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Author Correction: Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk

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Nature genetics 2020年第3期52卷 354页

作者： Iris E Jansen Jeanne E Savage Kyoko Watanabe Julien Bryois Dylan M Williams Stacy Steinberg Julia Sealock Ida K Karlsson Sara Hägg Lavinia Athanasiu Nicola Voyle Petroula Proitsi Aree Witoelar Sven Stringer Dag Aarsland Ina S Almdahl Fred Andersen Sverre Bergh Francesco Bettella Sigurbjorn Bjornsson Anne Brækhus Geir Bråthen Christiaan de Leeuw Rahul S Desikan Srdjan Djurovic Logan Dumitrescu Tormod Fladby Timothy J Hohman Palmi V Jonsson Steven J Kiddle Arvid Rongve Ingvild Saltvedt Sigrid B Sando Geir Selbæk Maryam Shoai Nathan G Skene Jon Snaedal Eystein Stordal Ingun D Ulstein Yunpeng Wang Linda R White John Hardy Jens Hjerling-Leffler Patrick F Sullivan Wiesje M van der Flier Richard Dobson Lea K Davis Hreinn Stefansson Kari Stefansson Nancy L Pedersen Stephan Ripke Ole A Andreassen Danielle Posthuma Department of Complex Trait Genetics Center for Neurogenomics and Cognitive Research Amsterdam Neuroscience VU University Amsterdam the Netherlands. Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam the Netherlands. Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden. deCODE Genetics/ Amgen Reykjavik Iceland. Interdisciplinary Graduate Program Vanderbilt University Nashville TN USA. Institute of Gerontology and Aging Research Network-Jönköping (ARN-J) School of Health and Welfare Jönköping University Jönköping Sweden. NORMENT K.G. Jebsen Centre for Psychosis Research Institute of Clinical Medicine University of Oslo Oslo Norway. Division of Mental Health and Addiction Oslo University Hospital Oslo Norway. Institute of Psychiatry Psychology and Neuroscience King's College London London UK. Institute of Clinical Medicine University of Oslo Oslo Norway. Center for Age-Related Diseases Stavanger University Hospital Stavanger Norway. Department of Neurology Akershus University Hospital Lørenskog Norway. AHUS Campus University of Oslo Oslo Norway. Department of Psychiatry of Old Age Oslo University Hospital Oslo Norway. Department of Community Medicine University of Tromsø Tromsø Norway. Norwegian National Advisory Unit on Ageing and Health Vestfold Hospital Trust Tønsberg Norway. Centre for Old Age Psychiatry Research Innlandet Hospital Trust Ottestad Norway. Department of Geriatric Medicine Landspitali University Hospital Reykjavik Iceland. Geriatric Department Oslo University Hospital Oslo Norway. Department of Neuromedicine and Movement Science Norwegian University of Science and Technology Trondheim Norway. Department of Neurology St Olav's Hospital Trondheim University Hospital Trondheim Norway. Neuroradiology Section Department of Radiology and Biomedical Imaging University of California San Francisco CA USA. Department

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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BIOM-51. MOLECULAR SUBTYPES, CLINICAL CHARACTERISTICS, AND THERAPEUTIC IMPLICATIONS FOR CNS TUMORS WITHBCOR/BCORL1FUSION/INTERNAL TANDEM DUPLICATION

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Neuro-Oncology 2024年第SUPPLEMENT_8期26卷 viii31-viii31页

作者： Gojo, Johannes Federico, Aniello Geisemeyer, Neal Schmitt-Hoffner, Felix Mauermann, Monika Sill, Martin Bruckner, Katharina Korshunov, Andrey Stichel, Damian Capper, David Tauziede-Espariat, Arnault Varlet, Pascale Aldape, Kenneth Abdullaev, Zied Donson, Andrew M Pahnke, Jens Schüller, Ulrich Galbraith, Kristyn Snuderl, Matija Alexandrescu, Sanda Filbin, Mariella Gramatzki, Dorothee Urbanic-Purkart, Tadeja Ziad, Fouzia Toledano, Helen Kerl, Kornelius Hasselblatt, Martin Papusha, Ludmila Brandner, Sebastian Łastowska, Maria Miele, Evelina Lugt, Jasper v d Bunt, Jens Kramm, Christof André, Nicolas Appay, Romain Bouchoucha, Yassine Hansford, Jordan Zapotocky, Michal Kranendonk, Mariette E Nobusawa, Sumihito Solomon, David Haberler, Christine Jones, Barbara Sturm, Dominik Sahm, Felix Jäger, Natalie Pfister, Stefan M Hoff, Katja v Kool, Marcel Department of Pediatrics and Adolescent Medicine Comprehensive Center for Pediatrics and Comprehensive Cancer Center Medical University of Vienna Vienna Austria Hopp Children’s Cancer Center (KITZ) Heidelberg Germany Division of Pediatric Neurooncology German Cancer Research Center (DKFZ) and German Cancer Research Consortium (DKTK) Heidelberg Germany Department of Neuropathology University Hospital Heidelberg (DKFZ) Heidelberg Germany Clinical Cooperation Unit Neuropathology German Cancer Research Center (DKFZ) Heidelberg Germany Department of Neuropathology Charité Universitätsmedizin Berlin Berlin Germany Department of Neuropathology GHU Paris Psychiatry and Neurosciences Sainte-Anne Hospital Paris France Laboratory of Pathology Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda USA Morgan Adams Foundation Pediatric Brain Tumor Research Program Department of Pediatrics University of Colorado School of Medicine Aurora USA Department of Pathology (PAT) Clinics for Laboratory Medicine (KLM) Oslo University Hospital (OUS) Oslo Norway Department of Pediatric Hematology and Oncology University Medical Center Hamburg-Eppendorf Hamburg Germany Department of Pathology New York University School of Medicine New York USA Department of Pathology Boston Children’s Hospital Harvard Medical School Boston USA Department of Pediatric Oncology Dana-Farber Boston Children’s Cancer and Blood Disorders Center Boston USA Department of Neurology Clinical Neuroscience Center University Hospital and University of Zurich Zurich Switzerland Department of Neurology and Neuroradiology Vascular and Interventional Radiology Auenbruggerplatz 22 8036 Graz Medical University of Graz Graz Austria Department of Pathology Waikato Hospital Hamilton New Zealand Faculty of Medicine Tel Aviv University Tel Aviv Israel Department of Pediatric Hematology-Oncology Schneider Children’s Medical Center Petah Tikva Tel Aviv Israel Department of Pedia

