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SLORETA and fMRI Detection of Medial Prefrontal Default Network Anomalies in Adult ADHD

Journal of Neurotherapy 2011年第4期15卷 358-373页

作者： Cannon, Rex Kerson, Cynthia Hampshire, Adam Clinical Neuroscience Self-Regulation and Biological Psychology Laboratory Department of Psychology University of Tennessee Knoxville TN United States Cole Neuroscience Center: Memory Disorders Clinic University of Tennessee Graduate School of Medicine Knoxville TN United States ISNR Research Foundation San Rafael CA 94901 1925 Francisco Boulevard E #12 United States Centre for Brain and Mind Department of Psychology University of Western Ontario London ON Canada

Attention deficit hyperactivity disorder (ADHD) is a developmental psychiatric disorder thought to affect approximately 5 to 10% of school-age children, of whom 30 to 65% continue to exhibit symptoms into adulthood. The prevalence of ADHD in adults is also an estimated 4%, second only to depression. Across studies there appear to be significant network dysfunctions involved in ADHD. Typically the foci of interest in ADHD included the insular cortices, frontal lobes, basal ganglia, and cerebellum. More recently, attention has been directed to the default network of the brain and its functional integrity in ADHD with focus on the precuneus and parietal lobes and interactions with medial prefrontal cortices. Functional magnetic resonance imaging (fMRI) measures neurovascular coupling as measured by the blood oxygenated level dependent signal (BOLD). Electroencephalogram (EEG) measures brain electrical information. Because fMRI is an indirect measure of neuronal activity and EEG is a direct measure, combining the results from these two imaging modalities under the same task conditions may provide a more complete story as to the what (EEG) and where (fMRI) activity exists. This article discusses the benefits of using standardized low resolution electromagnetic tomography (sLORETA) analysis of the EEG as compared to fMRI. The goal of the study, the data from which we use for our justification, was to discover the functional differences in ADHD and non-ADHD brains with different brain imaging modalities. We hoped to elucidate functional connectivity patterns by interpreting the data acquired with the EEG using sLORETA and the data acquired with the fMRI scans. We further hoped to find correlation with the sLORETA and fMRI interpretations so as to confirm that EEG is an adequate stand-alone methodology to evaluate ADHD. Participants included 6 ADHD and 7 non-ADHD subjects. They were initially interviewed by phone and administered the Connors Rating Scale and the Mini Intern

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Prospective Associations between Screen-based Sedentary Behaviors and Cognitive Performance among Children aged 5-7 Years

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Mental Health and Physical Activity 2025年

作者： Jiahui Wang Fabian Herold Zhihao Zhang Yanxia Chen Dominika M. Pindus Charles H. Hillman Qian Yu Kaiqi Guan Arthur F. Kramer Fred Paas Boris Cheval Matthew Heath Laurie Kramer André O. Werneck Neville Owen Mats Hallgren Shuo Lu Liye Zou Body-Brain-Mind Laboratory School of Psychology Shenzhen University Shenzhen 518060 China Department of Physiology Faculty of Medicine HMU Health and Medical University Erfurt Erfurt Thuringia Germany Department of Physical Education Shanghai Jiaotong University Shanghai China Beckman Institute University of Illinois Urbana-Champaign Urbana IL USA Department of Health and Kinesiology University of Illinois Urbana-Champaign Urbana IL USA Neuroscience Program University of Illinois Urbana-Champaign Urbana IL USA Center for Cognitive and Brain Health Northeastern University Boston MA 02115 USA Department of Psychology Northeastern University Boston MA 02115 USA Department of Physical Therapy Movement and Rehabilitation Sciences Northeastern University Boston MA 02115 USA Faculty of Education University of Macau Macau China Department of Psychology Education and Child Studies Erasmus University Rotterdam Rotterdam the Netherlands School of Education/Early Start University of Wollongong Wollongong Australia Department of Sport Sciences and Physical Education École normale supérieure de Rennes Bruz France VIPS2 Laboratory University of Rennes France Canadian Centre for Activity and Aging University of Western Ontario London ON N6A3K7 Canada Graduate Program in Neuroscience University of Western Ontario London ON N6A3K7 Canada Family Resiliency Center University of Illinois at Urbana-Champaign Urbana IL USA Department of Applied Psychology Northeastern University Boston MA USA Center for Epidemiological Research in Nutrition and Health Department of Nutrition School of Public Health Universidade de São Paulo (USP) Brazil Physical Activity Laboratory Baker Heart & Diabetes Institute Melbourne Victoria Australia Centre for Urban Transitions Swinburne University of Technology Melbourne Victoria Australia Epidemiology of Psychiatric Conditions Substance Use and Social Environment (EPiCSS) Department of Public Health Sciences Karolinska Ins

