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Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000-17: analysis for the Global Burden of Disease Study 2017 (vol 395, pg 1779, 2020)

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LANCET 2020年第10239期395卷 1762-1762页

作者： Reiner, R. C., Jr. Hay, S., I Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Global Health School of Medicine University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States College of Health and Medical Sciences Haramaya University Harar Ethiopia Department of Epidemiology and Biostatistics Haramaya University Harar Ethiopia Department of Medical Laboratory Sciences Haramaya University Harar Ethiopia School of Nursing and Midwifery Haramaya University Harar Ethiopia School of Pharmacy Haramaya University Harar Ethiopia School of Public Health Haramaya University Harar Ethiopia Haramaya University Harar Ethiopia Advanced Diagnostic and Interventional Radiology Research Center Tehran University of Medical Sciences Tehran Iran Cancer Biology Research Center Tehran University of Medical Sciences Tehran Iran Cancer Research Institute Tehran University of Medical Sciences Tehran Iran Department of Economics and Management Sciences for Health Tehran University of Medical Sciences Tehran Iran Department of Environmental Health Engineering Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Department of Health Management and Economics Tehran University of Medical Sciences Tehran Iran Department of Microbiology Tehran University of Medical Sciences Tehran Iran Department of Pharmacology Tehran University of Medical Sciences Tehran Iran Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Center Tehran University of Medical Sciences Tehran Iran Hematology-Oncology and Stem Cell Transplantation Research Center Tehran University of Medical Sciences Tehran Iran Iran National Institute of Health Research Tehran University of Medical Sciences Tehran Iran Metabolomics and

Summary Background Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat disease. Identifying subnational regions with the highest burden and mapping associated risk factors can aid in reducing preventable childhood *** We used Bayesian model-based geostatistics and a geolocated dataset comprising 15 072 746 children younger than 5 years from 466 surveys in 94 LMICs, in combination with findings of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, to estimate posterior distributions of diarrhoea prevalence, incidence, and mortality from 2000 to 2017. From these data, we estimated the burden of diarrhoea at varying subnational levels (termed units) by spatially aggregating draws, and we investigated the drivers of subnational patterns by creating aggregated risk factor *** The greatest declines in diarrhoeal mortality were seen in south and southeast Asia and South America, where 54·0% (95% uncertainty interval [UI] 38·1-65·8), 17·4% (7·7-28·4), and 59·5% (34·2-86·9) of units, respectively, recorded decreases in deaths from diarrhoea greater than 10%. Although children in much of Africa remain at high risk of death due to diarrhoea, regions with the most deaths were outside Africa, with the highest mortality units located in Pakistan. Indonesia showed the greatest within-country geographical inequality; some regions had mortality rates nearly four times the average country rate. Reductions in mortality were correlated to improvements in water, sanitation, and hygiene (WASH) or reductions in child growth failure (CGF). Similarly, most high-risk areas had poor WASH, high CGF, or low oral rehydration therapy *** By co-analysing geospatial trends in d

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Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

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The Lancet Respiratory Medicine 2020年第6期8卷 585-596页

