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Hybrid Biodegradable Polymer Stent Fabrication Using 3D Printers and Integration with Wireless sensors for Real-Time Pressure Monitoring In Blood Vessels 22

Hybrid Biodegradable Polymer Stent Fabrication Using 3D Prin...

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22nd International Conference on Solid-State sensors, Actuators and Microsystems, Transducers 2023

作者： Wei, Jin-Liang Oyunbaatar, Nomin-Erdene Kim, Dong-Su Lee, Dong-Weon Chonnam National University Department Of Mechanical Engineering Gwangju Korea Republic of Chonnam National University Center For Next-Generation Sensor Research And Development Gwangju Korea Republic of Chonnam National University Advanced Medical Device Research Center For Cardiovascular Disease Gwangju Korea Republic of

ISBN: (纸本)9784886864352

Cardiovascular diseases (CVD) continue to be a major cause of mortality worldwide. Although traditional treatment using stents has been effective in managing these diseases, it can lead to several adverse effects, including in-stent restenosis. To address this issue, we present the development of a novel hybrid polymer stent composed of polycaprolactone (PCL) and polylactic acid (PLA) that exhibits improved bending flexibility and radial force. The hybrid stent is integrated with a wireless sensor to enable real-time monitoring of pressure changes in the blood vessel. A MEMS-based LC-type wireless pressure sensor is fabricated, with unique microstructures incorporated into the stent to enhance the binding strength between the sensor and the stent. This approach holds promise for improving the clinical outcomes of CVD patients by providing accurate and timely detection of restenosis. © 2023 IEEJ.

关键词： Hybrid biodegradable stent In stent restenosis Smart stent Wireless pressure sensor

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Temperature-Dependent Mechanism of Short-Circuit Voltage Imbalance in Series-Connected SiC MOSFETs

Temperature-Dependent Mechanism of Short-Circuit Voltage Imb...

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International Symposium on Power Semiconductor Devices and Ics (ISPSD)

作者： He Du Ichiro Omura Shuhei Matsumoto Takuro Arai Next Generation Power Electronics Research Center Kyushu Institute of Technology Kitakyushu Japan Infrastructure Systems Research and Development Center Toshiba Infrastructure Systems & Solutions Corporation Tokyo Japan

ISBN: (数字)9798350394825

ISBN: (纸本)9798350394832

The series connection of SiC MOSFETs is a cost-effective solution to enable higher voltage applications. Nevertheless, proper voltage sharing remains challenging for reliable operation. This paper investigates the voltage imbalance issues during short-circuit stress. Experimental results show the unbalanced voltage of two devices even with similar characteristics. Since the imbalance issue is affected by swapping only the two gate drivers upside down, the intrinsic delay between gate drivers is regarded as an initial cause. The results from mixed-mode electro-thermal TCAD simulations indicate that the temperature-dependent mechanism plays a large role in the voltage imbalance.

关键词： MOSFET Thermal factors Silicon carbide Thermal resistance Simulation Voltage Gate drivers

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Carbon Nano Tubes-Incorporated Smart Stents to Improve Mechanical Strength and sensor Reliability

Carbon Nano Tubes-Incorporated Smart Stents to Improve Mecha...

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IEEE International Conference on Micro Electro Mechanical Systems

作者： Nomin-Erdene Oyunbaatar Dong-Weon Lee Department of Mechanical Engineering Chonnam National University Gwangju South Korea Center for Next-Generation Sensor Research and Development Chonnam National University Gwangju South Korea Advanced Medical Device Research Center for Cardiovascular Disease Chonnam National University Gwangju South Korea

Atherosclerosis, a primary manifestation, involves the accumulation of plaques within artery walls, gradually constricting them. To address such constriction, a common intervention involves the insertion of various stent into the affected blood vessels. In addition, the material properties of the stent are very important because the stent inserted into the human body is a foreign substance. Ideally, substances that are absorbed into the body over time are desirable. However, the bioabsorbable polymer stents developed to date have limitations due to their low mechanical elasticity of the materials. Furthermore, if the stents inserted into the blood vessel have a function to detect the restenosis at an early stage, a simple drug treatment can solve the blockage. In this paper, we propose a 3D-printed polymer stent with high radial strength integrated with an LC-type sensor to monitor pressure changes in blood vessels in real time. The wireless pressure sensor is fabricated using the photosensitive polymer SU-8, with a supporting micro-pillar at the center of the capacitor to improve sensor performance, while the 3D-printed stent is mixed with CNT to enhance mechanical strength. The connection and operational principles of the wireless pressure sensor are assessed through an inductance-capacitance coupling circuit. This method aims to enhance early detection of restenosis, offering a promising solution in cardiovascular care.

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AI Maintenance Techniques by Detecting Performance Degradation in Domain Shift Using Model Ensembles

AI Maintenance Techniques by Detecting Performance Degradati...

