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Supercomputing Frontiers and Innovations 2018年第4期5卷 67-72页

作者： Trifanov, Petr V. Kaneva, Valeriia N. Strijhak, Sergei V. Panteleev, Mikhail A. Ataullakhanov, Fazoil I. Dunster, Joanne Voevodin, Vadim V. Nechipurenko, Dmitry Y. Department of Physics Lomonosov Moscow State University Moscow Russia Dmitry Rogachev National Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia Center for Theoretical Problems of Physicochemical Pharmacology Moscow Russia Ivannikov Institute for System Programming of the RAS Moscow Russia Faculty of Biological and Medical Physics Moscow Institute of Physics and Technology Dolgoprudny Russia Institute for Cardiovascular and Metabolic Research School of Biological Sciences University of Reading Berkshire United Kingdom Research Computing Center of Lomonosov Moscow State University Moscow Russia

Formation of the platelet plug represents a primary response to the vessel wall injury, but may also result in vessel occlusion. The decrease of the local blood flow due to platelet thrombus formation may lead to serious complications, such as ischemic stroke and myocardial infarction. However, mechanisms responsible for regulation of thrombus dynamics are not clear. In order to get a deeper insight into the role of blood flow and platelet interactions in the formation of the primary platelet plug we developed a particle-based model of microvascular thrombosis using quasisteady flow approximation. In order to simulate thrombus dynamics at physiologically relevant timescales of several minutes, we took advantage of the supercomputer technologies. Our in silico analysis revealed the importance of platelet size heterogeneity for describing experimental data on microvascular thrombus formation. Thus, our model represents a useful tool for the supercomputeraided computational analysis of thrombus dynamics in the microvessels on physiologically relevant timescales. © The Author 2018.

关键词： Platelets

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Research on the multidimensional educational review strategy Based on MOOCs Integrated by the multidimensional learning theory

Research on the multidimensional educational review strategy...

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2015 World Congress on Engineering and Computer Science, WCECS 2015

作者： Ming, Li Ju, Zhang Jingzhong, Zhang Lian, Chen High Performance Computing Application R and D Center Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences Chongqing China Automated Reasoning and Cognition Key Laboratory of Chongqing Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences Chongqing China Laboratory for Automated Reasoning and Programming Chengdu Institute of Computer Applications Chinese Academy of Sciences Chengdu China

ISBN: (纸本)9789881925367

Through a detailed analysis of the theoretical basis for MOOCs in terms of educational learning theories, this paper attempts at finding the corresponding relationship between the theories and MOOCs, which not only theoretically explains the reasons why MOOCs exceed all the previous education models, but also empirically proves it with voluminous facts and data. The author conducts this research in the hope of enlightening the online education platform of other types. Besides, this paper provides the model framework and strategy to multidimensional educational review based on MOOCs. The model and strategy are applicable not only to MOOCs, the large-scale online education, but also to various online education platforms.

关键词： E-learning

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Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

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Nature communications 2018年第1期9卷 2162页