Background The 5- to 7-year shift is a critical period for cognitive development and is particularly sensitive to lifestyle factors such as sedentary behavior (SB). Screen-based activities can be classified into two types: mentally active SB requires higher cognitive engagement (e.g., computer use, electronic gaming), and mentally passive SB involves less cognitive engagement (e.g., TV-watching). Although there has been a growing interest in understanding the role of such forms of SB on cognitive development has emerged in recent years, our knowledge of its influence in early childhood is still relatively scant. Thus, this study aimed to advance our understanding of how screen-based SB influence cognitive development trajectories, considering the moderating role of the SB duration, SB type, and sex. Methods Data from 12,257 children (6178 Boys; 6079 Girls) in the UK Millennium Cohort Study (MCS), a longitudinal and nationally representative birth cohort study in the UK, were analyzed. The MCS includes children born between September 2000 and January 2002. For this study, we used data from wave 3 (at the age of 5 years) to assess the association between computer use/e-gaming and TV-watching time with cognitive performance assessed in wave 4 (at the age of 7 years). Cognitive performance was assessed using the British Ability Scales II (BAS II), including word reading and pattern construction tests, and an adapted National Foundation for Educational Research (NFER) Progress in Maths test. Statistical analyses were performed via a Generalized Linear Model (GLM) adjusted for confounders and stratified by sex. Results For boys, computer use/e-gaming at the age of 5 years was associated with better word reading performance at the age of 7 years for those who engaged in it for less than 1 hour ( β = 0.148, 95% CI: 0.081 to 0.215, p < 0.001) and 1 to 3 hours ( β = 0.209, 95% CI: 0.128 to 0.290, p < 0.001) per day. Regarding math performance, computer use/e-gaming for less t

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Cross-sectional and longitudinal associations between sedentary behavior and behavioral problems in children with overweight/obesity

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Mental Health and Physical Activity 2025年 29卷

作者： Kaiqi Guan Jiayi Yang Boris Cheval Matthew Health Fabian Herold André O. Werneck Cassandra J. Lowe Mats Hallgren Benjamin Tari Dominika Pindus Ryan S. Falck Markus Gerber Justin A. Haegele Arthur F. Kramer Neville Owen Charles H. Hillman Tianyou Guo Liye Zou Body-Brain-Mind Laboratory School of Psychology Shenzhen University Shenzhen 518060 China Department of Sport Sciences and Physical Education École Normale Supérieure de Rennes Bruz France VIPS2 Laboratory University of Rennes France Canadian Centre for Activity and Aging University of Western Ontario London ON N6A 3K7 Canada Graduate Program in Neuroscience The University of Western Ontario 1151 Richmond St London ON N6A 3K7 Canada School of Kinesiology Faculty of Health Sciences The University of Western Ontario 1151 Richmond St London ON N6A 3K7 Canada Department of Physiology Faculty of Medicine HMU Health and Medical University Erfurt Erfurt Germany Center for Epidemiological Research in Nutrition and Health Department of Nutrition School of Public Health Universidade de São Paulo São Paulo Brazil Department of Psychology University of Exeter UK Department of Global Public Health Karolinska Institute Stockholm Sweden Institute of Sport Exercise and Health Division of Surgery and Interventional Sciences University College London London UK Department of Health and Kinesiology University of Illinois Urbana-Champaign Urbana IL USA Beckman Institute for Advanced Science and Technology University of Illinois Urbana-Champaign Urbana IL USA Neuroscience Program University of Illinois Urbana-Champaign Urbana IL USA School of Biomedical Engineering University of British Columbia Vancouver BC Canada Department of Sport Exercise and Health University of Basel 4052 Basel Switzerland Center for Movement Health & Disability Old Dominion University Norfolk VA USA Darden College of Education & Professional Studies Old Dominion University Norfolk VA USA Center for Cognitive and Brain Health Northeastern University Boston MA USA Department of Psychology Northeastern University Boston MA 02115 USA Physical Activity Laboratory Baker Heart & Diabetes Institute Melbourne Victoria Australia Centre for Urban Transitions Swinburne University of