作者： Soriano, Joan B Kendrick, Parkes J Paulson, Katherine R Gupta, Vinay Abrams, Elissa M Adedoyin, Rufus Adesoji Adhikari, Tara Ballav Advani, Shailesh M Agrawal, Anurag Ahmadian, Elham Alahdab, Fares Aljunid, Syed Mohamed Altirkawi, Khalid A Alvis-Guzman, Nelson Anber, Nahla Hamed Andrei, Catalina Liliana Anjomshoa, Mina Ansari, Fereshteh Antó, Josep M Arabloo, Jalal Athari, Seyyede Masoume Athari, Seyyed Shamsadin Awoke, Nefsu Badawi, Alaa Banoub, Joseph Adel Mattar Bennett, Derrick A Bensenor, Isabela M Berfield, Kathleen S Sachiko Bernstein, Robert S Bhattacharyya, Krittika Bijani, Ali Brauer, Michael Bukhman, Gene Butt, Zahid A Cámera, Luis Alberto Car, Josip Carrero, Juan J Carvalho, Felix Castañeda-Orjuela, Carlos A Choi, Jee-Young Jasmine Christopher, Devasahayam J Cohen, Aaron J Dandona, Lalit Dandona, Rakhi Dang, Anh Kim Daryani, Ahmad de Courten, Barbora Demeke, Feleke Mekonnen Demoz, Gebre Teklemariam De Neve, Jan-Walter Desai, Rupak Dharmaratne, Samath Dhamminda Diaz, Daniel Douiri, Abdel Driscoll, Tim Robert Duken, Eyasu Ejeta Eftekhari, Aziz Elkout, Hajer Endries, Aman Yesuf Fadhil, Ibtihal Faro, Andre Farzadfar, Farshad Fernandes, Eduarda Filip, Irina Fischer, Florian Foroutan, Masoud Garcia-Gordillo, M.A. Gebre, Abadi Kahsu Gebremedhin, Ketema Bizuwork Gebremeskel, Gebreamlak Gebremedhn Gezae, Kebede Embaye Ghoshal, Aloke Gopal Gill, Paramjit Singh Gillum, Richard F Goudarzi, Houman Guo, Yuming Gupta, Rajeev Hailu, Gessessew Bugssa Hasanzadeh, Amir Hassen, Hamid Yimam Hay, Simon I Hoang, Chi Linh Hole, Michael K Horita, Nobuyuki Hosgood, H Dean Hostiuc, Mihaela Househ, Mowafa Ilesanmi, Olayinka Stephen Ilic, Milena D Irvani, Seyed Sina Naghibi Islam, Sheikh Mohammed Shariful Jakovljevic, Mihajlo Jamal, Amr A Jha, Ravi Prakash Jonas, Jost B Kabir, Zubair Kasaeian, Amir Kasahun, Gebremicheal Gebreslassie Kassa, Getachew Mullu Kefale, Adane Teshome Kengne, Andre Pascal Khader, Yousef Saleh Khafaie, Morteza Abdullatif Khan, Ejaz Ahmad Khan, Junaid Khubchandani, Jagdish Kim, Young-Eun Kim, Yun Jin Kisa, Hospital Universitario de La Princesa (Princess University Hospital) Madrid Spain Autonomous University of Madrid Madrid Spain Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES) (Center for Biomedical Research in Respiratory Diseases Network) Madrid Spain Institute for Health Metrics and Evaluation Seattle WA United States Department of Surgery University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Department of Global Health University of Washington Seattle WA United States Department of Medicine University of Washington Seattle WA United States University of Washington Seattle WA United States Section of Allergy and Clinical Immunology University of Manitoba Winnipeg MB Canada Ophthalmology Department University of Manitoba Winnipeg MB Canada Department of Paediatrics University of British Columbia Vancouver BC Canada School of Population and Public Health University of British Columbia Vancouver BC Canada Department of Medical Rehabilitation Obafemi Awolowo University Ile-Ife Nigeria Department of Public Health Aarhus University Aarhus Denmark Nepal Health Frontiers University of Southern Denmark Kathmandu Nepal Social Behavioral Research Branch National Institute of Health Bethesda MD United States Department of Oncology Georgetown University Washington DC United States Institute of Genomics and Integrative Biology Council of Scientific & Industrial Research Delhi India Internal Medicine Baylor College of Medicine Houston TX United States Research Center for Chronic Kidney Disease Tabriz University of Medical Sciences Tabriz Iran Research Center for Evidence Based Medicine Tabriz University of Medical Sciences Tabriz Iran Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems Baku Azerbaijan Mayo Evidence-based Practice Center Mayo Clinic Foundat

