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Distributed Winding IPM Motor with an Amorphous Metal Stator Core

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IEEJ Transactions on Industry Applications 2022年第4期142卷 309-315页

作者： Enomoto, Yuji Kimura, Mamoru Marukawa, Yasuhiro Sano, Hirohisa Research & Development Group Hitachi Ltd. 7-1-1 Omika-cho Ibaraki Hitachi319-1292 Japan Next Generation Tatara Co-Creation Centrer Simane University 1060 Nishikawatsu-cho Shimane Matsue-shi690-8504 Japan Global Research & Innovative Technology Center Hitachi Metals Ltd. 5200 Mikajiri Saitama Kumagaya360-8577 Japan

We have been studying the application of amorphous metal with low loss to axial gap motors. However, because radial gap motors are used extensively, we are also considering a motor structure involving the application of amorphous metal to radial gap motors. In this study, we analyzed and evaluated an IPM motor to evaluate the improvement in efficiency caused by the use of amorphous metal for the entire stator cores. Creating an efficiency map of the prototype and comparing the efficiencies confirmed a significant improvement in efficiency in the low torque and high frequency bands. © 2022 The Institute of Electrical Engineers of Japan.

关键词： Efficiency

Improved Performance of Multilayer Assembled Piezoelectric Nanogenerator with Electrospun Nanofiber Mats for Self-Powered Wearable sensors

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SSRN 2023年

作者： Mahanty, Biswajit Prasad, Gajula Shanmugasundaram, Arunkumar Ghosh, Sujoy Kumar Lee, Dong-Weon MEMS and Nanotechnology Laboratory School of Mechanical Engineering School of Mechanical Engineering Chonnam National University 77 Yongbong-ro Buk-gu Gwangju61186 Korea Republic of Advanced Medical Device Research Center for Cardiovascular Disease Chonnam National University 77 Yongbong-ro Buk-gu Gwangju61186 Korea Republic of Department of Condensed Matter Physics and Material Sciences S.N. Bose National Centre for Basic Sciences Block JD Sector III Salt Lake Kolkata7000106 India Center for Next-Generation Sensor Research and Development Chonnam National University 77 Yongbong-ro Buk-gu Gwangju61186 Korea Republic of

The limited throughput, sensitivity, and stability of piezoelectric nanogenerators (PENGs) have impeded their adoption in practical, long-term applications as self-powered wearable sensors. Although stacking piezoelectric layers is considered as an effective approach to improve their electrical performance, the overall enhancement does not consistently equate to the sum of individual single-layer PENG (S-PENG) performances, due to factors such as interfacial losses and coupling effects between layers. To overcome these limitations, we report on an enhanced performance multilayer piezoelectric nanogenerator (M-PENG) fabricated by alternatively stacking layers of barium titanate nanoparticles (BT NPs) and graphite nanosheets (GNS)-embedded poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) nanofibers (NFs) mats. The results demonstrate that the M-PENG's output open circuit voltage (Voc) gradually improved as the number of layers increased to six, ultimately achieving a Vocof 350 V, a short circuit current (Isc) of 6 µA, and a power density of 3.62 W m-2. The electrical performance of the 6L M-PENG surpassed the Voc values of single layer-PENGs and 6L M-PENG based on P10BT NFs and P0.10GNS NFs by factors of 12.5, 15.9, 1.75, and 1.42, respectively. Furthermore, the device exhibited an average mechano-sensitivity of 20±1.4 V kPa-1 under 10 kPa and 13.45±2.3 V kPa-1 under 10-100 kPa conditions. The improved performance of the M-PENG is attributed to the stretching and in situ poling during electrospinning, as well as the synergistic contribution of the BT NPs and GNS to the piezoelectric performance enhancement of the composite nanofibers. Due to its enhanced pressure sensitivity and superior output performance, the M-PENG holds potential for widespread application in self-powered wearable sensors designed to capture various human motions, including gesture monitoring, speech recognition, and emotion detection. Owing to the facile fabrication process, remarkabl

关键词： Multilayers

Improved Performance of Multilayer Assembled Piezoelectric Nanogenerator with Electrospun Nanofiber Mats for Self-Powered Wearable sensors