Background Sedentary behaviors (ST) are linked to children's mental health, including internalizing and externalizing problems. Research on these associations in children with overweight/obesity is limited. To this end, we examined cross-sectional and longitudinal associations between sedentary time (ST) and behavioral problems in children with overweight/obesity, followed by an investigation of potential sex-related differences. Methods We included 2273 children with overweight/obesity (49.9 % boys) from the UK Millennium Cohort Study. Accelerometer-measured sedentary time (ST) and MVPA were collected at age 7, and behavioral problems were assessed at ages 7 and 11 via the Strengths and Difficulties Questionnaire (SDQ). General linear models were used to examine how ST at 7 years of age was cross-sectionally and longitudinally associated with externalizing and internalizing, while ethnicity, SDQ scores, parental psychological distress, highest parental education, household poverty, and moderate-to-vigorous physical activity (MVPA) were statistically controlled. These analyses are followed by an analysis investigating sex-related differences. Results In the cross-sectional analyses, more ST was associated with fewer externalizing problems at 7 years among boys (β: −0.008, 95 % CI: −0.013, −0.003) and girls (β: −0.006, 95 % CI: −0.011, −0.001) without controlling for MVPA. More ST at 7 years was associated with fewer externalizing problems (β: −0.010, 95 %CI: −0.015, −0.004) only among boys when adjusting for MVPA. In the longitudinal analysis, more ST at 7 years was associated with fewer externalizing problems at 11 years for boys (β: −0.006, 95 %CI: −0.010, −0.001) and girls (β: −0.007, 95 %CI: −0.012, −0.002) without controlling for MVPA. When adjusting for MVPA at 7 years, more ST at 7 years was associated with fewer externalizing problems at 11 years for girls (β: −0.006, 95 %CI: −0.013, 0.000). Conclusions In overweight/obese children, device-measured ST at the

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A nigroincertal projection mediates aversion and enhances coping responses to potential threat

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FASEB Journal 2023年第12期37卷 e23322-e23322页

作者： Ho, Ping-Chen Hsiao, Fu-Yun Chiu, Shi-Hong Lee, Syun-Ruei Yau, Hau-Jie The Laboratory for Neural Circuits and Behaviors Graduate Institute of Brain and Mind Sciences National Taiwan University Taipei Taiwan School of Medicine National Taiwan University Taipei Taiwan Neurobiology and Cognitive Science Center National Taiwan University Taipei Taiwan Taiwan International Graduate Program in Interdisciplinary Neuroscience National Taiwan University and Academia Sinica Taipei Taiwan Ph.D. Program in Translational Medicine National Taiwan University and Academia Sinica Taipei Taiwan

Recent studies have shown that the non-DA neurons in the ventral tegmental area (VTA) and substantia nigra (SN) not only modulate motivational behaviors but also regulate defensive behaviors. While zona incerta (ZI) is a threat-responsive substrate and receives innervations from the ventral midbrain, the function of the ventral midbrain-to-ZI connection remains poorly defined. Here, we demonstrate that the ZI receives heterogenous innervations from the ventral midbrain. By utilizing a retrograde AAV preferentially labeling non-DA neurons in the ventral midbrain, we found that ZI-projecting non-DA cells in the ventral midbrain are activated by restraint stress. We focused on the SN and found that SN-to-ZI GABAergic input is engaged by a predatory odor. Sustained pan-neuronal SN-to-ZI activation results in aversion and enhances defensive behaviors, likely through a disinhibition mechanism to recruit downstream brain regions that regulate defensive behaviors. Collectively, our results reveal a novel role of nigroincertal projection in mediating negative valence and regulating defensive behaviors. © 2023 Federation of American Societies for Experimental Biology.

