检索结果-内蒙古大学图书馆

The immune-chemo-embolization effect of temperature sensitive gold nanomedicines against liver cancer

Nano research 2023年第2期16卷 2749-2761页

作者： Yiming Liu Dingwen Shi Yanqiao Ren Ling Li Yanbing Zhao Chuansheng Zheng Xiangliang Yang Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China National Engineering Research Center for Nanomedicine Key Laboratory of Molecular Biophysics of Ministry of EducationCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China School of Biomedical Engineering Hubei University of Science and TechnologyXianning 437100China Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Hubei Engineering Research Center for Biomaterials and Medical Protective MaterialsHuazhong University of Science and TechnologyWuhan 430074China GBA Research Innovation Institute for Nanotechnology Guangzhou 510530China Hubei Province Key Laboratory of Molecular Imaging Wuhan 430022China

Although transcatheter arterial chemo-embolization(TACE)plays a key role on clinical treatment of hepatocellular carcinoma(HCC),it was greatly limited by the poor synergistic effect between chemotherapeutics and physical embolization to tumor-feeding *** the present work,a temperature sensitive polymer poly(N-isopropylacrylamide-b-methacrylic acid)(PNA),which was modified with gold nanoparticles(AuNP@PNA),was successfully used to encapsulate doxorubicin(DOX)by electrostatic binding with their carboxyl *** resultant gold nanomedicines(AuNP@PNA/DOX)exhibited temperature responsive sol-gel phase transition,favorable shear thinning effect and X-ray *** in vivo evaluation of vascular embolization on VX2-tumor-bearing rabbits,AuNP@PNA/DOX exhibited far better antitumor efficacy than Lipiodol/DOX,on either tumor growth inhibition,proliferation,apoptosis,necrosis or *** to sufficient embolization to tumor vascular networks,AuNP@PNA/DOX down-regulated the expression levels of HIF-1α,VEGF and MMP-9,and prompted more efficient activation on CD3+/CD8+T cells and the related cytokines,suggesting the synergistic effect between AuNP@PNA and DOX on the improvement of post-operative tumor immunosuppressive *** their favorable pharmcokinetics and biocompatibility,AuNP@PNA/DOX is promising to be developed as a multi-functional artery-imaging/embolic agent with immune-chemo-embolization for enhancing TACE efficacy on HCC.

关键词： temperature sensitive nanogels gold nanoparticles transcatheter arterial chemo-embolization(TACE) antitumor immune response

来源：评论

学校读者我要写书评

暂无评论

VIPNet: Combining Viewpoint Information and Shape Priors for Instant Multi-view 3D Reconstruction 17th

VIPNet: Combining Viewpoint Information and Shape Priors fo...

引用

17th Asian Conference on Computer Vision, ACCV 2024

作者： Ye, Weining Li, Zhixuan Jiang, Tingting School of Computer Science Peking University Beijing100871 China College of Computing and Data Science Nanyang Technological University Singapore Singapore National Engineering Research Center of Visual Technology National Key Laboratory for Multimedia Information Processing School of Computer Science National Biomedical Imaging Center Peking University Beijing100871 China

ISBN: (纸本)9789819609680

While the multi-view 3D reconstruction task has made significant progress, existing methods simply fuse multi-view image features without effectively leveraging available auxiliary information, especially the viewpoint information for guiding and associating features of different views. To this end, we propose to enhance multi-view 3D reconstruction with the power of viewpoint information. Specifically, a simple-yet-effective viewpoint estimator is designed to learn and provide comprehensive viewpoint knowledge for locating and associating learned features from different views. Moreover, to improve the 3D reconstruction quality when 2D images of only very few viewpoints are available, we propose to learn the shape prior knowledge to provide sufficient shape information for compensating the limited 2D observations. Overall, we present VIPNet, benefiting from Viewpoint Information and Shape Prior learning for high-quality multi-view 3D reconstruction. Extensive experiments validate the effectiveness of the proposed VIPNet, which achieves state-of-the-art performance on challenging datasets and shows well generalization ability in real-world scenarios. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： 3D modeling

来源：评论

学校读者我要写书评

暂无评论

Impact of random and scattered coincidences from outside of field of view on positron emission tomography/computed tomography imaging with different reconstruction protocols

