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Biomechanical research using advanced micro-nano devices: In-Vitro cell Characterization focus

Journal of Advanced Research 2024年

作者： Yan, Shiqiang Lu, Yan An, Changming Hu, Wanglai Chen, Yaofeng Li, Ziwen Wei, Wenbo Chen, Zongzheng Zeng, Xianhai Xu, Wei Lv, Zhenghua Pan, Fan Gao, Wei Wu, Yongyan Shenzhen Institute of Otolaryngology & Key Laboratory of Otolaryngology Longgang Otolaryngology Hospital Guangdong Shenzhen 518172 China Center of Cancer Immunology Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Guangdong Shenzhen 518055 China Department of Otolaryngology Head & Neck Surgery The First Hospital Jinzhou Medical University Liaoning Jinzhou 121001 China Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer Department of Otolaryngology Head & Neck Surgery First Hospital of Shanxi Medical University Shanxi Taiyuan 030001 China Department of Head and Neck Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China Translational Research Institute People's Hospital of Zhengzhou University Academy of Medical Science Henan International Joint Laboratory of Non-coding RNA and Metabolism in Cancer Zhengzhou University Henan Zhengzhou 450003 China Shenzhen University General Hospital & Shenzhen University Clinical Medical Academy Shenzhen University Guangdong Shenzhen 518055 China College of Chemistry & Pharmacy Northwest A&F University Shaanxi Yangling 712100 China The First Affiliated Hospital of Shenzhen University Shenzhen Second People's Hospital Guangdong Shenzhen 518035 China Department of Otolaryngology-Head and Neck Surgery Shandong Provincial ENT Hospital Shandong University Shandong Jinan 250022 China

Background: Cells in the body reside in a dynamic microenvironment subjected to various physical stimuli, where mechanical stimulation plays a crucial role in regulating cellular physiological behaviors and functions. Aim of Review: Investigating the mechanisms and interactions of mechanical transmission is essential for understanding the physiological and functional interplay between cells and physical stimuli. Therefore, establishing an in vitro biomechanical stimulation cell culture system holds significant importance for research related to cellular biomechanics. Key Scientific Concepts of Review: In this review, we primarily focused on various biomechanically relevant cell culture systems and highlighted the advancements and prospects in their preparation processes. Firstly, we discussed the types and characteristics of biomechanics present in the microenvironment within the human body. Subsequently, we introduced the research progress, working principles, preparation processes, potential advantages, applications, and challenges of various biomechanically relevant in vitro cell culture systems. Additionally, we summarized and categorized currently commercialized biomechanically relevant cell culture systems, offering a comprehensive reference for researchers in related fields. © 2024

关键词： Biomechanical stimulation Cell culture systems Cellular biomechanics In vitro models Microenvironment

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Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026

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The Lancet Global health 2023年第3期11卷 e385-e413页