关键词： defensive behavior stress substantia nigra ventral tegmental area zona increta

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25th Annual Computational neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts

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BMC neuroscience 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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Optogenetic Neural Probes: Fiberless, High-Density, Artifact-Free Neuromodulation : (Invited)

Optogenetic Neural Probes: Fiberless, High-Density, Artifact...

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International Electron Devices Meeting (IEDM)

作者： Eunah Ko Kanghwan Kim Mihály Vöröslakos Sungjin Oh György Buzsáki Kensall D. Wise Euisk Yoon Department of Electrical Engineering and Computer Science University of Michigan Ann Arbor MI USA Center for BioMicrosystems Brain Science Institute Korea Institute of Science and Technology Seoul Korea Neuroscience Institute Langone Medical Center New York University New York NY USA Department of Biomedical Engineering University of Michigan Ann Arbor MI USA Center for Nanomedicine Institute for Basic Science (IBS) and Graduate Program of Nano Biomedical Engineering (Nano BME) Advanced Science Institute Yonsei University Seoul Korea

ISBN: (纸本)9781665489607

Evolution of “Michigan Probes” has enabled unraveling the connectivity of neurons at cellular resolution and their dynamic interaction within and across brain areas that underlie behavioral and cognitive functions. Recently, micro-LEDs were monolithically integrated for optogenetic neuromodulation at scale without requiring external optical fiber connection. The ‘hectoSTAR’ micro-LED optoelectrode features 256 recording electrodes and 128 stimulation micro-LEDs in four silicon micro-needle shanks, covering a large volume with 1.3-mm × 0.9-mm cross-sectional area located as deep as 6 mm inside the brain. Technical challenges to overcome in scaling of optogenetic probes will be discussed, followed by future direction.

关键词： Optical fibers Electrodes brain Optogenetics Silicon Recording Optical fiber devices

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Thalamo-cortical structural co-variation networks are related to familial risk for schizophrenia in the context of lower nuclei volume estimates in patients: an ENIGMA study

