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Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021

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The Lancet 2023年第10397期402卷 203-234页

作者： Ong, Kanyin Liane Stafford, Lauryn K. McLaughlin, Susan A. Boyko, Edward J. Vollset, Stein Emil Smith, Amanda E. Dalton, Bronte E. Duprey, Joe Cruz, Jessica A. Hagins, Hailey Lindstedt, Paulina A. Aali, Amirali Abate, Yohannes Habtegiorgis Abate, Melsew Dagne Abbasian, Mohammadreza Abbasi-Kangevari, Zeinab Abbasi-Kangevari, Mohsen ElHafeez, Samar Abd Abd-Rabu, Rami Abdulah, Deldar Morad Abdullah, Abu Yousuf Md Abedi, Vida Abidi, Hassan Aboagye, Richard Gyan Abolhassani, Hassan Abu-Gharbieh, Eman Abu-Zaid, Ahmed Adane, Tigist Demssew Adane, Denberu Eshetie Addo, Isaac Yeboah Adegboye, Oyelola A. Adekanmbi, Victor Adepoju, Abiola Victor Adnani, Qorinah Estiningtyas Sakilah Afolabi, Rotimi Felix Agarwal, Gina Aghdam, Zahra Babaei Agudelo-Botero, Marcela Arriagada, Constanza Elizabeth Aguilera Agyemang-Duah, Williams Ahinkorah, Bright Opoku Ahmad, Danish Ahmad, Rizwan Ahmad, Sajjad Ahmad, Aqeel Ahmadi, Ali Ahmadi, Keivan Ahmed, Ali Ahmed, Luai A. Ahmed, Syed Anees Ajami, Marjan Akinyemi, Rufus Olusola Al Hamad, Hanadi Al Hasan, Syed Mahfuz AL-Ahdal, Tareq Mohammed Ali Alalwan, Tariq A. Al-Aly, Ziyad AlBataineh, Mohammad T. Alcalde-Rabanal, Jacqueline Elizabeth Alemi, Sharifullah Ali, Hassam Alinia, Tahereh Aljunid, Syed Mohamed Almustanyir, Sami Al-Raddadi, Rajaa M. Alvis-Guzman, Nelson Amare, Firehiwot Ameyaw, Edward Kwabena Amiri, Sohrab Amusa, Ganiyu Adeniyi Andrei, Catalina Liliana Anjana, Ranjit Mohan Ansar, Adnan Ansari, Golnoosh Ansari-Moghaddam, Alireza Anyasodor, Anayochukwu Edward Arabloo, Jalal Aravkin, Aleksandr Y. Areda, Demelash Arifin, Hidayat Arkew, Mesay Armocida, Benedetta Arnlov, Johan Artamonov, Anton A. Arulappan, Judie Aruleba, Raphael Taiwo Arumugam, Ashokan Aryan, Zahra Asemu, Mulu Tiruneh Asghari-Jafarabadi, Mohammad Askari, Elaheh Asmelash, Daniel Astell-Burt, Thomas Athar, Mohammad Athari, Seyyed Shamsadin Atout, Maha Moh'd Wahbi Avila-Burgos, Leticia Awaisu, Ahmed Azadnajafabad, Sina Darshan, B.B. Babamohamadi, Hassan Badar, Muhammad Badawi, Alaa Badiye, Ashish D. Baghcheghi, Nayereh Baghe Institute for Health Metrics and Evaluation School of Medicine General Medicine Service Department of Veterans Affairs Seattle WA United States Department of Health Metrics Sciences School of Medicine Faculty of Medicine France Department of Clinical Governance and Quality Improvement Aleta Wondo Hospital Aleta Wondo Ethiopia Department of Nursing Woldia University Woldia Ethiopia Department of Nursing Department of Orthopedic Surgery Orthopaedic Surgery Social Determinants of Health Research Center Non-communicable Diseases Research Center Epidemiology Department Evidence-Based Practice Center Community and Maternity Nursing Unit University of Duhok Duhok Iraq School of Planning Faculty of Environment Department of Public Health Sciences Penn State College of Medicine Pennsylvania State University Hershey PA United States Biocomplexity Institute Virginia Tech Blacksburg VA United States College of Medicine Department of Public Health Laboratory Technology Sciences Department Department of Family and Community Health University of Health and Allied Sciences Ho Ghana Research Center for Immunodeficiencies Department of Biosciences and Nutrition Karolinska University Hospital Huddinge Sweden Clinical Sciences Department Department of Surgery Department of Surgery Department of Obstetrics & Gynecology College of Graduate Health Sciences University of Tennessee Memphis TN United States Department of Obstetrics & Gynecology Department of Clinical and Psychosocial Epidemiology Department of Anesthesia and Critical Care Centre for Social Research in Health Quality and Systems Performance Unit Cancer Institute NSW Sydney NSW Australia Department of Public Health and Tropical Medicine HIV and Infectious Diseases Department Jhpiego Abuja Nigeria Adolescent Research and Care Department Adolescent Friendly Research Initiative and Care Ado Ekiti Nigeria Department of Epidemiology Department of Epidemiology and Medical Statistics Department of Family Medicine McMaster University

Background: Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Glo...

