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TP53 loss creates therapeutic vulnerability in colorectal cancer (vol 30, pg 697, 2015)

NATURE 2021年第7875期597卷 E6-E6页

作者： Liu, Yunhua Zhang, Xinna Han, Cecil Wan, Guohui Huang, Xingxu Ivan, Cristina Jiang, Dahai Rodriguez-Aguayo, Cristian Lopez-Berestein, Gabriel Rao, Pulivarthi H. Maru, Dipen M. Pahl, Andreas He, Xiaoming Sood, Anil K. Ellis, Lee M. Anderl, Jan Lu, Xiongbin Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Gynaecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston USA Center for RNA Interference and Non-coding RNAs The University of Texas MD Anderson Cancer Center Houston TX USA Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX USA School of Life Science and Technology ShanghaiTech University Shanghai China Department of Paediatrics Baylor College of Medicine Houston TX USA Department of Pathology The University of Texas MD Anderson Cancer Center Houston TX USA Heidelberg Pharma GmbH Ladenburg Germany Department of Biomedical Engineering The Ohio State University Columbus OH USA Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA

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Author Correction: Regulation of hnRNPA1 by micrornas controls the miR-18a-K-RAS axis in chemotherapy-resistant ovarian cancer

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Cell discovery 2023年第1期9卷 111页

作者： Cristian Rodriguez-Aguayo Paloma Del C Monroig Roxana S Redis Emine Bayraktar Maria I Almeida Cristina Ivan Enrique Fuentes-Mattei Mohammed H Rashed Arturo Chavez-Reyes Bulent Ozpolat Rahul Mitra Anil K Sood George A Calin Gabriel Lopez-Berestein Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX USA. Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX USA. Instituto de Investigação e Inovação em Saúde/Institute for Research and Innovation in Health (I3S) and Instituto de Engenharia Biomédica (INEB) University of Porto Porto Portugal. Department of Pharmacology and Toxicology Faculty of Pharmacy The University of Al-Azhar Cairo Egypt. Center for Research and Advanced Studies National Polytechnic Institute (CINVESTAV del IPN) Monterrey Mexico. Department of Gynecologic Oncology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX USA. glopez@***. Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX USA. glopez@***. Department of Gynecologic Oncology The University of Texas MD Anderson Cancer Center Houston TX USA. glopez@***.

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A Retrospective Analysis for Different Routes of Administration in Mice-Percutaneous Retro-Orbital, Jugular Catheter, Tail Vein and Femoral Cut Down Injections

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Journal of Biosciences and Medicines 2020年第9期8卷 131-141页

作者： Priyanka Prathipati Cristian Rodriguez-Aguayo Brian L Walton Anil K. Sood Jamieson Greaver Christopher F. Janssen Gabriel Lopez-Berestein Department of Advanced Cardiopulmonary Therapies and Transplantation Center for Advanced Heart Failure University of Texas Health Science Center at Houston Houston TX USA Department of Experimental Therapeutics University of Texas M.D. Anderson Cancer Center Houston TX USA The Center for RNA Interference and Non-Coding RNA University of Texas M.D. Anderson Cancer Center Houston TX USA Department of Cancer Biology University of Texas M.D. Anderson Cancer Center Houston TX USA Department of Gynecology Oncology & Reproductive Medicine University of Texas M.D. Anderson Cancer Center Houston TX USA Interdisciplinary Research Center for Laboratory Animal Medicine and Care University of Texas Health Science Center at Houston Houston TX USA

Liposomes effectively transport fatty proteins to targeted tissues. Laboratory experiments use multiple methods to administer liposomes, but comparison of these methods is not available. In this retrospective study, we characterized and compared four intravenous administration routes (tail vein, jugular catheter, femoral vein and percutaneous retro-orbital injections) in murine models. ApoE^-/- mice were used to compare administration routes. Results indicate that the jugular catheter route delivered the highest amount of liposomes to tissues due to longer period of injections compared to other routes;however, this route failed to remain patent for 8/10 animals. Delivery via tail vein, femoral vein and percutaneous retro-orbital injections resulted in similar accumulation in the organs. When including technical difficulty and expense, percutaneous retro-orbital injections of liposomes are the most convenient and efficacious approach.