Background: Previous attempts to characterise the burden of chronic respiratory diseases have focused only on specific disease conditions, such as chronic obstructive pulmonary disease (COPD) or asthma. In this study, we aimed to characterise the burden of chronic respiratory diseases globally, providing a comprehensive and up-to-date analysis on geographical and time trends from 1990 to 2017. Methods: Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, we estimated the prevalence, morbidity, and mortality attributable to chronic respiratory diseases through an analysis of deaths, disability-adjusted life-years (DALYs), and years of life lost (YLL) by GBD super-region, from 1990 to 2017, stratified by age and sex. Specific diseases analysed included asthma, COPD, interstitial lung disease and pulmonary sarcoidosis, pneumoconiosis, and other chronic respiratory diseases. We also assessed the contribution of risk factors (smoking, second-hand smoke, ambient particulate matter and ozone pollution, household air pollution from solid fuels, and occupational risks) to chronic respiratory disease-attributable DALYs. Findings: In 2017, 544·9 million people (95% uncertainty interval [UI] 506·9–584·8) worldwide had a chronic respiratory disease, representing an increase of 39·8% compared with 1990. Chronic respiratory disease prevalence showed wide variability across GBD super-regions, with the highest prevalence among both males and females in high-income regions, and the lowest prevalence in sub-Saharan Africa and south Asia. The age-sex-specific prevalence of each chronic respiratory disease in 2017 was also highly variable geographically. Chronic respiratory diseases were the third leading cause of death in 2017 (7·0% [95% UI 6·8–7·2] of all deaths), behind cardiovascular diseases and neoplasms. Deaths due to chronic respiratory diseases numbered 3 914 196 (95% UI 3 790 578–4 044 819) in 2017, an increase of 18·0% since 1990, while

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Proceedings of the EuBIC-MS 2020 Developers’ Meeting

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EuPA Open Proteomics 2020年 24卷 1-6页

作者： Christopher Ashwood Wout Bittremieux Eric W. Deutsch Nadezhda T. Doncheva Viktoria Dorfer Ralf Gabriels Vladimir Gorshkov Surya Gupta Andrew R. Jones Lukas Käll Dominik Kopczynski Lydie Lane Ludwig Lautenbacher Marc Legeay Marie Locard-Paulet Bart Mesuere Yasset Perez-Riverol Eugen Netz Sander Willems European Bioinformatics Community for Mass Spectrometry (info@***) Denmark Department of Cellular and Integrative Physiology University of Nebraska Medical Center Omaha USA Department of Computer Science University of Antwerp Antwerp Belgium Institute for Systems Biology Seattle WA 98109 USA Novo Nordisk Foundation Center for Protein Research University of Copenhagen Denmark Bioinformatics Research Group University of Applied Sciences Upper Austria Hagenberg Austria VIB-UGent Center for Medical Biotechnology VIB Ghent Belgium Department of Biochemistry and Molecular Biology University of Southern Denmark Denmark Institute of Systems Molecular and Integrative Biology University of Liverpool UK Science for Life Laboratory KTH - Royal Institute of Technology Solna Stockholm Sweden Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. Dortmund Germany SIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine Faculty of Medicine Geneva University Geneva Switzerland Technical University of Munich Chair for Proteomics and Bioanalytics Freising Germany European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SD UK Applied Bioinformatics Dept. of Computer Science University of Tübingen Tübingen Germany Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San Diego La Jolla CA 92093 USA Center for non-coding RNA in Technology and Health Department of Veterinary and Animal Sciences University of Copenhagen Denmark Department of Biomolecular Medicine Ghent University Ghent Belgium Department of Applied Mathematics Computer Science and Statistics Ghent University Ghent Belgium Biomolecular Interactions Max Planck Institute for Developmental Biology Tübingen Germany

The 2020 European Bioinformatics Community for Mass Spectrometry (EuBIC-MS) Developers’ meeting was held from January 13 th to January 17 th 2020 in Nyborg, Denmark. Among the participants were scientists as well as developers working in the field of computational mass spectrometry (MS) and proteomics. The 4-day program was split between introductory keynote lectures and parallel hackathon sessions. During the latter, the participants developed bioinformatics tools and resources addressing outstanding needs in the community. The hackathons allowed less experienced participants to learn from more advanced computational MS experts, and to actively contribute to highly relevant research projects. We successfully produced several new tools that will be useful to the proteomics community by improving data analysis as well as facilitating future research. All keynote recordings are available on https://***/10.5281/zenodo.3890181 .