Central nervous system (CNS) tumors with eitherBCORinternal tandem duplication (BCORITD) or gene fusions involvingBCOR/BCORL1(BCORFUS) are recognized as tumor types with characteristic molecular and clinical features but lacking clear therapeutic guidance. In an extensive international effort, we compiled a retrospective cohort of 229 (148BCORITD, 81BCORFUS) unique cases via molecular profiling of CNS tumors. By analyzing DNA methylation patterns of 220 tumors we confirmed distinct epigenetic profiles ofBCORITD versusBCORFUS. The majority (91 percent) ofBCORFUS primary tumors was localized in the supratentorial region whereasBCORITD were localized across all anatomical CNS compartments. Median patient age at diagnosis was 20 years forBCORFUS and 4 years forBCORITD. Metastatic disease was rare inBCORFUS patients but more common inBCORITD tumors where 10 percent presented with metastatic disease and one third showed CNS or (rarely) extra-CNS metastasis in the course of disease. This was also reflected in clinical outcome as 5-year overall survival (OS) was 89 percent in BCOR FUS but 61 percent inBCORITD. In contrast, 5-year progression-free survival (PFS) was comparable reaching 27 percent inBCORFUS and 30 percent inBCORITD. Integrating treatment details we found a trend towards benefit of gross-total resection on OS (BCORFUS, n=18, p<0.08;BCORITD, n=67, p<0.12) but not for PFS (BCORFUS, n=16, p<0.33;BCORITD, n=64, p<0.59). Radiotherapy was associated with improved PFS (BCORFUS, n=18, p<0.01;BCORITD, n=70, p<0.001) and OS (BCORFUS, n=20, p<0.01;BCORITD, n=73, p<0.001). Further in-depth analyses of clinical outcome parameters (primary metastatic disease, radiotherapy approach, chemotherapy type, patient age) are currently ongoing. In summary, we provide first robust annotation of CNSBCORtumor types, clinical outcomes and therapy.

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Abstracts

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JOURNAL OF SPINAL CORD MEDICINE 2021年第SUPPL 1期44卷 S278-S324页

作者： [Anonymous] Department of Medicine Division of Physical Medicine and Rehabilitation University of Toronto Toronto ON CA KITE - Toronto Rehabilitation Institute University Health Network Toronto ON CA Institute for Health Policy Management and Evaluation University of Toronto Toronto ON CA Rehabilitation Sciences Institute University of Toronto Toronto ON CA Institute of Medical Sciences University of Toronto Toronto ON CA. Rehabilitation Sciences Institute University of Toronto ON CA KITE Research Institute-Toronto Rehab-University Health Network Toronto ON CA Physical Therapy Department University of Toronto ON CA Praxis Spinal Cord Institute Vancouver BC Université de Montréal (École de réadaptation) Montreal QC CA Institut de réadaptation Gingras-Linsay-de-Montréal Montreal QC CA Division of Physical Medicine & Rehabilitation Department of Medicine Faculty of Medicine & Dentistry University of Alberta Edmonton AB CA University of Calgary Calgary AB CA Alberta Health Services Centre for Family Medicine Kitchener ON CA McMaster University Department of Family Medicine Hamilton ON CA Dept. of Physical Therapy University of Toronto Toronto ON CA KITE-University Health Network Toronto ON CA Praxis Spinal Cord Institute Vancouver BC CA Center for Interdisciplinary Research in Rehabilitation and Social Integration (CIRRIS) Quebec City QC CA Dept. of Rehabilitation Laval University Quebec City QC CA Institute of Health Policy Management and Evaluation University of Toronto Toronto ON CA School of Rehabilitation Science University of Saskatchewan Saskatoon SK CA Ontario Neurotrauma Foundation Toronto ON CA Canadian Spinal Research Organization Toronto ON CA CIUSSS du Centre-Sud-de-l ‘Île-de-Montréal (Installation Gingras-Lindsay) Montréal QC CA École de réadaptation Université de Montréal Montréal QC CA First Steps Wellness Centre Regina SK CA Stan Cassidy Centre for Rehabilitation Horizon Health Network Fredericton NB CA Departmen

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Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study

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Psychiatry Research 2024年 342卷 115972-115972页