关键词： Femoral Vein Jugular Catheter Liposomes Retro-Orbital Tail Vein

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Corrigendum to "PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis" [EBioMedicine 40 (2019) 290-304]

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EBioMedicine 2022年 83卷 104194页

作者： Cristian Rodriguez-Aguayo Emine Bayraktar Cristina Ivan Burcu Aslan Junhua Mai Guangan He Lingegowda S Mangala Dahai Jiang Archana S Nagaraja Bulent Ozpolat Arturo Chavez-Reyes Mauro Ferrari Rahul Mitra Zahid H Siddik Haifa Shen Xianbin Yang Anil K Sood Gabriel Lopez-Berestein Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Medical Biology Faculty of Medicine University of Gaziantep Gaziantep 27310 Turkey. Department of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USA. Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Department of Gynecologic Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Centro de Investigación y Estudios Avanzados del IPN Unidad Monterrey Apodaca NL CP. 66600 Mexico. AM Biotechnologies LLC 12521 Gulf Freeway Houston TX 77034 USA. Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Electronic address: glopez@***.

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RETRACTION: miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2 (vol 512,pg 431, 2014) (Retraction of Vol 512, Pg 431, 2014)

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NATURE 2020年第7810期582卷 134-134页

作者： Krzeszinski, Jing Y. Wei, Wei Huynh, HoangDinh Jin, Zixue Wang, Xunde Chang, Tsung-Cheng Xie, Xian-Jin He, Lin Mangala, Lingegowda S. Lopez-Berestein, Gabriel Sood, Anil K. Mendell, Joshua T. Wan, Yihong Department of Pharmacology The University of Texas Southwestern Medical Center Dallas USA Department of Molecular Biology The University of Texas Southwestern Medical Center Dallas USA Simmons Cancer Center The University of Texas Southwestern Medical Center Dallas USA Department of Clinical Sciences The University of Texas Southwestern Medical Center Dallas USA Division of Cellular and Developmental Biology Molecular and Cell Biology Department University of California at Berkeley Berkeley California USA Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston USA Center for RNA Interference and Non-coding RNA The University of Texas MD Anderson Cancer Center Houston USA Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston USA Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston USA

A Retraction to this paper has been published and can be accessed via a link at the top of the paper.

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Lncrnas-directed PTEN enzymatic switch governs epithelial-mesenchymal transition

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细胞研究（英文版） 2019年第4期29卷 286-304页

作者： Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Department of hepatobiliary Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu Province China Department of Molecular and Human Genetics Baylor College of Medicine Houston TX 77030 USA Lester and Sue Smith Breast Center Baylor College of Medicine Houston TX 77030 USA Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Institute of Immunology Third Military Medical University 400038 Chongqing China Department of Biochemistry and Molecular Biology The University of Texas Health Science Center at Houston McGroven Medical School Houston TX 77030 USA Department of Systems Biology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Department of Surgery Duke University School of Medicine Durham NC 27710 USA Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA program in Cancer Biology Graduate School of Biomedical Sciences The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA program in Cancer Biology Graduate School of Biomedical Sciences The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Center for RNA Interference and Non-Coding RNAs The University of Texas MD Anderson Cancer Center Houston TX 77030 USA

Despite the structural consenvation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase ***,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase ***,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding rna,GAEA (Glucose Aroused for EMT Activation),which associates with an rna-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of *** MEX3C-catalyzed PTENK27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase *** this altered enzymatic activity,PTENK27-polyub dephosphorylates the phosphoserine/threonine residues of TWlST1,SNAI1,and YAP1,leading to accumulation of these master regulators of *** with genetic inhibition of PTENK27polyUb,by a single nucieotide mutation generated using CRISPR/Cas9 (PtenK80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing *** findings illustrate an unexpected paradigm in which the Incrna-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development.

