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PERFORMANCE OF A 2D-SWE METHOD FOR THE DIAGNOSIS OF LIVER FIBROSIS USING TRANSIENT ELASTOGRAPHY AS REFERENCE METHOD

Ultrasound in Medicine & Biology 2022年 48卷 S31-S31页

作者： Foncea, Camelia Popescu, Alina Lupusoru, Raluca Cotrau, Radu Bende, Felix Moga, Tudor Sirli, Roxana Sporea, Ioan Department of Internal Medicine II Division of Gastroenterology and Hepatology Center for Advanced Research in Gastroenterology and Hepatology "Victor Babes" University of Medicine and Pharmacy Timisoara Romania Center for Advanced Hepatology Research of the Academy of Medical Sciences Timișoara Romania “Victor Babes” University of Medicine and Pharmacy Center for Modeling Biological Systems and Data Analysis Department of Functional Sciences Timisoara Romania

ObjectivesLiver fibrosis is a progressive process leading to liver cirrhosis. Several non-invasive elastography techniques were developed in order to perform liver stiffness measurements (LS). The aim of this study was to evaluate the performance and feasibility of 2D-Shear Wave Elastography (2D-SWE) for liver fibrosis (LF) assessment using Transient Elastography (TE) as the reference method. Materials67 subjects were included, 65% (44/67) male, mean age 55.6 ± 13.2, in which LS was evaluated in the same session by TE (FibroScan Compact M 530) and 2D-SWE (Samsung-Medison RS85). Reliable LS measurements were defined for TE the median value of 10 measurements with an IQR/M≤30%, while for 2D-SWE the median value of 10 measurements, with a reliability measurement index (RMI)≥ 0.5 and IQR/M ≤30%. For classification of LF severity we used TE as reference method with cut-off value ≥ 7 kPa for at least significant liver fibrosis [1]. ResultsReliable measurements by TE and 2D-SWE were obtained in all 67 cases. A strong correlation was found between 2D-SWE and TE, r=0.83. The best cut-off value for 2D-SWE in identifying at least significant fibrosis (F≥2) was >7 kPa [AUROC=0.91, 95% CI (0.82;0.97), p<0.0001, Se=81.8%, Sp=80.0%, PPV=66.7%, NPV=90.0%]. Conclusions2D-SWE is a feasible method for assessing liver fibrosis, that strongly correlates with TE results.

关键词： liver fibrosis elastography 2D-SWE

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Anthropogenic emission is the main contributor to the rise of atmospheric methane during 1993-2017

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国家科学评论（英文版） 2022年第5期9卷 149-161页

作者： Zhen Zhang Benjamin Poulter Sara Knox Ann Stavert Gavin McNicol Etienne Fluet-Chouinard Aryeh Feinberg Yuanhong Zhao Philippe Bousquet Josep G.Canadell Anita Ganesan Gustaf Hugelius George Hurtt Robert B.Jackson Prabir K.Patra Marielle Saunois Lena H?glund-lsaksson Chunlin Huang Abhishek Chatterjee Xin Li Department of Geographical Sciences University of MarylandCollege ParkMD 20742USA Biospheric Sciences Laboratory NASA Goddard Space Flight CenterGreenbeltMD 20771USA Department of Geography University of British ColumbiaVancouver V6T 1Z2Canada Global Carbon Project CSIRO Oceans and AtmosphereCanberraACT 2601Australia Department of Earth and Environmental Sciences University of Illinois ChicagoChicagoIL 60607USA Department of Earth System Science Stanford UniversityStanfordCA 94305USA Institute for Data Systems and SocietyMassachusetts Institute of TechnologyCambridgeMA 02139USA College of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdao 266000China Laboratoire des Sciences du Climat et de I'Environment LSCE-IPSL(CEA-CNRS-UVSQ)Université Paris-SaclayGif-sur-Yvette 91191France School of Geographical Sciences University of BristolBristol BS8 1RLUK Department of Physical Geography and Bolin Centre for Climate Research Stockholm UniversityStockholm SE-10691Sweden Department of Earth System Science Stanford UniversityStanfordCA 94305USA Woods Institute for the Environment and Precourt Institute for Energy Stanford UniversityStanfordCA 94305USA Research Institute for Global Change JAMSTECYokohama 236-0001Japan International Institute for Applied Systems Analysis(IIASA) Laxenburg A-2361Austria Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhou 730000China Global Modeling and Assimilation Office NASA Goddard Space Flight CenterGreenbeltMD 20771USA Universities Space Research Association ColumbiaMD 21046USA Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China