作者： Micah, Angela E. Bhangdia, Kayleigh Cogswell, Ian E. Lasher, Dylan Lidral-Porter, Brendan Maddison, Emilie R. Nguyen, Trang Nhu Ngoc Patel, Nishali Pedroza, Paola Solorio, Juan Stutzman, Hayley Tsakalos, Golsum Wang, Yifeng Warriner, Wesley Zhao, Yingxi Zlavog, Bianca S. Abbafati, Cristiana Abbas, Jaffar Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abdelmasseh, Michael Abdulah, Deldar Morad Abedi, Aidin Abegaz, Kedir Hussein Abhilash, E.S. Aboagye, Richard Gyan Abolhassani, Hassan Abrigo, Michael R.M. Abubaker Ali, Hiwa Abu-Gharbieh, Eman Adem, Mohammed Hussien Afzal, Muhammad Sohail Ahmadi, Ali Ahmed, Haroon Ahmed Rashid, Tarik Aji, Budi Akbarialiabad, Hossein Akelew, Yibeltal Al Hamad, Hanadi Alam, Khurshid Alanezi, Fahad Mashhour Alanzi, Turki M. Al-Hanawi, Mohammed Khaled Alhassan, Robert Kaba Aljunid, Syed Mohamed Almustanyir, Sami Al-Raddadi, Rajaa M. Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw T. Ameyaw, Edward Kwabena Amini-Rarani, Mostafa Amu, Hubert Ancuceanu, Robert Andrei, Tudorel Anwar, Sumadi Lukman Appiah, Francis Aqeel, Muhammad Arabloo, Jalal Arab-Zozani, Morteza Aravkin, Aleksandr Y. Aremu, Olatunde Aruleba, Raphael Taiwo Athari, Seyyed Shamsadin Avila-Burgos, Leticia Ayanore, Martin Amogre Azari, Samad Baig, Atif Amin Bantie, Abere Tilahun Barrow, Amadou Baskaran, Pritish Basu, Sanjay Batiha, Abdul-Monim Mohammad Baune, Bernhard T. Berezvai, Zombor Bhardwaj, Nikha Bhardwaj, Pankaj Bhaskar, Sonu Boachie, Micheal Kofi Bodolica, Virginia Botelho, João Silva Botelho Braithwaite, Dejana Breitborde, Nicholas J.K. Busse, Reinhard Cahuana-Hurtado, Lucero Catalá-López, Ferrán Chansa, Collins Charan, Jaykaran Chattu, Vijay Kumar Chen, Simiao Chukwu, Isaac Sunday Dadras, Omid Dandona, Lalit Dandona, Rakhi Dargahi, Abdollah Debela, Sisay Abebe Denova-Gutiérrez, Edgar Desye, Belay Dharmaratne, Samath Dhamminda Diao, Nancy Doan, Linh Phuong Dodangeh, Milad dos Santos, Wendel Mombaque Doshmangir, Leila Dube, John Eini, Ebrahim El Sayed Zaki, Maysaa El Tantawi, Maha Enyew, Daniel Berhanie Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Applied Mathematics University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Nuffield Department of Medicine University of Oxford Oxford United Kingdom Department of Juridical and Economic Studies La Sapienza University Rome Italy Antai College of Economics Shanghai Jiao Tong University Shanghai China Non-communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Center Tehran University of Medical Sciences Tehran Iran Children’s Medical Center Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Tehran Heart Center Tehran University of Medical Sciences Tehran Iran Faculty of Medicine Tehran University of Medical Sciences Tehran Iran National Institute for Health Research Tehran University of Medical Sciences Tehran Iran Department of Pharmacology Tehran University of Medical Sciences Tehran Iran Department of Cardiology Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Center Tehran University of Medical Sciences Tehran Iran Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Department of Neurology Tehran University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Epidemiology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Health Economics and Statistics Shahid Beheshti University of Medical Sciences Tehran Iran Department of Neurosurgery Shahid Beheshti University of Medical Sciences Tehran Iran Ophthalmic R

Background: The COVID-19 pandemic highlighted gaps in health surveillance systems, disease prevention, and treatment globally. Among the many factors that might have led to these gaps is the issue of the financing of national health systems, especially in low-income and middle-income countries (LMICs), as well as a robust global system for pandemic preparedness. We aimed to provide a comparative assessment of global health spending at the onset of the pandemic;characterise the amount of development assistance for pandemic preparedness and response disbursed in the first 2 years of the COVID-19 pandemic;and examine expectations for future health spending and put into context the expected need for investment in pandemic preparedness. Methods: In this analysis of global health spending between 1990 and 2021, and prediction from 2021 to 2026, we estimated four sources of health spending: development assistance for health (DAH), government spending, out-of-pocket spending, and prepaid private spending across 204 countries and territories. We used the Organisation for Economic Co-operation and Development (OECD)'s Creditor Reporting System (CRS) and the WHO Global health Expenditure Database (GHED) to estimate spending. We estimated development assistance for general health, COVID-19 response, and pandemic preparedness and response using a keyword search. health spending estimates were combined with estimates of resources needed for pandemic prevention and preparedness to analyse future health spending patterns, relative to need. Findings: In 2019, at the onset of the COVID-19 pandemic, US$9·2 trillion (95% uncertainty interval [UI] 9·1–9·3) was spent on health worldwide. We found great disparities in the amount of resources devoted to health, with high-income countries spending $7·3 trillion (95% UI 7·2–7·4) in 2019;293·7 times the $24·8 billion (95% UI 24·3–25·3) spent by low-income countries in 2019. That same year, $43·1 billion in development assistance was provided

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A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement

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Life Medicine 2024年第1期3卷 5页

作者： Aging Biomarker Consortium, Mengmeng Jiang Zhuozhao Zheng Xuan Wang Yanhao Chen Jing Qu Qiurong Ding Weiqi Zhang You-Shuo Liu Jichun Yang Weiqing Tang Yunlong Hou Jinhan He Lin Wang Pengyu Huang Lin-Chen Li Zhiying He Qiang Gao Qian Lu Lai Wei Yan-Jiang Wang Zhenyu Ju Jian-Gao Fan Xiong Zhong Ruan Youfei Guan Guang-Hui Liu Gang Pei Jian Li Yunfang Wang State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Institute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing 100101 China Department of Radiology Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Beijing 102218 China Hepatopancreatobiliary Center Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Beijing 102218 China CAS Key Laboratory of Nutrition Metabolism and Food Safety Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai 200031 China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics Chinese Academy of Sciences and China National Center for Bioinformation Beijing 100101 China Department of Geriatrics the Second Xiangya Hospital and the Institute of Aging and Geriatrics Central South University Changsha 410011 China Department of Physiology and Pathophysiology School of Basic Medical Sciences State Key Laboratory of Vascular Homeostasis and Remodeling Center for Non-coding RNA Medicine Peking University Health Science Center Beijing 100191 China The Key Laboratory of Geriatrics Beijing Institute of Geriatrics Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing Hospital/National Center of Gerontology of National Health Commission Beijing 100730 China Yiling Pharmaceutical Academician Workstation Shijiazhuang 050035 China Department of Pharmacy West China Hospital of Sichuan University Chengdu 610041 China Department of Hepatobiliary Surgery Xijing Hospital Fourth Military Medical University Xi?an 710032 China State Key Laboratory of Advanced Medical Materials and Devices Engineering Research Center of Pulmonary and Critical Care Medicine Technology and Device

In human aging, liver aging per se not only increases susceptibility to liver diseases but also increases vulnerability of other organs given its central role in regulating metabolism. Total liver function tends to be well maintained in the healthy elderly, so liver aging is generally difficult to identify early. In response to this critical challenge, the Aging Biomarker Consortium of China has formulated an expert consensus on biomarkers of liver aging by synthesizing the latest scientific literature, comprising insights from both scientists and clinicians. This consensus provides a comprehensive assessment of biomarkers associated with liver aging and presents a systematic framework to characterize these into three dimensions: functional, imaging, and humoral. For the functional domain, we highlight biomarkers associated with cholesterol metabolism and liver-related coagulation function. For the imaging domain, we note that hepatic steatosis and liver blood flow can serve as measurable biomarkers for liver aging. Finally, in the humoral domain, we pinpoint hepatokines and enzymatic alterations worthy of attention. The aim of this expert consensus is to establish a foundation for assessing the extent of liver aging and identify early signs of liver aging-related diseases, thereby improving liver health and the healthy life expectancy of the elderly population.

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Publisher Correction: Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor micrornas

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Nature communications 2018年第1期9卷 160页

作者： Ivan Vannini Petra M Wise Kishore B Challagundla Meropi Plousiou Mirco Raffini Erika Bandini Francesca Fanini Giorgia Paliaga Melissa Crawford Manuela Ferracin Cristina Ivan Linda Fabris Ramana V Davuluri Zhiyi Guo Maria Angelica Cortez Xinna Zhang Lu Chen Shuxing Zhang Cecilia Fernandez-Cymering Leng Han Silvia Carloni Samanta Salvi Hui Ling Mariam Murtadha Paolo Neviani Barbara J Gitlitz Ite A Laird-Offringa Patrick Nana-Sinkam Massimo Negrini Han Liang Dino Amadori Amelia Cimmino George A Calin Muller Fabbri Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) S.r.l. IRCCS Gene Therapy Unit Meldola FC 47014 Italy. Departments of Pediatrics and Molecular Microbiology & Immunology Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California Children's Center for Cancer and Blood Diseases and The Saban Research Institute Children's Hospital Los Angeles Los Angeles CA 90027 USA. Department of Biochemistry & Molecular Biology University of Nebraska Medical Center 985870 Nebraska Medical Center Omaha NE 68198 USA. Department of Internal Medicine Division of Pulmonary Allergy Critical Care and Sleep Medicine The Ohio State University Columbus OH 43210 USA. Department of Experimental Diagnostic and Specialty Medicine- DIMES University of Bologna Bologna 40126 Italy. Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. The Center for RNA Interference and Non-coding RNAs The University of Texas MD Anderson Cancer Center Houston TX USA. Departments of Preventive Medicine and Neurological Surgery Northwestern University-Feinberg School of Medicine Chicago IL 60611 USA. Department of Experimental Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Integrated Molecular Discovery Laboratory Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Division of Pre-Clinical Innovation National Center for Advancing Translational Sciences (NCATS) Rockville MD 20850 USA. Department of Molecular Virology Immunology and Medical Genetics Comprehensive Cancer Center Ohio State University Columbus OH 43210 USA. Department of Biochemistry and Molecular Biology McGovern Medical School The University of Texas Health Science Center at Hou