Background: Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050. Methods: Estimates of diabetes prevalence and burden were computed in 204 countries and territories, across 25 age groups, for males and females separately and combined;these estimates comprised lost years of healthy life, measured in disability-adjusted life-years (DALYs;defined as the sum of years of life lost [YLLs] and years lived with disability [YLDs]). We used the Cause of Death Ensemble model (CODEm) approach to estimate deaths due to diabetes, incorporating 25 666 location-years of data from vital registration and verbal autopsy reports in separate total (including both type 1 and type 2 diabetes) and type-specific models. Other forms of diabetes, including gestational and monogenic diabetes, were not explicitly modelled. Total and type 1 diabetes prevalence was estimated by use of a Bayesian meta-regression modelling tool, DisMod-MR 2.1, to analyse 1527 location-years of data from the scientific literature, survey microdata, and insurance claims;type 2 diabetes estimates were computed by subtracting type 1 diabetes from total estimates. Mortality and prevalence estimates, along with standard life expectancy and disability weights, were used to calculate YLLs, YLDs, and DALYs. When appropriate, we extrapolated estimates to a hypothetical population with a standardised age structure to allow comparison in populations with different age structures. We used the comparative r

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Correction: DYRK1A-related intellectual disability: a syndrome associated with congenital anomalies of the kidney and urinary tract

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Genetics in medicine : official journal of the American College of Medical Genetics 2020年第4期22卷 821页

作者： Alexandria T M Blackburn Nasim Bekheirnia Vanessa C Uma Mark E Corkins Yuxiao Xu Jill A Rosenfeld Matthew N Bainbridge Yaping Yang Pengfei Liu Suneeta Madan-Khetarpal Mauricio R Delgado Louanne Hudgins Ian Krantz David Rodriguez-Buritica Patricia G Wheeler Lihadh Al-Gazali Aisha Mohamed Saeed Mohamed Al Shamsi Natalia Gomez-Ospina Hsiao-Tuan Chao Ghayda M Mirzaa Angela E Scheuerle Mary K Kukolich Fernando Scaglia Christine Eng Helen Rankin Willsey Michael C Braun Dolores J Lamb Rachel K Miller Mir Reza Bekheirnia Department of Pediatrics Pediatric Research Center University of Texas Health Science Center McGovern Medical School Houston TX USA. Program in Genetics and Epigenetics The University of Texas MD Anderson Cancer Center University of Texas Health Science Center Graduate School of Biomedical Sciences Houston TX USA. Renal Section Department of Pediatrics Baylor College of Medicine Houston TX USA. Texas Children's Hospital Houston TX USA. Baylor College of Medicine Houston TX USA. Department of Psychiatry Weill Institute for Neurosciences University of California San Francisco CA USA. Department of Molecular and Cell Biology University of California Berkeley CA USA. Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA. Codified Genomics LLC Houston TX USA. Rady Children's Institute for Genomic Medicine San Diego CA USA. Baylor Genetics Houston TX USA. Children's Hospital of Pittsburgh of UPMC University of Pittsburgh School of Medicine Pittsburgh PA USA. Department of neurology and Neurotherapeutics The University of Texas Southwestern Medical Center Dallas TX USA. Department of Pediatrics Division of Medical Genetics Stanford University Stanford CA USA. Division of Human Genetics The Children's Hospital of Philadelphia and the Department of Pediatrics Perelman School of medicine at University of Pennsylvania Philadelphia PA USA. Department of Pediatrics McGovern Medical School The University of Texas Health Science Center at Houston Houston TX USA. Arnold Palmer Hospital Orlando FL USA. College of Medicine and Health Sciences United Arab Emirates University Al-Ain United Arab Emirates. Paediatrics Department Tawam Hospital Al-Ain United Arab Emirates. Department of Pediatrics Section of Neurology and Developmental Neuroscience Baylor College of Medicine Houston TX USA. Department of Neuroscience Baylor College of Medicine Houston TX USA. Jan and Dan Duncan Neurological Research Institute Texas Child

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Author Correction: A consensus protocol for functional connectivity analysis in the rat brain

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Nature neuroscience 2023年 2023 Apr 18页