作者： Solmi, Marco Thompson, Trevor Estradé, Andrés Agorastos, Agorastos Radua, Joaquim Cortese, Samuele Dragioti, Elena Vancampfort, Davy Thygesen, Lau Caspar Aschauer, Harald Schlögelhofer, Monika Aschauer, Elena Schneeberger, Andres Huber, Christian G. Hasler, Gregor Conus, Philippe Cuénod, Kim Q. Do von Känel, Roland Arrondo, Gonzalo Fusar-Poli, Paolo Gorwood, Philip Llorca, Pierre-Michel Krebs, Marie-Odile Scanferla, Elisabetta Kishimoto, Taishiro Rabbani, Golam Skonieczna-Żydecka, Karolina Brambilla, Paolo Favaro, Angela Takamiya, Akihiro Zoccante, Leonardo Colizzi, Marco Bourgin, Julie Kamiński, Karol Moghadasin, Maryam Seedat, Soraya Matthews, Evan Wells, John Vassilopoulou, Emilia Gadelha, Ary Su, Kuan-Pin Kwon, Jun Soo Kim, Minah Lee, Tae Young Papsuev, Oleg Manková, Denisa Boscutti, Andrea Gerunda, Cristiano Saccon, Diego Righi, Elena Monaco, Francesco Croatto, Giovanni Cereda, Guido Demurtas, Jacopo Brondino, Natascia Veronese, Nicola Enrico, Paolo Politi, Pierluigi Ciappolino, Valentina Pfennig, Andrea Bechdolf, Andreas Meyer-Lindenberg, Andreas Kahl, Kai G. Domschke, Katharina Bauer, Michael Koutsouleris, Nikolaos Winter, Sibylle Borgwardt, Stefan Bitter, Istvan Balazs, Judit Czobor, Pál Unoka, Zsolt Mavridis, Dimitris Tsamakis, Konstantinos Bozikas, Vasilios P. Tunvirachaisakul, Chavit Maes, Michael Rungnirundorn, Teerayuth Supasitthumrong, Thitiporn Haque, Ariful Brunoni, Andre R. Costardi, Carlos Gustavo Schuch, Felipe Barreto Polanczyk, Guilherme Luiz, Jhoanne Merlyn Fonseca, Lais Aparicio, Luana V. Valvassori, Samira S. Nordentoft, Merete Vendsborg, Per Hoffmann, Sofie Have Sehli, Jihed Sartorius, Norman Heuss, Sabina Guinart, Daniel Hamilton, Jane Kane, John Rubio, Jose Sand, Michael Koyanagi, Ai Solanes, Aleix Andreu-Bernabeu, Alvaro Cáceres, Antonia San José Arango, Celso Díaz-Caneja, Covadonga M. Hidalgo-Mazzei, Diego Vieta, Eduard Gonzalez-Peñas, Javier Fortea, Lydia Parellada, Mara Fullana, Miquel A. Verdolini, Norma Andrlíková, Eva Janků, Karolina Millan, Mark J. Honciuc, Mihaela Moniuszko-Mal University of Ottawa Department of Psychiatry ON Canada The Ottawa Hospital Department of Mental Health ON Canada Ottawa Hospital Research Institute (OHRI) Neurosciences Program Ottawa Ontario Canada Early Psychosis: Interventions and Clinical-detection (EPIC) Lab Department of Psychosis Studies Institute of Psychiatry Psychology & Neuroscience King's College London London United Kingdom Centre for Innovation in Mental Health-Developmental Lab School of Psychology University of Southampton and NHS Trust Southampton United Kingdom Charité Universitätsmedizin Berlin Department of Child and Adolescent Psychiatry Berlin Germany Centre for Chronic Illness and Ageing University of Greenwich London United Kingdom University of Southampton Centre for Innovation in Mental Health Southampton United Kingdom Universidad Católica Department of Psychology Montevideo Uruguay Aristotle University of Thessaloniki II. Dept. of Psychiatry Division of Neurosciences Medical School Faculty of Health Sciences Greece Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Imaging of Mood- and Anxiety-Related Disorders (IMARD) University of Barcelona CIBERSAM Instituto de Salud Carlos III Barcelona Spain Karolinska Institutet Centre for Psychiatric Research and Education Department of Clinical Neuroscience Stockholm Sweden Linköping University Pain and Rehabilitation Centre and Department of Health Medicine and Caring Sciences Linköping Sweden University of Ioannina Research Laboratory Psychology of Patients Families & Health Professionals Department of Nursing School of Health Sciences Ioannina Greece Katholieke Universiteit Leuven (KU Leuven) Department of Rehabilitation Sciences Leuven Belgium National Institute of Public Health University of Southern Denmark Denmark BioPsyC - Biopsychosocial Corporation Non-profit association for Research Funding Ltd. Vienna Austria University of California San Diego California United States University of Basel Universitä

International studies measuring wellbeing/multidimensional mental health before/ during the COVID-19 pandemic, including representative samples for >2 years, identifying risk groups and coping strategies are lacking. COH-FIT is an online, international, anonymous survey measuring changes in well-being (WHO-5) and a composite psychopathology P-score, and their associations with COVID-19 deaths/restrictions, 12 a-priori defined risk individual/cumulative factors, and coping strategies during COVID-19 pandemic (26/04/2020-26/06/2022) in 30 languages (representative, weighted non-representative, adults). T-test, χ², penalized cubic splines, linear regression, correlation analyses were conducted. Analyzing 121,066/142,364 initiated surveys, WHO-5/P-score worsened intra-pandemic by 11.1±21.1/13.2±17.9 points (effect size d=0.50/0.60) (comparable results in representative/weighted non-probability samples). Persons with WHO-5 scores indicative of depression screening (<50, 13% to 32%) and major depression (<29, 3% to 12%) significantly increased. WHO-5 worsened from those with mental disorders, female sex, COVID-19-related loss, low-income country location, physical disorders, healthcare worker occupations, large city location, COVID-19 infection, unemployment, first-generation immigration, to age=18-29 with a cumulative effect. Similar findings emerged for P-score. Changes were significantly but minimally related to COVID-19 deaths, returning to near-pre-pandemic values after >2 years. The most subjectively effective coping strategies were exercise and walking, internet use, social contacts. Identified risk groups, coping strategies and outcome trajectories can inform global public health strategies. © 2024 The Authors

关键词： Covid-19 Mental health P-factor Pandemic Psychiatry Psychopathology Survey Well-being WHO-5

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Abstracts for the 6th Congress of Asian Sleep Research Society