Atmospheric methane(CH4)concentrations have shown a puzzling resumption in growth since 2007 following a period of stabilization from 2000 to *** hypotheses have been proposed to explain the temporal variations in CH4 growth,and attribute the rise of atmospheric CH4 either to increases in emissions from fossil fuel activities,agriculture and natural wetlands,or to a decrease in the atmospheric chemical ***,we use a comprehensive ensemble of CH4 source estimates and isotopic δ13C-CH4 source signature data to show that the resumption of CH4 growth is most likely due to increased anthropogenic *** emission scenarios that have the fewest biases with respect to isotopic composition suggest that the agriculture,landfill and waste sectors were responsible for 53±13％of the renewed growth over the period 2007-2017 compared to 2000-2006;industrial fossil fuel sources explained an additional 34±24％,and wetland sources contributed the least at 13±9％.The hypothesis that a large increase in emissions from natural wetlands drove the decrease in atmospheric δ13C-CH4 values cannot be reconciled with current process-based wetland CH4 *** finding suggests the need for increased wetland measurements to better understand the contemporary and future role of wetlands in the rise of atmospheric methane and climate *** findings highlight the predominant role of anthropogenic activities in driving the growth of atmospheric CH4 concentrations.

关键词： greenhouse gas carbon cycle climate mitigation wetland methane isotope

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NONINVASIVE biological FIBROSIS SCORES, USEFUL TOOLS FOR EVALUATING NAFLD PATIENTS

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Ultrasound in Medicine & Biology 2022年 48卷 S31-S32页

作者： Cotrau, Radu Popescu, Alina Sporea, Ioan Lupusoru, Raluca Foncea, Camelia Bende, Felix Sirli, Roxana Department of Internal Medicine II Division of Gastroenterology and Hepatology Center for Advanced Research in Gastroenterology and Hepatology "Victor Babes" University of Medicine and Pharmacy Timisoara Romania Center for Advanced Hepatology Research of the Academy of Medical Sciences Timișoara Romania Center for Modeling Biological Systems and Data Analysis Department of Functional Sciences “Victor Babes” University of Medicine and Pharmacy Timisoara Romania Gastroenterology and Hepatology Timisoara Romania

ObjectivesSeveral noninvasive biological scores were developed to predict liver fibrosis (LF) in patients with non-alcoholic fatty liver disease (NAFLD). We aimed to assess the correlation between AST to Platelet Ratio Index (APRI), Fibrosis 4 (FIB-4) Index and BARD score vs. Transient Elastography (TE), in a group of NAFLD patients. MaterialsWe conducted a prospective study, which included 74 patients with NAFLD, (mean age 54.5 ± 11.6 years, 49.4% female). All patients were evaluated clinically (Body mass index- BMI, waist circumference), by serum markers (aspartate transaminase-AST, alanine aminotransferase -ALT, platelets count, gamma glutamyl transferases- GGT, triglycerides), as well as by TE (FibroScan Compact M 530). Based on specific formulas, we calculated APRI, FIB-4 index and, BARD, scores [1]. To discriminate advanced fibrosis (F≥3) by means of TE, we used the cut-off value of 9.7 kPa [2]. ResultsOut of 74 patients with NAFLD, 10.8% (8/74) patients had advanced fibrosis based on TE measurements. Using APRI cut-off <2 (100% patients) to rule out advanced fibrosis, we found a NPV of 91.7%. A weak, but significant correlation between liver stiffness (LS) assessed by TE and APRI score was found (r=0.31, p<0.0001). Using FIB-4 cut-off <2.6 to rule out advanced fibrosis (91.2% - 68/74 patients), we found out a NPV of 92.8%. FIB-4 score was weakly correlated to TE measurements, but statistically significant (r=0.20 , p=0.006). Regarding BARD score, 36.4% (27/74) of patients had a BARD score <2, used to rule out advanced fibrosis, with a NPV of 100%. ConclusionsAPRI, BARD and FIB-4 can rule out advanced fibrosis. These simple scores could be the basis for evaluation on LF in order to evaluate the need for further investigations