引用

Nuclear Science and Techniques 2023年第12期34卷 40-52页

作者： Mahak Osouli Alamdari Pardis Ghafarian Arman Rahmim Mehrdad Bakhshayesh‑Karam Mohammad Reza Ay Department of Medical Physics Iran University of Medical SciencesTehranIran Chronic Respiratory Diseases Research Center National Research Institute of Tuberculosis and Lung Diseases(NRITLD)Shahid Beheshti University of Medical SciencesTehranIran PET/CT and Cyclotron Center Masih Daneshvari HospitalShahid Beheshti University of Medical SciencesTehranIran Departments of Radiology and Physics University of British ColumbiaVancouverBCCanada Research Center for Molecular and Cellular Imaging Advanced Medical Technologies and Equipment InstituteTehran University of Medical SciencesTehranIran Department of Medical Physics and Biomedical Engineering Tehran University of Medical SciencesTehranIran

Image quality in positron emission tomography(PET)is affected by random and scattered coincidences and reconstruction *** this study,we investigated the effects of scattered and random coincidences from outside the field of view(FOV)on PET image quality for different reconstruction *** was performed on the Discovery 690 PET/CT scanner,using experimental configurations including the NEMA phantom(a body phantom,with six spheres of different sizes)with a signal background ratio of 4:*** NEMA phantom(phantom I)was scanned separately in a one-bed *** simulate the effect of random and scatter coincidences from outside the FOV,six cylindrical phantoms with various diameters were added to the NEMA phantom(phantom II).The 18 emission datasets with mean intervals of 15 min were acquired(3 min/scan).The emission data were reconstructed using different *** image quality parameters were evaluated by both *** in the signal-to-noise ratio(SNR)in a 28-mm(10-mm)sphere of phantom II were 37.9%(86.5%)for ordered-subset expectation maximization(OSEM-only),36.8%(81.5%)for point spread function(PSF),32.7%(80.7%)for time of flight(TOF),and 31.5%(77.8%)for OSEM+PSF+TOF,respectively,indicating that OSEM+PSF+TOF reconstruction had the lowest noise levels and lowest coefficient of variation(COV)*** and scatter coincidences from outside the FOV induced lower SNR,lower contrast,and higher COV values,indicating image deterioration and significantly impacting smaller sphere *** reconstruction protocols,OSEM+PSF+TOF and OSEM+PSF showed higher contrast values for sphere sizes of 22,28,and 37 mm and higher contrast recovery coefficient values for smaller sphere sizes of 10 and 13 mm.

关键词： Positron emission tomography/computed tomography(PET/CT) Random coincidences Scatter coincidences·Time of flight(TOF) Point spread function(PSF) Field of view(FOV) Noise equivalent count rate(NECR) Signal-toNoise ratio(SNR)

来源：评论

学校读者我要写书评

暂无评论

A new three-dimensional elastography using phase based shifted Fourier transform

引用

Medicine in Novel Technology and Devices 2022年第4期16卷 323-334页

作者： Hadis Faraji Alireza Shirazinodeh Najmeh Meimani Hossein Ahmadi Noubari Bahador Makki Abadi Research Center for Molecular and Cellular Imaging Imam Khomeini HospitalTehranIran Department of Biomedical Engineering Science and Research BranchIslamic Azad UniversityTehranIran Department of Medical Physics and Biomedical Engineering Tehran University of Medical ScienceTehranIran Department of Electrical and Computer Engineering University of British ColumbiaCanada

Elastography is an imaging technique with the ability to determine low quantities of some of the mechanical properties of *** aim of our research is to design a new 3D algorithm using the Shifted Fourier Transform(SFT)to perform a quasi-static *** innovative idea is implementation of a 3D convolution instead of using three 2D *** first,we collected the raw data from Abaqus engineering software in the form of breast tissue with a coefficient of elasticity of healthy tissue and tumor tissue with a coefficient of elasticity of tumor *** primary raw data consists of a number of points with x,y and z specified for tumor and healthy breast *** this step,we simulated the displacements in directions of x,y and z at each point of the prescribed tissues for 15 mm displacement of probe in–Y direction then we collected 1831 points for tumor and 4186 points for breast before and after *** applying a novel reconstruction algorithm,we convolved all images with the 3D Gabor filters to obtain phases,represented displacements of the breast and tumor images for before and after *** reach this goal,we designed a Gabor filter bank based on the dimensions of the input images in different scales,directions,and *** the 3D SFT,we calculated the displacements of the breast and tumor tissues followed by 3D elastogram representation of the ***,we implemented a 2D analysis of SFT in order to investigate validation of the 3D *** 2D algorithm,we used three two-dimensional convulsions in XY,YZ and XZ *** results obtained from the small displacements marked by circles,confirmed the accuracy of the 3D SFT *** areas of interest are the tumor areas in the 2D analysis.