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Sleep and Biological Rhythms 2009年第4期7卷 A1-A49页

作者： Seog Ju Kim In Kyoon Lyoo Yu-Jin Lee Do-Un Jeong Hirohiko Kanai Masanori Ookubo Atsushi Yoshimura Masako Okawa Noto Yamada Takeshi Munezawa Yoshitaka Kaneita Yoneatsu Osaki Hideyuki Kanda Tadahiro Ohtsu Masumi Minowa Kenji Suzuki Susumu Hijuchi Hiroyuki Suzuki Takashi Ohida Takashi Abe Yoko Komada Shoichi Asaoka Yuichi Inoue Jin-Seong Lee Sang-Yong Cho Deependra Kumar Hruda N. Mallick Velayudhan M. Kumar Mahesh K. Kaushik Akihiro Karashima Noiihiro Katayama Mitsuyuki Nakao Ravindra P. Nagendra Sathiamma Sulekha Sathyaprabha T. Narasappa Pradhan Nityanadan Bindu M. Kutty M. Nirmala P. N. Ravindra Basavaraj Ramappa Tubaki T. N. Sathyaprabha D. Sudhakar G. S. Lavekar C. R. Chandrashekar Kazuyoshi Kitaoka Mika Shimizu Sachiko Chikahisa Kazuo Yoshizaki Hiroyoshi Sei Jong-Won Kim Misa Takegami Shin Yamazaki Yasuaki Hayashino Rei Ono Koji Otani Miho Sekiguchi Shinichi Konno Shunichi Fukuhara Antonia J. Jakobson Paul Fitzgerald Russell Conduit Xin Shirley Li Siu Ping Joyce Lam Wai Man Mandy Yu Yun Kwok Wing Kazue Okamoto-Mizuno Koh Mizuno Mituaki Yamamoto Shuichiro Shirakawa Hirokazu Doi Mikako Kato Kazuyuki Shinohara Masako Tamaki Shiori Matsuda Katsuo Yamazaki Tadao Hori Keiko Ogawa Kazumi Takahashi Kunio Kitahama Katuo Yamazaki Yoshimasa Koyama Kohei Shioda Yugo Ueda Yukiko Nakamura Clara Inoue Kazushige Goto Sunao Uchida Yuko Morita Yoshiko Honda Tohru Kodama Mari Hagihara Toru Nakajima Masato Saito Yoshihiko Koga Shinichiro Tanaka Hiroshi Yamadera Madoka Takahara Sachiko Suwa Minoru Onozuka Sadao Sato Fumiharu Togo Taiki Komatsu Takeshi Mitani Jongbae Choi Bin Zhang Taeko Sasai Hiromi Mitsubayashi Mitsuhiro Ohtsu Isao Hasegawa Tatsuya Ishii Akira Komori Asami Suzuki Yue Nakahara Mitsuyasu Hiroki Mariko Nakauma Nobuo Someya Tomomasa Ochiai Shouhei Komori Rayleigh Ping-Ying Chiang Zai-Ting Yeh Seong T. Kim Seung H. Yoon Jeong S. Kwon Jong H. Choi Hyung J. Ahn Youngsoo Kim Bolortuya Yunren Lichao Chen Radhika Basheer Robert W. Mccarley Robert E. Strecker Makoto Honda Tetsuaki Arai Miyuki Fukazawa Yutaka Honda Kuniaki T Department of Psychiatry Gachon University of Medicine and Science Incheon Republic of Korea Department of Psychiatry Seoul National University Seoul Republic of Korea Department of Neuropsychiatry and Center for Sleep and Chronobiology Seoul National University Hospital Seoul Republic of Korea Department of Neuropsychiatry Seoul National University Hospital Seoul Republic of Korea Seoul National University Hospital Seoul Republic of Korea Department of Psychiatry Shiga University of Medical Science Otsu Japan Division of Public Health Department of Social Medicine Nihon University School of Medicine Tokyo Japan Department of Public Health Nihon University School of Medicine Tokyo Japan Division of Environmental and Preventive Medicine Department of Social Medicine Faculty of Medicine Tottori University Yonago Japan Department of Hygiene and Preventive Medicine Fukushima Medical University Fukushima Japan Department of Public Health Showa University School of Medicine Tokyo Japan Faculty of Humanities Seitoku University Matsudo Japan Section on Behavioral Science Division of Clinical Research National Hospital Organization Kurihama Alcoholism Center Yokosuka Japan Department of Otolaryngology Second Hospital Fujita Health University Nagoya Japan National Hospital Organization Kurihama Alcoholism Center Kanagawa Japan Metropolitan Police Department Criminal Investigation Laboratory Tokyo Japan Japan Somnology Center Neuropsychiatrie Research Institute Tokyo Japan Department of Somnology Tokyo Medical University Tokyo Japan Japan Somnology Center Neuropsychiatric Research Institute Tokyo Japan Department of Somnology Tokyo Medical and Dental University Tokyo Japan Center for Sleep and Chronobiology Department of Psychiatry and Behavioral Science Seoul National University College of Medicine Seoul Republic of Korea Department of Psychiatry and Behavioral Science Center for Sleep and Chronobiology Seoul Republic of Korea Department of Physiology Al

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Equivalency of the diagnostic accuracy of the PHQ-8 and PHQ-9: a systematic review and individual participant data meta-analysis (vol 50, pg 1368, 2020)

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PSYCHOLOGICAL MEDICINE 2020年第16期50卷 2816-2816页