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SSRN 2023年

作者： Mahanty, Biswajit Prasad, Gajula Shanmugasundaram, Dr. Arunkumar Ghosh, Sujoy Kumar Lee, Dong-Weon MEMS and Nanotechnology Laboratory School of Mechanical Engineering School of Mechanical Engineering Chonnam National University 77 Yongbong-ro Buk-gu Gwangju61186 Korea Republic of Advanced Medical Device Research Center for Cardiovascular Disease Chonnam National University 77 Yongbong-ro Buk-gu Gwangju61186 Korea Republic of Department of Condensed Matter Physics and Material Sciences S.N. Bose National Centre for Basic Sciences Block JD Sector III Kolkata Salt Lake7000106 India Center for Next-Generation Sensor Research and Development Chonnam National University 77 Yongbong-ro Buk-gu Gwangju61186 Korea Republic of

The limited throughput, sensitivity, and stability of piezoelectric nanogenerators (PENGs) have impeded their adoption in practical, long-term applications as self-powered wearable sensors. Although stacking piezoelectric layers is considered as an effective approach to improve their electrical performance, the overall enhancement does not consistently equate to the sum of individual single-layer PENG (S-PENG) performances, due to factors such as interfacial losses and coupling effects between layers. To overcome these limitations, we report on an enhanced performance multilayer piezoelectric nanogenerator (M-PENG) fabricated by alternatively stacking layers of barium titanate nanoparticles (BT NPs) and graphite nanosheets (GNS)-embedded poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) nanofibers (NFs) mats. The results demonstrate that the M-PENG's output open circuit voltage (Voc) gradually improved as the number of layers increased to six, ultimately achieving a Voc of 350 V, a short circuit current (Isc) of 6 µA, and a power density of 3.62 W m-2. The electrical performance of the 6L M-PENG surpassed the Voc values of single layer-PENGs and 6L M-PENG based on P10BT NFs and P0.10GNS NFs by factors of 12.5, 15.9, 1.75, and 1.42, respectively. Furthermore, the device exhibited an average mechano-sensitivity of 20±1.4 V kPa-1 under 10 kPa and 13.45±2.3 V kPa-1 under 10-100 kPa conditions. The improved performance of the M-PENG is attributed to the stretching and in situ poling during electrospinning, as well as the synergistic contribution of the BT NPs and GNS to the piezoelectric performance enhancement of the composite nanofibers. Due to its enhanced pressure sensitivity and superior output performance, the M-PENG holds potential for widespread application in self-powered wearable sensors designed to capture various human motions, including gesture monitoring, speech recognition, and emotion detection. Owing to the facile fabrication process, remarkab

关键词： Multilayers

Establishment of a novel adjuvant screening system for the development of intranasal vaccine adjuvants

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Vaccine 2025年 58卷 127267-127267页

作者： Sasaki, Eita Hamaguchi, Isao Hasegawa, Hideki Takahashi, Yoshimasa Research Center for Vaccine Development National Institute of Infectious Diseases Japan Institute for Health Security 1–23–1 Toyama Tokyo Shinjuku 162–8640 Japan Influenza Research Center National Institute of Infectious Diseases Japan Institute for Health Security 4–7–1 Gakuen Tokyo Musashi–Murayama 208–0011 Japan Department of Clinical Laboratory Subaru Health Insurance Society Ota Memorial Hospital Gunma Japan Center for Next-Generation Biologics Research National Institute of Infectious Diseases Japan Institute for Health Security 4–7–1 Gakuen Tokyo Musashi–Murayama 208–0011 Japan

Vaccine adjuvants play a pivotal role in enhancing the immunogenicity of vaccines. Some vaccine modalities, such as subunit vaccines and split vaccines, are inherently poorly immunogenic and benefit greatly from combination with adjuvants. Notable examples, such as the herpes zoster glycoprotein E subunit vaccine and the Novavax COVID-19 (NVX-CoV2373) vaccine, underscore the importance of adjuvants in vaccination. Mucosal vaccines, and intranasal vaccines in particular, are gaining increasing attention for their potential to combat respiratory viral infections more effectively than subcutaneous and intramuscular vaccines. This is because mucosal vaccines can induce immunoglobulin (Ig)A production at mucosal surfaces to prevent the transmission of respiratory viruses such as influenza and severe acute respiratory syndrome coronavirus 2. However, few adjuvanted mucosal vaccines have been approved to date. To address this gap, we developed an adjuvant screening system to identify adjuvants suitable for use in combination with intranasal vaccines from a list of existing approved drugs or pharmaceutical additives. By analyzing biomarker gene expression levels, our screening system was able to predict the adjuvanticity and toxicity of a given adjuvant candidate in a short time. Using this screening system, we have to date identified some pharmaceutical additives, which induced a robust antigen-specific IgA antibody response following a single intranasal administration, without significant leukopenic toxicity or type I interferon inducibility. In this review, we discuss the development of our novel adjuvant evaluation system and its potential to enhance the efficacy of mucosal vaccines. © 2025