作者： Joanes Grandjean Gabriel Desrosiers-Gregoire Cynthia Anckaerts Diego Angeles-Valdez Fadi Ayad David A Barrière Ines Blockx Aleksandra Bortel Margaret Broadwater Beatriz M Cardoso Marina Célestine Jorge E Chavez-Negrete Sangcheon Choi Emma Christiaen Perrin Clavijo Luis Colon-Perez Samuel Cramer Tolomeo Daniele Elaine Dempsey Yujian Diao Arno Doelemeyer David Dopfel Lenka Dvořáková Claudia Falfán-Melgoza Francisca F Fernandes Caitlin F Fowler Antonio Fuentes-Ibañez Clément M Garin Eveline Gelderman Carla E M Golden Chao C G Guo Marloes J A G Henckens Lauren A Hennessy Peter Herman Nita Hofwijks Corey Horien Tudor M Ionescu Jolyon Jones Johannes Kaesser Eugene Kim Henriette Lambers Alberto Lazari Sung-Ho Lee Amanda Lillywhite Yikang Liu Yanyan Y Liu Alejandra López-Castro Xavier López-Gil Zilu Ma Eilidh MacNicol Dan Madularu Francesca Mandino Sabina Marciano Matthew J McAuslan Patrick McCunn Alison McIntosh Xianzong Meng Lisa Meyer-Baese Stephan Missault Federico Moro Daphne M P Naessens Laura J Nava-Gomez Hiroi Nonaka Juan J Ortiz Jaakko Paasonen Lore M Peeters Mickaël Pereira Pablo D Perez Marjory Pompilus Malcolm Prior Rustam Rakhmatullin Henning M Reimann Jonathan Reinwald Rodrigo Triana Del Rio Alejandro Rivera-Olvera Daniel Ruiz-Pérez Gabriele Russo Tobias J Rutten Rie Ryoke Markus Sack Piergiorgio Salvan Basavaraju G Sanganahalli Aileen Schroeter Bhedita J Seewoo Erwan Selingue Aline Seuwen Bowen Shi Nikoloz Sirmpilatze Joanna A B Smith Corrie Smith Filip Sobczak Petteri J Stenroos Milou Straathof Sandra Strobelt Akira Sumiyoshi Kengo Takahashi Maria E Torres-García Raul Tudela Monica van den Berg Kajo van der Marel Aran T B van Hout Roberta Vertullo Benjamin Vidal Roël M Vrooman Victora X Wang Isabel Wank David J G Watson Ting Yin Yongzhi Zhang Stefan Zurbruegg Sophie Achard Sarael Alcauter Dorothee P Auer Emmanuel L Barbier Jürgen Baudewig Christian F Beckmann Nicolau Beckmann Guillaume J P C Becq Erwin L A Blezer Radu Bolbos Susann Boretius Sandrine Bouvard Eike Budinger Joseph D Buxbaum Diana Cash Victor Donders Institute for Brain Behaviour and Cognition Radboud University Nijmegen The Netherlands. joanes.grandjean@radboudumc.nl. Department for Medical Imaging Radboud University Medical Center Nijmegen The Netherlands. joanes.grandjean@radboudumc.nl. Cerebral Imaging Centre Douglas Mental Health University Institute Verdun QC Canada. Integrated Program in Neuroscience McGill University Montreal QC Canada. Bio-imaging Lab University of Antwerp Antwerp Belgium. µNEURO Research Centre of Excellence University of Antwerp Antwerp Belgium. Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro Mexico. Biological and Biomedical Engineering McGill University Montreal QC Canada. McConnell Brain Imaging Centre McGill University Montreal QC Canada. Montreal Neurological Institute McGill University Montreal QC Canada. UMR INRAE/CNRS 7247 Physiologie des Comportements et de la Reproduction Physiologie de la reproduction et des comportements Centre de recherche INRAE de Nouzilly Tours France. Department of Neurology and Neurosurgery McGill University Montreal QC Canada. Center for Animal MRI University of North Carolina at Chapel Hill Chapel Hill NC USA. Department of Neurology University of North Carolina at Chapel Hill Chapel Hill NC USA. Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill NC USA. Preclinical MRI Champalimaud Research Champalimaud Centre for the Unknown Lisbon Portugal. Laboratoire des Maladies Neurodégénératives Molecular Imaging Research Center (MIRCen) Université Paris-Saclay Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA) CNRS Fontenay-aux-Roses France. Departamento de Neurobiología Conductual y Cognitiva Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro México. Translational Neuroimaging and Neural Control Group High-Field Magnetic Resonance Max Planck Institute for Biological Cyberneti

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Genome wide conditional mouse knockout resources

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Drug Discovery Today: Disease Models 2016年 20卷 3-12页

作者： Kaloff, C. Anastassiadis, K. Ayadi, A. Baldock, R. Beig, J. Birling, M.-C. Bradley, A. Brown, S.D.M. Bürger, A. Bushell, W. Chiani, F. Collins, F.S. Doe, B. Eppig, J.T. Finnell, R.H. Fletcher, C. Flicek, P. Fray, M. Friedel, R.H. Gambadoro, A. Gates, H. Hansen, J. Herault, Y. Hicks, G.G. Hörlein, A. Hrabé de Angelis, M. Iyer, V. de Jong, P.J. Koscielny, G. Kühn, R. Liu, P. Lloyd, K.C.K. Lopez, R.G. Marschall, S. Martínez, S. McKerlie, C. Meehan, T. von Melchner, H. Moore, M. Murray, S.A. Nagy, A. Nutter, L.M.J. Pavlovic, G. Pombero, A. Prosser, H. Ramirez-Solis, R. Ringwald, M. Rosen, B. Rosenthal, N. Rossant, J. Ruiz Noppinger, P. Ryder, E. Skarnes, W.C. Schick, J. Schnütgen, F. Schofield, P. Seisenberger, C. Selloum, M. Smedley, D. Simpson, E.M. Stewart, A.F. Teboul, L. Tocchini Valentini, G.P. Valenzuela, D. West, A.P. Wurst, W. Institute of Developmental Genetics Helmholtz Zentrum Muenchen Neuherberg D-85764 Germany Biotechnology Center (BIOTEC) of the Technische Universität Dresden Dresden 01307 Germany CELPHEDIA PHENOMIN Institut Clinique de la Souris (ICS) CNRS INSERM University of Strasbourg 1 rue Laurent Fries Illkirch-Graffenstaden F-67404 France MRC Human Genetics Unit Institute of Genetics and Molecular Medicine University of Edinburgh College of Medicine and Veterinary Medicine Edinburgh EH4 2XU Scotland United Kingdom The Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton Cambridge CB101HH United Kingdom Mammalian Genetics Unit and Mary Lyon Centre MRC Harwell Harwell Science and Innovation Campus Oxfordshire OX110RD United Kingdom Monterotondo Mouse Clinic Italian National Research Council (CNR) Institute of Cell Biology and Neurobiology Monterotondo-Scalo Rome I-00015 Italy National Human Genome Research Institute National Institutes of Health Bethesda 20892 MD United States The Jackson Laboratory Bar Harbor 04609 ME United States Dell Pediatric Research Institute The University of Texas at Austin Austin 78712 TX United States University of Texas at Austin Austin 78712 TX United States National Institutes of Health Bethesda 20205 MD United States European Bioinformatics Institute (EBI) Hinxton Cambridge CB101ST United Kingdom Fishberg Department of Neuroscience Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York 10029 New York United States Institut de Génétique et de Biologie Moléculaire et Cellulaire Université de Strasbourg 1 rue Laurent Fries Illkirch 67404 France Centre National de la Recherche Scientifique UMR7104 Illkirch France Institut National de la Santé et de la Recherche Médicale U964 Illkirch France Université de Strasbourg 1 rue Laurent Fries Illkirch 67404 France University of Manitoba Manitoba Institute of Cell Biology Winnipeg R3EOV9 MB Canada Institute of Epidemiology II Helmh

