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Publisher Correction: Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor micrornas

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Nature communications 2018年第1期9卷 160页

作者： Ivan Vannini Petra M Wise Kishore B Challagundla Meropi Plousiou Mirco Raffini Erika Bandini Francesca Fanini Giorgia Paliaga Melissa Crawford Manuela Ferracin Cristina Ivan Linda Fabris Ramana V Davuluri Zhiyi Guo Maria Angelica Cortez Xinna Zhang Lu Chen Shuxing Zhang Cecilia Fernandez-Cymering Leng Han Silvia Carloni Samanta Salvi Hui Ling Mariam Murtadha Paolo Neviani Barbara J Gitlitz Ite A Laird-Offringa Patrick Nana-Sinkam Massimo Negrini Han Liang Dino Amadori Amelia Cimmino George A Calin Muller Fabbri Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) S.r.l. IRCCS Gene Therapy Unit Meldola FC 47014 Italy. Departments of Pediatrics and Molecular Microbiology & Immunology Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California Children's Center for Cancer and Blood Diseases and The Saban Research Institute Children's Hospital Los Angeles Los Angeles CA 90027 USA. Department of Biochemistry & Molecular Biology University of Nebraska Medical Center 985870 Nebraska Medical Center Omaha NE 68198 USA. Department of Internal Medicine Division of Pulmonary Allergy Critical Care and Sleep Medicine The Ohio State University Columbus OH 43210 USA. Department of Experimental Diagnostic and Specialty Medicine- DIMES University of Bologna Bologna 40126 Italy. Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. The Center for RNA Interference and Non-coding RNAs The University of Texas MD Anderson Cancer Center Houston TX USA. Departments of Preventive Medicine and Neurological Surgery Northwestern University-Feinberg School of Medicine Chicago IL 60611 USA. Department of Experimental Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Integrated Molecular Discovery Laboratory Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Division of Pre-Clinical Innovation National Center for Advancing Translational Sciences (NCATS) Rockville MD 20850 USA. Department of Molecular Virology Immunology and Medical Genetics Comprehensive Cancer Center Ohio State University Columbus OH 43210 USA. Department of Biochemistry and Molecular Biology McGovern Medical School The University of Texas Health Science Center at Hou

In the originally published version of this Article, the positions of the final two authors in the author list were inadvertently inverted during the production process. This error has now been corrected in both the P...

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Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis

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SCIENCE TRANSLATIONAL MEDICINE 2022年第669期14卷 eabo1981页

作者： Zhang, Yaohua Sun, Chengcao Li, Yajuan Qin, Juan Amancherla, Kaushik Jing, Ying Hu, Qingsong Liang, Ke Zhang, Zhao Ye, Youqiong Huang, Lisa A. Nguyen, Tina K. Egranov, Sergey D. Zhao, Zilong Wu, Andrew Xi, Yutao Yao, Jun Hung, Mien-Chie Calin, George A. Cheng, Jie Lim, Bora Lehmann, Lorenz H. Salem, Joe-Elie Johnson, Douglas B. Curran, Michael A. Yu, Dihua Han, Leng Darabi, Radbod Yang, Liuqing Moslehi, Javid J. Lin, Chunru Univ Texas MD Anderson Canc Ctr Dept Mol & Cellular Oncol Houston TX 77030 USA Capital Med Univ Beijing Inst Brain Disorders Collaborat Innovat Ctr Brain Disorders Beijing 10069 Peoples R China Univ Calif San Francisco Div Cardiol Sect Cardio Oncol & Immunol San Francisco CA 94143 USA Univ Calif San Francisco Cardiovasc Res Inst San Francisco CA 94143 USA Vanderbilt Univ Sch Med Dept Med Nashville TN 37232 USA Univ Texas Hlth Sci Ctr Houston Dept Biochem & Mol Biol McGovern Med Sch Houston TX 77030 USA St Lukes Hosp Texas Heart Inst Houston TX 77030 USA China Med Univ Grad Inst Biomed Sci Res Ctr Canc Biol Taichung 404 Taiwan China Med Univ Ctr Mol Med Taichung 404 Taiwan Asia Univ Dept Biotechnol Taichung 413 Taiwan Univ Texas MD Anderson Canc Ctr Div Canc Med Dept Expt Therapeut Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Ctr RNA Interference & Non Coding RNAs Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Breast Med Oncol Houston TX 77030 USA Univ Heidelberg Hosp Dept Cardiol Heidelberg Germany Heidelberg Univ Hosp Cardio Oncol Unit Heidelberg Germany German Cardiovasc Res Ctr DZHK Partner site Heidelberg Mannheim Germany German Canc Res Ctr Heidelberg Germany Sorbonne Univ Dept Pharmacol Assistance Publ Hop Paris AP HP INSERM CIC1901UNICOGRECOCardiooncol Program Paris France Vanderbilt Univ Sch Med Vanderbilt Ingram Canc Ctr Nashville TN 37232 USA Univ Texas MD Anderson Canc Ctr Oncol Res Biol & Immunotherapy Translat ORBIT Dept Immunol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Grad Sch Biomed Sci Houston TX 77030 USA Texas A&M Univ Inst Biosci & Technol Ctr Epigenet & Dis Prevent Houston TX 77030 USA Univ Texas Hlth Sci Ctr Houston Brown Fdn Inst Mol Med Prevent Human Dis IMM Ctr Stem Cell & Regenerat Med CSCRM Houston TX 77030 USA Incyte Corp Wilmington DE 19803 USA Univ Sci & Technol China Div Life Sci & Med Affiliated Hosp USTC 1 Hefei 230001 Anhui Peoples R China

Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer treatment but are associated with myocarditis. Here, we report that tumor-bearing mice exhibited response to treatment with combinatorial anti-programmed cell death 1 and anti-cytotoxic T lymphocyte antigen-4 antibodies but also presented with cardiovascular toxicities observed clinically with ICI therapy, including myocarditis and arrhythmia. Female mice were preferentially affected with myocarditis compared to male mice, consistent with a previously described genetic model of ICI myocarditis and emerging clinical data. Mechanistically, myocardial tissue from ICI-treated mice, the genetic mouse model, and human heart tissue from affected patients with ICI myocarditis all exhibited down-regulation of MANF (mesencephalic astrocyte-derived neurotrophic factor) and HSPA5 (heat shock 70-kDa protein 5) in the heart;this down-regulation was particularly notable in female mice. ICI myocarditis was amplified by heart-specific genetic deletion of mouse Manf and was attenuated by administration of recombinant MANF protein, suggesting a causal role. Ironically, both MANF and HSPA5 were transcriptionally induced by liganded estrogen receptor beta and inhibited by androgen receptor. However, ICI treatment reduced serum estradiol concentration to a greater extent in female compared to male mice. Treatment with an estrogen receptor beta-specific agonist and androgen depletion therapy attenuated ICI-associated cardiac effects. Together, our data suggest that ICI treatment inhibits estradiol-dependent expression of MANF/HSPA5 in the heart, curtailing the cardiomyocyte response to immune injury. This endocrine-cardiac-immune pathway offers new insights into the mechanisms of sex differences in cardiac disease and may offer treatment strategies for ICI myocarditis.

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Publisher Correction: Regulation of cellular sterol homeostasis by the oxygen responsive noncoding rna lincNORS

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Nature communications 2020年第1期11卷 5737页

