantification of the stochastic component, here defined as brain noise, is challenging without making assumptions on the deterministic dynamics. Leveraging on Approximate Entropy, in this study we present a methodological framework aimed to estimate intrinsic stochastic brain dynamics through fMRI data analysis without making assumption on the deterministic model. We estimated brain noise from fMRI series of 200 participants from the publicly available Cam-CAN dataset, aiming to quantify the amount of stochastic dynamics in different brain regions. Moreover, we hypothesize that a functional relationship exists between intrinsic brain noise and subject's age. Results indicate that a significant part - approximately 18% to 60% - of the fMRI signal power can be attributed to the intrinsic stochastic dynamics within the brain, and a linear augmentation is reported in association with the maturation process. These findings underscore the physiological importance of characterizing neural noise and its unique distributions across various brain regions. © 2024 IEEE.

关键词： Stochastic models

来源：评论

学校读者我要写书评

暂无评论

The Role of Echocardiography Segmentation Evaluation Metrics in Clinical Diagnosis 3

The Role of Echocardiography Segmentation Evaluation Metrics...

引用

3rd International Conference on Computer Vision and Pattern Analysis, ICCPA 2023

作者： Chen, Zihang Zhang, Shihui Hou, Siyu Zhao, Weijie Liu, Jingyang Xiao, Jingjing Bioengineering College Chongqing University Chongqing China Department of Medical Engineering Xinqiao Hospital Army Medical University Chongqing China School of Biomedical Engineering and Medical Imaging Army Medical University Chongqing China Bio-Med Informatics Research Center & Clinical Research Center Xinqiao Hospital Army Medical University Chongqing China

ISBN: (纸本)9781510667563

Echocardiography segmentation is important to quantify cardiac function. Although the segmentation algorithms have achieved considerable performance in image segmentation, the significance of those state-of-the-art (SOTA) segmentation algorithms for clinical diagnosis is not clear. Therefore, this paper comprehensively discussed the significance of the SOTA segmentation algorithm for clinical diagnosis by using segmentation evaluation metrics and diagnostic evaluation metrics. Firstly, four different SOTA segmentation algorithms were used to segment the 2D echocardiography, and the segmentation results were evaluated by using the Dice similarity coefficient (DSC) and Hausdorff distance (HD) which were defined as the segmentation evaluation metrics). Secondly, on the basis of the segmented areas, four diagnose-related image features were extracted, including lower wall thickness (LWT), front wall thickness (FWT), left ventricular transverse diameter (LVTD), and left atrial thickness (LAT). Then, the correlation and difference of those features extracted from the segmented areas and ground truth were statistically analyzed, which were defined as diagnostic evaluation metrics. The results showed that SwinUNet model had the best segmentation results in terms of segmentation evaluation metrics. Among them, SwinUNet's mHD value reached (16.95±1.38)mm and its mDSC value reached (90.16±2.78)%. However, for diagnostic evaluation metrics, there was a significant difference in the LVTD (P © 2023 SPIE.

关键词： Echocardiography

来源：评论

学校读者我要写书评

暂无评论

Altered topology in cortical morphometric similarity network in recurrent major depressive disorder

引用

Journal of Psychiatric research 2025年 181卷 206-213页

作者： Xu, Ziyun Zhou, Zhifeng Tao, Weiqun Lai, Wentao Qian, Long Cui, Wei Peng, Bo Zhang, Yingli Hou, Gangqiang Neuropsychiatry Imaging Center Department of Radiology Shenzhen Kangning Hospital Shenzhen Mental Health Center Guangdong Shenzhen 518020 China Department of Psychiatry Acute Intervention Female Ward 1 Shenzhen Kangning Hospital Shenzhen Mental Health Center Shenzhen 518000 China Department of Depressive Disorder Shenzhen Kangning Hospital Shenzhen Mental Health Center Shenzhen 518000 China Department of Biomedical Engineering College of Engineering Peking University Beijing 100871 China MR Research GE Healthcare Beijing 100176 China

Background: Recurrent major depressive disorder (RDD) is increasingly understood to be associated with a 'disconnection' within the brain areas. But, the true understanding of cortical connectivities remains challenging. Morphometric similarity network (MSN) with multi-modal magnetic resonance imaging (MRI) could provide more information about cortical micro-architecture changes in individuals with RDD. Methods: Here, we integrated multi-modal features from T1-weighted imaging, diffusion tensor imaging (DTI), and inhomogeneous magnetization transfer imaging (ihMT) to construct MSN. We used graph theory to calculate topological changes in MSN and explore their relationship with the severity and recurrence. The topological properties of 42 RDD patients were compared with 56 age, sex, and education-matched healthy controls. Results: RDD subjects showed significantly decreased global efficiency, increased characteristic path length, reduced nodal efficiencies in the parietal lobe, subcortical area, and temporal lobe, increased betweenness centrality in the left supplementary motor area (SMA), decreased intra-modular connections in the parietal module and decreased inter-modular connections between the parietal and prefrontal modules. Notably, the global efficiency, characteristic path length, local efficiency of the right superior parietal gyrus, and inter-modular connections between the parietal and prefrontal modules were significantly associated with the number of depressive episodes. The betweenness centrality in SMA and the intra-modular connections in the parietal module showed a positive relationship with 17-item Hamilton Rating Scale for Depression (HAMD) scores. Conclusions: The altered topology of MSN may serve as potential underlying pathological mechanisms of RDD. The impaired information integration of the network, particularly the disconnection within the fronto-parietal network, may be associated with the recurrence of depression. The SMA and the fronto-p

关键词： Diffusion tensor imaging Graph theory Inhomogeneous magnetization transfer imaging Morphometric similarity network Recurrent depressive disorder

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：