The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic ...

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Assessing the impact of falls on neuropsychiatric symptoms in patients with neurodegenerative disease

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Alzheimer's & Dementia 2023年第S18期19卷

作者： Goldin Joghataie Allison Ann Dilliott Andrew R Frank Anthony E Lang Angela C Roberts Angela Troyer Brian Levine Stephen R. Arnott Brian Tan Corinne E. Fischer Connie Marras Donna Kwan Douglas Munoz David F. Tang-Wai Elizabeth Finger Ekaterina Rogaeva Joseph B Orange Joel Ramirez Kelly M Sunderland Lorne Zinman Malcolm Binns Michael Borrie Mario Masellis Morris Freedman Manuel Montero-Odasso Miracle Ozzoude Robert Bartha Richard H. Swartz Agessandro Abrahao Bill McIlroy Michael J. Strong Carmela Tartaglia University of Toronto Toronto ON Canada University Health Network Toronto ON Canada The Tanz Centre for Research in Neurodegenerative Diseases Toronto ON Canada The Krembil Brain Institute at Toronto Western Hospital Toronto ON Canada Institute of Medical Science Temerty Faculty of Medicine Toronto ON Canada Western University London ON Canada University of Ottawa Ottawa ON Canada Krembil Brain Institute Toronto ON Canada Movement Disorder Clinic Toronto Western Hospital University Health Network Toronto ON Canada Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto ON Canada The Edmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic Toronto ON Canada Canadian Centre for Activity and Aging London ON Canada Ontario Neurodegenerative Disease Research Initiative Toronto ON Canada Baycrest Health Sciences Centre Toronto ON Canada Rotman Research Institute Toronto ON Canada Baycrest Hospital Toronto ON Canada Sunnybrook Health Sciences Centre Toronto ON Canada St. Michael’s Hospital Toronto ON Canada Keenan Research Centre for Biomedical Science St. Michael’s Hospital Toronto ON Canada Faculty of Medicine Department of Psychiatry University of Toronto Toronto ON Canada Institute of Medical Sciences University of Toronto Toronto ON Canada Keenan Research Centre for Biomedical Science the Li Ka Shing Knowledge Institute St. Michael’s Hospital Toronto ON Canada Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson’s disease Toronto ON Canada Queens University Kingston ON Canada Queen’s University Kingston ON Canada Rotman Research Institute Baycrest Health Sciences Toronto ON Canada Temerty Faculty of Medicine University of Toronto Toronto ON Canada Edmond J Safra Program for Parkinson Disease and the Morton and Gloria Shulman Movement Disorder Clinic Toronto Western Hospital University Health Network Toron

Background Falls are the most common injury faced by older adults and those with neurodegenerative diseases. Falls can result in concussion/mild traumatic brain injury(mTBI). Concussions in older adults or those with ...

Background Falls are the most common injury faced by older adults and those with neurodegenerative diseases. Falls can result in concussion/mild traumatic brain injury(mTBI). Concussions in older adults or those with neurodegenerative disease can have a significant impact on behavior as post-concussion symptoms include neuropsychiatric issues. We hypothesized that there is a relationship between past fall and neuropsychiatric symptoms and neuropsychiatric symptom severity. Methods We used data on falls and Neuropsychiatric Inventory (NPI) from the Ontario Neurodegenerative Disease Research Initiative dataset for 480 individuals with neurodegenerative diseases (Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic lateral sclerosis, frontotemporal dementia and vascular cognitive impairment). We used the Chi-squared and Mann-Whitney tests to compare frequency of NPI symptoms (anxiety, depression, irritability, disinhibition, apathy, delusions, hallucinations, agitation, euphoria, motor-disturbance, night-time behaviour, appetite), and total NPI severity and distress, respectively, between patients with and without falls in the past 12 months. Results Comparing patients with falls (n = 169; mean-age = 68.3±9; 36% F) to patients without falls (n = 311; mean-age = 68.7±7; 32% F), there was a significantly higher frequency of anxiety (Chi-squared test, X 2 (df = 1, N = 480) = 12.859, P-value = 0.0003); higher median anxiety severity (Mann-Whitney/Wilcoxon-test p-value = 0.0002); and higher median partner anxiety distress (Wilcox test p-value = 0.0006) in those who had had a previous fall compared to those who had not, even with multiple comparison correction. Depression, apathy, disinhibition, night-time behaviours, and eating/appetite changes and total NPI severity were significantly worse in those with previous falls but did not survive multiple comparison correction. Conclusion We found that anxiety frequency, severity and distress were much higher in patients with neu