关键词： Non-alcoholic fatty liver disease Liver fibrosis.Non-invasive biological scores: APRI FIB-4 BARD

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PERFORMANCE OF P-SWE AND 2D-SWE WITH THREE PROBES FROM A NEW ULTRASOUND MACHINE FOR THE PREDICTION OF ADVANCED LIVER FIBROSIS USING TRANSIENT ELASTOGRAPHY AS A REFERENCE METHOD

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Ultrasound in Medicine & Biology 2022年 48卷 S3-S3页

作者： Sporea, Ioan Lupusoru, Raluca Sirli, Roxana Bende, Felix Popa, Alexandru Cotrau, Radu Popescu, Alina Department of Internal Medicine II Division of Gastroenterology and Hepatology Center for Advanced Research in Gastroenterology and Hepatology "Victor Babes" University of Medicine and Pharmacy Timisoara Romania Center for Advanced Hepatology Research of the Academy of Medical Sciences Timișoara Romania Center for Modeling Biological Systems and Data Analysis Department of Functional Sciences “Victor Babes” University of Medicine and Pharmacy Timisoara Romania Gastroenterology and Hepatology Timisoara Romania

ObjectivesThe aim of this study was to assess the performance and optimal cut-off points for p-SWE and 2D-SWE for the non-invasive assessment of advanced liver fibrosis, using transient elastography as a reference method. MaterialsSiemens ACUSON Sequoia (5C-1 convex transducer and Deep Abdominal Transducer-DAX) and FibroScan Compact M 530 (M and XL probes) were used. We included 198 consecutive patients with or without chronic liver disease that had all five LS values available. LS was evaluated in the same session by 3 elastographic techniques: TE, p-SWE and 2D-SWE. Reliable measurements were defined as the median value of 10 measurements and an IQR/M<0.3. For cACLD, the transient elastography cut-off point of 9.5 kPa was used [1]. ResultsFrom the 198 patients, 41.5% were women and 58.5% were men, mean age 54.8 ±13.8 years. The best cut-off values cACLD were: for 2D-SWE- 5C1 probe:>8.8 kPa, Se=97.7%, Sp=38.6%, AUC=0.84, p< 0.0001;DAX probe:>7.6 kPa, Se= 40.9%, Sp=99.9%, AUC=0.84, p< 0.0001; ForpSWE- 5C1 probe: >9.1 kPa, Se=54.5%, Sp=97.7%, AUC=0.86, p< 0.0001; DAXprobe: > 8.8 kPa, Se=50%, Sp=98.5%, AUC=0.88, p<0.0001. ConclusionsThe best cut-off value for predicting cACLD in pSWE range between 8.8 kPa and 9.1 kPa and for 2D-SWE raged between 7.6 kPa and 8.8 kPa.

关键词： Liver elastography cACLD- compensated advanced chronic liver disease

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LIVER FIBROSIS AND STEATOSIS ASSESSMENT USING ELASTOGRAPHIC TECHNIQUES: A COMPARISON BETWEEN NONALCOHOLIC FATTY LIVER DISEASE AND ALCOHOLIC LIVER DISEASE

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Ultrasound in Medicine & Biology 2022年 48卷 S32-S32页

作者： Foncea, Camelia Sporea, Ioan Lupusoru, Raluca Cotrau, Radu Bende, Felix Sirli, Roxana Popescu, Alina Department of Internal Medicine II Division of Gastroenterology and Hepatology Center for Advanced Research in Gastroenterology and Hepatology "Victor Babes" University of Medicine and Pharmacy Timisoara Romania Center for Advanced Hepatology Research of the Academy of Medical Sciences Timișoara Romania Center for Modeling Biological Systems and Data Analysis Department of Functional Sciences “Victor Babes” University of Medicine and Pharmacy Timisoara Romania Gastroenterology and Hepatology Timisoara Romania