关键词： 3D elastography 3D shifted Fourier Transform 3D and 2D Gabor filters Breast and tumor tissues Reconstruction algorithm

来源：评论

学校读者我要写书评

暂无评论

Erratum to“Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer”

引用

research 2024年第3期6卷 797-798页

作者： Yun Zhou Mian Yu Changjun Tie Yang Deng Junqing Wang Yunfei Yi Fan Zhang Chenyi Huang Hairong Zheng Lin Mei Meiying Wu School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China Paul C.Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300192China

In the research Article “Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer,” the authors made an error in Fig. 6A. In Fig. 6A, the image of “pre” in the “Free Cy5-siRNA” group was misused. When incorporating the final images in Fig. 6A, another image of “24 h” in the “Free Cy5-siRNA” group was inadvertently chosen as the “Pre” image, so they appear to be remarkably similar. After the error was discovered, the authors repeated the experiments that concluded that this error did not affect the results, discussion, or conclusion of this paper. Figure 6A has now been corrected in the PDF and HTML (full text).

关键词： Internal Cancer Breast

来源：评论

学校读者我要写书评

暂无评论

Enhanced diabetic wound healing using platelet-derived extracellular vesicles and reduced graphene oxide in polymer-coordinated hydrogels

引用

Journal of Nanobiotechnology 2023年第1期21卷 1-17页

作者： Hao, Ping-Chien Burnouf, Thierry Chiang, Chih-Wei Jheng, Pei-Ru Szunerits, Sabine Yang, Jen-Chang Chuang, Er-Yuan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei10617 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei11031 Taiwan Univ. Lille CNRS Centrale Lille Univ. Polytechnique Hauts-de-France UMR 8520 IEMN LilleF- 59000 France Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei110-52 Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei11031 Taiwan

Impaired wound healing is a significant complication of diabetes. Platelet-derived extracellular vesicles (pEVs), rich in growth factors and cytokines, show promise as a powerful biotherapy to modulate cellular proliferation, angiogenesis, immunomodulation, and inflammation. For practical home-based wound therapy, however, pEVs should be incorporated into wound bandages with careful attention to delivery strategies. In this work, a gelatin-alginate hydrogel (GelAlg) loaded with reduced graphene oxide (rGO) was fabricated, and its potential as a diabetic wound dressing was investigated. The GelAlg@rGO-pEV gel exhibited excellent mechanical stability and biocompatibility in vitro, with promising macrophage polarization and reactive oxygen species (ROS)-scavenging capability. In vitro cell migration experiments were complemented by in vivo investigations using a streptozotocin-induced diabetic rat wound model. When exposed to near-infrared light at 2 W cm− 2, the GelAlg@rGO-pEV hydrogel effectively decreased the expression of inflammatory biomarkers, regulated immune response, promoted angiogenesis, and enhanced diabetic wound healing. Interestingly, the GelAlg@rGO-pEV hydrogel also increased the expression of heat shock proteins involved in cellular protective pathways. These findings suggest that the engineered GelAlg@rGO-pEV hydrogel has the potential to serve as a wound dressing that can modulate immune responses, inflammation, angiogenesis, and follicle regeneration in diabetic wounds, potentially leading to accelerated healing of chronic wounds. © 2023, BioMed Central Ltd., part of Springer Nature.