关键词： Computational mass spectrometry Mass spectrometry Proteomics Bioinformatics Spectrum clustering Phosphoproteomics XIC extraction Proteomics graph networks Predicted spectra Metaproteomics Functional annotations Benchmark development

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Clinical and genetic delineation of autosomal recessive and dominant ACTL6B-related developmental brain disorders

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Genetics in Medicine 2025年第4期27卷 101251页

作者： Cali, Elisa Quirin, Tania Rocca, Clarissa Efthymiou, Stephanie Riva, Antonella Marafi, Dana Zaki, Maha S. Suri, Mohnish Dominguez, Roberto Elbendary, Hasnaa M. Alavi, Shahryar Abdel-Hamid, Mohamed S. Morsy, Heba Mau-Them, Frederic Tran Nizon, Mathilde Tesner, Pavel Ryba, Lukáš Zafar, Faisal Rana, Nuzhat Saadi, Nebal W. Firoozfar, Zahra Gencpinar, Pinar Unay, Bulent Ustun, Canan Bruel, Ange-Line Coubes, Christine Stefanich, Jennifer Sezer, Ozlem Agolini, Emanuele Novelli, Antonio Vasco, Gessica Lettori, Donatella Milh, Mathieu Villard, Laurent Zeidler, Shimriet Opperman, Henry Strehlow, Vincent Issa, Mahmoud Y. El Khassab, Hebatallah Chand, Prem Ibrahim, Shahnaz Rashidi-Nezhad, Ali Miryounesi, Mohammad Larki, Pegah Morrison, Jennifer Cristian, Ingrid Thiffault, Isabelle Bertsch, Nicole L. Noh, Grace J. Pappas, John Moran, Ellen Marinakis, Nikolaos M. Traeger-Synodinos, Joanne Hosseini, Susan Abbaszadegan, Mohammad Reza Caumes, Roseline Vissers, Lisenka E.L.M. Neshatdoust, Maedeh Montazer Zohour, Mostafa El Fahime, Elmostafa Canavati, Christina Kamal, Lara Kanaan, Moien Askander, Omar Voinova, Victoria Levchenko, Olga Haider, Shahzhad Halbach, Sara S. Elias Maia, Rayana Mansoor, Salehi Jain, Vivek Tawde, Sanjukta Challa, Viveka Santhosh R. Gowda, Vykuntaraju K. Srinivasan, Varunvenkat M. Victor, Lucas Alves Pinero-Banos, Benito Hague, Jennifer ElAwady, Heba Ahmed Maria de Miranda Henriques-Souza, Adelia Cheema, Huma Arshad Anjum, Muhammad Nadeem Idkaidak, Sara Alqarajeh, Firas Atawneh, Osama Mor-Shaked, Hagar Harel, Tamar Zifarelli, Giovanni Bauer, Peter Kok, Fernando Kitajima, Joao Paulo Monteiro, Fabiola Josahkian, Juliana Lesca, Gaetan Chatron, Nicolas Ville, Dorothe Murphy, David Neul, Jeffrey L. Mullegama, Sureni V. Begtrup, Amber Herman, Isabella Mitani, Tadahiro Posey, Jennifer E. Tay, Chee Geap Javed, Iram Carr, Lucinda Kanani, Farah Beecroft, Fiona Hane, Lee Abdelkreem, Elsayed Macek, Milan Bispo, Luciana Elmaksoud, Marwa Abd Hashemi-Gorji, Farzad Pehlivan, Davut Amor, David J. Jamra, Rami Abou Chung, Wend Department of Neuromuscular Diseases University College London Queen Square Institute of Neurology London United Kingdom RNA Molecular Biology Fonds de la Recherche Scientifique (F.R.S./FNRS) Université libre de Bruxelles (ULB) Biopark campus Gosselies Belgium Department of Neurosciences Rehabilitation Ophthalmology Genetics Maternal and Child Health University of Genoa Genoa Italy Department of Molecular and Human Genetics Baylor College of Medicine Houston TX United States Department of Pediatrics Faculty of Medicine Kuwait University Safat Kuwait Clinical Genetics Department Human Genetics and Genome Research Institute National Research Centre Cairo Egypt UK National Paediatric Ataxia Telangiectasia Clinic Nottingham University Hospitals NHS Trust Nottingham United Kingdom Nottingham Clinical Genetics Service Nottingham University Hospitals NHS Trust Nottingham United Kingdom Department of Physiology Perelman School of Medicine University of Pennsylvania Philadelphia PA United States Palindrome Isfahan Iran Medical Molecular Genetics Department Human Genetics and Genome Research Institute National Research Centre Cairo Egypt Human Genetics Department Medical Research Institute Alexandria University Egypt Unité Fonctionnelle 6254 d'Innovation en Diagnostique Génomique des Maladies Rares Pôle de Biologie CHU Dijon Bourgogne Dijon France INSERM UMR1231 GAD Dijon France Service de génétique médicale CHU de Nantes Nantes France Institut du thorax INSERM CNRS UNIV Nantes Nantes France Department of Biology and Medical Genetics 2nd Faculty of Medicine Charles University and Motol University Hospital Prague Czech Republic Department of Paediatric Neurology Children's Hospital and Institute of Child Health Multan Pakistan College of Medicine/University of Baghdad Unit of Pediatric Neurology Children Welfare Teaching Hospital Baghdad Iraq İzmir Katip Çelebi University Tepecik Training and Research Department of Pediatric Neurology Izmir Türkiye U