ObjectivesAlcoholic liver disease (ALD) and Non-alcoholic fatty liver disease (NAFLD) are becoming the most common causes of chronic liver diseases and the leading causes of liver transplantation. Developing non-invasive methods for liver fibrosis and steatosis assessment are needed in these patients. In addition to Transient Elastography (TE), new methods were developed. Aimto evaluate and compare the performance of two point shear wave elastography techniques (pSWE and Auto pSWE) for the assessment of fibrosis and of Ultrasound Derived Fat Fraction (UDFF) for the assessment of steatosis, in patients with NAFLD and ALD using TE with Controlled Attenuation Parameter (CAP) as a reference methods. MaterialsA prospective study was conducted in which 166 consecutive patients with previously diagnosed ALD and NAFLD were included. All were evaluated in the same session by pSWE, Auto pSWE and UDFF, implemented in a Siemens ACUSON Sequoia system, using a Deep Abdominal Transducer (DAX), and by TE with CAP, implemented in a FibroScan Compact M 530 system (M and XL probes). Reliable measurements were defined as the median value of 10 measurements with an IQR/M<0.3. The following TE cut-off values were used: for significant fibrosis (F≥2) - 9 kPa for ALD and 8.2 kPa for NAFLD [1,2]. For mild (S1) steatosis, the following CAP cut-off values were used: 268 dB/m for ALD and 294 dB/m for NAFLD [3]. ResultsFibrosis distribution was the following: in the ALD group F≥2 -10% (5/48) patients and F4 -25% (12/48) patients; in the NAFLD group, F≥2 -4.2% (5/118) patients and F4- 6% (7/118) patients. In the ALD group 50% (24/48) had severe steatosis and in the NAFLD- 39% (46/118), with no significant differences between the two groups, p-values >0.05. The best cut-off values for identifying significant fibrosis (F≥2) with p-SWE and Auto pSWE in ALD patients were: >7 kPa, with AUCs (0.94 and 0.90), Se (83.3% and 41.6%), Sp (83.3% and 100%); in NAFLD patients: >5.2 kPa, AUCs (0.71 and 0.75)

关键词： Liver fibrosis Steatosis ALD NAFLD Auto pSWE UDFF

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COMPARISON BETWEEN TWO 2D-SWE TECHNIQUES USING TRANSIENT ELASTOGRAPHY AS A REFERENCE METHOD FOR LIVER STIFFNESS ASSESSMENT

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Ultrasound in Medicine & Biology 2022年 48卷 S29-S30页

作者： Popescu, Alina Foncea, Camelia Cotrau, Radu Lupusoru, Raluca Sirli, Roxana Sporea, Ioan Department of Internal Medicine II Division of Gastroenterology and Hepatology Center for Advanced Research in Gastroenterology and Hepatology "Victor Babes" University of Medicine and Pharmacy Timisoara Romania Center for Advanced Hepatology Research of the Academy of Medical Sciences Timișoara Romania Center for Modeling Biological Systems and Data Analysis Department of Functional Sciences “Victor Babes” University of Medicine and Pharmacy Timisoara Romania Gastroenterology and Hepatology Timisoara Romania

ObjectivesUltrasound-based liver elastography techniques are non-invasive methods used for the assessment of liver stiffness (LS). In addition to Transient Elastography (TE), new methods were developed. Aimto compare the performance of 2D-SWE technique implemented on two different ultrasound probes from different vendors for the assessment of liver stiffness measurements (LSM) using transient elastography (TE) as reference method. MaterialsA prospective study was conducted in which LSM were performed in 201 consecutive patients with or without chronic liver disease, evaluated in the same session by 2D-SWE and TE implemented on the following systems: Siemens ACUSON Sequoia (5C-1 convex transducer and Deep Abdominal Transducer-DAX), Aixplorer Mach 30 (C2-1X convex transducer) and FibroScan Compact M 530 (M and XL probes). Reliable measurements were defined as the median value of 10 measurements and an IQR/M<0.3. For significant fibrosis a cut-off value for TE of 7 kPa was used, for advanced fibrosis 9.5 kPa and for liver cirrhosis 12 kPa [1] ResultsFrom 201 patients, 198 patients had reliable measurements in all techniques and were included in the final analysis, mean age 54.8±13.3 years, mean BMI28.8 ± 5.0, 58% (116/198)men. 58.5% were without or with mild fibrosis, 14.1% had significant fibrosis, 6.2% had advanced fibrosis and 21.2% had liver cirrhosis. For significant fibrosis the performance was slightly better for *** (AUROC=0.89, p<0.0001, >7.3 kPa, Se=85.1%, Sp=87.9%) followed by 2D-SWE.5C1 (AUROC=0.79, p<0.0001, >6.9 kPa, Se=33.7%, Sp=96.7%) and *** (AUROC=0.78, p<0.0001, >6.3 kPa, Se= 36.4%, Sp=96.7%), p=0.01. For advanced fibrosis the best performance was slightly better by *** (AUROC=0.92, p<0.0001, >8.8 kPa, Se=92.5%, Sp=91.9%), and by *** (AUROC=0.86, p<0.0001, >7.6 kPa, Se= 38.8%, Sp=99.3%), followed by 2D-SWE.5C1 (AUROC=0.84, p<0.0001, >8.6 kPa, Se=38.8%, Sp=96.5%), p=0.02. For liver cirrhosis the performances were similar: 2