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A head-to-head comparison of plasma phosphorylated tau assays in the real-world memory clinic

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Alzheimer's & Dementia 2022年第S6期18卷

作者： Marc Suárez-Calvet Nicholas J. Ashton Albert Puig-Pijoan Marta Milà-Alomà Aida Fernández-Lebrero Greta García-Escobar Fernándo González-Ortiz Przemyslaw Radoslaw Kac Wagner Scheeren Brum Andréa Lessa Benedet Juan Lantero Rodriguez Theresa A. Day Jeffrey L. Dage Jeroen Vanbrabant Erik Stoops Eugeen Vanmechelen Gallen Triana-Baltzer Setareh Moughadam Hartmuth C. Kolb Paula Ortiz-Romero Thomas K Karikari Carolina Minguillón Juan José Hernández Sánchez Irene Navalpotro-Gómez Oriol Grau-Rivera Rosa María Manero Víctor Puente-Periz Rafael de la Torre Jaume Roquer Henrik Zetterberg Kaj Blennow Hospital del Mar Medical Research Institute (IMIM) Barcelona Spain Servei de Neurologia Hospital del Mar Barcelona Spain Barcelonaβeta Brain Research Center (BBRC) Pasqual Maragall Foundation Barcelona Spain Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES) Madrid Spain NIHR Biomedical Research Centre for Mental Health & Biomedical Research Unit for Dementia at South London & Maudsley NHS Foundation London United Kingdom Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology The Sahlgrenska Academy University of Gothenburg Mölndal Sweden Wallenberg Centre for Molecular and Translational Medicine University of Gothenburg Gothenburg Sweden King’s College London Institute of Psychiatry Psychology & Neuroscience Maurice Wohl Clinical Neuroscience Institute London United Kingdom Department of Medicine Universitat Autònoma de Barcelona Barcelona Spain Universitat Pompeu Fabra Barcelona Spain Graduate Program in Biological Sciences: Biochemistry Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology University of Gothenburg Mölndal Sweden Institute of Neuroscience & Physiology Department of Psychiatry & Neurochemistry The Sahlgrenska Academy University of Gothenburg Mölndal Sweden Lilly Research Laboratories Eli Lilly and Company Indianapolis IN USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN USA Eli Lilly and Company Indianapolis IN USA ADx NeuroSciences NV Technologiepark 94 Ghent 9052 Belgium ADx NeuroSciences Ghent Belgium Janssen Research & Development San Diego CA USA IMIM (Hospital del Mar Medical Research Institute) Barcelona Spain Laboratori de Referència de Catalunya Barcelona Spain Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN) Madrid Spain Clinical Neurochemistry Laboratory S

Background Several blood phosphorylated tau (P-tau) species (P-tau181, P-tau217, and P-tau231) have shown high accuracy to detect AD pathology, but a direct comparison of the main blood P-tau assays in a real-world me...

Background Several blood phosphorylated tau (P-tau) species (P-tau181, P-tau217, and P-tau231) have shown high accuracy to detect AD pathology, but a direct comparison of the main blood P-tau assays in a real-world memory clinic is needed. The main aim of this study is to perform a head-to-head comparison of 9 plasma Tau assays and determine their accuracy to discriminate between symptomatic AD from non-AD. Method This is an observational and cross-sectional study in the BIODEGMAR cohort, which includes patients presenting with cognitive complaints at the Cognitive Decline and Movement Disorders Unit of Hospital del Mar (Barcelona, Spain). Patients were classified into an AD CSF profile group or a non-AD CSF profile group according to their CSF Aβ42/P-tau181 ratio (Lumipulse, Fujirebio), and the discrimination accuracy of 9 plasma Tau assays was tested. All plasma samples were treated identically and measurements were performed in a blinded fashion. Result A total of 197 participants (109 women [55.3%]; mean [SD] age, 72.3 [5.83] years), were investigated. All plasma Tau biomarkers were significantly higher in the AD CSF profile group than in the non-AD CSF profile group. For plasma Tau biomarkers, the largest effect sizes were found in plasma Janssen P-tau217 (r = 0.76), Lilly P-tau217 (r = 0.73), ADx P-tau181 (r = 0.73), Lilly P-tau181 (r = 0.68), and UGot P-tau231 (r = 0.63). All plasma Tau biomarkers significantly discriminated between patients with an AD CSF profile group from those with a non-AD CSF profile. The AUC of plasma Tau biomarkers were the following (from highest to lower): Janssen P-tau217 (0.96; 95% CI, 0.93-0.99), ADx P-tau181 (0.94; 95% CI, 0.91-0.97) and Lilly P-tau217 (0.94; 95% CI, 0.90-0.98), Lilly P-tau181 (0.91; 95% CI, 0.87-0.96), UGot P-tau231 (0.88; 95% CI, 0.83-0.93), Quanterix P-tau181 (0.80; 95% CI, 0.73-0.87), UGot P-tau181 (0.80; 95% CI, 0.73-0.87), Lilly Total-tau (0.73; 95% CI, 0.65-0.81), and ADx P-tau231 (0.66; 95% CI, 0.58-0.74