作者： Sílvia Bonàs-Guarch Marta Guindo-Martínez Irene Miguel-Escalada Niels Grarup David Sebastian Elias Rodriguez-Fos Friman Sánchez Mercè Planas-Fèlix Paula Cortes-Sánchez Santi González Pascal Timshel Tune H Pers Claire C Morgan Ignasi Moran Goutham Atla Juan R González Montserrat Puiggros Jonathan Martí Ehm A Andersson Carlos Díaz Rosa M Badia Miriam Udler Aaron Leong Varindepal Kaur Jason Flannick Torben Jørgensen Allan Linneberg Marit E Jørgensen Daniel R Witte Cramer Christensen Ivan Brandslund Emil V Appel Robert A Scott Jian'an Luan Claudia Langenberg Nicholas J Wareham Oluf Pedersen Antonio Zorzano Jose C Florez Torben Hansen Jorge Ferrer Josep Maria Mercader David Torrents Barcelona Supercomputing Center (BSC) Joint BSC-CRG-IRB Research Program in Computational Biology 08034 Barcelona Spain. Genomic Programming of Beta-cells Laboratory Institut d'Investigacions August Pi i Sunyer (IDIBAPS) 08036 Barcelona Spain. Instituto de Salud Carlos III Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) 28029 Madrid Spain. Section of Epigenomics and Disease Department of Medicine Imperial College London London W12 0NN UK. The Novo Nordisk Foundation Center for Basic Metabolic Research Section for Metabolic Genetics Faculty of Health and Medical Sciences University of Copenhagen 2100 Copenhagen Denmark. Institute for Research in Biomedicine (IRB Barcelona) The Barcelona Institute of Science and Technology Baldiri Reixac 10-12 08028 Barcelona Spain. Departament de Bioquímica i Biomedicina Molecular Facultat de Biologia Universitat de Barcelona 08028 Barcelona Spain. Computer Sciences Department Barcelona Supercomputing Center (BSC-CNS) 08034 Barcelona Spain. Department of Epidemiology Research Statens Serum Institut 2300 Copenhagen Denmark. Division of Endocrinology and Center for Basic and Translational Obesity Research Boston Children's Hospital Boston MA 02116 USA. Medical and Population Genetics Program Broad Institute of MIT and Harvard Cambridge MA 02142 USA. ISGlobal Centre for Research in Environmental Epidemiology (CREAL) 08003 Barcelona Spain. CIBER Epidemiología y Salud Pública (CIBERESP) 28029 Madrid Spain. Universitat Pompeu Fabra (UPF) 08003 Barcelona Spain. Artificial Intelligence Research Institute (IIIA) Spanish Council for Scientific Research (CSIC) 28006 Madrid Spain. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA 02142 USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA 02114 USA. Division of General Internal Medicine Massachusetts General Hospital Bost

In the originally published version of this Article, the affiliation details for Santi González, Jian'an Luan and Claudia Langenberg were inadvertently omitted. Santi González should have been affiliated with 'Barcelona Supercomputing center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology, 08034 Barcelona, Spain', and Jian'an Luan and Claudia Langenberg should have been affiliated with 'MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK'. Furthermore, the abstract contained an error in the SNP ID for the rare variant in chromosome Xq23, which was incorrectly given as rs146662057 and should have been rs146662075. These errors have now been corrected in both the PDF and HTML versions of the Article.

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How file access patterns influence interference among cluster applications

How file access patterns influence interference among cluste...

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IEEE International Conference on Cluster Computing

作者： Chih-Song Kuo Aamer Shah Akihiro Nomura Satoshi Matsuoka Felix Wolf Department of Computer Science RWTH Aachen University Aachen Germany German Research School for Simulation Sciences Laboratory for Parallel Programming Aachen Germany Tokyo Institute of Technology Global Scientific Information and Computing Center Tokyo Japan

On large-scale clusters, tens to hundreds of applications can simultaneously access a parallel file system, leading to contention and in its wake to degraded application performance. However, the degree of interference depends on the specific file access pattern. On the basis of synchronized time-slice profiles, we compare the interference potential of different file access patterns. We consider both micro-benchmarks, to study the effects of certain patterns in isolation, and realistic applications to gauge the severity of such interference under production conditions. In particular, we found that writing large files simultaneously with small files can slow down the latter at small chunk sizes but the former at larger chunk sizes. We further show that such effects can seriously affect the runtime of real applications-up to a factor of five in one instance. In the future, both our insights and profiling techniques can be used to automatically classify the interference potential between applications and to adjust scheduling decisions accordingly.

关键词： Interference Servers Throughput Benchmark testing Market research Degradation Aggregates

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Performance Characterization of SPEC CPU2006 Benchmarks on Intel and AMD Platform

Performance Characterization of SPEC CPU2006 Benchmarks on I...

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International Workshop on Education technology and Computer Science, ETCS

作者： Shengmei Li Buqi Cheng Xingyu Gao Lin Qiao Zhizhong Tang Department of Computer Science and Technology Tsinghua University Beijing China Programming Systems Laboratory Intel China Research Center Limited Beijing China Chinese Academy and Sciences Beijing China

For understanding the performance differences caused by different computer architectures and optimization technologies, the paper characterizes performance of SPEC CPU2006 benchmarks both on Intel and AMD platform. Using the performance events collected by Performance Monitor Unit, we compare their performance differences and analyze the causes from the features of architectures and the optimization technologies. Our results and analysis help the programmers better understand the memory performance and branch prediction performance which are caused by architectures and guide them in the optimization. The analysis also help the processor architects better balance among the key architecture factors such as memory disambiguation and hardware prefetch when doing architecture design decision.