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IEEE International Symposium on Multimedia

作者： Keita Yamane Akira Kitayama Keigo Hasegawa Yusuke Obonai Hiroto Sasao Sensing Integration Innovation Center Center for Digital Service Research & Development Group Hitachi Ltd. Tokyo Japan Next Generation Engineering Development Department Research and Development Division Hitachi Kokusai Electric Inc. Tokyo Japan

ISBN: (数字)9798331511111

ISBN: (纸本)9798331511128

We propose the method to automatically detect performance degradation due to domain shifts, such as changes in location and weather, for object detection AI. The algorithm is based on the conventional method of estimating uncertainty using the diversity from a deep ensemble. However, by introducing a “background class”, models that do not output bounding boxes (i.e., models with false negatives) which were previously ignored are also included in the uncertainty definition. The correlation between this new uncertainty and model performance was evaluated using a custom-created gas station dataset, and showed a strong negative correlation (−0.96 or less) compared to the conventional method. This results indicats that the proposed method considering the false negative model can accurately detect performance degradation.

关键词： Degradation Uncertainty Correlation Surveillance Object detection Cameras Maintenance Artificial intelligence Meteorology

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Companding Curve Optimization to Maximize SNDR for High Dynamic Range Image sensors

Companding Curve Optimization to Maximize SNDR for High Dyna...

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IEEE sensorS

作者： HoJoon Lee SeungHyung Lee Oded Drori KyungChoon Lee YoungKyun Jeong Next Generation Sensor Development Team S.LSI Gyeonggi Korea Image sensors Automotive algorithms. Samsung Semiconductor Israel R&D center (SIRC) Tel Aviv Israel

ISBN: (数字)9798350363517

ISBN: (纸本)9798350363524

The demand for automotive image sensors with high dynamic range(HDR) and increased resolution has prompted significant advancements in their development. Due to the demands of High Dynamic Range (HDR), modern automotive image sensors require up to 28 bits per pixel, surpassing the capacity of existing image transmission protocols. Hence, automotive image sensors employ a PieceWise Linear (PWL) companding, which offers efficient computation, albeit with the trade-off of data loss. In order to mitigate data loss, we propose a method to optimize the companding curve by leveraging sensor characteristics, including Signal-to-Noise Ratio (SNR) profile and SNR drop at transition. Our method achieves higher Signal-to-Noise-and-Distortion (SNDR) up to 5.2 dB and image quality compared to conventional companding curves.

关键词： Image sensors Image quality Protocols Image resolution Image communication Distortion High dynamic range Vehicle dynamics Optimization Signal to noise ratio

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Metabolic impacts of long-chain fatty acids on cardiomyocyte maturation in neonatal mammalian hearts

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Methods 2025年 241卷 114-127页

作者： Seong-Eung Cha Mi Nam Lee Eung-Sam Kim Department of Biological Sciences and Biotechnology Chonnam National University Gwangju 61186 Republic of Korea Department of Biological Sciences Chonnam National University Gwangju 61186 Republic of Korea Research Center of Ecomimetics Institute of Sustainable Ecological Environment Chonnam National University Gwangju 61186 Republic of Korea Center for Next-Generation Sensor Research and Development Chonnam National University Gwangju 61186 Republic of Korea

Cardiomyocytes are essential models for cardiac disease modeling, drug development, and regenerative therapies. Specifically, human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as widely used cellular models with high reproducibility. However, cardiomyocytes generated in vitro tend to remain immature and insufficient in replicating the electrophysiological and mechanical functions of adult cardiomyocytes, limiting the clinical and experimental applications of these models. Thus, various biochemical and biophysical strategies have been explored to promote the maturation of cardiomyocytes, to address these limitations, and more accurately mimic the characteristics of mature cardiomyocytes. This review summarizes recent studies on multiple methodologies employed to induce cardiomyocyte maturation, with a particular emphasis on the role of long-chain fatty acids (LCFAs). The evidence summarized in this review is derived from studies utilizing cardiomyocytes from neonatal mice or rats and hiPSC-CMs. Meanwhile, immature cardiomyocytes have been demonstrated to predominantly rely on glycolysis, transitioning to oxidative phosphorylation through maturation, which enhances electrical stability, contractility, and structural organization. LCFAs play a key role in the cardiomyocyte maturation process by serving as key metabolic factors that generate ATP through mitochondrial β-oxidation, thereby improving metabolic efficiency. Additionally, LCFAs are involved in activating cytoskeletal components and signaling pathways integral to cardiomyocyte contractility. Importantly, studies suggest that when multiple biochemical and biophysical stimuli are simultaneously applied, various aspects of cardiomyocyte maturation are synergistically accelerated. Therefore, future studies focusing on the coordinated application of these regulatory factors are expected to enhance the maturation process, ultimately contributing to the generation of mature cardiomyo

关键词： Breast milk Cardiomyocyte In situ longitudinal monitoring Long-chain fatty acids Metabolic maturation

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NOVEL HIGH-THROUGHPUT HEART-ON-A-CHIP PLATFORM WITH MEA AND STRAIN sensorS FOR ELECTRO-MECHANICAL SENSING 25

NOVEL HIGH-THROUGHPUT HEART-ON-A-CHIP PLATFORM WITH MEA AND ...