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Biological psychiatry 2025年

作者： Annalisa Lella Linda A Antonucci Roberta Passiatore Loredana Bellantuono Pierluigi Selvaggi Teresa Popolizio Guido Di Sciascio Alessandro Saponaro Patrizia Ricci Mario Altamura Giuseppe Blasi Antonio Rampino Chris Vriend Vince D Calhoun Kelly Rootes-Murdy Aaron L Goldman Inmaculada Baeza Josefina Castro-Fornieles Gisela Sugranyes Elena De la Serna Edith Pomarol-Clotet Mar Fatjó-Vilas Raymond Salvador Andriana Karuk Paola Fuentes-Claramonte David C Glahn Amanda L Rodrigue John Blangero Lei Wang Taeyoung Lee Karolin E Einenkel Saskia Hamers Oliver Gruber Adrian Preda Young-Chul Chung Soyolsaikhan Odkhuu Corentin Vallée Paola Dazzan Machteld Marcelis Stijn Michielse Katharina Brosch Frederike Stein Igor Nenadić Benjamin Straube Florian Thomas-Odenthal Tilo Kircher Sean Carruthers Susan L Rossell Phillip J Sumner Tamsyn E Van Rheenen Caroline Demro Ian S Ramsay Scott R Sponheim Rebekka Lencer Susanne Meinert Tim Hahn Udo Dannlowski Dominik Grotegerd Mariateresa Ciccarelli Felice Iasevoli Giuseppe Pontillo Godfrey D Pearlson Derin Cobia Fabrizio Piras Nerisa Banaj Daniela Vecchio Marjolein E A Barendse Neeltje E M van Haren Hang Joon Jo Kang Sim Yann Quidé Melissa J Green Rachael Slate Giacomo Cecere Wolfgang Omlor Stephanie Homan Philipp Homan Sophia I Thomopoulos Jessica A Turner Theo G M van Erp Paul M Thompson Alessandro Bertolino Giulio Pergola Department of Translational Biomedicine and Neuroscience (DiBraiN)-University of Bari Aldo Moro Bari Italy. Department of Translational Biomedicine and Neuroscience (DiBraiN)-University of Bari Aldo Moro Bari Italy Lieber Institute for Brain Development Johns Hopkins Medical Campus Baltimore MD USA. Istituto Nazionale di Fisica Nucleare Bari Italy. Azienda Ospedaliero-Universitaria Consorziale Policlinico Bari Italy. Neuroradiology Unit Scientific Institute for Research Hospitalization and Health Care Casa Sollievo della Sofferenza 71013 San Giovanni Rotondo Foggia Italy. Department of Mental Health ASL Bari Bari Italy. Department of Mental Health ASL Brindisi Brindisi Italy. Department of Mental Health ASL Barletta Andria Trani BAT Italy. Department of Clinical and Experimental Medicine University of Foggia Italy. Amsterdam UMC Vrije Universiteit Amsterdam Department of Psychiatry and Department of Anatomy and Neuroscience de Boelelaan 1117 Amsterdam the Netherlands Compulsivity Impulsivity and Attention Amsterdam Neuroscience de Boelelaan 1117 Amsterdam the Netherlands. Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia Institute of Technology Georgia State University Emory University Atlanta GA USA. Department of Child and Adolescent Psychiatry and Psychology 2021 SGR 01319 Institute of Neuroscience Hospital Clínic Barcelona Barcelona University of Barcelona Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) CIBERSAM Spain. FIDMAG Germanes Hospitalàries Research Foundation CIBERSAM ISCIII Barcelona Spain. Department of Psychiatry and Behavioral Sciences Boston Children's Hospital Boston MA USA Department of Psychiatry Harvard Medical School Boston MA USA Olin Neuropsychiatry Research Center Institute of Living Hartford CT USA. Department of Psychiatry Harvard Medical School Boston MA USA. Department of Human Genetics and South Texas Diabetes and Obesity Institute School of

BACKGROUND:Structural brain differences in the thalamus and the cortex have been widely reported in schizophrenia (SCZ) relative to neurotypical controls (NC). Most prior studies examined the thalamus as a whole, single region-of-interest. Additionally, findings in individuals at familial high-risk for schizophrenia (FHR) remain inconclusive. Here, we investigated whether local and network-wide thalamic-related structural alterations vary as a function of familial risk for schizophrenia. METHODS:Structural MRI scans were obtained from 5,197 participants (3,409 NC, 257 FHR, 1,531 SCZ) across 32 cross-sectional samples within the ENIGMA Consortium. Random-effects meta-analyses, and network analyses were conducted on (i) local thalamic alterations (volume estimates of seven thalamic subdivisions), and (ii) network-wide thalamic alterations (thickness and surface-related thalamo-cortical/cortico-cortical co-variation patterns) across groups (NC, FHR, SCZ). RESULTS:Individuals with SCZ showed significantly lower gray matter volume estimates in the anterior, pulvinar, medial, posterior, and ventral thalamic subdivisions compared to NC (q<0.05). FHR did not differ from NC. At the network-wide level, thalamo-cortical co-variations discriminated FHR from NC (q<0.05), with FHR showing intermediate co-variation between SCZ and NC. Cortico-cortical co-variation patterns revealed that SCZ and FHR shared similarly disconnected clustering configurations, distinct from NC (q<0.05). CONCLUSIONS:Results revealed lower thalamic volume estimates in SCZ but not in FHR, hence yielding no evidence of a familial risk trait, whereas thalamo-cortical and cortico-cortical co-variation estimates were associated with familial risk for SCZ These findings suggest that, once the thalamus is parsed into subdivisions, network-wide thalamo-cortical features may identify trait-dependent, neurobiological correlates of genetic risk for SCZ.