作者： Xue Wu Cristina M Niculite Mihai Bogdan Preda Annalisa Rossi Toma Tebaldi Elena Butoi Mattie K White Oana M Tudoran Daniela N Petrusca Amber S Jannasch William P Bone Xingyue Zong Fang Fang Alexandrina Burlacu Michelle T Paulsen Brad A Hancock George E Sandusky Sumegha Mitra Melissa L Fishel Aaron Buechlein Cristina Ivan Spyros Oikonomopoulos Myriam Gorospe Amber Mosley Milan Radovich Utpal P Davé Jiannis Ragoussis Kenneth P Nephew Bernard Mari Alan McIntyre Heiko Konig Mats Ljungman Diana L Cousminer Paolo Macchi Mircea Ivan Department of Microbiology and Immunology Indiana University School of Medicine Indianapolis IN 46202 USA. Department of Medicine Indiana University School of Medicine Indianapolis IN 46202 USA. "Victor Babes" National Institute of Pathology Bucharest Romania. Institute of Cellular Biology and Pathology "Nicolae Simionescu" Bucharest Romania. Laboratory of Molecular and Cellular Neurobiology Department of Cellular Computational and Integrative Biology-CIBIO University of Trento Trento Italy. Laboratory of Translational Genomics Department of Cellular Computational and Integrative Biology-CIBIO University of Trento Trento Italy. Yale Cancer Center Yale University School of Medicine New Haven CT 06520 USA. The Oncology Institute "Prof Dr. Ion Chiricuta" Cluj-Napoca Romania. Metabolite Profiling Facility Bindley Bioscience Center Purdue University West Lafayette IN 47907 USA. Department of Genetics Department of Systems Pharmacology and Translational Therapeutics Institute of Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA. Department of Cellular and Integrative Physiology Indiana University School of Medicine Indianapolis IN USA. Departments of Radiation Oncology and Environmental Health Sciences Center for RNA Biomedicine University of Michigan Ann Arbor MI 48109 USA. Department of Surgery Indiana University School of Medicine Indianapolis IN 46202 USA. Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis IN 46202 USA. Melvin and Bren Simon Cancer Center Indiana University Indianapolis IN USA. Department of Obstetrics and Gynecology Indiana University School of Medicine Indianapolis IN 46202 USA. Department of Pharmacology and Toxicology Department of Pediatrics Wells Center for Pediatric Research Indiana University School of Medicine Indianapolis IN 46202 USA. Indiana University Center for Genomics and Bioinformatics

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

关键词： Long non-coding rnas Homeostasis

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A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement

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Life Medicine 2024年第1期3卷 5页

作者： Aging Biomarker Consortium, Mengmeng Jiang Zhuozhao Zheng Xuan Wang Yanhao Chen Jing Qu Qiurong Ding Weiqi Zhang You-Shuo Liu Jichun Yang Weiqing Tang Yunlong Hou Jinhan He Lin Wang Pengyu Huang Lin-Chen Li Zhiying He Qiang Gao Qian Lu Lai Wei Yan-Jiang Wang Zhenyu Ju Jian-Gao Fan Xiong Zhong Ruan Youfei Guan Guang-Hui Liu Gang Pei Jian Li Yunfang Wang State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Institute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing 100101 China Department of Radiology Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Beijing 102218 China Hepatopancreatobiliary Center Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Beijing 102218 China CAS Key Laboratory of Nutrition Metabolism and Food Safety Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai 200031 China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics Chinese Academy of Sciences and China National Center for Bioinformation Beijing 100101 China Department of Geriatrics the Second Xiangya Hospital and the Institute of Aging and Geriatrics Central South University Changsha 410011 China Department of Physiology and Pathophysiology School of Basic Medical Sciences State Key Laboratory of Vascular Homeostasis and Remodeling Center for Non-coding RNA Medicine Peking University Health Science Center Beijing 100191 China The Key Laboratory of Geriatrics Beijing Institute of Geriatrics Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing Hospital/National Center of Gerontology of National Health Commission Beijing 100730 China Yiling Pharmaceutical Academician Workstation Shijiazhuang 050035 China Department of Pharmacy West China Hospital of Sichuan University Chengdu 610041 China Department of Hepatobiliary Surgery Xijing Hospital Fourth Military Medical University Xi?an 710032 China State Key Laboratory of Advanced Medical Materials and Devices Engineering Research Center of Pulmonary and Critical Care Medicine Technology and Device

In human aging, liver aging per se not only increases susceptibility to liver diseases but also increases vulnerability of other organs given its central role in regulating metabolism. Total liver function tends to be well maintained in the healthy elderly, so liver aging is generally difficult to identify early. In response to this critical challenge, the Aging Biomarker Consortium of China has formulated an expert consensus on biomarkers of liver aging by synthesizing the latest scientific literature, comprising insights from both scientists and clinicians. This consensus provides a comprehensive assessment of biomarkers associated with liver aging and presents a systematic framework to characterize these into three dimensions: functional, imaging, and humoral. For the functional domain, we highlight biomarkers associated with cholesterol metabolism and liver-related coagulation function. For the imaging domain, we note that hepatic steatosis and liver blood flow can serve as measurable biomarkers for liver aging. Finally, in the humoral domain, we pinpoint hepatokines and enzymatic alterations worthy of attention. The aim of this expert consensus is to establish a foundation for assessing the extent of liver aging and identify early signs of liver aging-related diseases, thereby improving liver health and the healthy life expectancy of the elderly population.