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Correction: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

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Molecular psychiatry 2023年第10期28卷 4320页

作者： Willem B Bruin Yoshinari Abe Pino Alonso Alan Anticevic Lea L Backhausen Srinivas Balachander Nuria Bargallo Marcelo C Batistuzzo Francesco Benedetti Sara Bertolin Triquell Silvia Brem Federico Calesella Beatriz Couto Damiaan A J P Denys Marco A N Echevarria Goi Khia Eng Sónia Ferreira Jamie D Feusner Rachael G Grazioplene Patricia Gruner Joyce Y Guo Kristen Hagen Bjarne Hansen Yoshiyuki Hirano Marcelo Q Hoexter Neda Jahanshad Fern Jaspers-Fayer Selina Kasprzak Minah Kim Kathrin Koch Yoo Bin Kwak Jun Soo Kwon Luisa Lazaro Chiang-Shan R Li Christine Lochner Rachel Marsh Ignacio Martínez-Zalacaín Jose M Menchon Pedro S Moreira Pedro Morgado Akiko Nakagawa Tomohiro Nakao Janardhanan C Narayanaswamy Erika L Nurmi Jose C Pariente Zorrilla John Piacentini Maria Picó-Pérez Fabrizio Piras Federica Piras Christopher Pittenger Janardhan Y C Reddy Daniela Rodriguez-Manrique Yuki Sakai Eiji Shimizu Venkataram Shivakumar Blair H Simpson Carles Soriano-Mas Nuno Sousa Gianfranco Spalletta Emily R Stern S Evelyn Stewart Philip R Szeszko Jinsong Tang Sophia I Thomopoulos Anders L Thorsen Tokiko Yoshida Hirofumi Tomiyama Benedetta Vai Ilya M Veer Ganesan Venkatasubramanian Nora C Vetter Chris Vriend Susanne Walitza Lea Waller Zhen Wang Anri Watanabe Nicole Wolff Je-Yeon Yun Qing Zhao Wieke A van Leeuwen Hein J F van Marle Laurens A van de Mortel Anouk van der Straten Ysbrand D van der Werf Paul M Thompson Dan J Stein Odile A van den Heuvel Guido A van Wingen Amsterdam UMC location University of Amsterdam Department of Psychiatry Meibergdreef 9 Amsterdam The Netherlands. willembenjamin@***. Amsterdam Neuroscience Amsterdam The Netherlands. willembenjamin@***. Department of Psychiatry Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan. Department of Psychiatry Bellvitge University Hospital Barcelona Spain. Department of Clinical Science Faculty of Medicine University of Barcelona Barcelona Spain. IDIBELL Bellvitge University Hospital Barcelona Spain. CIBERSAM Instituto de Salud Carlos III Madrid Spain. Department of Psychiatry Yale University New Haven CT USA. Department of Child and Adolescent Psychiatry Faculty of Medicine Technische Universität Dresden Dresden Germany. Department of Psychiatry National Institute of Mental Health And Neurosciences (NIMHANS) Bangalore India. Radiology Service Diagnosis Image Center Hospital Clinic de Barcelona Barcelona Spain. Magnetic Resonance Image Core Facility Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain. Department of Psychiatry University of Sao Paulo School of Medicine Sao Paulo Brazil. Department of Methods and Techniques in Psychology Pontifical Catholic University Sao Paulo Brazil. Vita-Salute San Raffaele University Milano Italy. Psychiatry & Clinical Psychobiology Division of Neuroscience IRCCS Scientific Institute Ospedale San Raffaele Milano Italy. Bellvitge Biomedical Research Insitute-IDIBELL Bellvitge University Hospital Barcelona Spain. Department of Child and Adolescent Psychiatry and Psychotherapy University Hospital of Psychiatry University of Zurich Zurich Switzerland. Neuroscience Center Zurich University of Zurich and ETH Zurich Zurich Switzerland. Life and Health Sciences Research Institute (ICVS) School of Medicine University of Minho Braga Portugal. ICVS/3B's PT Government Associate Laboratory Braga/Guimarães Portugal. Clinical Academic Center-Braga Braga Portuga

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Neural Correlates of Mild Behavioral Impairment in older adults across the neurodegenerative spectrum

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Alzheimer's & Dementia 2023年第S18期19卷