In the originally published version of this Article, the positions of the final two authors in the author list were inadvertently inverted during the production process. This error has now been corrected in both the P...

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Publisher Correction: Regulation of cellular sterol homeostasis by the oxygen responsive noncoding rna lincNORS

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Nature communications 2020年第1期11卷 5737页

作者： Xue Wu Cristina M Niculite Mihai Bogdan Preda Annalisa Rossi Toma Tebaldi Elena Butoi Mattie K White Oana M Tudoran Daniela N Petrusca Amber S Jannasch William P Bone Xingyue Zong Fang Fang Alexandrina Burlacu Michelle T Paulsen Brad A Hancock George E Sandusky Sumegha Mitra Melissa L Fishel Aaron Buechlein Cristina Ivan Spyros Oikonomopoulos Myriam Gorospe Amber Mosley Milan Radovich Utpal P Davé Jiannis Ragoussis Kenneth P Nephew Bernard Mari Alan McIntyre Heiko Konig Mats Ljungman Diana L Cousminer Paolo Macchi Mircea Ivan Department of Microbiology and Immunology Indiana University School of Medicine Indianapolis IN 46202 USA. Department of Medicine Indiana University School of Medicine Indianapolis IN 46202 USA. "Victor Babes" National Institute of Pathology Bucharest Romania. Institute of Cellular Biology and Pathology "Nicolae Simionescu" Bucharest Romania. Laboratory of Molecular and Cellular Neurobiology Department of Cellular Computational and Integrative Biology-CIBIO University of Trento Trento Italy. Laboratory of Translational Genomics Department of Cellular Computational and Integrative Biology-CIBIO University of Trento Trento Italy. Yale Cancer Center Yale University School of Medicine New Haven CT 06520 USA. The Oncology Institute "Prof Dr. Ion Chiricuta" Cluj-Napoca Romania. Metabolite Profiling Facility Bindley Bioscience Center Purdue University West Lafayette IN 47907 USA. Department of Genetics Department of Systems Pharmacology and Translational Therapeutics Institute of Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA. Department of Cellular and Integrative Physiology Indiana University School of Medicine Indianapolis IN USA. Departments of Radiation Oncology and Environmental Health Sciences Center for RNA Biomedicine University of Michigan Ann Arbor MI 48109 USA. Department of Surgery Indiana University School of Medicine Indianapolis IN 46202 USA. Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis IN 46202 USA. Melvin and Bren Simon Cancer Center Indiana University Indianapolis IN USA. Department of Obstetrics and Gynecology Indiana University School of Medicine Indianapolis IN 46202 USA. Department of Pharmacology and Toxicology Department of Pediatrics Wells Center for Pediatric Research Indiana University School of Medicine Indianapolis IN 46202 USA. Indiana University Center for Genomics and Bioinformatics

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Highlights from the 11th ISCB Student Council Symposium 2015. Dublin, Ireland. 10 July 2015

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BMC bioinformatics 2016年第3期17 Suppl 3卷 95页

