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Novel bioengineered hydrogel combined with brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor improves functional recovery following traumatic contusive spinal cord injury

Novel bioengineered hydrogel combined with brain-derived neu...

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2nd International Neural Regeneration Symposium(INRS2012)(第二届国际神经再生高峰论坛)

作者： Melissa J.Walker Xiao-Ming Xu Wenjie Wu Lingxiao Deng Jian Zou Chandler L.Walker Qingbo Lu Naikui Liu Xuejun Wen Ning Zhang Departments of Bioengineering Cell Biology & Anatomy Orthopedic Surgery Hollings Cancer Center Clemson University and Medical University of South Carolina Charleston South Carolina USA Department of Neurological Surgery Indiana University School of Medicine Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis Indiana USA Indiana Spinal Cord and Brain Injury Research Group Indiana University School of Medicine Medical Neuroscience Graduate Program Indiana University School of Medicine Departments of Bioengineering Microbiology & Immunology and Cell Biology & Anatomy Clemson University and Medical University of South Carolina Charleston South Carolina USA Department of Anatomy & Cell Biology Indiana University School of Medicine

The initial mechanical insult resulting from traumatic spinal cord injury (SCI) causes the disruption of local vasculature and tissue structure followed by a secondary wave of injury involving hemorrhage, ischemia, edema, excitotoxicity, and inflammation, which leads to neuronal death, axonal degeneration, and inhibitory glial scar formation.

关键词： spinal cord injury hydrogel neurotrauma

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SLORETA and fMRI Detection of Medial Prefrontal Default Network Anomalies in Adult ADHD

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Journal of Neurotherapy 2011年第4期15卷 358-373页

作者： Cannon, Rex Kerson, Cynthia Hampshire, Adam Clinical Neuroscience Self-Regulation and Biological Psychology Laboratory Department of Psychology University of Tennessee Knoxville TN United States Cole Neuroscience Center: Memory Disorders Clinic University of Tennessee Graduate School of Medicine Knoxville TN United States ISNR Research Foundation San Rafael CA 94901 1925 Francisco Boulevard E #12 United States Centre for Brain and Mind Department of Psychology University of Western Ontario London ON Canada

Attention deficit hyperactivity disorder (ADHD) is a developmental psychiatric disorder thought to affect approximately 5 to 10% of school-age children, of whom 30 to 65% continue to exhibit symptoms into adulthood. The prevalence of ADHD in adults is also an estimated 4%, second only to depression. Across studies there appear to be significant network dysfunctions involved in ADHD. Typically the foci of interest in ADHD included the insular cortices, frontal lobes, basal ganglia, and cerebellum. More recently, attention has been directed to the default network of the brain and its functional integrity in ADHD with focus on the precuneus and parietal lobes and interactions with medial prefrontal cortices. Functional magnetic resonance imaging (fMRI) measures neurovascular coupling as measured by the blood oxygenated level dependent signal (BOLD). Electroencephalogram (EEG) measures brain electrical information. Because fMRI is an indirect measure of neuronal activity and EEG is a direct measure, combining the results from these two imaging modalities under the same task conditions may provide a more complete story as to the what (EEG) and where (fMRI) activity exists. This article discusses the benefits of using standardized low resolution electromagnetic tomography (sLORETA) analysis of the EEG as compared to fMRI. The goal of the study, the data from which we use for our justification, was to discover the functional differences in ADHD and non-ADHD brains with different brain imaging modalities. We hoped to elucidate functional connectivity patterns by interpreting the data acquired with the EEG using sLORETA and the data acquired with the fMRI scans. We further hoped to find correlation with the sLORETA and fMRI interpretations so as to confirm that EEG is an adequate stand-alone methodology to evaluate ADHD. Participants included 6 ADHD and 7 non-ADHD subjects. They were initially interviewed by phone and administered the Connors Rating Scale and the Mini Intern

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Active microglia from aged mice are less sensitive to anti-inflammatory feedback from IL-4