作者： Neda Rashidi-Ranjbar Nathan W Churchill Sandra E. Black Sanjeev Kumar Carmela Tartaglia Morris Freedman Anthony E Lang Thomas Steeves Richard H. Swartz Gustavo Saposnik Donna Kwan Paula McLaughlin Angela Troyer Sean Symons Stephen C. Strother Michael Borrie Andrew R Frank Stephen H Pasternak Bruce G. Pollock Tarek K. Rajji Dallas Seitz David F. Tang-Wai Leanne Casaubon Jennifer Mandzia Mandar Jog Mario Masellis Christopher J. M. Scott Sabrina M. Adamo Miracle Ozzoude Zahinoor Ismail David G. Munoz Dar Dowlatshahi Ayman Hassan Connie Marras Robert Bartha Joel Ramirez Courtney Berezuk Melissa F. Holmes Demetrios J. Sahlas Alisia Southwell Stephen R. Arnott David A. Grimes Tom A. Schweizer Corinne E. Fischer University of Toronto Toronto ON Canada Keenan Research Centre for Biomedical Science the Li Ka Shing Knowledge Institute St. Michael’s Hospital Toronto ON Canada LC Campbell Cognitive Neurology Research Unit Sunnybrook Research Institute University of Toronto Toronto ON Canada Division of Neurology Department of Medicine University of Toronto Toronto ON Canada Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health Toronto ON Canada Department of Psychiatry Temerty Faculty of Medicine University of Toronto Toronto ON Canada Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto ON Canada Division of Neurology Krembil Neuroscience Centre Toronto Western Hospital University Health Network Memory Clinic Toronto ON Canada Department of Medicine University of Toronto Toronto ON Canada Rotman Research Institute Baycrest Health Sciences Toronto ON Canada Krembil Brain Institute Toronto ON Canada Hurvitz Brain Sciences Program Sunnybrook Research Institute Toronto ON Canada Li Ka Shing Knowledge Institute Toronto ON Canada Ontario Neurodegenerative Disease Research Initiative Toronto ON Canada Sunnybrook Health Sciences Centre Toronto ON Canada Rotman Research Institute Baycrest University of Toronto Toronto ON Canada Lawson Health Research Institute Western University London ON Canada University of Ottawa Ottawa ON Canada Parkwood Institute/St Joseph’s Healthcare Center London ON Canada University of Calgary Calgary AB Canada Western University London ON Canada LC Campbell Cognitive Neurology Research Unit Sunnybrook Research Institute Toronto ON Canada Canadian Partnership for Stroke Recovery Toronto ON Canada Sandra Black Centre for Brain Resilience and Recovery Sunnybrook Research Institute Toronto ON Canada University of Calgary Cumming School of Medicine Calgary AB Canada Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON

Background Mild behavioral impairment (MBI) is a syndrome characterized by later life onset, persistent neuropsychiatric symptoms (NPS) in non-demented older adults. MBI can co-occur with Mild Cognitive Impairment (MC...

Background Mild behavioral impairment (MBI) is a syndrome characterized by later life onset, persistent neuropsychiatric symptoms (NPS) in non-demented older adults. MBI can co-occur with Mild Cognitive Impairment (MCI) and has a range of neurodegenerative etiologies including Alzheimer’s disease (AD), Cerebrovascular Disease (CVD), and Parkinson’s disease (PD). MBI is associated with poorer cognitive and psychosocial function and an increased risk of developing dementia. Thus, we aimed to explore the structural neural correlates of MBI, specifically in the regions known to be associated with cognitive impairment (i.e., corticolimbic and frontal-executive circuits), across multiple neurodegenerative diagnoses from the Ontario Neurodegenerative Disease Research Initiative (ONDRI). Method We assessed the association between MBI and brain structural alterations via T1-weighted imaging in three groups with Montreal Cognitive Assessment scores ³19: individuals with MCI (due to AD; n = 37), CVD (n = 129), and PD (n = 127). NPS scores were derived from the Neuropsychiatric Inventory (NPI-Q) domains, and categorized as NPS+ (i.e., NPI score>0); and NPS- (NPI score = 0). We selected regions of interest from the corticolimbic and frontal-executive circuits to measure brain structure using cortical thickness and subcortical volume. Partial correlation, corrected for age, sex, and education was used to assess the association between MBI and brain structural alterations. Result Overall, apathy, depression, and anxiety, which map to the decreased motivation and emotional dysregulation MBI domains, had a high prevalence across all the groups. In the brain-MBI association analysis, apathy was associated with decreased thickness of the l-rostral middle frontal, r-superior temporal, and frontal pole in the PD and CVD (but not MCI) groups. Anxiety was associated with decreased volume of the right hippocampus and amygdala in the MCI group, but not CVD or PD (FDR p< 0.05). No structural

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Corrigendum to "Dementia diagnostic and treatment services in the Western Pacific: challenges, preparedness and opportunities in the face of amyloid-targeting therapies" [The Lancet Regional Health-Western Pacific, Volume 50, September 2024, 101183]

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The Lancet regional health. Western Pacific 2024年 52卷 101249页

作者： Claire O'Callaghan Johannes C Michaelian Yoko Aihara Veeda Michelle Anlacan Christopher Chen Gary Cheung Etuini Ma'u Tuan Anh Nguyen Ming-Chyi Pai Anna Palagyi Maw Pin Tan Shyh Poh Teo Yuda Turana Huali Wang Gloria Wong Sharon L Naismith Brain and Mind Centre and School of Medical Sciences Faculty of Medicine and Health University of Sydney Australia. Healthy Brain Ageing Program Brain and Mind Centre and Charles Perkins Centre School of Psychology Faculty of Science University of Sydney NSW Australia. Graduate School of Health Sciences Okayama University Japan. Department of Neurosciences College of Medicine and Philippine General Hospital University of the Philippines Manila Manila Philippines. Memory Aging and Cognition Centre Departments of Pharmacology and Psychological Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore. Department of Psychological Medicine School of Medicine Faculty of Medical and Health Sciences The University of Auckland Auckland New Zealand. National Ageing Research Institute School of Health Sciences Swinburne University of Technology UniSA Clinical & Health Sciences University of South Australia Australia. Division of Behavioral Neurology Department of Neurology Medical College and Hospital National Cheng Kung University Tainan Taiwan. The George Institute for Global Health University of New South Wales Sydney Australia. Division of Geriatric Medicine Department of Medicine Faculty of Medicine Universiti Malaya Kuala Lumpur Malaysia. PAPRSB Institute of Health Sciences Universiti Brunei Darussalam Brunei Darussalam. Department of Neurology School of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia Jakarta Indonesia. Dementia Care and Research Center Peking University Institute of Mental Health (Sixth Hospital) No. 51 Huayuanbei Road Beijing 100191 China. Department of Social Work and Social Administration The University of Hong Kong and School of Psychology and Clinical Language Sciences University of Reading United Kingdom.