关键词： Microarchitecture Decoding Educational technology Paper technology programming profession Performance analysis Computer science Computer architecture Hardware Prefetching

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Flexible object encapsulation for ambient oriented programming 1

Flexible object encapsulation for ambient oriented programmi...

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1st Dynamic Languages Symposium, DLS 2005

作者： De Meuter, Wolfgang Tanter, Éric Mostinckx, Stijn Van Cutsem, Tom Dedecker, Jessie Laboratoire d'Informatique Fondamontale de Lille Universit é des Sciences et Technologies de Lille France Programming Technology Lab Vrije Universiteit Brussel Belgium Center for Web Research DCC University of Chile Chile

ISBN: (纸本)1595932836

In the emerging field of Ambient Intelligence (AmI), software is deployed in wireless open networks of mobile devices. Such open networks require stringent security measures as unknown and untrusted hosts may join the network. In an object-oriented language, where objects are distributed and moved across the network, it thus becomes important to be able to enforce object encapsulation. In contemporary object-oriented programming languages, powerful operations such as object extension (inheritance), cloning and reflection, are typically provided via omnipotent language operators that fail to uphold object encapsulation, because they can be applied without the explicit consent of the concerned object. This paper formulates a language design principle -extreme encapsulation- that precludes the use of such harmful operators, and proposes a corresponding language feature -method attributes- that makes it possible to provide the flexibility of object extension, cloning and reflection without compromising on object encapsulation. Although some existing object-based languages can be said to support extreme encapsulation, our contribution is to support it in a delegation-based, prototype-based language named ChitChat. Copyright 2005 ACM.

关键词： Cloning

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Symposia lectures

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Journal of Biosciences 1999年第1期24卷 5-31页

作者： F. Parak A. Ostermann G. U. Nienhaus Nobuo Niimura William A. Eaton Stephen J. Hagen Eric R. Henry James Hofrichter Gouri Jas Lisa Lapidus Victor Muñoz Chih-chen Wang Abani Bhuyan Javant Udgaonkar Heinz Rüterians Derek N. Woolfson M. D. Finucane J. H. Lees M. J. Pandya G. Spooner M. Tuna Wilma K. Olson K. V. R. Chary E. Westhof I. G. Wool C. C. Correll V. I. Ivanov S. A. Bondarenko E. M. Zdobnov A. D. Beniaminov E. E. Minyat N. B. Ulyanov Dale B. Wigley Nobuo Shimamoto Takashi Kinebuchi Hiroyuki Kabata Osamu Kurosawa Masao Washizu Barbara Baird David Holowka H. Belrhali P. Nollert A. Royant J. P. Rosenbusch E. M. Landau E. Pebav-Peyroula Anil K. Lala Patrick R. D’Silva Daniela Pietrobon Paolo Pinton Paulo Magalhaes Anna Chiesa Marisa Brini Tullio Pozzan Rosario Rizzuto M. Montai Shu-Rong Wang José L. Carrascosa B. Bhattacharyya Ian A. Wilson Dinakar M. Salunke Kurt Drickamer Anne Imberty A. Surolia Louise N. Johnson Michal Neeman S. M. Prince K. McLuskey R. J. Cogdell K. McAuley N. W. Isaacs G. Venturoli F. Drepper J. C. Williams J. P. Allen X. Lin P. Mathis R. van Grondelle Wolfgang Junge T. Tsukihara K. Shinzawa-Itoh R. Nakashima E. Yamashita M. J. Fei N. Inoue T. Tomizaki C. Peters Libeu S. Yoshikawa Patrick Chaussepied Keiichi Namba Marie-France Carlier Fariza Ressacl Valerie Laurent Thomas Loisel Coumaran Egile Philippe Sansonetti Dominique Pantaloni Manju Bansal E. W. Knapp M. G. Ullmann A. Amadei B. L. de Groot M. A. Ceruso M. Paci H. J. C. Berendsen A. Di Nola V. Di Francesco P. J. Munson J. Garnier Sung-Hou Kim Jean-Michel Claverie Ian C. P. Smith P. T. Callaghan Bruce Cornell Ratna S. Phadke Kazuhiko Kinosita D. Goldfarb I. Qromov C. Shutter I. Pecht P. Manikandan R. Carmieli T. Shane David S. Moss Clare E. Sansom Jeremy K. Cockcroft Ian J. Tickle Huub C. P. Driessen J. Raul Grigera Ramen K. Poddar Charles R. Cantor Barry Robson Jean Garnier John Helliwell Sunney I. Chan Ronald Rock Physik-Department El7 Technische Universität München Garching Abteilung Biophysik Universität Ulm Ulm Advanced Science Research Center Japan Atomic Energy Research Institute Japan Laboratory of Chemical Physics NIDDK National Institutes of Health Bethesda USA National Lab of Biomacromolecules Institute of Biophysics Beijing China National Centre for Biological Sciences Bangalore Institute of Biophysical Chemistry University of Frankfurt Frankfurt/Main Germany Centre for Biomolecular Design and Drug Development University of Sussex UK Rutgers University Piscataway USA Department of Chemical Sciences Tata Institute of Fundamental Research Mumbai India IBMC-CNRS Strasbourg France Department of Biochemistry and Molecular Biology The University of Chicago Chicago USA Engelhardt Institute of Molecular Biology RAS Moscow Russia Sir William Dunn School of Pathology University of Oxford Oxford UK Structural Biology Center National Institute of Genetics Japan Faculty of Engineering Kyoto University Kyoto Advance Co. Tokyo Japan Department of Chemistry and Chemical Biology Cornell University Ithaca Institute de Biologie Structurale Joseph Fourier Grenoble Cedex 1 France Biomembrane Lab Department of Chemistry and Biotechnology CenterIndian Institute of Technology Bombay Powai Mumbai India Dept of Biomedical Sciences Univ. of Padova Italy Dept. Exp. Diagn. Med. Sect. Gen. Pathol Ferrara Italy Department of Biology University of California San Diego La Jolla USA Chinese Academy of Sciences Institute of Biophysics Beijing China Centra Nacional de Biotecnología CSIC. Campus de la Universidad Autónoma de Madrid Cantoblanco Spain Dept.of Biochemistry Bose Institute Calcutta-54 India The Scripps Research Institute La Jolla National Institute of Immunology New Delhi India Glycobiology Institute Department of Biochemistry University of Oxford Oxford UK Centre de Recherches sur les Macromolécules Végétales-CNRS Grenoble cedex 9 France Molecular Biophysics Uni