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brain, Behavior, and Immunity 2011年 25卷 S188-S189页

作者： Fenn, A.M. Henry, C.J. Huang, Y. Godbout, J.P. Ohio State University Institute for Behavioral Medicine Research Columbus OH 43210 USA Neuroscience Graduate Studies Program USA Department of Molecular Virology Immunology and Medical Genetics USA Biochemistry Program USA Center for Brain and Spinal Cord Repair USA

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125. Peripheral lipopolysaccharide (LPS) injection causes amplified microglial activation, enhanced macrophage trafficking to the brain, and prolonged sickness behavior in socially defeated mice

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brain, Behavior, and Immunity 2011年 25卷 S215-S215页

作者： Wohleb, E.S. Fenn, A.M. Godbout, J.P. Sheridan, J.F. Neuroscience Graduate Studies Program The Ohio State University Columbus OH 43210 USA Oral Biology Section USA Molecular Virology Immunology and Medical Genetics USA Institute for Behavioral Medicine Research USA Center for Brain and Spinal Cord Injury USA

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The Scale of Experience

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Science 2008年第5885期321卷 46-47页

作者： Michael E. Hasselmo Center for Memory and Brain Department of Psychology and Program in Neuroscience Boston University Boston MA 02215 USA.

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Linking cellular mechanisms to behavior: Entorhinal persistent spiking and membrane potential oscillations may underlie path integration, grid cell firing, and episodic memory

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Neural Plasticity 2008年第1期2008卷 658323页

作者： Hasselmo, Michael E. Brandon, Mark P. Center for Memory and Brain Department of Psychology and Program in Neuroscience Boston University Boston MA 02215 2 Cummington Sreet United States

The entorhinal cortex plays an important role in spatial memory and episodic memory functions. These functions may result from cellular mechanisms for integration of the afferent input to entorhinal cortex. This article reviews physiological data on persistent spiking and membrane potential oscillations in entorhinal cortex then presents models showing how both these cellular mechanisms could contribute to properties observed during unit recording, including grid cell firing, and how they could underlie behavioural functions including path integration. The interaction of oscillations and persistent firing could contribute to encoding and retrieval of trajectories through space and time as a mechanism relevant to episodic memory.

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脑内注射脂多糖后常驻小胶质细胞死亡而中性粒细胞和单核细胞浸润成为主要炎症细胞

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神经损伤与功能重建 2008年第1期3卷 47-52,55页

作者： KYUNG-AE JI MYUNG-SOON YANG HEY-KYEONG JEONG KYOUNG-JIN MIN SEUNG-HEE KANG ILO JOU AND EUN-HYE JOE 王雪贞（编译）卜碧涛（校） Neuroscience Graduate Program Ajou University School of Medicine Suwon Korea Department of Pharmacology Ajou University School of Medicine Suwon Korea Brain Disease Research Center Ajou University School of Medicine Suwon Korea Department of Radiation Oncology Ajou University School of Medicine Suwon Korea Chronic Inflammatory Disease Research Center Ajou University School of Medicine Suwon Korea 不详

为了研究小胶质细胞和血中炎症细胞对脑炎症的影响,在正常和白细胞减少大鼠的黑质致密部(SNpc)、皮层和海马注射脂多糖(LPS),用特异标记来研究中性粒细胞、小胶质细胞和单核细胞的行为学。CD11b+和Iba-1+阳性细胞在正常脑和LPS注射后6h... 详细信息