关键词： Familial high risk for schizophrenia meta-analyses morphometric measures structural neuroimaging thalamic subdivisions thalamo-cortical networks

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Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain

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Neurobiology of Pain 2019年 5卷 100022-100022页

作者： Moutal, Aubin Luo, Shizhen Largent-Milnes, Tally M. Vanderah, Todd W. Khanna, Rajesh Department of Pharmacology College of Medicine University of Arizona Tucson 85724 AZ United States Department of Anesthesiology College of Medicine University of Arizona Tucson 85724 AZ United States Neuroscience Graduate Interdisciplinary Program College of Medicine University of Arizona Tucson 85724 AZ United States The Center for Innovation in Brain Sciences University of Arizona Tucson 85724 AZ United States

Neuropathic pain results from nerve injuries that cause ectopic firing and increased nociceptive signal transmission due to activation of key membrane receptors and channels. The dysregulation of trafficking of voltage-gated ion channels is an emerging mechanism in the etiology of neuropathic pain. We identify increased phosphorylation of collapsin response mediator protein 2 (CRMP2), a protein reported to regulate presynaptic voltage-gated calcium and sodium channels. A spared nerve injury (SNI) increased expression of a cyclin dependent kinase 5 (Cdk5)-phosphorylated form of CRMP2 in the dorsal horn of the spinal cord and the dorsal root ganglia (DRG) in the ipsilateral (injured) versus the contralateral (non-injured) sites. Biochemical fractionation of spinal cord from SNI rats revealed the increase in Cdk5-mediated CRMP2 phosphorylation to be enriched to pre-synaptic sites. CRMP2 has emerged as a central node in assembling nociceptive signaling complexes. Knockdown of CRMP2 using a small interfering RNA (siRNA) reversed SNI-induced mechanical allodynia implicating CRMP2 expression as necessary for neuropathic pain. Intrathecal expression of a CRMP2 resistant to phosphorylation by Cdk5 normalized SNI-induced mechanical allodynia, whereas mimicking constitutive phosphorylation of CRMP2 resulted in induction of mechanical allodynia in naïve rats. Collectively, these results demonstrate that Cdk5-mediated CRMP2 phosphorylation is both necessary and sufficient for peripheral neuropathic pain. © 2018 The Authors

关键词： CRMP2 Cyclin-dependent kinase 5 Neuropathic pain Phosphorylation Spared nerve injury

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Mechanisms of carbachol oscillations

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BMC neuroscience 2007年第2期8卷 1-1页

作者： Theoden I Netoff Lisa Giocomo John A White Department of Biomedical Engineering University of Minnesota Minneapolis MN USA Program in Neuroscience Center for Memory and Brain Boston University Boston MA USA Department of Biomedical Engineering Boston University Boston MA USA

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A consensus protocol for functional connectivity analysis in the rat brain (vol 26, pg 673, 2023)

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NATURE neuroscience 2023年第6期26卷 1127-1128页