作者： Wu, Yin Levis, Brooke Riehm, Kira E. Saadat, Nazanin Levis, Alexander W. Azar, Marleine Rice, Danielle B. Boruff, Jill Cuijpers, Pim Gilbody, Simon Ioannidis, John P. A. Kloda, Lorie A. McMillan, Dean Patten, Scott B. Shrier, Ian Ziegelstein, Roy C. Akena, Dickens H. Arroll, Bruce Ayalon, Liat Baradaran, Hamid R. Baron, Murray Bombardier, Charles H. Butterworth, Peter Carter, Gregory Chagas, Marcos H. Chan, Juliana C. N. Cholera, Rushina Conwell, Yeates de Manvan Ginkel, Janneke M. Fann, Jesse R. Fischer, Felix H. Fung, Daniel Gelaye, Bizu Goodyear-Smith, Felicity Greeno, Catherine G. Hall, Brian J. Harrison, Patricia A. Harter, Martin Hegerl, Ulrich Hides, Leanne Hobfoll, Stevan E. Hudson, Marie Hyphantis, Thomas Inagaki, Masatoshi Jette, Nathalie Khamseh, Mohammad E. Kiely, Kim M. Kwan, Yunxin Lamers, Femke Liu, Shen-Ing Lotrakul, Manote Loureiro, Sonia R. Lowe, Bernd McGuire, Anthony Mohd-Sidik, Sherina Munhoz, Tiago N. Muramatsu, Kumiko Osorio, Flavia L. Patel, Vikram Pence, Brian W. Persoons, Philippe Picardi, Angelo Reuter, Katrin Rooney, Alasdair G. Santos, Ina S. Shaaban, Juwita Sidebottom, Abbey Simning, Adam Stafford, Lesley Sung, Sharon Tan, Pei Lin Lynnette Turner, Alyna van Weert, Henk C. White, Jennifer Whooley, Mary A. Winkley, Kirsty Yamada, Mitsuhiko Benedetti, Andrea Thombs, Brett D. [a1]Lady Davis Institute for Medical Research Jewish General Hospital Montréal Québec Canada [a2]Department of Psychiatry McGill University Montréal Québec Canada [a3]Department of Epidemiology Biostatistics and Occupational Health McGill University Montréal Québec Canada [a4]Department of Psychology McGill University Montréal Québec Canada [a5]Schulich Library of Physical Sciences Life Sciences and Engineering McGill University Montreal Quebec Canada [a6]Department of Clinical Neuro and Developmental Psychology Amsterdam Public Health Research Institute Vrije Universiteit Amsterdam the Netherlands [a7]Hull York Medical School and the Department of Health Sciences University of York Heslington York UK [a8]Department of Medicine Department of Health Research and Policy Department of Biomedical Data Science Department of Statistics Stanford University Stanford California USA [a9]Library Concordia University Montréal Québec Canada [a10]Department of Community Health Sciences University of Calgary Calgary Alberta Canada [a11]Hotchkiss Brain Institute and O’Brien Institute for Public Health University of Calgary Calgary Alberta Canada [a12]Department of Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA [a13]Department of Psychiatry Makerere University College of Health Sciences Kampala Uganda [a14]Department of General Practice and Primary Health Care University of Auckland Auckland New Zealand [a15]Louis and Gabi Weisfeld School of Social Work Bar Ilan University Ramat Gan Israel [a16]Endocrine Research Center Institute of Endocrinology and Metabolism Iran University of Medical Sciences Tehran Iran [a17]Ageing Clinical & Experimental Research Team Institute of Applied Health Sciences School of Medicine Medical Sciences and Nutrition University of Aberdeen Aberdeen Scotland UK [a18]Department of Medicine McGill University Montréal Québec Canada [a19]Department of Rehabilitation Medicine University of Washington S

BackgroundItem 9 of the Patient Health Questionnaire-9 (PHQ-9) queries about thoughts of death and self-harm, but not suicidality. Although it is sometimes used to assess suicide risk, most positive responses are not associated with suicidality. The PHQ-8, which omits Item 9, is thus increasingly used in research. We assessed equivalency of total score correlations and the diagnostic accuracy to detect major depression of the PHQ-8 and *** conducted an individual patient data meta-analysis. We fit bivariate random-effects models to assess diagnostic ***16 742 participants (2097 major depression cases) from 54 studies were included. The correlation between PHQ-8 and PHQ-9 scores was 0.996 (95% confidence interval 0.996 to 0.996). The standard cutoff score of 10 for the PHQ-9 maximized sensitivity + specificity for the PHQ-8 among studies that used a semi-structured diagnostic interview reference standard (N = 27). At cutoff 10, the PHQ-8 was less sensitive by 0.02 (−0.06 to 0.00) and more specific by 0.01 (0.00 to 0.01) among those studies (N = 27), with similar results for studies that used other types of interviews (N = 27). For all 54 primary studies combined, across all cutoffs, the PHQ-8 was less sensitive than the PHQ-9 by 0.00 to 0.05 (0.03 at cutoff 10), and specificity was within 0.01 for all cutoffs (0.00 to 0.01).ConclusionsPHQ-8 and PHQ-9 total scores were similar. Sensitivity may be minimally reduced with the PHQ-8, but specificity is similar.