关键词： Adjuvant Biomarker Genomics Influenza vaccine Intranasal vaccine SARS-CoV-2

Probing the Chemical Space of Guanidino-Carboxylic Acids to Identify the First Blockers of the Creatine-Transporter-1

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SSRN 2024年

作者： Farr, Clemens V. Xiao, Yi El-Kasaby, Ali Schupp, Manuel Hotka, Matej Di Mauro, Giovanni Clarke, Amy Fernandez, Miryam Pastor Sandtner, Walter Stockner, Thomas Klade, Christoph Maulide, Nuno Freissmuth, Michael Institute of Pharmacology Gaston H. Glock Research Laboratories for Exploratory Drug Development Center of Physiology and Pharmacology Medical University of Vienna Vienna Austria Institute of Organic Chemistry University of Vienna Währinger Strasse 38 Vienna1090 Austria CeMM Research Center for Molecular Medicine Austrian Academy of Sciences Lazarettgasse 14 AKH BT 25.3. Vienna1090 Austria AOP Orphan Pharmaceuticals GmbH Leopold-Ungar-Platz 2 Vienna1190 Austria Christian Doppler Laboratory for Entropy-Oriented Drug Design Institute of Organic Chemistry University of Vienna Währinger Strasse 38 Vienna1090 Austria NeGeMac Research Platform for Next Generation Macrocycles Vienna1090 Austria

The creatine transporter-1 (CRT-1/SLC6A8) maintains the uphill transport of creatine into cells against a steep concentration gradient. Cellular creatine accumulation is required to support the ATP-buffering by phosphocreatine. More than 60 compounds have been explored in the past for their ability to inhibit cellular creatine uptake, but the number of active compounds is very limited. Here, we show that all currently known inhibitors are full alternative substrates. We analyzed their structure-activity relation for inhibition of CRT-1 to guide a rational approach to the synthesis of novel creatine transporter ligands. Measurements of both, inhibition of [3H]creatine uptake and transport associated currents, allowed for differentiating between full and partial substrates and true inhibitors. This combined approach led to a refined understanding of the structural requirements for binding to CRT-1, which translated into the identification of three novel compounds, which blocked CRT-1 transport, albeit with low affinity, two new alternative full substrates and one partial substrate. © 2024, The Authors. All rights reserved.

关键词： Substrates

Assessment of cardiomyocyte maturity by measuring changes in contractile force according to drug concentration 23

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Assessment of cardiomyocyte maturity by measuring changes in...

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

作者： Kim, Jong Yun Lee, Dong-Weon Graduate School of Mechanical Engineering Chonnam National University Korea Republic of School of Mechanical Engineering Chonnam National University Korea Republic of Center for Next-generation Sensor Research and Development Chonnam National University Korea Republic of

ISBN: (纸本)9781733419000

In this paper, the maturation status of cardiomyocytes according to the substrate types such as conductivity and mechanical properties was evaluated through the measurement of cardiac contractility. Polydimethylsiloxane, Polyimide and SU-8 materials were used for cell culture and the groove structures were integrated on the substrate to mimic the extracellular matrix. Western blot and ICC staining analysis confirmed that cardiomyocytes are the most mature on SU-8 materials. Further, SU-8 cantilevers were fabricated for quantitative measurement of cardiac contractility. Finally, fabricated SU-8 cantilevers were coated with a conductive material to evaluate the maturation and drug reactivity of cardiomyocytes through contraction force. © 2019 CBMS-0001.

关键词： Conductive materials

Surface-textured photosensitive polymer thin film as new crack-based strain sensor to monitor human motion 23

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Surface-textured photosensitive polymer thin film as new cra...