关键词： Epithelial-mesenchymal transition Long non-coding rnas Ubiquitylation

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Fatty Acid Binding Protein-4 Silencing Attenuates Atherosclerosis Progression by Affecting Macrophage Apoptosis and Autophagy

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Journal of Biosciences and Medicines 2019年第7期7卷 99-109页

作者： Siqin Zhaorigetu Priyanka Prathipati Cristian Rodriguez-Aguayo Brian L. Walton Anil K. Sood Gabriel Berestein-Lopez Department of Pediatric Surgery Center for Advanced Heart Failure University of Texas Health Science Center at Houston Houston TX USA Department of Advanced Cardiopulmonary Therapies and Transplantation Center for Advanced Heart Failure University of Texas Health Science Center at Houston Houston TX USA Department of Experimental Therapeutics The University of Texas M.D. Anderson Cancer Center Houston TX USA The Center for RNA Interference and Non-Coding RNA The University of Texas M.D. Anderson Cancer Center Houston TX USA Department of Cancer Biology The University of Texas M.D. Anderson Cancer Center Houston TX USA Department of Gynecology Oncology & Reproductive Medicine The University of Texas M.D. Anderson Cancer Center Houston TX USA

Background: Atherosclerosis, which is the principal cause of heart attacks and strokes, is the leading cause of death in the United States. Various biological processes such as apoptosis and autophagy are involved in almost every stage of atherosclerosis, which could lead to plaque instability causing stroke and death. Fatty Acid Binding Protein 4 (FABP4) is an adipokine released by macrophages and is involved in multiple disease conditions including stroke. However, the association of FABP4 with macrophage apoptosis and autophagy in atherosclerosis has not been elucidated. We hypothesize that silencing FABP4 protein could be a novel therapeutic approach to attenuate macrophage apoptosis and autophagy thereby minimizing plaque instability in atherosclerosis. Methods: RAW264 mouse macrophage cells were transfected with sirna control liposome quantum dots (QD), siFABP4 liposome QD at the concentration of 150 μg/ml total lipids, or TNF-α at 100 ng/ml. Western blot and reverse phase protein array (RPPA) analysis were completed. Results: Inhibiting the translation of FABP4 blocked the apoptotic pathway as evidenced from the increased expression of anti-apoptotic BCL-xL and BCL-2 along with reduced expression of BAX and activated Caspase 3 levels. Beclin-1 and LC3-II levels were also reduced with knocking down FABP4 indicating the attenuation of autophagy. Conclusion: Targeting FABP4 protects against macrophage processes associated with the progression of atherosclerosis.

关键词： Atherosclerosis Apoptosis Liposomes Macrophages FABP4

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Corrigendum to 'Exosomal mirna confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in ovarian cancer' [EBioMedicine 38 (2018) 100-112]

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EBioMedicine 2020年 52卷 102630页

作者： Pinar Kanlikilicer Recep Bayraktar Merve Denizli Mohammed H Rashed Cristina Ivan Burcu Aslan Rahul Mitra Kubra Karagoz Emine Bayraktar Xinna Zhang Cristian Rodriguez-Aguayo Amr Ahmed El-Arabey Nermin Kahraman Seyda Baydogan Ozgur Ozkayar Michael L Gatza Bulent Ozpolat George A Calin Anil K Sood Gabriel Lopez-Berestein Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center 1901 East Road Unit 1950 Houston TX 77030 USA Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center 1901 East Road Unit 1950 Houston TX 77030 USA. Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX USA Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. Rutgers Cancer Institute of New Jersey New Brunswick NJ USA. Pharmacology and Toxicology Department Faculty of Pharmacy Al-Azhar University Nasr City Cairo Egypt. Hacettepe University Ankara Turkey. Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX USA. Electronic address: glopez@***.