关键词： Liver elastography 2D-SWE tehniques,Chronic liver disease

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#4901 THE EFFECT OF CHRONIC KIDNEY DISEASE IN CONTRAST-ENHANCED ULTRASONOGRAPHY WITH ARRIVAL TIME PARAMETRIC IMAGING

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Nephrology Dialysis Transplantation 2023年第SUPPLEMENT_1期38卷

作者： Marc, Luciana Lupusoru, Raluca Mihaescu, Adelina Schiller, Oana-Marina Chisavu, Lazar Pascota, Razvan Dragota Olariu, Nicu Schiller, Adalbert “Victor Babeș” University of Medicine and Pharmacy Dept. of Internal Medicine II – Division of Nephrology Timisoara Romania “Victor Babeș” University of Medicine and Pharmacy Centre for Molecular Research in Nephrology and Vascular Disease Faculty of Medicine Timisoara Romania County Emergency Hospital “Pius Brinzeu” Nephrology Clinic Timisoara Romania “Victor Babeș” University of Medicine and Pharmacy Center for Modeling Biological Systems and Data Analysis Dept. of Functional Sciences Timisoara Romania “Avitum” Hemodialysis Center Timisoara Romania

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#6030 CARDIAC ULTRASOUND ASSESSMENT AND THE NOVEL INFLAMMATION, FIBROSIS AND CALCIFICATION BIOMARKERS IN ESKD PATIENTS ON HD THERAPY: A PILOT STUDY

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Nephrology Dialysis Transplantation 2023年第SUPPLEMENT_1期38卷

作者： Schiller, Adalbert Bob, Flaviu Mihaescu, Adelina Chisavu, Lazar Marc, Luciana Schiller, Oana-Marina Lupusoru, Raluca Ivan, Viviana “Victor Babeș” University of Medicine and Pharmacy Dept. of Internal Medicine II – Division of Nephrology Timisoara Romania “Victor Babeș” University of Medicine and Pharmacy Centre for Molecular Research in Nephrology and Vascular Disease Faculty of Medicine Timisoara Romania County Emergency Hospital “Pius Brinzeu” Nephrology Clinic Timisoara Romania “Victor Babeș” University of Medicine and Pharmacy Center for Modeling Biological Systems and Data Analysis Dept. of Functional Sciences Timisoara Romania County Emergency Hospital “Pius Brinzeu” Cardiology Clinic Timisoara Romania

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STEATOSIS AND FIBROSIS PREDICTIVE SCORES IN PATIENTS WITH TYPE 2 DIABETES

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Ultrasound in Medicine & Biology 2022年 48卷 S11-S12页

作者： Mare, Ruxandra - Georgeta Lupusoru, Raluca Sporea, Ioan Popescu, Alina Sima, Alexandra Timar, Romulus Sirli, Roxana Department of Internal Medicine II Division of Gastroenterology and Hepatology Center for Advanced Research in Gastroenterology and Hepatology "Victor Babes" University of Medicine and Pharmacy Timisoara Romania Center for Advanced Hepatology Research of the Academy of Medical Sciences Timisoara Romania Center for Modeling Biological Systems and Data Analysis Department of Functional Sciences “Victor Babes” University of Medicine and Pharmacy Timisoara Romania Gastroenterology and Hepatology Timisoara Romania Department of Internal Medicine II Division of Diabetes and Metabolic Disorders "Victor Babes" University of Medicine and Pharmacy Timisoara Romania