关键词： Platelets

来源：评论

学校读者我要写书评

暂无评论

Triphenylamine-AIEgens photoactive materials for cancer theranostics

引用

Chinese Chemical Letters 2024年第6期35卷 86-94页

作者： Junjie Wang Yan Wang Zhengdong Li Changqiang Xie Musammir Khan Xingzhou Peng Fabiao Yu State Key Laboratory of Digital Medical Engineering School of Biomedical EngineeringHainan UniversityHaikou 570228China Key Laboratory of Biomedical Engineering of Hainan Province One Health InstituteHainan UniversityHaikou 570228China Key Laboratory of Hainan Trauma and Disaster Rescue The First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikou 571199China Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices Key Laboratory of Emergency and TraumaMinistry of EducationKey Laboratory of Hainan Functional Materials and Molecular ImagingCollege of Emergency and TraumaHainan Medical UniversityHaikou 571199China Precision Medical Center Guangyuan City Centre hospitalGuangyuan 628099China School of Natural Sciences(SNS) National University of Science and Technology(NUST)H-12Islamabad 44000Pakistan

Triphenylamine(TPA)-based aggregation-induced emission luminogens(TPA-AIEgens),a type of photoactive material utilizing the typical TPA moiety,has recently attracted increasing attention for the diagnostics and treatment of tumors due to their remarkable chemo-physical performance in optoelectronic ***-AIEgens are distinguished from other photoactive agents by their strong fluorescence,good sensitivity,high signal-to-noise ratio,resistance to photobleaching,and lack of high concentration or aggregation-caused fluoresce quenching *** this review,we summarize the current advancements and the biomedical progress of TPA-AIEgens in tumor ***,the design principles of TPAAIEgens photoactive agents as well as the advanced targeting strategies for nuclei,cell membranes,cell organelle and tumors were introduced,***,the applications of TPA-AIEgens in tumor diagnosis and therapeutic techniques were ***,the challenges and prospects of TPA-AIEgens for cancer therapy were *** given landscape of the TPA-AIEgens hereby is meaningful for the further design and utilization of the novel photoactive material,which could be beneficial for the development of clinic applications.

关键词： Triphenylamine AIEgens Targeting Theranostics Phototherapy Immunotherapy

来源：评论

学校读者我要写书评

暂无评论

Association between antiplatelet medication and cerebral microbleeds in stroke-free population

引用

Journal of Geriatric Cardiology 2022年第6期19卷 409-417页

作者： Miao-Xin YU Ya-Nan JIA Dan-Dan YANG Run-Hua ZHANG Yong JIANG Gui-Tao ZHANG Hui-Yu QIAO Hua-Lu HAN Rui SHEN Zi-Han NING Xi-Hai ZHAO Gai-Fen LIU Yong-Jun WANG Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology the Third Hospital of Hebei Medical UniversityShijiazhuangChina Department of Radiology Beijing Geriatric HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Center for Biomedical Imaging Research Department of Biomedical EngineeringTsinghua UniversityBeijingChina Beijing Institute of Brain Disorders Capital Medical UniversityBeijingChina

BACKGROUND Cerebral microbleeds(CMBs)may increase the risk of future intracerebral hemorrhage and ischemic ***,It is unclear whether antiplatelet medication is associated with *** study aimed to investigate the association between antiplatelet medication and CMBs in a community-based stroke-free *** In this cross-sectional study,stroke-free participants aged 18-85 years were recruited from a community in Beijing,***,clinical,and antiplatelet medication data were collected through a questionnaire,and all participants underwent blood tests and brain magnetic resonance imaging at *** presence,count,and location of CMBs were evaluated using susceptibility-weighted *** association between antiplatelet medication and the presence of CMBs was analyzed using multivariable logistic *** associations between antiplatelet medication and CMBs by location(lobar,deep brain or infratentorial,and mixed regions)were also analyzed using multinomial logistic regression.A linear regression analysis was conducted to determine the association between antiplatelet medication and the log-transformed number of *** Of the 544 participants(mean age:58.65±13.66 years,217 males),119 participants(21.88%)had CMBs,and 64 participants(11.76%)used antiplatelet *** medication was found to be associated with CMBs at any location[odds ratio(OR)=2.39,95%CI:1.24-4.58]and lobar region(OR=2.83,95%CI:1.36-5.86),but not with the number of CMBs(β=0.14,95%CI:-0.21-0.48).Among antiplatelet medications,aspirin use was found to be associated with any CMB(OR=3.17,95%CI:1.49-6.72)and lobar CMBs(OR=3.61,95%CI:1.57-8.26).CONCLUSIONS Antiplatelet medication was associated with CMBs in stroke-free participants,particularly lobar *** antiplatelet medications,aspirin use was associated with any CMB and lobar *** findings suggest that it might be essential to optimize the management of antiplatelet medication in t

关键词： medication 3.0T antiplatelet

来源：评论

学校读者我要写书评

暂无评论

Double exposure ESPI for non-contact surface topography tracking 37

Double exposure ESPI for non-contact surface topography trac...