关键词： Depression diagnostic accuracy individual participant data meta-analysis meta-analysis PHQ-8 PHQ-9 screening systematic review

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CRISIS AFAR: an international collaborative study of the impact of the COVID-19 pandemic on mental health and service access in youth with autism and neurodevelopmental conditions

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Molecular autism 2023年第1期14卷 7页

作者： Bethany Vibert Patricia Segura Louise Gallagher Stelios Georgiades Panagiota Pervanidou Audrey Thurm Lindsay Alexander Evdokia Anagnostou Yuta Aoki Catherine S Birken Somer L Bishop Jessica Boi Carmela Bravaccio Helena Brentani Paola Canevini Alessandra Carta Alice Charach Antonella Costantino Katherine T Cost Elaine A Cravo Jennifer Crosbie Chiara Davico Federica Donno Junya Fujino Alessandra Gabellone Cristiane T Geyer Tomoya Hirota Stephen Kanne Makiko Kawashima Elizabeth Kelley Hosanna Kim Young Shin Kim So Hyun Kim Daphne J Korczak Meng-Chuan Lai Lucia Margari Lucia Marzulli Gabriele Masi Luigi Mazzone Jane McGrath Suneeta Monga Paola Morosini Shinichiro Nakajima Antonio Narzisi Rob Nicolson Aki Nikolaidis Yoshihiro Noda Kerri Nowell Miriam Polizzi Joana Portolese Maria Pia Riccio Manabu Saito Ida Schwartz Anish K Simhal Martina Siracusano Stefano Sotgiu Jacob Stroud Fernando Sumiya Yoshiyuki Tachibana Nicole Takahashi Riina Takahashi Hiroki Tamon Raffaella Tancredi Benedetto Vitiello Alessandro Zuddas Bennett Leventhal Kathleen Merikangas Michael P Milham Adriana Di Martino Autism Center Child Mind Institute 101 E 56Th Street Third Floor New York NY USA. Department of Psychiatry School of Medicine Trinity College Dublin Dublin Ireland. Department of Psychiatry and Behavioural Neurosciences McMaster University Hamilton ON Canada. Unit of Developmental and Behavioral Pediatrics First Department of Pediatrics School of Medicine National & Kapodistrian University of Athens "Aghia Sophia" Children's Hospital Athens Greece. Neurodevelopmental and Behavioral Phenotyping Service National Institute of Mental Health Bethesda MD USA. Center for the Developing Brain Child Mind Institute New York NY USA. Autism Research Centre Bloorview Research Institute Holland Bloorview Kids Rehabilitation Hospital Toronto ON Canada. Department of Paediatrics University of Toronto Toronto ON Canada. Medical Institute of Developmental Disabilities Research Showa University Tokyo Japan. Department of Pediatrics School of Medicine University of Toronto Toronto ON Canada. Division of Paediatric Medicine Hospital for Sick Children Toronto ON Canada. Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences University of California San Francisco CA USA. Department of Biomedical Sciences Section of Neuroscience & Clinical Pharmacology University of Cagliari Cagliari Italy. UOSD di Neuropsichiatria Infantile - Dipartimento di Scienze Mediche Traslazionali Università Federico II di Napoli Naples Italy. Department of Psychiatry Hospital das Clinicas HCFMUSP Faculty of Medicine University of São Paulo (USP) São Paulo Brazil. Department of Health Sciences Università Degli Studi Di Milano Milan Italy. Epilepsy Center - Sleep Medicine Center Childhood and Adolescence Neuropsychiatry Unit ASST SS. Paolo E Carlo San Paolo Hospital Milan Italy. Department of Medical Surgical and Pharmacy Unit of Child Neuropsychiatry University Hospital of Sassari Sassari Italy. Department of Psychiatry Hospital for Sick Children Peter

BACKGROUND:Heterogeneous mental health outcomes during the COVID-19 pandemic are documented in the general population. Such heterogeneity has not been systematically assessed in youth with autism spectrum disorder (ASD) and related neurodevelopmental disorders (NDD). To identify distinct patterns of the pandemic impact and their predictors in ASD/NDD youth, we focused on pandemic-related changes in symptoms and access to services. METHODS:Using a naturalistic observational design, we assessed parent responses on the Coronavirus Health and Impact Survey Initiative (CRISIS) Adapted For Autism and Related neurodevelopmental conditions (AFAR). Cross-sectional AFAR data were aggregated across 14 European and North American sites yielding a clinically well-characterized sample of N = 1275 individuals with ASD/NDD (age = 11.0 ± 3.6 years; n females = 277). To identify subgroups with differential outcomes, we applied hierarchical clustering across eleven variables measuring changes in symptoms and access to services. Then, random forest classification assessed the importance of socio-demographics, pre-pandemic service rates, clinical severity of ASD-associated symptoms, and COVID-19 pandemic experiences/environments in predicting the outcome subgroups. RESULTS:Clustering revealed four subgroups. One subgroup-broad symptom worsening only (20%)-included youth with worsening across a range of symptoms but with service disruptions similar to the average of the aggregate sample. The other three subgroups were, relatively, clinically stable but differed in service access: primarily modified services (23%), primarily lost services (6%), and average services/symptom changes (53%). Distinct combinations of a set of pre-pandemic services, pandemic environment (e.g., COVID-19 new cases, restrictions), experiences (e.g., COVID-19 Worries), and age predicted each outcome subgroup. LIMITATIONS:Notable limitations of the study are its cross-sectional nature and focus on the first six mont

关键词： Autism spectrum disorder Behavioral problems COVID-19 pandemic Mental health outcomes Neurodevelopmental conditions Prediction Public health Risk and resilience factors Sleep

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Correction: Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients

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Translational psychiatry 2022年第1期12卷 278页