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Author Correction: Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation

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Nature communications 2022年第1期13卷 3352页

作者： Yiyan Zheng Ritika Sethi Lingegowda S Mangala Charlotte Taylor Juliet Goldsmith Ming Wang Kenta Masuda Eli M Carrami David Mannion Fabrizio Miranda Sandra Herrero-Gonzalez Karin Hellner Fiona Chen Abdulkhaliq Alsaadi Ashwag Albukhari Donatien Chedom Fotso Christopher Yau Dahai Jiang Sunila Pradeep Cristian Rodriguez-Aguayo Gabriel Lopez-Berestein Stefan Knapp Nathanael S Gray Leticia Campo Kevin A Myers Sunanda Dhar David Ferguson Robert C Bast Anil K Sood Frank von Delft Ahmed Ashour Ahmed Ovarian Cancer Cell Laboratory Weatherall Institute of Molecular Medicine University of Oxford Headington Oxford OX3 9DS UK. Nuffield Department of Obstetrics & Gynaecology University of Oxford Women's Centre John Radcliffe Hospital Oxford OX3 9DU UK. Structural Genomics Consortium Nuffield Department of Medicine University of Oxford Old Road Campus Research Building Oxford OX3 7DQ UK. Department of Gynecologic Oncology The University of Texas MD Anderson Cancer Center 1515 Holcombe Blvd Houston TX 77030 USA. Center for RNAi and Non-Coding RNA The University of Texas MD Anderson Cancer Center 1515 Holcombe Blvd Houston TX 77030 USA. Biochemistry Department Faculty of Science King Abdulaziz University Jeddah 21551 Saudi Arabia. Wellcome Trust Centre for Human Genetics and NIHR Biomedical Research Centre Roosevelt Drive Oxford OX3 7BN UK. Department of Statistics 1 South Parks Road Oxford OX1 3TG UK. Department of Experimental Therapeutics University of Texas MD Anderson Cancer Center Houston TX USA. Goethe-University Frankfurt Institute for Pharmaceutical Chemistry and Buchmann Institute for Life Sciences Riedberg Campus Frankfurt am Main 60438 Germany. Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Boston MA 02115 USA. Department of Cancer Biology Dana-Farber Cancer Institute Boston MA 02215 USA. Department of Oncology University of Oxford Old Road Campus Research Building Roosevelt Drive Oxford OX3 7DQ UK. Department of Histopathology Oxford University Hospitals Oxford OX3 9DU UK. Nuffield Division of Clinical Laboratory Sciences Radcliffe Department of Medicine University of Oxford Oxford University Hospitals Oxford UK. Diamond Light Source Ltd Harwell Science and Innovation Campus Didcot OX11 0QX UK. Department of Biochemistry University of Johannesburg Auckland Park 2006 South Africa. Ovarian Cancer Cell Laboratory Weatherall Institute of Molecular Medicine University of Oxford Headingt

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Highlights from the 11th ISCB Student Council Symposium 2015. Dublin, Ireland. 10 July 2015

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BMC bioinformatics 2016年第Sup3期17 Suppl 3卷 95页