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INTEGRATING THE DATA ENCRYPTION STANDARD INTO COMPUTER-NETWORKS

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IEEE TRANSACTIONS ON COMMUNICATIONS 1981年第6期29卷 762-772页

作者： SMID, ME Center for Programming Science and Technology Institute for Computer Sciences and Technology National Bureau of Standards Washington D.C. DC USA

The NBS Data Encryption Standard may be integrated into computer networks to protect personal (nonshared) files, to communicate securely both on- and off-line with local and remote users, to protect against key substitution, to authenticate system users, to authenticate data, and to provide digital signatures using a nonpublic key encryption algorithm. Key notarization facilities give users the capability of exercising a set of commands for key management as well as for data encryption functions. The facilities perform notarization which, upon encryption, seals a key or password with the identities of the transmitter and intended receiver. Thus, in order to decrypt a message, the receiver must authenticate himself and supply the correct identity of the transmitter. This feature eliminates the threat of key substitution which must be protected against to attain a high level of security.

关键词： Cryptography Computer networks Protection Transmitters NIST Communication standards Digital signatures Identity-based encryption Seals Security

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AMBIGUITY IN PROCESSING BOOLEAN QUERIES ON TDMS TREE-STRUCTURES - A STUDY OF 4 DIFFERENT PHILOSOPHIES

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IEEE TRANSACTIONS ON SOFTWARE ENGINEERING 1980年第4期6卷 357-372页

作者： HARDGRAVE, WT Center for Programming Sciences and Technology Institute for Computer Sciences and Technology National Bureau of Standards

This paper defines and demonstrates four philosophies for processing queries on tree structures; shows that the data semantics of queries shuld be described by designating sets of nodes from which v values for attnbutes may be returned to the data consumer; shows that the data semantics of database processing can be specified totally independent of any madhine, file structure, or implementation; shows that set theory is a natural and effective vehicle for analyzing the semantics of queries on tree structures; and finally, shows that Bolts is an adequate formalism for conveying the semantics of tree structure processing.

关键词： Tree Structures Ambiguity Boolean Database Hierarchical Information Query Query Language Semantics TDMS Tree

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