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125. Peripheral lipopolysaccharide (LPS) injection causes amplified microglial activation, enhanced macrophage trafficking to the brain, and prolonged sickness behavior in socially defeated mice

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brain, Behavior, and Immunity 2011年 25卷 S215-S215页

作者： Wohleb, E.S. Fenn, A.M. Godbout, J.P. Sheridan, J.F. Neuroscience Graduate Studies Program The Ohio State University Columbus OH 43210 USA Oral Biology Section USA Molecular Virology Immunology and Medical Genetics USA Institute for Behavioral Medicine Research USA Center for Brain and Spinal Cord Injury USA

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Comparative effectiveness of psychotherapies in adults with posttraumatic stress disorder: a network meta-analysis of randomised controlled trials

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Psychological medicine 2023年第13期53卷 6376-6388页

作者： Ninik Yunitri Hsin Chu Xiao Linda Kang Bayu Satria Wiratama Tso-Ying Lee Li-Fang Chang Doresses Liu Christina Yeni Kustanti Kai-Jo Chiang Ruey Chen Philip Tseng Kuei-Ru Chou School of Nursing College of Nursing Taipei Medical University Taipei Taiwan. Mental Health and Psychiatric Nursing Department Faculty of Nursing Universitas Muhammadiyah Jakarta Indonesia. Institute of Aerospace and Undersea Medicine School of Medicine National Defense Medical Center Taipei Taiwan. Department of Neurology Tri-Service General Hospital National Defense Medical Center Taipei Taiwan. School of Nursing University of Pennsylvania Philadelphia USA. Department of Biostatistics Epidemiology and Population Health Universitas Gadjah Mada Yogyakarta Indonesia. Nursing Research Center Department of Nursing Taipei Medical University Hospital Taipei Taiwan. Department of Medical Education & Emergency and Critical Care Medicine Taipei Medical University Hospital Taipei Taiwan. School of Nursing National Defense Medical Center Taipei Taiwan. Graduate Institute of Medical Sciences National Defense Medical Center Taipei Taiwan. Department of Nursing Wan Fang Hospital Taipei Medical University Taipei Taiwan. Center for Nursing and Healthcare Research in Clinical Practice Application Wan Fang Hospital Taipei Medical University Taipei Taiwan. Sekolah Tinggi Ilmu Kesehatan Bethesda Yakkum Yogyakarta Indonesia. Department of Nursing Tri-Service General Hospital National Defense Medical Center Taipei Taiwan. Department of Nursing Taipei Medical University-Shuang Ho Hospital New Taipei Taiwan. Post-Baccalaureate Program in Nursing College of Nursing Taipei Medical University Taipei Taiwan. Graduate Institute of Mind Brain and Consciousness Taipei Medical University Taipei Taiwan. Brain and Consciousness Research Center TMU - Shuang Ho Hospital New Taipei Taiwan. Research Center for Mind Brain & Learning National Chengchi University Taipei Taiwan. Psychiatric Research Center Taipei Medical University Hospital Taipei Taiwan. Neuroscience Research Center Taipei Medical University Taipei Taiwan.

BACKGROUND:Evidence on the long-term comparative effectiveness of posttraumatic stress disorder (PTSD) psychotherapies in adults remains unknown. Therefore, we performed an extensive network meta-analysis of randomised controlled trials (RCTs) to determine the comparative effectiveness of psychotherapies for people diagnosed with PTSD. METHODS:A comprehensive search was conducted in Cochrane library, Embase, Medline-OVID, PubMed, Scopus, and Psych-Info until March 2021. Studies on the effectiveness of cognitive processing therapy (CPT), cognitive therapy (CT), eye movement desensitisation reprocessing (EMDR), narrative exposure therapy (NET), prolonged exposure (PE), cognitive behavioural therapy (CBT), present-centred therapy (PCT), brief eclectic psychotherapies (BEP), psychodynamic therapy (PDT) or combination therapies compared to no treatment (NT) or treatment as usual (TAU) in adults with PTSD were included. Frequentist and Bayesian approaches were used for analysis in R-software. RESULTS:We included 98 RCTs with 5567 participants from 18 897 studies. CPT, EMDR, CT, NET, PE, CBT, and PCT were significant to reduce PTSD symptoms (SMD range: -1.53 to -0.75; Certainty: very low to high) at immediate post-treatment and ranked accordingly. Longitudinal analysis found EMDR (1.02) and CPT (0.85) as the significant therapies with large effect size in short-term and long-term follow-up, respectively. NET and CPT showed higher proportion of loss of PTSD diagnosis (RR range: 5.51-3.45) while there were no significant psychotherapies for retention rate compared to NT. CONCLUSIONS:Our findings provide evidence for improving current guidelines and informing clinical decision-making for PTSD management. However, the best PTSD treatment plan should be tailored to patients' needs, characteristics, and clinician expertise. REGISTRATION:PROSPERO CRD42020162143.