Purpose: This study aims to comprehensively delineate the phenotypic spectrum of ACTL6B-related disorders, previously associated with both autosomal recessive and autosomal dominant neurodevelopmental disorders. Molecularly, the role of the nucleolar protein ACTL6B in contributing to the disease has remained unclear. Methods: We identified 105 affected individuals, including 39 previously reported cases, and systematically analyzed detailed clinical and genetic data for all individuals. Additionally, we conducted knockdown experiments in neuronal cells to investigate the role of ACTL6B in ribosome biogenesis. Results: Biallelic variants in ACTL6B are associated with severe-to-profound global developmental delay/intellectual disability, infantile intractable seizures, absent speech, autistic features, dystonia, and increased lethality. De novo monoallelic variants result in moderate-to-severe global developmental delay/intellectual disability, absent speech, and autistic features, whereas seizures and dystonia were less frequently observed. Dysmorphic facial features and brain abnormalities, including hypoplastic corpus callosum, and parenchymal volume loss/atrophy, are common findings in both groups. We reveal that in the nucleolus, ACTL6B plays a crucial role in ribosome biogenesis, particularly in pre-rrna processing. Conclusion: This study provides a comprehensive characterization of the clinical spectrum of both autosomal recessive and dominant forms of ACTL6B-associated disorders. It offers a comparative analysis of their respective phenotypes provides a plausible molecular explanation and suggests their inclusion within the expanding category of “ribosomopathies.” © 2024 The Authors

关键词： ACTL6B Autism BAFopathies Epileptic-dyskinetic encephalopathy Ribosomopathies

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Regulation of cellular sterol homeostasis by the oxygen responsive noncoding rna lincNORS (vol 1, 4755, 2020)

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NATURE COMMUNICATIONS 2020年第1期11卷 4755-4755页