作者： Klaus Oliver Schubert Anbupalam Thalamuthu Azmeraw T Amare Joseph Frank Fabian Streit Mazda Adl Nirmala Akula Kazufumi Akiyama Raffaella Ardau Bárbara Arias Jean-Michel Aubry Lena Backlund Abesh Kumar Bhattacharjee Frank Bellivier Antonio Benabarre Susanne Bengesser Joanna M Biernacka Armin Birner Cynthia Marie-Claire Micah Cearns Pablo Cervantes Hsi-Chung Chen Caterina Chillotti Sven Cichon Scott R Clark Cristiana Cruceanu Piotr M Czerski Nina Dalkner Alexandre Dayer Franziska Degenhardt Maria Del Zompo J Raymond DePaulo Bruno Étain Peter Falkai Andreas J Forstner Louise Frisen Mark A Frye Janice M Fullerton Sébastien Gard Julie S Garnham Fernando S Goes Maria Grigoroiu-Serbanescu Paul Grof Ryota Hashimoto Joanna Hauser Urs Heilbronner Stefan Herms Per Hoffmann Liping Hou Yi-Hsiang Hsu Stephane Jamain Esther Jiménez Jean-Pierre Kahn Layla Kassem Po-Hsiu Kuo Tadafumi Kato John Kelsoe Sarah Kittel-Schneider Ewa Ferensztajn-Rochowiak Barbara König Ichiro Kusumi Gonzalo Laje Mikael Landén Catharina Lavebratt Marion Leboyer Susan G Leckband Mario Maj Mirko Manchia Lina Martinsson Michael J McCarthy Susan McElroy Francesc Colom Marina Mitjans Francis M Mondimore Palmiero Monteleone Caroline M Nievergelt Markus M Nöthen Tomas Novák Claire O'Donovan Norio Ozaki Urban Ösby Sergi Papiol Andrea Pfennig Claudia Pisanu James B Potash Andreas Reif Eva Reininghaus Guy A Rouleau Janusz K Rybakowski Martin Schalling Peter R Schofield Barbara W Schweizer Giovanni Severino Tatyana Shekhtman Paul D Shilling Katzutaka Shimoda Christian Simhandl Claire M Slaney Alessio Squassina Thomas Stamm Pavla Stopkova Fasil Tekola-Ayele Alfonso Tortorella Gustavo Turecki Julia Veeh Eduard Vieta Stephanie H Witt Gloria Roberts Peter P Zandi Martin Alda Michael Bauer Francis J McMahon Philip B Mitchell Thomas G Schulze Marcella Rietschel Bernhard T Baune Discipline of Psychiatry School of Medicine University of Adelaide Adelaide SA Australia. Northern Adelaide Local Health Network Mental Health Services Adelaide SA Australia. Centre for Healthy Brain Ageing (CHeBA) School of Psychiatry University of New South Wales Sydney NSW Australia. Department of Genetic Epidemiology in Psychiatry Central Institute of Mental Health Medical Faculty Mannheim University of Heidelberg Mannheim Germany. Department of Psychiatry and Psychotherapy Charité-Universitätsmedizin Berlin Campus Charité Mitte Berlin Germany. Intramural Research Program National Institute of Mental Health National Institutes of Health US Department of Health & Human Services Bethesda MD USA. Department of Biological Psychiatry and Neuroscience Dokkyo Medical University School of Medicine Mibu Tochigi Japan. Unit of Clinical Pharmacology Hospital University Agency of Cagliari Cagliari Italy. Unitat de Zoologia i Antropologia Biològica (Dpt. Biologia Evolutiva Ecologia i Ciències Ambientals) Facultat de Biologia and Institut de Biomedicina (IBUB) University of Barcelona CIBERSAM Barcelona Spain. Department of Psychiatry Mood Disorders Unit HUG-Geneva University Hospitals Geneva Switzerland. Department of Molecular Medicine and Surgery Karolinska Institute Stockholm Sweden and Center for Molecular Medicine Karolinska University Hospital Stockholm Sweden. Department of Psychiatry University of California San Diego San Diego CA USA. INSERM UMR-S 1144 Université Paris Diderot Département de Psychiatrie et de Médecine Addictologique AP-HP Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal Paris France. Bipolar Disorder Program Institute of Neuroscience Hospital Clinic University of Barcelona IDIBAPS CIBERSAM Barcelona Catalonia Spain. Department of Psychiatry and Psychotherapeutic Medicine Research Unit for bipolar affective disorder Medical University of Graz Graz Austria. Department of Psychiatry and Psychology Mayo Clinic Rochester M

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Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study

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Translational psychiatry 2024年第1期14卷 109页