ObjectivesThe prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing in patients with type 2 diabetes (T2D), as a result, a systematic screening in this population should be performed. The aim of this study was to identify risk factors associated with moderate steatosis (S2) and advanced fibrosis (F≥3) and to develop a score that could be used in daily practice. MaterialsA prospective study on 534 patients with T2D was conducted using Vibration Controlled Transient Elastography (VCTE) to assess fibrosis severity and Controlled Attenuation Parameter (CAP) to assess steatosis severity. We stratified our cohort into study cohort (348 patients) and validation cohort (186 patients). We aimed for 10 valid CAP and liver stiffness measurements (LSM) with an IQR/Median <30%. A cut-off value of 290 dB/m was used to define S2 while for F≥3 a cut-off of 9.7 kPa [1]. For developing a score for stratifying the risk of moderate steatosis, and of advanced fibrosis, we used univariate and multivariate logistic regression analysis. ResultsOut of 534 patients, 62.7% had at least S2 and 19.2% had at least F≥3 by VCTE. In univariate analysis, BMI (p< 0.0001), waist circumference -WC (p< 0.0001), elevated levels of ALT (p=0.001), total cholesterol -TC (p=0.03), triglycerides-TG (p=0.01), fasting blood glucose (p=0.004) and presence of hypertension-HTA (p=0.04) were associated with at least moderate steatosis. The steatosis score is composed of: 0.5 points for high BMI (>32.1 kg/m2), TC (> 235 mg/dl), TG (>165 mg/dl), glycemia (> 200 mg/dl), ALT (> 40 U/L) and WC (> 100 cm) and 1 point for the presence of HTA. In univariate analysis, BMI (p< 0.0001), WC (p< 0.0001), elevated levels of AST (p=0.001), liver steatosis (p=0.03) were associated with at least F≥3. The fibrosis score is composed of: 0.5 points for high BMI (>32.4 kg/m2), AST (> 42 U/L), WC (> 110 cm) and for the presence of steatosis. The derived steatosis and fibrosis cut-offs for identifying patients with T2D we

关键词： fibrosis steatosis type 2 diabetes

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A systematic review of challenges and proposed solutions in modeling multimodal data

arXiv

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arXiv 2025年

作者： Farhadizadeh, Maryam Weymann, Maria Blaß, Michael Kraus, Johann Gundler, Christopher Walter, Sebastian Hempen, Noah Binder, Harald Binder, Nadine Institute of General Practice/Family Medicine Faculty of Medicine Medical Center University of Freiburg Elsässer Straße 2M Freiburg79110 Germany Freiburg Center for Data Analysis Modeling and AI University of Freiburg Ernst-Zermelo-Str. 1 Freiburg79104 Germany Institute of Medical Biometry and Statistics Faculty of Medicine Medical Center University of Freiburg Stefan-Meier-Straße 26 Freiburg79104 Germany Institute for Applied Medical Informatics University Medical Center Hamburg-Eppendorf Martinistraße 52 Hamburg20251 Germany Institute of Medical Systems Biology Ulm University Helmholtzstraße 16 Ulm89081 Germany Department of Computer Science Faculty of Engineering University of Freiburg Georges-Köhler-Allee 051 Freiburg79110 Germany

Multimodal data modeling has emerged as a powerful approach in clinical research, enabling the integration of diverse data types such as imaging, genomics, wearable sensors, and electronic health records. Despite its potential to improve diagnostic accuracy and support personalized care, modeling such heterogeneous data presents significant technical challenges. This systematic review synthesizes findings from 69 studies to identify common obstacles, including missing modalities, limited sample sizes, dimensionality imbalance, interpretability issues, and finding the optimal fusion techniques. We highlight recent methodological advances, such as transfer learning, generative models, attention mechanisms, and neural architecture search that offer promising solutions. By mapping current trends and innovations, this review provides a comprehensive overview of the field and offers practical insights to guide future research and development in multimodal modeling for medical applications. © 2025, CC BY.

关键词： Clinical research

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