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25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021

作者： Kanade, Pooja P. Kim, Dong-Su Oyunbaatar, Nomin-Erdene Lee, Dong-Weon MEMS and Nanotechnology Lab School of Mechanical Engineering Chonnam National University Gwangju Korea Republic of Center for Next Generation Sensor Research and Development Chonnam National University Gwangju Korea Republic of

ISBN: (纸本)9781733419031

This work demonstrates a novel biosensing platform for in vitro characterization of cardiomyocytes. This cantilever-based platform has the capability to measure the electrophysiology as well as the contractile profile of cardiomyocytes simultaneously with high throughput. This platform has been used to measure the contractile profile and field potential of cardiomyocytes day-wise, and understanding propagation of cardiomyocytes along the cantilever. The proposed platform has the potential to be used for high-throughput drug-induced toxicity screening. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： Electrophysiology

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Advancing Sensitivity in Measuring Cardiomyocyte Contraction Force Through Single-Crystal Silicon Strain sensors

Advancing Sensitivity in Measuring Cardiomyocyte Contraction...

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IEEE sensorS

作者： Haolan Sun Dong-Su Kim Jong-Yun Kim Yun-Jin Jeong Dong-Weon Lee School of Mechanical Engineering Chonnam National University Gwangju Republic of Korea Center for Next-Generation Sensor Research and Development Chonnam National University Gwangju Korea Advanced Medical Device Research Center for Cardiovascular Disease Chonnam National University Gwangju Korea

Our proposed method involves the utilization of an SU-8 cantilever integrated with a single-crystal silicon strain sensor, which facilitates both miniaturization and accurate detection of cardiomyocytes contraction force. The single-crystal silicon strain sensor exhibits remarkable electrical stability and exceptional sensitivity, surpassing metal sensors by a factor of 17, while achieving force measurements below 0.02µN. Furthermore, the compatibility of SU-8 with photolithography techniques enables convenient miniaturization and large-scale production of the device. The proposed device was used to study the effect of verapamil and isoproterenol on the contractile properties of cardiomyocytes, demonstrating its potential as an early predictor of cardiotoxic compounds in analytical drug discovery.

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Investigation of the Parasitic Inductance Influence on the Short-Circuit Behaviour of High Voltage IGBTs

Investigation of the Parasitic Inductance Influence on the S...

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Annual IEEE Conference on Applied Power Electronics Conference and Exposition (APEC)

This paper comprehensively investigates the high voltage insulated-gate bipolar transistor (IGBT) under short-circuit conditions, focusing on the impact of parasitic inductance. At first, the typical short-circuit performance of a 4.5 kV IGBT at different bias voltages is presented and the high equivalent parasitic inductance for the single-chip test is highlighted. Then, an appropriate bias voltage and fixed pulse time are selected as the test condition and the short circuit tests are performed with different values of parasitic inductance. The results show different gate-emitter voltage waveforms and short-circuit time durations. For comparison, the short-circuit test results of a 1.2 kV IGBT with different parasitic inductances are also included, which show consistent gate and current behaviour. A detailed analysis based on the TCAD simulation is included to explain this phenomenon.

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Microplastics as an Emerging Threat to Amphibians: Current Status and Future Perspectives

SSRN

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SSRN 2023年

作者： Rahman, Md Mizanur Kim, Eung-Sam Sung, Ha-Cheol Department of Biological Sciences Chonnam National University Gwangju61186 Korea Republic of Research Center of Ecomimetics Chonnam National University Gwangju61186 Korea Republic of Center for Next Generation Sensor Research and Development Chonnam National University Gwangju61186 Korea Republic of

Given their pervasiveness in the environment, particularly in aquatic ecosystems, plastics have posed a growing concern worldwide. Studies have shown that many vertebrates and invertebrates in marine, freshwater, and terrestrial ecosystems exhibit microplastic (MP) accumulation. Some research has indicated the fatal impacts of MPs on animals and their possible transfer through food chains. Thus, it is crucial to study MP pollution and its impacts on environment-sensitive and globally threatened animal groups, such as amphibians, which also play an important role in the energy transfer between ecosystems. Unfortunately, research in this field is lacking. Hence, sources of organized information are scarce. We systematically reviewed published literature on MPs in amphibians to fill this existing knowledge gap. Although many studies have focused on MP bioaccumulation, few research also focused on its impacts. We found that more than 80% of the studied species exhibited MP accumulation. MP particles can persist in different organs for a long time and get transferred to other trophic levels. MPs also exhibit cytotoxic and mutagenic effects and may have fatal impacts. Moreover, they can increase the disease susceptibility of amphibians. Thus, MPs are a potential threat to amphibians. It is therefore important to increase the scope and frequency of research on MP pollution and its impacts on amphibians. Furthermore, our review provides a generalized method for studying MPs in amphibians. Our study is significant for extending the knowledge of MPs and their impacts on amphibians and may serve as a guideline for future research. © 2023, The Authors. All rights reserved.

关键词： Bioaccumulation

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