作者： Grandjean, Joanes Desrosiers-Gregoire, Gabriel Anckaerts, Cynthia Angeles-Valdez, Diego Ayad, Fadi Barriere, David A. Blockx, Ines Bortel, Aleksandra Broadwater, Margaret Cardoso, Beatriz M. Celestine, Marina Chavez-Negrete, Jorge E. Choi, Sangcheon Christiaen, Emma Clavijo, Perrin Colon-Perez, Luis Cramer, Samuel Daniele, Tolomeo Dempsey, Elaine Diao, Yujian Doelemeyer, Arno Dopfel, David Dvorakova, Lenka Falfan-Melgoza, Claudia Fernandes, Francisca F. Fowler, Caitlin F. Fuentes-Ibanez, Antonio Garin, Clement M. Gelderman, Eveline Golden, Carla E. M. Guo, Chao C. G. Henckens, Marloes J. A. G. Hennessy, Lauren A. Herman, Peter Hofwijks, Nita Horien, Corey Ionescu, Tudor M. Jones, Jolyon Kaesser, Johannes Kim, Eugene Lambers, Henriette Lazari, Alberto Lee, Sung-Ho Lillywhite, Amanda Liu, Yikang Liu, Yanyan Y. Lopez-Castro, Alejandra Lopez-Gil, Xavier Ma, Zilu MacNicol, Eilidh Madularu, Dan Mandino, Francesca Marciano, Sabina McAuslan, Matthew J. McCunn, Patrick McIntosh, Alison Meng, Xianzong Meyer-Baese, Lisa Missault, Stephan Moro, Federico Naessens, Daphne M. P. Nava-Gomez, Laura J. Nonaka, Hiroi Ortiz, Juan J. Paasonen, Jaakko Peeters, Lore M. Pereira, Mickael Perez, Pablo D. Pompilus, Marjory Prior, Malcolm Rakhmatullin, Rustam Reimann, Henning M. Reinwald, Jonathan Del Rio, Rodrigo Triana Rivera-Olvera, Alejandro Ruiz-Perez, Daniel Russo, Gabriele Rutten, Tobias J. Ryoke, Rie Sack, Markus Salvan, Piergiorgio Sanganahalli, Basavaraju G. Schroeter, Aileen Seewoo, Bhedita J. Selingue, Erwan Seuwen, Aline Shi, Bowen Sirmpilatze, Nikoloz Smith, Joanna A. B. Smith, Corrie Sobczak, Filip Stenroos, Petteri J. Straathof, Milou Strobelt, Sandra Sumiyoshi, Akira Takahashi, Kengo Torres-Garcia, Maria E. Tudela, Raul van den Berg, Monica van der Marel, Kajo van Hout, Aran T. B. Vertullo, Roberta Vidal, Benjamin Vrooman, Roel M. Wang, Victora X. Wank, Isabel Watson, David J. G. Yin, Ting Zhang, Yongzhi Zurbruegg, Stefan Achard, Sophie Alcauter, Sarael Auer, Dorothee P. Barbier, Emmanuel L. Baudewig, Juergen Beckmann, Chri Donders Institute for Brain Behaviour and Cognition Radboud University Nijmegen The Netherlands Department for Medical Imaging Radboud University Medical Center Nijmegen The Netherlands Cerebral Imaging Centre Douglas Mental Health University Institute Verdun QC Canada Integrated Program in Neuroscience McGill University Montreal QC Canada Bio-imaging Lab University of Antwerp Antwerp Belgium µNEURO Research Centre of Excellence University of Antwerp Antwerp Belgium Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro Mexico Biological and Biomedical Engineering McGill University Montreal QC Canada McConnell Brain Imaging Centre McGill University Montreal QC Canada Montreal Neurological Institute McGill University Montreal QC Canada UMR INRAE/CNRS 7247 Physiologie des Comportements et de la Reproduction Physiologie de la reproduction et des comportements Centre de recherche INRAE de Nouzilly Tours France Department of Neurology and Neurosurgery McGill University Montreal QC Canada Center for Animal MRI University of North Carolina at Chapel Hill Chapel Hill NC USA Department of Neurology University of North Carolina at Chapel Hill Chapel Hill NC USA Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill NC USA Preclinical MRI Champalimaud Research Champalimaud Centre for the Unknown Lisbon Portugal Laboratoire des Maladies Neurodégénératives Molecular Imaging Research Center (MIRCen) Université Paris-Saclay Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA) CNRS Fontenay-aux-Roses France Departamento de Neurobiología Conductual y Cognitiva Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro México Translational Neuroimaging and Neural Control Group High-Field Magnetic Resonance Max Planck Institute for Biological Cybernetics Tuebingen Germany Graduate Training Centre of Neuroscience International Max

Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities collected under invasive or terminal procedures. Currently, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. Here we introduce StandardRat, a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisition and processing parameters, we initially aggregated 65 functional imaging datasets acquired from rats across 46 centers. We developed a reproducible pipeline for analyzing rat data acquired with diverse protocols and determined experimental and processing parameters associated with the robust detection of functional connectivity across centers. We show that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions. The protocol and processing pipeline described here is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience.

关键词： Databases Neural circuits

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