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Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis

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SCIENCE TRANSLATIONAL MEDICINE 2022年第669期14卷 eabo1981页

作者： Zhang, Yaohua Sun, Chengcao Li, Yajuan Qin, Juan Amancherla, Kaushik Jing, Ying Hu, Qingsong Liang, Ke Zhang, Zhao Ye, Youqiong Huang, Lisa A. Nguyen, Tina K. Egranov, Sergey D. Zhao, Zilong Wu, Andrew Xi, Yutao Yao, Jun Hung, Mien-Chie Calin, George A. Cheng, Jie Lim, Bora Lehmann, Lorenz H. Salem, Joe-Elie Johnson, Douglas B. Curran, Michael A. Yu, Dihua Han, Leng Darabi, Radbod Yang, Liuqing Moslehi, Javid J. Lin, Chunru Univ Texas MD Anderson Canc Ctr Dept Mol & Cellular Oncol Houston TX 77030 USA Capital Med Univ Beijing Inst Brain Disorders Collaborat Innovat Ctr Brain Disorders Beijing 10069 Peoples R China Univ Calif San Francisco Div Cardiol Sect Cardio Oncol & Immunol San Francisco CA 94143 USA Univ Calif San Francisco Cardiovasc Res Inst San Francisco CA 94143 USA Vanderbilt Univ Sch Med Dept Med Nashville TN 37232 USA Univ Texas Hlth Sci Ctr Houston Dept Biochem & Mol Biol McGovern Med Sch Houston TX 77030 USA St Lukes Hosp Texas Heart Inst Houston TX 77030 USA China Med Univ Grad Inst Biomed Sci Res Ctr Canc Biol Taichung 404 Taiwan China Med Univ Ctr Mol Med Taichung 404 Taiwan Asia Univ Dept Biotechnol Taichung 413 Taiwan Univ Texas MD Anderson Canc Ctr Div Canc Med Dept Expt Therapeut Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Ctr RNA Interference & Non Coding RNAs Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Breast Med Oncol Houston TX 77030 USA Univ Heidelberg Hosp Dept Cardiol Heidelberg Germany Heidelberg Univ Hosp Cardio Oncol Unit Heidelberg Germany German Cardiovasc Res Ctr DZHK Partner site Heidelberg Mannheim Germany German Canc Res Ctr Heidelberg Germany Sorbonne Univ Dept Pharmacol Assistance Publ Hop Paris AP HP INSERM CIC1901UNICOGRECOCardiooncol Program Paris France Vanderbilt Univ Sch Med Vanderbilt Ingram Canc Ctr Nashville TN 37232 USA Univ Texas MD Anderson Canc Ctr Oncol Res Biol & Immunotherapy Translat ORBIT Dept Immunol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Grad Sch Biomed Sci Houston TX 77030 USA Texas A&M Univ Inst Biosci & Technol Ctr Epigenet & Dis Prevent Houston TX 77030 USA Univ Texas Hlth Sci Ctr Houston Brown Fdn Inst Mol Med Prevent Human Dis IMM Ctr Stem Cell & Regenerat Med CSCRM Houston TX 77030 USA Incyte Corp Wilmington DE 19803 USA Univ Sci & Technol China Div Life Sci & Med Affiliated Hosp USTC 1 Hefei 230001 Anhui Peoples R China

Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer treatment but are associated with myocarditis. Here, we report that tumor-bearing mice exhibited response to treatment with combinatorial anti-programmed cell death 1 and anti-cytotoxic T lymphocyte antigen-4 antibodies but also presented with cardiovascular toxicities observed clinically with ICI therapy, including myocarditis and arrhythmia. Female mice were preferentially affected with myocarditis compared to male mice, consistent with a previously described genetic model of ICI myocarditis and emerging clinical data. Mechanistically, myocardial tissue from ICI-treated mice, the genetic mouse model, and human heart tissue from affected patients with ICI myocarditis all exhibited down-regulation of MANF (mesencephalic astrocyte-derived neurotrophic factor) and HSPA5 (heat shock 70-kDa protein 5) in the heart;this down-regulation was particularly notable in female mice. ICI myocarditis was amplified by heart-specific genetic deletion of mouse Manf and was attenuated by administration of recombinant MANF protein, suggesting a causal role. Ironically, both MANF and HSPA5 were transcriptionally induced by liganded estrogen receptor beta and inhibited by androgen receptor. However, ICI treatment reduced serum estradiol concentration to a greater extent in female compared to male mice. Treatment with an estrogen receptor beta-specific agonist and androgen depletion therapy attenuated ICI-associated cardiac effects. Together, our data suggest that ICI treatment inhibits estradiol-dependent expression of MANF/HSPA5 in the heart, curtailing the cardiomyocyte response to immune injury. This endocrine-cardiac-immune pathway offers new insights into the mechanisms of sex differences in cardiac disease and may offer treatment strategies for ICI myocarditis.