为了研究小胶质细胞和血中炎症细胞对脑炎症的影响,在正常和白细胞减少大鼠的黑质致密部(SNpc)、皮层和海马注射脂多糖(LPS),用特异标记来研究中性粒细胞、小胶质细胞和单核细胞的行为学。CD11b+和Iba-1+阳性细胞在正常脑和LPS注射后6h反应相似。注射后12hIba-1+细胞消失而CD11b+变成圆形。CD11b/Iba-1双阳性网状小胶质细胞在LPS注射后6h死亡。注射后12h检测到的CD11b+细胞是MPO+细胞。这些CD11b+/MPO+细胞在白细胞减少的大鼠脑内不出现,提示中性粒细胞浸润。MPO+中性粒细胞表达一氧化氮合酶(iNOS)、IL-1β、环氧合酶-2(COX-2)和单核细胞趋化蛋白-1(MCP-1),但在注射后18h死亡。在24h检测到的CD11b+细胞是浸润的单核细胞,因为这些细胞曾经是Iba-1+而且在白细胞减少的大鼠脑内不出现。而且,在LPS注射的脑内可以检测到移植的单核细胞。这些结果提示,在发生炎症的脑内,至少有一部分中性粒细胞和单核细胞被认为是活化的小胶质细胞。

关键词：小胶质细胞单核细胞中性粒细胞神经炎症

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Abstracts for the 6th Congress of Asian Sleep Research Society

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Sleep and Biological Rhythms 2009年第4期7卷 A1-A49页

作者： Seog Ju Kim In Kyoon Lyoo Yu-Jin Lee Do-Un Jeong Hirohiko Kanai Masanori Ookubo Atsushi Yoshimura Masako Okawa Noto Yamada Takeshi Munezawa Yoshitaka Kaneita Yoneatsu Osaki Hideyuki Kanda Tadahiro Ohtsu Masumi Minowa Kenji Suzuki Susumu Hijuchi Hiroyuki Suzuki Takashi Ohida Takashi Abe Yoko Komada Shoichi Asaoka Yuichi Inoue Jin-Seong Lee Sang-Yong Cho Deependra Kumar Hruda N. Mallick Velayudhan M. Kumar Mahesh K. Kaushik Akihiro Karashima Noiihiro Katayama Mitsuyuki Nakao Ravindra P. Nagendra Sathiamma Sulekha Sathyaprabha T. Narasappa Pradhan Nityanadan Bindu M. Kutty M. Nirmala P. N. Ravindra Basavaraj Ramappa Tubaki T. N. Sathyaprabha D. Sudhakar G. S. Lavekar C. R. Chandrashekar Kazuyoshi Kitaoka Mika Shimizu Sachiko Chikahisa Kazuo Yoshizaki Hiroyoshi Sei Jong-Won Kim Misa Takegami Shin Yamazaki Yasuaki Hayashino Rei Ono Koji Otani Miho Sekiguchi Shinichi Konno Shunichi Fukuhara Antonia J. Jakobson Paul Fitzgerald Russell Conduit Xin Shirley Li Siu Ping Joyce Lam Wai Man Mandy Yu Yun Kwok Wing Kazue Okamoto-Mizuno Koh Mizuno Mituaki Yamamoto Shuichiro Shirakawa Hirokazu Doi Mikako Kato Kazuyuki Shinohara Masako Tamaki Shiori Matsuda Katsuo Yamazaki Tadao Hori Keiko Ogawa Kazumi Takahashi Kunio Kitahama Katuo Yamazaki Yoshimasa Koyama Kohei Shioda Yugo Ueda Yukiko Nakamura Clara Inoue Kazushige Goto Sunao Uchida Yuko Morita Yoshiko Honda Tohru Kodama Mari Hagihara Toru Nakajima Masato Saito Yoshihiko Koga Shinichiro Tanaka Hiroshi Yamadera Madoka Takahara Sachiko Suwa Minoru Onozuka Sadao Sato Fumiharu Togo Taiki Komatsu Takeshi Mitani Jongbae Choi Bin Zhang Taeko Sasai Hiromi Mitsubayashi Mitsuhiro Ohtsu Isao Hasegawa Tatsuya Ishii Akira Komori Asami Suzuki Yue Nakahara Mitsuyasu Hiroki Mariko Nakauma Nobuo Someya Tomomasa Ochiai Shouhei Komori Rayleigh Ping-Ying Chiang Zai-Ting Yeh Seong T. Kim Seung H. Yoon Jeong S. Kwon Jong H. Choi Hyung J. Ahn Youngsoo Kim Bolortuya Yunren Lichao Chen Radhika Basheer Robert W. Mccarley Robert E. Strecker Makoto Honda Tetsuaki Arai Miyuki Fukazawa Yutaka Honda Kuniaki T Department of Psychiatry Gachon University of Medicine and Science Incheon Republic of Korea Department of Psychiatry Seoul National University Seoul Republic of Korea Department of Neuropsychiatry and Center for Sleep and Chronobiology Seoul National University Hospital Seoul Republic of Korea Department of Neuropsychiatry Seoul National University Hospital Seoul Republic of Korea Seoul National University Hospital Seoul Republic of Korea Department of Psychiatry Shiga University of Medical Science Otsu Japan Division of Public Health Department of Social Medicine Nihon University School of Medicine Tokyo Japan Department of Public Health Nihon University School of Medicine Tokyo Japan Division of Environmental and Preventive Medicine Department of Social Medicine Faculty of Medicine Tottori University Yonago Japan Department of Hygiene and Preventive Medicine Fukushima Medical University Fukushima Japan Department of Public Health Showa University School of Medicine Tokyo Japan Faculty of Humanities Seitoku University Matsudo Japan Section on Behavioral Science Division of Clinical Research National Hospital Organization Kurihama Alcoholism Center Yokosuka Japan Department of Otolaryngology Second Hospital Fujita Health University Nagoya Japan National Hospital Organization Kurihama Alcoholism Center Kanagawa Japan Metropolitan Police Department Criminal Investigation Laboratory Tokyo Japan Japan Somnology Center Neuropsychiatrie Research Institute Tokyo Japan Department of Somnology Tokyo Medical University Tokyo Japan Japan Somnology Center Neuropsychiatric Research Institute Tokyo Japan Department of Somnology Tokyo Medical and Dental University Tokyo Japan Center for Sleep and Chronobiology Department of Psychiatry and Behavioral Science Seoul National University College of Medicine Seoul Republic of Korea Department of Psychiatry and Behavioral Science Center for Sleep and Chronobiology Seoul Republic of Korea Department of Physiology Al