关键词： Effectiveness PTSD network meta-analysis psychotherapies

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Publisher Correction: Viewpoints: how the hippocampus contributes to memory, navigation and cognition

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Nature neuroscience 2018年第7期21卷 1018页

作者： John Lisman György Buzsáki Howard Eichenbaum Lynn Nadel Charan Ranganath A David Redish Department of Biology Brandeis University Waltham MA USA. Lisman@brandeis.edu. NYU Neuroscience Institute New York University New York NY USA. Center for Memory and Brain Boston University Boston MA USA. Department of Psychology and Cognitive Science Program University of Arizona Tucson Arizona USA. Center for Neuroscience and Department of Psychology University of California Davis CA USA. Department of Neuroscience University of Minnesota Minneapolis MN USA.

In the version of this article initially published, author Charan Ranganath's last name was misspelled Rangananth in the author list. Also, A. David Redish (redish@***) has been added as a corresponding author. The error has been corrected, and the corresponding author added, in the HTML and PDF versions of the article.

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CCL5 Protects Cortical Neuron Function by Regulating M2 Microglia Activation After Mild Traumatic brain Injury

SSRN

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SSRN 2022年

作者： Tsai, Yih-Jeng Ho, Man-Hau Yen, Chia-Hung Wang, Jia-Yi Burnouf, Thierry Chen, Chia-Yen Wang, Yun Chiang, Yung-Hsiao Hoffer, Barry J. Chou, Szu-Yi Department of Otolaryngology Head and Neck Surgery Shin Kong Wu HoSu Memorial Hospital Taipei Taiwan School of Medicine Fu Jen Catholic University New Taipei City Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University National Health Research Institute Taiwan Graduate Institute of Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Biological Science and Technology National Pingtung University of Science and Technology Neipu Pingtung91201 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Neurosurgery Taipei Medical University Hospital Taipei11031 Taiwan Neuroscience Research Center Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan NeuroTMULille International Laboratory Taipei Medical University Taipei Taiwan International PhD Program in Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei Taiwan Brain and Consciousness Research Centre TMU Shuang Ho Hospital New Taipei City Taiwan Center for Neuropsychiatric Research National Health Research Institutes Zhunan Miaoli County Taiwan Department of Surgery School of Medicine College of Medicine Taipei Medical University 11031 Taiwan Department of Neurosurgery Case Western Reserve University School of Medicine ClevelandOH United States Scientist Emeritus National Institutes of Health United States International Master Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Cytokines and chemokines play important roles in inflammation and repair following brain injury. M1 microglia are pro-inflammatory which produce cytokines and lead to neural injury;in contrast, M2 microglia are anti-inflammatory, release neurotrophic factors, and promote neural repair processes. Chemokine CCL5, increased after TBI, shows a neuroprotective function by reducing oxidative stress. CCL5 may contribute to the balance between oxidative stress and immune responses after brain injury. Herein, we investigated the role of CCL5 in microglial polarization after mild traumatic brain injury, focusing on the cerebral cortex.C57BL/6 and CCL5 knockout (CCL5-KO) mice were given a mild traumatic brain injury (TBI) using weight-drop. Neurological parameters such as motor and sensory functions were analyzed by mNSS score, accelerating rotarod, beam walking, and adhesive removal tests. Oxidative stress and neuron damage were measured by NADPH oxidase activity, hypoxyloprobe staining and FJC. Performance of motor and sensory functions in both WT and CCL5-KO mice were impaired after brain injury which recovered after 7 days-post-injury (dpi) in the WT group but only after 14 days in the CCL5-KO mouse group. RT-qPCR analysis revealed that pro-inflammation cytokines - IL-1β, TNF-α, and IL-6 were higher in CCL5-KO mice compared to WT mice at 4 and 14 dpi. In contrast, M2-like microglia markers - IL-10 and Agr-1 were increased in WT mouse cortical tissue at 4 dpi. Oxidative stress increased both M1 and M2- related cytokine expression in BV2 cells treated with H 2 O 2;CCL5 treatment increased M2- but suppressed M1- related cytokine gene activation. Intranasal delivery of CCL5 reduced neuronal oxidative stress, increased IL-10 expression and improved motor and sensory functions in CCL5-KO mice after brain *** summary, CCL5, which alters immune responses and protects neurons from TBI damage, has an important function in regulating M2-like microglial polarization during post-