[This corrects the article DOI: 10.1016/***.2024.101183.].

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Protective association ofHLA-DRB1*04 subtypes in neurodegenerative diseases implicates acetylated tau PHF6 sequences

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Alzheimer's & Dementia 2022年第S3期18卷

作者： Yann Le Guen Guo Luo Aditya Ambati Vincent Damotte Iris E Jansen Eric Yu Aude Nicolas Itziar de Rojas Thiago Peixoto Leal Akinori Miyashita Céline Bellenguez Michelle Mulan Lian Kayenat Parveen Takashi Morizono Hyeonseul Park Benjamin Grenier-Boley Tatsuhiko Naito Fahri Küçükali Seth D. Talyansky Selina Marie Yogeshwar Vicente Sempere Wataru Satake Victoria Álvarez-Martínez Beatrice Arosio Michael E Belloy Luisa Benussi Anne Boland Barbara Borroni María J. Bullido Paolo Caffarra Jordi Clarimon Antonio Daniele Daniel Darling Stéphanie Debette Jean-François Deleuze Martin Dichgans Carole Dufouil Emmanuel During Emrah Duzel Daniela Galimberti Guillermo García-Ribas Jose María García-Alberca Pablo García-González Vilmantas Giedraitis Oliver Goldhardt Caroline Graff Edna Grunblatt Olivier Hanon Lucrezia Hausner Stefanie Heilmann-Heimbach Henne Holstege Jakub Hort Yoo Jin Jung Deckert Jurgen Silke Kern Teemu Kuulasmaa Kun Ho Lee Ling Ling Carlo Masullo Patrizia Mecocci Shima Mehrabian Alexandre de Mendonça Mercè Boada Pablo Mir Susanne Moebus Fermin Moreno Benedetta Nacmias Gaël Nicolas Shumpei Niida Børge G. Nordestgaard Goran Papenberg Janne M. Papma Lucilla Parnetti Florence Pasquier Pau Pastor Oliver Peters Yolande A.L. Pijnenburg Gerard Piñol-Ripoll Julius Popp Laura Molina Raquel Puerta Jordi Pérez-Tur Innocenzo Rainero Luis Miguel Real Steffi G. Riedel-Heller Eloy Rodríguez Rodríguez José Luís Royo Dan Rujescu Nikolaos Scarmeas Philip Scheltens Norbert Scherbaum Anja Schneider Davide Seripa Ingmar Skoog Vincenzo Solfrizzi Gianfranco Spalletta Alessio Squassina John C van Swieten Raquel Sanchez-Valle Eng-King Tan Thomas Tegos Charlotte E. Teunissen Jesper Qvist Thomassen Lucio Tremolizzo Martin Vyhnalek Frans R.J. Verhey Margda Waern Jens Wiltfang Jing Zhang Henrik Zetterberg Kaj Blennow Julie Williams Philippe Amouyel Frank Jessen Patrick G Kehoe Ole Andreassen Cornelia M van Duijn Magda Tsolaki Pascual Sanchez-Juan Ruth Frikke-Schmidt Kristel Sleegers Tatsushi Toda Anna Zettergren Martin Ingelsson Yukinori Okad Stanford University Stanford CA USA Institut du Cerveau - Paris Brain Institute - ICM Paris CA France UMR1167 Université de Lille Inserm CHU Lille Institut Pasteur de Lille Lille France Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam Netherlands The Neuro (Montreal Neurological Institute-Hospital) McGill University Montreal QC Canada Univ. Lille Inserm CHU Lille Institut Pasteur de Lille U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement F-59000 Lille France Research Center and Memory Clinic Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC) Barcelona Spain Genomic Medicine Lerner Research Institute Cleveland Clinic Cleveland OH USA Department of Molecular Genetics Brain Research Institute Niigata University Niigata Japan Lee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore Singapore Division of Neurogenetics and Molecular Psychiatry Department of Psychiatry and Psychotherapy Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany Medical Genome Center Research Institute National Center for Geriatrics and Gerontology Obu Aichi Japan Department of Biomedical Science Chosun University Gwangju Korea Republic of (South) Department of Statistical Genetics Osaka University Graduate School of Medicine Sutia Japan VIB Center for Molecular Neurology VIB Antwerp Belgium Department of Neurology Graduate School of Medicine The University of Tokyo Tokyo Japan Hospital Universitario Central de Asturias Oviedo Spain Department of Clinical Sciences and Community Health University of Milan 20122 Milan Italy Milan Italy IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy Université Paris-Saclay Centre National de Génotypage Institut de Génomique / CEA Evry France Centre for Neurodegenerati

Background Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic Lateral Sclerosis (ALS) and other neurodegenerative diseases are responsible for considerable morbidity and mortality. With incidence rising...

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