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Metabolic impacts of long-chain fatty acids on cardiomyocyte maturation in neonatal mammalian hearts

Methods 2025年 241卷 114-127页

作者： Seong-Eung Cha Mi Nam Lee Eung-Sam Kim Department of Biological Sciences and Biotechnology Chonnam National University Gwangju 61186 Republic of Korea Department of Biological Sciences Chonnam National University Gwangju 61186 Republic of Korea Research Center of Ecomimetics Institute of Sustainable Ecological Environment Chonnam National University Gwangju 61186 Republic of Korea Center for Next-Generation Sensor Research and Development Chonnam National University Gwangju 61186 Republic of Korea

Cardiomyocytes are essential models for cardiac disease modeling, drug development, and regenerative therapies. Specifically, human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as widely used cellular models with high reproducibility. However, cardiomyocytes generated in vitro tend to remain immature and insufficient in replicating the electrophysiological and mechanical functions of adult cardiomyocytes, limiting the clinical and experimental applications of these models. Thus, various biochemical and biophysical strategies have been explored to promote the maturation of cardiomyocytes, to address these limitations, and more accurately mimic the characteristics of mature cardiomyocytes. This review summarizes recent studies on multiple methodologies employed to induce cardiomyocyte maturation, with a particular emphasis on the role of long-chain fatty acids (LCFAs). The evidence summarized in this review is derived from studies utilizing cardiomyocytes from neonatal mice or rats and hiPSC-CMs. Meanwhile, immature cardiomyocytes have been demonstrated to predominantly rely on glycolysis, transitioning to oxidative phosphorylation through maturation, which enhances electrical stability, contractility, and structural organization. LCFAs play a key role in the cardiomyocyte maturation process by serving as key metabolic factors that generate ATP through mitochondrial β-oxidation, thereby improving metabolic efficiency. Additionally, LCFAs are involved in activating cytoskeletal components and signaling pathways integral to cardiomyocyte contractility. Importantly, studies suggest that when multiple biochemical and biophysical stimuli are simultaneously applied, various aspects of cardiomyocyte maturation are synergistically accelerated. Therefore, future studies focusing on the coordinated application of these regulatory factors are expected to enhance the maturation process, ultimately contributing to the generation of mature cardiomyo

关键词： Breast milk Cardiomyocyte In situ longitudinal monitoring Long-chain fatty acids Metabolic maturation

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The K computer: Japanese next-generation supercomputer development project

The K computer: Japanese next-generation supercomputer devel...

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IEEE/ACM International Symposium on Low-Power Electronics and Design

作者： Yokokawa, Mitsuo Shoji, Fumiyoshi Uno, Atsuya Kurokawa, Motoyoshi Watanabe, Tadashi Research and Development Group Next-Generation Supercomputer RandD Center RIKEN Kobe Japan

ISBN: (纸本)9781612846590

The K computer is a distributed memory supercomputer system consisting of more than 80,000 compute nodes which is being developed by RIKEN as a Japanese national project. Its performance is aimed at achieving 10 peta-flops sustained in the LINPACK benchmark. The system is under installation and adjustment. The whole system will be operational in 2012. © 2011 IEEE.

关键词： Supercomputers

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Surface-patterned silicon cantilever integrated with strain sensor to evaluate contractile behaviors in real time 23

Surface-patterned silicon cantilever integrated with strain ...

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23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

作者： Dong, Mingming Oyunbaatar, Nomin-Erdene Kim, Dong-Su Lee, Dong-Weon Department of Mechanical Engineering Chonnam National University Korea Republic of Center for Next-Generation Sensor Research and Development Chonnam National University Korea Republic of

ISBN: (纸本)9781733419000

The microcantilever system acts as a biological culture platform to perform in vitro measurements of cellular tissue. In this study, surface-patterned silicon cantilevers integrated with strain sensors are designed to measure mechanical properties of growing cardiomyocytes in vitro. An anisotropic wet-etching technique is used to generate groove patterns on the surface of the silicon cantilever. The groove patterns guide the growth direction of the cells and increase the adhesion between the cells and the cantilever. The mechanical properties of the cardiomyocytes are measured by the integrated strain sensor which is positioned on a fixed end of the cantilever. The proposed MEMS-based cantilever sensor is expected to be employed in various biomedical fields. © 2019 CBMS-0001.

关键词： Strain

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Establishment of a novel adjuvant screening system for the development of intranasal vaccine adjuvants

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Vaccine 2025年 58卷 127267-127267页

作者： Sasaki, Eita Hamaguchi, Isao Hasegawa, Hideki Takahashi, Yoshimasa Research Center for Vaccine Development National Institute of Infectious Diseases Japan Institute for Health Security 1–23–1 Toyama Tokyo Shinjuku 162–8640 Japan Influenza Research Center National Institute of Infectious Diseases Japan Institute for Health Security 4–7–1 Gakuen Tokyo Musashi–Murayama 208–0011 Japan Department of Clinical Laboratory Subaru Health Insurance Society Ota Memorial Hospital Gunma Japan Center for Next-Generation Biologics Research National Institute of Infectious Diseases Japan Institute for Health Security 4–7–1 Gakuen Tokyo Musashi–Murayama 208–0011 Japan