关键词： Polarization

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Neurovascular coupling in eye-open-eye-close task and resting state: Spectral correspondence between concurrent EEG and fMRI

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NeuroImage 2024年 289卷 120535-120535页

作者： Kung, Yi-Chia Li, Chia-Wei Hsu, Ai-Ling Liu, Chi-Yun Wu, Changwei W. Chang, Wei-Chou Lin, Ching-Po Department of Radiology Tri-Service General Hospital National Defense Medical Center Taipei Taiwan Department of Radiology Wan Fang Hospital Taipei Medical University Taipei Taiwan Bachelor Program in Artificial Intelligence Chang Gung University Taoyuan Taiwan Department of Psychiatry Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan Graduate Institute of Mind Brain and Consciousness Taipei Medical University Taipei Taiwan Research Center of Sleep Medicine Taipei Medical University Hospital Taipei Taiwan Institute of Neuroscience National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Education and Research Taipei City Hospital Taipei Taiwan

Neurovascular coupling serves as an essential neurophysiological mechanism in functional neuroimaging, which is generally presumed to be robust and invariant across different physiological states, encompassing both task engagement and resting state. Nevertheless, emerging evidence suggests that neurovascular coupling may exhibit state dependency, even in normal human participants. To investigate this premise, we analyzed the cross-frequency spectral correspondence between concurrently recorded electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data, utilizing them as proxies for neurovascular coupling during the two conditions: an eye-open-eye-close (EOEC) task and a resting state. We hypothesized that given the state dependency of neurovascular coupling, EEG-fMRI spectral correspondences would change between the two conditions in the visual system. During the EOEC task, we observed a negative phase-amplitude-coupling (PAC) between EEG alpha-band and fMRI visual activity. Conversely, in the resting state, a pronounced amplitude-amplitude-coupling (AAC) emerged between EEG and fMRI signals, as evidenced by the spectral correspondence between the EEG gamma-band of the midline occipital channel (O_z) and the high-frequency fMRI signals (0.15–0.25 Hz) in the visual network. This study reveals distinct scenarios of EEG-fMRI spectral correspondence in healthy participants, corroborating the state-dependent nature of neurovascular coupling. © 2024

关键词： Amplitude-amplitude-coupling (AAC) Electroencephalography (EEG) Functional magnetic resonance imaging (FMRI) Hilbert-Huang transform (HHT) Neurovascular coupling Phase-amplitude-coupling (PAC) Resting state

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Author Correction: Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex

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Nature neuroscience 2020年第1期23卷 152页

作者： Rianne D Stowell Grayson O Sipe Ryan P Dawes Hanna N Batchelor Katheryn A Lordy Brendan S Whitelaw Mark B Stoessel Jean M Bidlack Edward Brown Mriganka Sur Ania K Majewska Department of Neuroscience University of Rochester Medical Center Rochester NY USA. Neuroscience Graduate Program University of Rochester Medical Center Rochester NY USA. Picower Institute for Learning and Memory Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge MA USA. Department of Pharmacology and Physiology University of Rochester Medical Center Rochester NY USA. Department of Biomedical Engineering University of Rochester Rochester NY USA. Department of Neuroscience University of Rochester Medical Center Rochester NY USA. ania_majewska@urmc.rochester.edu. Center for Visual Science University of Rochester Medical Center Rochester NY USA. ania_majewska@urmc.rochester.edu.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood

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Neurobiology of Sleep and Circadian Rhythms 2024年 16卷 100103页

作者： Jameson, Alexis N. Siemann, Justin K. Grueter, Carrie A. Grueter, BradA. McMahon, Douglas G. Neuroscience Graduate Program Vanderbilt University Nashville 37232 TN United States Vanderbilt Brain Institute Vanderbilt University Nashville 37232 TN United States Kennedy Center for Research on Human Development Vanderbilt University Nashville 37232 TN United States Department of Anesthesiology Vanderbilt University Medical Center Nashville 37232 TN United States Vanderbilt Center for Addiction Research Vanderbilt University Nashville 37232 TN United States Department of Molecular Physiology and Biophysics Vanderbilt University Nashville 37232 TN United States Department of Pharmacology Vanderbilt University Nashville 37232 TN United States Department of Biological Sciences Vanderbilt University Nashville 37232 TN United States