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

作者： Park, Jongsung Kim, Dong-Su Kim, Ji-Kwan Lee, Dong-Weon Department of Mechanical Engineering Chonnam National University Korea Republic of School of Mechanical Metallic Mold Engineering Gwangju University Korea Republic of Center for Next-generation Sensor Research and Development Chonnam National University Korea Republic of

ISBN: (纸本)9781733419000

The main objective of this research is develop a new crack sensor based on a V-groove textured SU-8 thin film. The fabrication method proposed here is very simple and more reliable compared to previous methods. The crack sensor based on the V-groove textured SU-8 thin film is employed to effectively monitor the motion of the multi-axial joints of human fingers. In addition, generation of the Morse code is demonstrated using the fabricated flexible strain sensor and the response time of the sensor is less than 100 ms. We believe that the proposed V-groove textured crack sensor has a great potential to detect the multiple motion in various human activities. © 2019 CBMS-0001.

关键词： Thin films

Investigated a Pll Surface-Modified Nylon 11 Electrospun as a Highly Tribo-Positive Frictional Layer to Enhance Output Performance of Triboelectric Nanogenerators and Self-Powered Wearable sensors

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SSRN 2022年

作者： Prasad, Gajula Graham, Sontyana Adonijah Yu, Jae Su Kim, Hong Doo Lee, Dong-Weon MEMS and Nanotechnology Laboratory Department of Mechanical Engineering Chonnam National University Gwangju61186 Korea Republic of Institute for Wearable Convergence Electronics Department of Electronic Engineering Kyung Hee University Yongin17104 Korea Republic of Department of Engineering for information and Electronics Kyung Hee University Yongin17104 Korea Republic of Center for Next-generation Research and Development Chonnam National University Gwangju61186 Korea Republic of

Surface modification of tribo layers is a key factor for enhancing the output performance of triboelectric nanogenerators (TENGs). This study reports a unique and facile poly-L-lysine (PLL) surface-modification technique to enhance the positive polarity of Nylon 11 electrospun membranes. The triboelectric output performances of open circuit potential (VOC) and short circuit current (ISC) significantly increased by more than five times (from 26 to 137 V), and more than four times (from 0.8 to 3.4 µA), respectively, after PLL surface modification (PNy 11). Further to minimize the triboelectric loss and enhance the TENG performance, various dielectric materials (MXene and SrTiO3) were incorporated into the Ecoflex counter layer. Among the tribo pairs, the 10 wt.% SrTiO3-embedded Ecoflex (EC10S) and PNy 11 showed better triboelectric performance (270 V and 7.2 µA) at a working load of 8.5 N and frequency of 5 Hz. The optimized EC10S+PNy 11 TENG showed a power density of 2 W/m2 at 70 MΩ;it successfully powered low-power electronics (stopwatch) and lit up 111 LEDs. The proposed EC10S+PNy 11 triboelectric sensor (without spacer) was successfully demonstrated in various self-powered sensor applications such as motion detection, differentiation of various degrees of joint motions, voice detection, and health care applications for monitoring real-time human activities. Therefore, the EC10S+PNy 11 device shows potential for application in portable electronics and self-powered wearable sensor applications. © 2022, The Authors. All rights reserved.

关键词： Titanium compounds

Correction: Enhanced cardiomyocyte structural and functional anisotropy through synergetic combination of topographical, conductive, and mechanical stimulation

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Lab on a chip 2023年第1期24卷 149页

作者： Jongyun Kim Arunkumar Shanmugasundaram Cheong Bin Lee Jae Rim Kim Jeong Jae Park Eung-Sam Kim Bong-Kee Lee Dong-Weon Lee MEMS and Nanotechnology Laboratory School of Mechanical Engineering Chonnam National University Gwangju 61186 Republic of Korea. mems@jnu.ac.kr. Advanced Medical Device Research Center for Cardiovascular Disease Chonnam National University Gwangju 61186 Republic of Korea. Department of Biological Sciences Chonnam National University Gwangju 61186 Republic of Korea. Center for Next-Generation Sensor Research and Development Chonnam National University Gwangju 61186 Republic of Korea.

Correction for 'Enhanced cardiomyocyte structural and functional anisotropy through synergetic combination of topographical, conductive, and mechanical stimulation' by Jongyun Kim , , 2023, , 4540-4551, https:...

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