Vaccine adjuvants play a pivotal role in enhancing the immunogenicity of vaccines. Some vaccine modalities, such as subunit vaccines and split vaccines, are inherently poorly immunogenic and benefit greatly from combination with adjuvants. Notable examples, such as the herpes zoster glycoprotein E subunit vaccine and the Novavax COVID-19 (NVX-CoV2373) vaccine, underscore the importance of adjuvants in vaccination. Mucosal vaccines, and intranasal vaccines in particular, are gaining increasing attention for their potential to combat respiratory viral infections more effectively than subcutaneous and intramuscular vaccines. This is because mucosal vaccines can induce immunoglobulin (Ig)A production at mucosal surfaces to prevent the transmission of respiratory viruses such as influenza and severe acute respiratory syndrome coronavirus 2. However, few adjuvanted mucosal vaccines have been approved to date. To address this gap, we developed an adjuvant screening system to identify adjuvants suitable for use in combination with intranasal vaccines from a list of existing approved drugs or pharmaceutical additives. By analyzing biomarker gene expression levels, our screening system was able to predict the adjuvanticity and toxicity of a given adjuvant candidate in a short time. Using this screening system, we have to date identified some pharmaceutical additives, which induced a robust antigen-specific IgA antibody response following a single intranasal administration, without significant leukopenic toxicity or type I interferon inducibility. In this review, we discuss the development of our novel adjuvant evaluation system and its potential to enhance the efficacy of mucosal vaccines. © 2025

关键词： Adjuvant Biomarker Genomics Influenza vaccine Intranasal vaccine SARS-CoV-2

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NOVEL HIGH-THROUGHPUT HEART-ON-A-CHIP PLATFORM WITH MEA AND STRAIN sensorS FOR ELECTRO-MECHANICAL SENSING 25

NOVEL HIGH-THROUGHPUT HEART-ON-A-CHIP PLATFORM WITH MEA AND ...

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25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021

作者： Kanade, Pooja P. Kim, Dong-Su Oyunbaatar, Nomin-Erdene Lee, Dong-Weon MEMS and Nanotechnology Lab School of Mechanical Engineering Chonnam National University Gwangju Korea Republic of Center for Next Generation Sensor Research and Development Chonnam National University Gwangju Korea Republic of

ISBN: (纸本)9781733419031

This work demonstrates a novel biosensing platform for in vitro characterization of cardiomyocytes. This cantilever-based platform has the capability to measure the electrophysiology as well as the contractile profile of cardiomyocytes simultaneously with high throughput. This platform has been used to measure the contractile profile and field potential of cardiomyocytes day-wise, and understanding propagation of cardiomyocytes along the cantilever. The proposed platform has the potential to be used for high-throughput drug-induced toxicity screening. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： Electrophysiology

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Gyroscopes based on surface acoustic waves

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Micro and Nano Systems Letters 2015年第1期3卷 1-10页

作者： Oh, Haekwan Lee, Ki Jung Lee, Keekeun Yang, Sang Sik Division of Electrical and computer engineering Ajou University Suwon 443-749 South Korea Next Generation Convergence Sensor Research Center KETI Seongnam 463-816 South Korea

This review gives an overview of the development of surface acoustic wave (SAW) based gyroscopes. Different types of SAW based gyroscope are first presented, which are categorized into standing-wave based or progressive-wave based gyroscopes according to their respective mechanisms. In addition, multi-axis detectable SAW based gyroscopes are also introduced in this review. Different principles, structures, production methods, and control technologies are analyzed. © 2015, Oh et al.;licensee Springer.

关键词： Gyroscope Interference effect Multi-axis detectable gyroscope Progressive wave Standing wave Surface acoustic wave (SAW)

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Assessment of cardiomyocyte maturity by measuring changes in contractile force according to drug concentration 23

Assessment of cardiomyocyte maturity by measuring changes in...

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23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

作者： Kim, Jong Yun Lee, Dong-Weon Graduate School of Mechanical Engineering Chonnam National University Korea Republic of School of Mechanical Engineering Chonnam National University Korea Republic of Center for Next-generation Sensor Research and Development Chonnam National University Korea Republic of

ISBN: (纸本)9781733419000

In this paper, the maturation status of cardiomyocytes according to the substrate types such as conductivity and mechanical properties was evaluated through the measurement of cardiac contractility. Polydimethylsiloxane, Polyimide and SU-8 materials were used for cell culture and the groove structures were integrated on the substrate to mimic the extracellular matrix. Western blot and ICC staining analysis confirmed that cardiomyocytes are the most mature on SU-8 materials. Further, SU-8 cantilevers were fabricated for quantitative measurement of cardiac contractility. Finally, fabricated SU-8 cantilevers were coated with a conductive material to evaluate the maturation and drug reactivity of cardiomyocytes through contraction force. © 2019 CBMS-0001.

关键词： Conductive materials

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Surface-textured photosensitive polymer thin film as new crack-based strain sensor to monitor human motion 23

Surface-textured photosensitive polymer thin film as new cra...