引用

Practical Holography XXXVII: Displays, Materials, and Applications 2023

作者： Wang, Hui Omidi, Parsa Diop, Mamadou Carson, Jeffrey J.L. Imaging Program Lawson Health Research Institute LondonON Canada School of Biomedical Engineering The University of Western Ontario LondonON Canada Department of Medical Biophysics The University of Western Ontario LondonON Canada Department of Surgery The University of Western Ontario LondonON Canada

ISBN: (纸本)9781510659957

In this paper, we introduce an electronic speckle pattern interferometry (ESPI) method for rapid assessment of transient deformations on an opaque object. The method records the change in speckle patterns over time, which relate to the change in phase of the reflected light. The system was capable of high-speed recordings enabled by a camera capable of double exposure and external triggering. Experiments were performed on an opaque PDMS phantom to track rapid surface movements from a piezoelectric acoustic driver located at the back of phantom. Acoustic pulses of different period and amplitude were tested. In each double exposure recording cycle, the image pair were digitally subtracted to reveal the change in the speckle pattern, which represented the change in phase of the object beam relative to the reference. We developed custom software to process the data, including an algorithm to unwrap the phase maps. Experiments revealed an ultimate sensitivity to displacements of approximately 1 nm for signals ranging in period from 50 µs to 200 µs. Future work will examine the capabilities of the system with respect to surfaces with different optical absorption and scattering characteristics. © 2023 SPIE.

关键词： Phantoms

来源：评论

学校读者我要写书评

暂无评论

Magneto-mechanical effect of magnetic microhydrogel for improvement of magnetic neuro-stimulation

引用

Nano research 2023年第5期16卷 7393-7404页

作者： Le Xue Qing Ye Linyuan Wu Dong Li Siyuan Bao Qingbo Lu Sha Liu Dongke Sun Zonghai Sheng Zhijun Zhang Ning Gu Jianfei Sun State Key Laboratory of Bioelectronics Jiangsu Key Laboratory of Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210009China School of Mechanic Engineering Southeast UniversityNanjing 211189China Department of Neurology Affiliated Zhongda HospitalSchool of MedicineInstitution of NeuropsychiatrySoutheast UniversityNanjing 210009China Paul C.Lauterbur Research Center for Biomedical Imaging Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong ProvinceShenzhen Key Laboratory of Ultrasound Imaging and TherapyCAS Key Laboratory of Health InformaticsInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Mental Health and Public Health Faculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Medicine Nanjing UniversityNanjing 210008China

Superparamagnetic iron oxide(SPIO)nanoparticles play an important role in mediating precise and effective magnetic neurostimulation and can help overcome limitations related to penetration depth and spatial ***,nanoparticles readily diffuse in vivo,decreasing the spatial resolution and activation *** this study,we employed a microfluidic means to fabricate injectable microhydrogels encapsulated with SPIO nanoparticles,which significantly improved the stability of nanoparticles,increased the magnetic properties,reinforced the stimulation *** fabricated magnetic microhydrogels were highly uniform in size and sphericity,enabling minimally invasive injection into brain *** long-term residency in the cortex up to 22 weeks and the safety of brain tissue were shown using a mouse *** addition,we quantitatively determined the magneto-mechanical force yielded by only one magnetic microhydrogel using a video-based *** force was found to be within 7–8 pN under 10 Hz magnetic stimulation by both theoretical simulation and experimental ***,electrophysiological measurement of brain slices showed that the magnetic microhydrogels offer significant advantages in terms of neural activation relative to dissociative SPIO nanoparticles.A universal strategy is thus offered for performing magnetic neuro-stimulation with an improved prospect for biomedical translation.

关键词： magnetic stimulation superparamagnetic iron oxide(SPIO)nanoparticles magnetic microhydrogel long-term residency magneto-mechanical effect

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：