作者： Katie Wilkins Mehedi Hassan Margherita Francescatto Jakob Jespersen R. Gonzalo Parra Bart Cuypers Dan DeBlasio Alexander Junge Anupama Jigisha Farzana Rahman Griet Laenen Sander Willems Lieven Thorrez Yves Moreau Nagarajan Raju Sonia Pankaj Chothani C. Ramakrishnan Masakazu Sekijima M. Michael Gromiha Paddy J Slator Nigel J Burroughs Przemysław Szałaj Zhonghui Tang Paul Michalski Oskar Luo Xingwang Li Yijun Ruan Dariusz Plewczynski Giulia Fiscon Emanuel Weitschek Massimo Ciccozzi Paola Bertolazzi Giovanni Felici Bart Cuypers Pieter Meysman Manu Vanaerschot Maya Berg Hideo Imamura Jean-Claude Dujardin Kris Laukens Westa Domanova James R. Krycer Rima Chaudhuri Pengyi Yang Fatemeh Vafaee Daniel J. Fazakerley Sean J. Humphrey David E. James Zdenka Kuncic Plant Pathology and Plant-Microbe Biology Section School of Integrative Plant Science Cornell University Ithaca NY USA Graduate Field of Computational Biology Cornell University Ithaca NY USA School of Computing & Mathematics University of South Wales Cardiff UK Department of Genome Biology for Neurodegenerative Diseases German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association ᅟ Germany Department of Surgery Massachusetts General Hospital The Broad Institute of MIT and Harvard Boston USA Department of Systems Biology Technical University of Denmark Kemitorvet Denmark Protein Physiology Lab Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Buenos Aires Argentina Molecular Parasitology Unit (MPU) Institute of Tropical Medicine Nationalestraat 155 2000 Antwerp Belgium Advanced Database Research and Modeling (ADReM) research group University of Antwerp Middelheimlaan 1 2020 Antwerpen Belgium Department of Computer Science University of Arizona Tucson AZ 84721 USA Department of Veterinary Clinical and Animal Sciences Center for non-coding RNA in Technology and Health University of Copenhagen Copenhagen Denmark University College Dublin Dublin Ireland Department of Electrical Engineering (ESAT) STADIUS Center for Dynamical Systems Signal Processing and Data Analytics KU Leuven Leuven Belgium iMinds Medical IT Department Leuven Belgium Scientific Institute of Public Health (WIV-ISP) Platform of Biotechnology and Molecular Biology (PBB) Brussels Belgium Department of Development and Regeneration @ Kulak KU Leuven Kortrijk Belgium Department of Biotechnology Bhupat and Jyoti Metha School of Biosciences Indian Institute of Technology Madras Chennai 600036 Tamilnadu India Philips Research North America 345 Scarborough Road Briarcliff Manor NY 10510 USA Global Scientific Information and Computing Center (GSIC) Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo 152-8550 Japan Systems Biology C

A1 Highlights from the eleventh ISCB Student Council Symposium 2015 Katie Wilkins, Mehedi Hassan, Margherita Francescatto, Jakob Jespersen, R. Gonzalo Parra, Bart Cuypers, Dan DeBlasio, Alexander Junge, Anupama Jigisha, Farzana Rahman O1 Prioritizing a drug’s targets using both gene expression and structural similarity Griet Laenen, Sander Willems, Lieven Thorrez, Yves Moreau O2 Organism specific protein-rna recognition: A computational analysis of protein-rna complex structures from different organisms Nagarajan Raju, Sonia Pankaj Chothani, C. Ramakrishnan, Masakazu Sekijima; M. Michael Gromiha O3 Detection of Heterogeneity in Single Particle Tracking Trajectories Paddy J Slator, Nigel J Burroughs O4 3D-NOME: 3D NucleOme Multiscale Engine for data-driven modeling of three-dimensional genome architecture Przemysław Szałaj, Zhonghui Tang, Paul Michalski, Oskar Luo, Xingwang Li, Yijun Ruan, Dariusz Plewczynski O5 A novel feature selection method to extract multiple adjacent solutions for viral genomic sequences classification Giulia Fiscon, Emanuel Weitschek, Massimo Ciccozzi, Paola Bertolazzi, Giovanni Felici O6 A Systems Biology Compendium for Leishmania donovani Bart Cuypers, Pieter Meysman, Manu Vanaerschot, Maya Berg, Hideo Imamura, Jean-Claude Dujardin, Kris Laukens O7 Unravelling signal coordination from large scale phosphorylation kinetic data Westa Domanova, James R. Krycer, Rima Chaudhuri, Pengyi Yang, Fatemeh Vafaee, Daniel J. Fazakerley, Sean J. Humphrey, David E. James, Zdenka Kuncic

关键词： Visceral Leishmaniasis Feature Selection Method Frequent Itemset Mining Leishmania Donovani Student Council

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