作者： Wu, Xue Niculite, Cristina M. Preda, Mihai Bogdan Rossi, Annalisa Tebaldi, Toma Butoi, Elena White, Mattie K. Tudoran, Oana M. Petrusca, Daniela N. Jannasch, Amber S. Bone, William P. Zong, Xingyue Fang, Fang Burlacu, Alexandrina Paulsen, Michelle T. Hancock, Brad A. Sandusky, George E. Mitra, Sumegha Fishel, Melissa L. Buechlein, Aaron Ivan, Cristina Oikonomopoulos, Spyros Gorospe, Myriam Mosley, Amber Radovich, Milan Dave, Utpal P. Ragoussis, Jiannis Nephew, Kenneth P. Mari, Bernard McIntyre, Alan Konig, Heiko Ljungman, Mats Cousminer, Diana L. Macchi, Paolo Ivan, Mircea Department of Microbiology and Immunology Indiana University School of Medicine Indianapolis IN 46202 USA Department of Medicine Indiana University School of Medicine Indianapolis IN 46202 USA “Victor Babes” National Institute of Pathology Bucharest Romania Institute of Cellular Biology and Pathology “Nicolae Simionescu” Bucharest Romania Laboratory of Molecular and Cellular Neurobiology Department of Cellular Computational and Integrative Biology - CIBIO University of Trento Trento Italy Laboratory of Translational Genomics Department of Cellular Computational and Integrative Biology - CIBIO University of Trento Trento Italy Yale Cancer Center Yale University School of Medicine New Haven CT 06520 USA The Oncology Institute “Prof Dr. Ion Chiricuta” Cluj-Napoca Romania Metabolite Profiling Facility Bindley Bioscience Center Purdue University West Lafayette IN 47907 USA Department of Genetics Department of Systems Pharmacology and Translational Therapeutics Institute of Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Department of Cellular and Integrative Physiology Indiana University School of Medicine Indianapolis IN USA Departments of Radiation Oncology and Environmental Health Sciences Center for RNA Biomedicine University of Michigan Ann Arbor MI 48109 USA Department of Surgery Indiana University School of Medicine Indianapolis IN 46202 USA Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis IN 46202 USA Melvin and Bren Simon Cancer Center Indiana University Indianapolis IN USA Department of Obstetrics and Gynecology Indiana University School of Medicine Indianapolis IN 46202 USA Department of Pharmacology and Toxicology Department of Pediatrics Wells Center for Pediatric Research Indiana University School of Medicine Indianapolis IN 46202 USA Indiana University Center for Genomics and Bioinformatics Bloomington IN 47405 USA Center

We hereby provide the initial portrait of lincNORS, a spliced lincrna generated by the MIR193BHG locus, entirely distinct from the previously described miR-193b-365a tandem. While inducible by low O2 in a variety of cells and associated with hypoxia in vivo, our studies show that lincNORS is subject to multiple regulatory inputs, including estrogen signals. Biochemically, this lincrna fine-tunes cellular sterol/steroid biosynthesis by repressing the expression of multiple pathway components. Mechanistically, the function of lincNORS requires the presence of RALY, an rna-binding protein recently found to be implicated in cholesterol homeostasis. We also noticed the proximity between this locus and naturally occurring genetic variations highly significant for sterol/steroid-related phenotypes, in particular the age of sexual maturation. An integrative analysis of these variants provided a more formal link between these phenotypes and lincNORS, further strengthening the case for its biological relevance. noncoding transcripts contribute to the adaptation of cellular processes to oxygen levels. Here the authors characterize a hypoxia responsive lncrna lincNORS and show that it has a role in cellular sterol homeostasis.