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Regulation of cellular sterol homeostasis by the oxygen responsive noncoding rna lincNORS (vol 1, 4755, 2020)

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NATURE COMMUNICATIONS 2020年第1期11卷 4755-4755页

作者： Wu, Xue Niculite, Cristina M. Preda, Mihai Bogdan Rossi, Annalisa Tebaldi, Toma Butoi, Elena White, Mattie K. Tudoran, Oana M. Petrusca, Daniela N. Jannasch, Amber S. Bone, William P. Zong, Xingyue Fang, Fang Burlacu, Alexandrina Paulsen, Michelle T. Hancock, Brad A. Sandusky, George E. Mitra, Sumegha Fishel, Melissa L. Buechlein, Aaron Ivan, Cristina Oikonomopoulos, Spyros Gorospe, Myriam Mosley, Amber Radovich, Milan Dave, Utpal P. Ragoussis, Jiannis Nephew, Kenneth P. Mari, Bernard McIntyre, Alan Konig, Heiko Ljungman, Mats Cousminer, Diana L. Macchi, Paolo Ivan, Mircea Department of Microbiology and Immunology Indiana University School of Medicine Indianapolis IN 46202 USA Department of Medicine Indiana University School of Medicine Indianapolis IN 46202 USA “Victor Babes” National Institute of Pathology Bucharest Romania Institute of Cellular Biology and Pathology “Nicolae Simionescu” Bucharest Romania Laboratory of Molecular and Cellular Neurobiology Department of Cellular Computational and Integrative Biology - CIBIO University of Trento Trento Italy Laboratory of Translational Genomics Department of Cellular Computational and Integrative Biology - CIBIO University of Trento Trento Italy Yale Cancer Center Yale University School of Medicine New Haven CT 06520 USA The Oncology Institute “Prof Dr. Ion Chiricuta” Cluj-Napoca Romania Metabolite Profiling Facility Bindley Bioscience Center Purdue University West Lafayette IN 47907 USA Department of Genetics Department of Systems Pharmacology and Translational Therapeutics Institute of Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Department of Cellular and Integrative Physiology Indiana University School of Medicine Indianapolis IN USA Departments of Radiation Oncology and Environmental Health Sciences Center for RNA Biomedicine University of Michigan Ann Arbor MI 48109 USA Department of Surgery Indiana University School of Medicine Indianapolis IN 46202 USA Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis IN 46202 USA Melvin and Bren Simon Cancer Center Indiana University Indianapolis IN USA Department of Obstetrics and Gynecology Indiana University School of Medicine Indianapolis IN 46202 USA Department of Pharmacology and Toxicology Department of Pediatrics Wells Center for Pediatric Research Indiana University School of Medicine Indianapolis IN 46202 USA Indiana University Center for Genomics and Bioinformatics Bloomington IN 47405 USA Center

We hereby provide the initial portrait of lincNORS, a spliced lincrna generated by the MIR193BHG locus, entirely distinct from the previously described miR-193b-365a tandem. While inducible by low O2 in a variety of cells and associated with hypoxia in vivo, our studies show that lincNORS is subject to multiple regulatory inputs, including estrogen signals. Biochemically, this lincrna fine-tunes cellular sterol/steroid biosynthesis by repressing the expression of multiple pathway components. Mechanistically, the function of lincNORS requires the presence of RALY, an rna-binding protein recently found to be implicated in cholesterol homeostasis. We also noticed the proximity between this locus and naturally occurring genetic variations highly significant for sterol/steroid-related phenotypes, in particular the age of sexual maturation. An integrative analysis of these variants provided a more formal link between these phenotypes and lincNORS, further strengthening the case for its biological relevance. noncoding transcripts contribute to the adaptation of cellular processes to oxygen levels. Here the authors characterize a hypoxia responsive lncrna lincNORS and show that it has a role in cellular sterol homeostasis.

关键词： Long non-coding rnas Long non-coding rnas Homeostasis Homeostasis

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