Day length, or photoperiod, is a reliable environmental cue encoded by the brain's circadian clock that indicates changing seasons and induces seasonal biological processes. In humans, photoperiod, age, and sex have been linked to seasonality in neuropsychiatric disorders, as seen in Seasonal Affective Disorder, Major Depressive Disorder, and Bipolar Disorder. The nucleus accumbens is a key locus for the regulation of motivated behaviors and neuropsychiatric disorders. Using periadolescent and young adult male and female mice, here we assessed photoperiod's effect on serotonin and dopamine tissue content in the nucleus accumbens core, as well as on accumbal synaptic dopamine release and uptake. We found greater serotonin and dopamine tissue content in the nucleus accumbens from young adult mice raised in a Short winter-like photoperiod. In addition, dopamine release and clearance were greater in the nucleus accumbens from young adult mice raised in a Long summer-like photoperiod. Importantly, we found that photoperiod's effects on accumbal dopamine tissue content and release were sex-specific to young adult females. These findings support that in mice there are interactions across age, sex, and photoperiod that impact critical monoamine neuromodulators in the nucleus accumbens which may provide mechanistic insight into the age and sex dependencies in seasonality of neuropsychiatric disorders in humans. © 2024 The Authors

关键词： Adolescence Dopamine Nucleus accumbens Photoperiod Sex differences

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Cover Image, Volume 29, Issue 9

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Hippocampus 2019年第9期29卷

作者： Beate Knauer Motoharu Yoshida International Graduate School of Neuroscience Ruhr University Bochum Bochum Germany Faculty of Psychology Mercator Research Group – Structure of Memory Ruhr University Bochum Bochum Germany Institute of Pathophysiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany Leibniz Institute for Neurobiology (LIN) Magdeburg Germany German Center for Neurodegenerative Diseases (DZNE) Magdeburg Germany Center for Behavioral Brain Sciences Magdeburg Germany

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Physiologic Artifacts When Combining EEG and tDCS

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brain Stimulation 2017年第4期10卷 e33-e33页

作者： Nigel Gebodh Devin Adair Kenneth Chelette Zeinab Esmaeilpour Marom Bikson Jacek Dmochowski Adam Woods Emily Kappenman Neural Engineering Laboratory Department of Biomedical Engineering The City College of the City University of New York New York NY USA Department of Psychology The Graduate Center at City University of New York New York NY USA ANT Neuro North America Madison WI USA Biomedical Engineering Department Amirkabir University of Technology Tehran Iran Center for Cognitive Aging and Memory Institute on Aging McKnight Brain Institute Department of Aging and Geriatric Research University of Florida Gainesville FL USA Center for Cognitive Aging and Memory Institute on Aging McKnight Brain Institute Department of Neuroscience University of Florida Gainesville FL USA Center for Mind & Brain and Department of Psychology University of California Davis CA USA

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Novel bioengineered hydrogel combined with brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor improves functional recovery following traumatic contusive spinal cord injury

Novel bioengineered hydrogel combined with brain-derived neu...

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2nd International Neural Regeneration Symposium(INRS2012)(第二届国际神经再生高峰论坛)

作者： Melissa J.Walker Xiao-Ming Xu Wenjie Wu Lingxiao Deng Jian Zou Chandler L.Walker Qingbo Lu Naikui Liu Xuejun Wen Ning Zhang Departments of Bioengineering Cell Biology & Anatomy Orthopedic Surgery Hollings Cancer Center Clemson University and Medical University of South Carolina Charleston South Carolina USA Department of Neurological Surgery Indiana University School of Medicine Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis Indiana USA Indiana Spinal Cord and Brain Injury Research Group Indiana University School of Medicine Medical Neuroscience Graduate Program Indiana University School of Medicine Departments of Bioengineering Microbiology & Immunology and Cell Biology & Anatomy Clemson University and Medical University of South Carolina Charleston South Carolina USA Department of Anatomy & Cell Biology Indiana University School of Medicine

The initial mechanical insult resulting from traumatic spinal cord injury (SCI) causes the disruption of local vasculature and tissue structure followed by a secondary wave of injury involving hemorrhage, ischemia, edema, excitotoxicity, and inflammation, which leads to neuronal death, axonal degeneration, and inhibitory glial scar formation.

关键词： spinal cord injury hydrogel neurotrauma

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