关键词： Long non-coding rnas Long non-coding rnas Homeostasis Homeostasis

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Association between nonalcoholic Fatty Liver Disease and Carotid Artery Disease in a Community-Based Chinese Population： A Cross-Sectional Study

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Chinese Medical Journal 2018年第19期131卷 2269-2276页

作者： Yu-Chen Guo Yong Zhou Xing Gao Yan Yao Bin Geng Qing-Hua Cui Ji-Chun Yang Hong-Pu Hu Department of Health Information Management Institute of Medical Information Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100020 China Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Hypertension Center Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College State Key Laboratory of Cardiovascular Disease Beijing 100037 China Department of Biomedical Informatics School of Basic Medical Sciences Key Laboratory of Molecular Cardiovascular Science of the Ministry of Education Center for Non-coding RNA Medicine Peking University Health Science Center Beijing 100191 China Department of Physiology and Pathophysiology School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China

Background： nonalcoholic fatty liver disease （NAFLD） is one of the most common chronic liver diseases with a high prevalence in the general population. The association between NAFLD and cardiovascular disease has been well addressed in previous studies. However, whether NAFLD is associated with carotid artery disease in a community-based Chinese population remained unclear. The aim of this study was to investigate the association between NAFLD and carotid artery disease. Methods： A total of 2612 participants （1091 men and 1521 women） aged 40 years and older from Jidong of Tangshan city （China） were selected for this study. NAFLD was diagnosed by abdominal ultrasonography. The presence of carotid stenosis or plaque was evaluated by carotid artery ultrasonography. Logistic regression was used to analyze the association between NAFLD and carotid artery disease. Results： Participants with NAFLD have a higher prevalence of carotid stenosis （12.9% vs. 4.6%） and carotid plaque （21.9% vs. 15.0%） than those without NAFLD. After adjusting for age, gender, smoking status, income, physical activity, diabetes, hypertension, triglyceride, waist-hip ratio, and high-density lipoprotein, NAFLD is significantly associated with carotid stenosis （odds ratio [OR]： 2.06, 95% confidence interval [CI]： 1.45-2.91）, but the association between NAFLD and carotid plaque is not statistically significant （OR： 1. 10, 95% CI： 0.86-1.40）. Conclusion： A significant association between NAFLD and carotid stenosis is found in a Chinese population.

关键词： Association Carotid Artery Disease Carotid Stenosis nonalcoholic Fatty Liver Disease

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Author Correction: Hypoxia-mediated downregulation of mirna biogenesis promotes tumour progression

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Nature communications 2020年第1期11卷 2867页

作者： Rajesha Rupaimoole Sherry Y Wu Sunila Pradeep Cristina Ivan Chad V Pecot Kshipra M Gharpure Archana S Nagaraja Guillermo N Armaiz-Pena Michael McGuire Behrouz Zand Heather J Dalton Justyna Filant Justin Bottsford Miller Chunhua Lu Nouara C Sadaoui Lingegowda S Mangala Morgan Taylor Twan van den Beucken Elizabeth Koch Cristian Rodriguez-Aguayo Li Huang Menashe Bar-Eli Bradly G Wouters Milan Radovich Mircea Ivan George A Calin Wei Zhang Gabriel Lopez-Berestein Anil K Sood Department of Gynecologic Oncology The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA. Graduate School of Biomedical Sciences The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA. Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA. Department of Molecular Therapeutics University of North Carolina Lineberger Comprehensive Cancer Center 101 Manning Drive Chapel Hill NC 27599 USA. Department of Medical Biophysics University of Toronto Toronto ON Canada M5G 1L7. Princess Margaret Cancer Centre and Campbell Family Institute for Cancer Research University Health Network Toronto ON Canada M5G 1L7. Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA. Department of Cancer Biology The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA. Department of Surgery Microbiology and Immunology Indiana University 980W Walnut Street Indianapolis IN 46202 USA. Department of Medicine Microbiology and Immunology Indiana University 980W Walnut Street Indianapolis IN 46202 USA. Department of Pathology The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA. Department of Gynecologic Oncology The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA. asood@***. Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA. asood@***. Department of Cancer Biology The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA. asood@***.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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The Sierra Platinum Service for generating peak-calls for replicated ChIP-seq experiments

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BMC Research Notes 2018年第1期11卷 1-5页