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23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

作者： Park, Jongsung Kim, Dong-Su Kim, Ji-Kwan Lee, Dong-Weon Department of Mechanical Engineering Chonnam National University Korea Republic of School of Mechanical Metallic Mold Engineering Gwangju University Korea Republic of Center for Next-generation Sensor Research and Development Chonnam National University Korea Republic of

ISBN: (纸本)9781733419000

The main objective of this research is develop a new crack sensor based on a V-groove textured SU-8 thin film. The fabrication method proposed here is very simple and more reliable compared to previous methods. The crack sensor based on the V-groove textured SU-8 thin film is employed to effectively monitor the motion of the multi-axial joints of human fingers. In addition, generation of the Morse code is demonstrated using the fabricated flexible strain sensor and the response time of the sensor is less than 100 ms. We believe that the proposed V-groove textured crack sensor has a great potential to detect the multiple motion in various human activities. © 2019 CBMS-0001.

关键词： Thin films

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Vertically aligned one-dimensional ZnO/V2O5 core-shell hetero-nanostructure for photoelectrochemical water splitting

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Journal of Energy Chemistry 2020年第10期29卷 262-274页

作者： Tian-Feng Hou Muhammad Ali Johar Ramireddy Boppella Mostafa Afifi Hassan Swati J.Patil Sang-Wan Ryu Dong-Weon Lee MEMS and Nanotechnology Laboratory School of Mechanical EngineeringChonnam National UniversityGwangju 61186Republic of Korea Center for Next-generation Sensor Research and Development Chonnam National UniversityGwangju 61186Republic of Korea Department of Physics Chonnam National UniversityGwangju 61186Republic of Korea Nanomaterials Laboratory Inorganic and Physical Chemistry DivisionCSIR-Indian Institute of Chemical TechnologyHyderabad 500007TelanganaIndia

The vertically aligned one-dimensional(1 D)core-shell structure can maximize the exposure and use of the functionally active surface while maintaining the geometric effects caused by the underlying ***,we have fabricated 1 D vertically aligned ZnO/V2O5 core-shell hetero-nanostructure nanorod arrays(NRs)for photoelectrochemical(PEC)water ***/V2O5 NRs were prepared through the hydrothermal growing of ZnO NRs and then radio frequency(RF)magnetron sputtering deposition of V2O5 for 300,600 and 900 *** photocurrent density of ZnO/V2O5-based photoanodes was gradually increased with the sputtering time,reaching the maximum value of 1.21 m A/cm^2 at 1.23 V *** hydrogen electrode(RHE)for ZnO/V2O5-600,whereas for pure ZnO-based photoanode was 0.42 mA/cm^*** incident photon to electron conversion efficiency(IPCE)of ZnO/V2O5-600 evaluated to be 82.3%which was 2.3 times higher than that of ZnO(36.4%).The improved PEC performance of ZnO/V2O5-600 is because the core-shell structure with a moderate thickness of the V2O5 layer has the extremely high carrier density,largest electrochemically active surface area(ECSA),largest carrier density,lowest charge recombination rate,and the longest lifetime of e-h pairs due to the formation of the staggered gap *** study provides an effective way to design and fabrication of hetero-nanostructures for highefficiency photoelectrodes.

关键词： ZnO/V2O5 core-shell hetero-nanostructure Staggered heterojunction PEC water splitting

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Hybrid Biodegradable Polymer Stent Fabrication Using 3D Printers and Integration with Wireless sensors for Real-Time Pressure Monitoring In Blood Vessels 22

Hybrid Biodegradable Polymer Stent Fabrication Using 3D Prin...

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22nd International Conference on Solid-State sensors, Actuators and Microsystems, Transducers 2023

作者： Wei, Jin-Liang Oyunbaatar, Nomin-Erdene Kim, Dong-Su Lee, Dong-Weon Chonnam National University Department Of Mechanical Engineering Gwangju Korea Republic of Chonnam National University Center For Next-Generation Sensor Research And Development Gwangju Korea Republic of Chonnam National University Advanced Medical Device Research Center For Cardiovascular Disease Gwangju Korea Republic of

ISBN: (纸本)9784886864352

Cardiovascular diseases (CVD) continue to be a major cause of mortality worldwide. Although traditional treatment using stents has been effective in managing these diseases, it can lead to several adverse effects, including in-stent restenosis. To address this issue, we present the development of a novel hybrid polymer stent composed of polycaprolactone (PCL) and polylactic acid (PLA) that exhibits improved bending flexibility and radial force. The hybrid stent is integrated with a wireless sensor to enable real-time monitoring of pressure changes in the blood vessel. A MEMS-based LC-type wireless pressure sensor is fabricated, with unique microstructures incorporated into the stent to enhance the binding strength between the sensor and the stent. This approach holds promise for improving the clinical outcomes of CVD patients by providing accurate and timely detection of restenosis. © 2023 IEEJ.

关键词： Hybrid biodegradable stent In stent restenosis Smart stent Wireless pressure sensor

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