作者： Katie Wilkins Mehedi Hassan Margherita Francescatto Jakob Jespersen R. Gonzalo Parra Bart Cuypers Dan DeBlasio Alexander Junge Anupama Jigisha Farzana Rahman Griet Laenen Sander Willems Lieven Thorrez Yves Moreau Nagarajan Raju Sonia Pankaj Chothani C. Ramakrishnan Masakazu Sekijima M. Michael Gromiha Paddy J Slator Nigel J Burroughs Przemysław Szałaj Zhonghui Tang Paul Michalski Oskar Luo Xingwang Li Yijun Ruan Dariusz Plewczynski Giulia Fiscon Emanuel Weitschek Massimo Ciccozzi Paola Bertolazzi Giovanni Felici Pieter Meysman Manu Vanaerschot Maya Berg Hideo Imamura Jean-Claude Dujardin Kris Laukens Westa Domanova James R. Krycer Rima Chaudhuri Pengyi Yang Fatemeh Vafaee Daniel J. Fazakerley Sean J. Humphrey David E. James Zdenka Kuncic Plant Pathology and Plant-Microbe Biology Section School of Integrative Plant Science Cornell University Ithaca USA Graduate Field of Computational Biology Cornell University Ithaca USA School of Computing & Mathematics University of South Wales Cardiff UK Department of Genome Biology for Neurodegenerative Diseases German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association ᅟ Germany Department of Surgery Massachusetts General Hospital The Broad Institute of MIT and Harvard Boston USA Department of Systems Biology Technical University of Denmark Kemitorvet Denmark Protein Physiology Lab Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Buenos Aires Argentina Molecular Parasitology Unit (MPU) Institute of Tropical Medicine Antwerp Belgium Advanced Database Research and Modeling (ADReM) research group University of Antwerp Antwerpen Belgium Department of Computer Science University of Arizona Tucson USA Department of Veterinary Clinical and Animal Sciences Center for non-coding RNA in Technology and Health University of Copenhagen Copenhagen Denmark University College Dublin Dublin Ireland Department of Electrical Engineering (ESAT) STADIUS Center for Dynamical Systems Signal Processing and Data Analytics KU Leuven Leuven Belgium Minds Medical IT Department Leuven Belgium Scientific Institute of Public Health (WIV-ISP) Platform of Biotechnology and Molecular Biology (PBB) Brussels Belgium Department of Development and Regeneration @ Kulak KU Leuven Kortrijk Belgium Department of Biotechnology Bhupat and Jyoti Metha School of Biosciences Indian Institute of Technology Madras Chennai India Philips Research North America Briarcliff Manor USA Global Scientific Information and Computing Center (GSIC) Tokyo Institute of Technology Tokyo Japan Systems Biology Centre University of Warwick Senate House Coventry UK Systems Biology Doctoral Training Centre University of Warwick Senate House Coventry UK Center for B

A1 Highlights from the eleventh ISCB Student Council Symposium 2015 Katie Wilkins, Mehedi Hassan, Margherita Francescatto, Jakob Jespersen, R. Gonzalo Parra, Bart Cuypers, Dan DeBlasio, Alexander Junge, Anupama Jigisha, Farzana Rahman O1 Prioritizing a drug’s targets using both gene expression and structural similarity Griet Laenen, Sander Willems, Lieven Thorrez, Yves Moreau O2 Organism specific protein-rna recognition: A computational analysis of protein-rna complex structures from different organisms Nagarajan Raju, Sonia Pankaj Chothani, C. Ramakrishnan, Masakazu Sekijima; M. Michael Gromiha O3 Detection of Heterogeneity in Single Particle Tracking Trajectories Paddy J Slator, Nigel J Burroughs O4 3D-NOME: 3D NucleOme Multiscale Engine for data-driven modeling of three-dimensional genome architecture Przemysław Szałaj, Zhonghui Tang, Paul Michalski, Oskar Luo, Xingwang Li, Yijun Ruan, Dariusz Plewczynski O5 A novel feature selection method to extract multiple adjacent solutions for viral genomic sequences classification Giulia Fiscon, Emanuel Weitschek, Massimo Ciccozzi, Paola Bertolazzi, Giovanni Felici O6 A Systems Biology Compendium for Leishmania donovani Bart Cuypers, Pieter Meysman, Manu Vanaerschot, Maya Berg, Hideo Imamura, Jean-Claude Dujardin, Kris Laukens O7 Unravelling signal coordination from large scale phosphorylation kinetic data Westa Domanova, James R. Krycer, Rima Chaudhuri, Pengyi Yang, Fatemeh Vafaee, Daniel J. Fazakerley, Sean J. Humphrey, David E. James, Zdenka Kuncic

关键词： Visceral Leishmaniasis Feature Selection Method Frequent Itemset Mining Leishmania Donovani Student Council

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