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Mechanisms of carbachol oscillations

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BMC neuroscience 2007年第2期8卷 1-1页

作者： Theoden I Netoff Lisa Giocomo John A White Department of Biomedical Engineering University of Minnesota Minneapolis MN USA Program in Neuroscience Center for Memory and Brain Boston University Boston MA USA Department of Biomedical Engineering Boston University Boston MA USA

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Hebbian synaptic modification in cortical circuits and memory-guided behavior in spatial alternation and delayed non-match to position

Hebbian synaptic modification in cortical circuits and memor...

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International Joint Conference on Neural Networks, IJCNN 2005

作者： Hasselmo, Michael E. Zilli, Eric Program in Neuroscience Center for Memory and Brain Boston University 2 Cummington St. Boston MA 02215

ISBN: (纸本)0780390482

Numerous studies have focused on the mechanisms of Hebbian synaptic plasticity within the hippocampal formation and neocortical structures, but the specific role of this plasticity in regulating behavior remains unclear. This paper presents a model demonstrating how Hebbian synaptic modification could mediate the context-dependent retrieval of episodes necessary for memory-guided behavior in specific tasks, and could also contribute to prefrontal mechanisms for regulation of goal-directed behavior. This modeling effectively links neurophysiological data to the functional role of Hebbian synaptic modification and theta rhythm oscillations. The model simulates data on neuronal spike firing and field potentials in the hippocampus, including 1.) the phenomenon of theta phase precession of place cells, 2.) the contextsensitivity of neuronal firing ("splitter cells") during spatial alternation, and 3.) the selective changes in theta phase precession across different trials on the same day.

关键词： Neural networks

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