作者： Wiegreffe, Daniel Müller, Lydia Steuck, Jens Zeckzer, Dirk Stadler, Peter F. Image and Signal Processing Group Department of Computer Science University of Leipzig Augustusplatz 10 Leipzig 04109 Germany Natural Language Processing Department Department of Computer Science University of Leipzig Augustusplatz 10 Leipzig 04109 Germany Bioinformatics Group Department of Computer Science University of Leipzig Härtelstraße 16-18 Leipzig 04107 Germany Interdisciplinary Center for Bioinformatics University of Leipzig Härtelstraße 16-18 Leipzig 04107 Germany Max Planck Institute MIS Inselstraße 22 Leipzig 04103 Germany Fraunhofer Institute for Cell Therapy and Immunology IZI Perlickstraße 1 Leipzig 04103 Germany Institute for Theoretical Chemistry University of Vienna Währinger Straße 17 Vienna 1090 Austria Center for Non-coding RNA in Technology and Health University of Copenhagen Grønnegårdsvej 3 Copenhagen 1870 Denmark Santa Fe Institute 1399 Hyde Park Road Santa Fe 87501 NM United States

Objective: Sierra Platinum is a fast and robust peak-caller for replicated ChIP-seq experiments with visual quality-control and -steering. The required computing resources are optimized but still may exceed the resources available to researchers at biological research institutes. Results: Sierra Platinum Service provides the full functionality of Sierra Platinum: using a web interface, a new instance of the service can be generated. Then experimental data is uploaded and the computation of the peaks is started. Upon completion, the results can be inspected interactively and then downloaded for further analysis, at which point the service terminates. © 2018 The Author(s).

关键词： ChIP-seq Histone modifications Peak-caller Replicate analysis

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Author Correction: A bioabsorbable mechanoelectric fiber as electrical stimulation suture

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Nature communications 2025年第1期16卷 898页

作者： Zhouquan Sun Yuefan Jin Jiabei Luo Linpeng Li Yue Ding Yu Luo Yan Qi Yaogang Li Qinghong Zhang Kerui Li Haibo Shi Shankai Yin Hongzhi Wang Hui Wang Chengyi Hou State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University Shanghai P. R. China. Shanghai Key Laboratory of Sleep Disordered Breathing Department of Otolaryngology-Head and Neck Surgery Otolaryngology Institute of Shanghai JiaoTong University Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai P. R. China. Shanghai Key Laboratory of Sleep Disordered Breathing Department of Otolaryngology-Head and Neck Surgery Otolaryngology Institute of Shanghai JiaoTong University Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai P. R. China. lilp@***. Department of General Surgery Tongji Hospital Tongji University Medical School Shanghai P. R. China. Shanghai Engineering Research Center of Pharmaceutical Intelligent Equipment Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Non-coding RNA Institute for Frontier Medical Technology School of Chemistry and Chemical Engineering Shanghai University of Engineering Science Shanghai P. R. China. Yangzhi Rehabilitation Hospital Affiliated to Tongji University Tongji University School of Medicine Shanghai P. R. China. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University Shanghai P. R. China. wanghz@***. Shanghai Key Laboratory of Sleep Disordered Breathing Department of Otolaryngology-Head and Neck Surgery Otolaryngology Institute of Shanghai JiaoTong University Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai P. R. China. wangh2005@alumni.***. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University Shanghai P. R. China. hcy@dhu.edu.cn.

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Corrigendum: FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair

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Carcinogenesis 2019年第7期40卷 936页

作者： Yun-Yong Park Sung Yun Jung Nicholas B Jennings Cristian Rodriguez-Aguayo Guang Peng Se-Ra Lee Sang Bae Kim Kyounghyun Kim Sun-Hee Leem Shiaw-Yih Lin Gabriel Lopez-Berestein Anil K Sood Ju-Seog Lee Department of Systems Biology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Biochemistry and Molecular Biology Baylor College of Medicine Houston TX USA. Department of Gynecologic Oncology Houston TX USA. Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Biology and Biomedical Science Dong-A University Busan Korea. Institute of Biosciences and Technology Texas A&M University Health Science Center Houston TX USA. Deparment of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX USA. Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX USA.

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