作者： Anna H Ou Sara B Rosenthal Mazda Adli Kazufumi Akiyama Nirmala Akula Martin Alda Azmeraw T Amare Raffaella Ardau Bárbara Arias Jean-Michel Aubry Lena Backlund Michael Bauer Bernhard T Baune Frank Bellivier Antonio Benabarre Susanne Bengesser Abesh Kumar Bhattacharjee Joanna M Biernacka Pablo Cervantes Guo-Bo Chen Hsi-Chung Chen Caterina Chillotti Sven Cichon Scott R Clark Francesc Colom David A Cousins Cristiana Cruceanu Piotr M Czerski Clarissa R Dantas Alexandre Dayer Maria Del Zompo Franziska Degenhardt J Raymond DePaulo Bruno Étain Peter Falkai Frederike Tabea Fellendorf Ewa Ferensztajn-Rochowiak Andreas J Forstner Louise Frisén Mark A Frye Janice M Fullerton Sébastien Gard Julie S Garnham Fernando S Goes Maria Grigoroiu-Serbanescu Paul Grof Oliver Gruber Ryota Hashimoto Joanna Hauser Urs Heilbronner Stefan Herms Per Hoffmann Andrea Hofmann Liping Hou Stephane Jamain Esther Jiménez Jean-Pierre Kahn Layla Kassem Tadafumi Kato Sarah Kittel-Schneider Barbara König Po-Hsiu Kuo Ichiro Kusumi Nina Lackner Gonzalo Laje Mikael Landén Catharina Lavebratt Marion Leboyer Susan G Leckband Carlos A López Jaramillo Glenda MacQueen Mario Maj Mirko Manchia Cynthia Marie-Claire Lina Martinsson Manuel Mattheisen Michael J McCarthy Susan L McElroy Francis J McMahon Philip B Mitchell Marina Mitjans Francis M Mondimore Palmiero Monteleone Caroline M Nievergelt Markus M Nöthen Tomas Novák Urban Ösby Norio Ozaki Sergi Papiol Roy H Perlis Claudia Pisanu James B Potash Andrea Pfennig Daniela Reich-Erkelenz Andreas Reif Eva Z Reininghaus Marcella Rietschel Guy A Rouleau Janusz K Rybakowski Martin Schalling Peter R Schofield K Oliver Schubert Thomas G Schulze Barbara W Schweizer Florian Seemüller Giovanni Severino Tatyana Shekhtman Paul D Shilling Kazutaka Shimoda Christian Simhandl Claire M Slaney Alessio Squassina Thomas Stamm Pavla Stopkova Sarah K Tighe Alfonso Tortorella Gustavo Turecki Eduard Vieta Julia Volkert Stephanie Witt Naomi R Wray Adam Wright L Trevor Young Peter P Zandi John R Kelsoe Department of Psychiatry University of California San Diego La Jolla CA USA. Center for Computational Biology and Bioinformatics Department of Medicine University of California San Diego La Jolla CA USA. Department of Psychiatry and Psychotherapy Charité- Universitätsmedizin Berlin Campus Charité Mitte Berlin Germany. Fliedner Klinik Berlin Center for Psychiatry Psychotherapy and Psychosomatic Medicine Berlin Germany. Department of Biological Psychiatry and Neuroscience Dokkyo Medical University School of Medicine Mibu Japan. Intramural Research Program National Institute of Mental Health National Institutes of Health US Department of Health & Human Services Bethesda MD USA. Department of Psychiatry Dalhousie University Halifax NS Canada. National Institute of Mental Health Klecany Czech Republic. Discipline of Psychiatry University of Adelaide Adelaide SA Australia. Unit of Clinical Pharmacology Hospital University Agency of Cagliari Cagliari Italy. Department of Evolutive Biology Ecology and Environmental Sciences Facultat de Biologia and Institut de Biomedicina (IBUB) Universitat de Barcelona Barcelona Spain. CIBER de Salud Mental ISCIII Madrid Barcelona Catalonia Spain. Department of Mental Health and Psychiatry Mood Disorders Unit-Geneva University Hospitals Geneva Switzerland. Department of Molecular Medicine and Surgery Karolinska Institutet and Center for Molecular Medicine Karolinska University Hospital Stockholm Sweden. Department of Psychiatry and Psychotherapy University Hospital Carl Gustav Carus Medical Faculty Technische Universität Dresden Dresden Germany. Department of Psychiatry University of Münster Münster Germany. INSERM UMR-S 1144-Université Paris Cité Département de Psychiatrie et de Médecine Addictologique AP-HP Groupe Hospitalier Lariboisière-F Widal Paris France. Bipolar and Depressive Disorders Unit Institute of Neuroscience Hospital Clinic University of Barcelona IDIBAPS CIBERSAM ISCIII Barcelona Catalonia Spa

Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.

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Correction: Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals

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Molecular psychiatry 2024年第1期29卷 56页

作者： Sean R McWhinney Katharina Brosch Vince D Calhoun Benedicto Crespo-Facorro Nicolas A Crossley Udo Dannlowski Erin Dickie Lorielle M F Dietze Gary Donohoe Stefan Du Plessis Stefan Ehrlich Robin Emsley Petra Furstova David C Glahn Alfonso Gonzalez-Valderrama Dominik Grotegerd Laurena Holleran Tilo T J Kircher Pavel Knytl Marian Kolenic Rebekka Lencer Igor Nenadić Nils Opel Julia-Katharina Pfarr Amanda L Rodrigue Kelly Rootes-Murdy Alex J Ross Kang Sim Antonín Škoch Filip Spaniel Frederike Stein Patrik Švancer Diana Tordesillas-Gutiérrez Juan Undurraga Javier Vázquez-Bourgon Aristotle Voineskos Esther Walton Thomas W Weickert Cynthia Shannon Weickert Paul M Thompson Theo G M van Erp Jessica A Turner Tomas Hajek Department of Psychiatry Dalhousie University Halifax NS Canada. Department of Psychiatry and Psychotherapy Philipps-University Marburg Marburg Germany. Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State Georgia Tech Emory University Atlanta GA USA. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) Madrid Spain. IBiS University Hospital Virgen del Rocio Sevilla Spain. Department of Psychiatry School of Medicine University of Sevilla Sevilla Spain. Department of Psychiatry School of Medicina Pontificia Universidad Católica de Chile Santiago Chile. Department of Psychosis Studies King's College London London UK. Institute for Translational Psychiatry University of Münster Münster Germany. Centre for Addiction & Mental Health Department of Psychiatry University of Toronto Toronto ON Canada. Centre for Neuroimaging & Cognitive Genomics (NICOG) Clinical Neuroimaging Laboratory NCBES Galway Neuroscience Centre College of Medicine Nursing and Health Sciences National University of Ireland Galway Galway Ireland. Department of Psychiatry Faculty of Medicine and Health Sciences Stellenbosch University Cape Town South Africa. SAMRC Genomics of Brain Disorders Unit Cape Town South Africa. Translational Developmental Neuroscience Section Division of Psychological and Social Medicine and Developmental Neurosciences Faculty of Medicine TU Dresden Dresden Germany. National Institute of Mental Health Klecany Czech Republic. Department of Psychiatry & Behavioral Sciences Boston Children's Hospital Boston MA USA. Department of Psychiatry Harvard Medical School Boston MA USA. Olin Neuropsychiatry Research Center Institute of Living Hartford CT USA. School of Medicine Universidad Finis Terrae Santiago Chile. Early Intervention in Psychosis Program Instituto Psiquiátrico 'Dr. José Horwitz B.' Santiago Chile. Charles University Third Faculty of Medicine Prague Czech Republic. Department

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