检索结果-内蒙古大学图书馆

Erratum to: Targeting the PELP1-KDM1 axis as a potential therapeutic strategy for breast cancer

Breast Cancer Research 2012年第6期14卷 1-2页

作者： Valerie Cortez Monica Mann Seshidhar Tekmal Ratna K Vadlamudi Takayoshi Suzuki Naoki Miyata Cristian Rodriguez-Aguayo Gabriel Lopez-Berestein Anil K Sood Department of Obstetrics and Gynecology University of Texas Health Science Center San Antonio TX 78229 USA Department of Cell and Structural Biology University of Texas Health Science Center San Antonio TX 78229 USA Cancer Therapy and Research Center University of Texas Health Science Center San Antonio TX 78229 USA Graduate School of Medical Science Kyoto Prefectural University of Medicine 13 Taishogun Nishitakatsukasa-Cho Kita-ku Kyoto 403-8334 Japan PRESTO Japan Science and Technology Agency 4-1-8 Honcho Kawaguchi Saitama 332-0012 Japan Graduate School of Pharmaceutical Sciences Nagoya City University 3-1 Tanabe-dori Mizuho-ku Nagoya Aichi 467-8673 Japan Department of Gynecologic Oncology University of Texas MD Anderson Cancer Center Houston TX 78030 USA Center for RNA Interference and Non-coding RNA University of Texas MD Anderson Cancer Center Houston TX 78030 USA Department of Cancer Biology University of Texas MD Anderson Cancer Center Houston TX 78030 USA

来源：评论

学校读者我要写书评

暂无评论

P-219 The role of the putative tumor suppressor protein spinophilin in colorectal cancer

引用

Annals of Oncology 2015年 26卷 iv64-iv64页

作者： V. Stiegelbauer A. Ress D. Schwarzenbacher A. Deutsch S. Perakis H. Ling C. Ivan G. Calin A. Gerger B. Rinner M. Pichler Division of Oncology Department of Internal Medicine Medical University of Graz Graz Austria Division of Haematology Department of Internal Medicine Medical University of Graz Graz Austria Department of Experimental Therapeutics University of Texas MD Anderson Cancer Center Houston Texas Center for RNA Interference and Non-Coding RNAs The University of Texas MD Anderson Cancer Center Houston Texas Center for Medical Research Medical University of Graz Graz Austria

来源：评论

学校读者我要写书评

暂无评论

CORRIGENDUM: GATA3 as a master regulator for interactions of tumor-associated macrophages with high-grade serous ovarian carcinoma

引用

Cellular signalling 2022年 89卷 110147页

作者： Amr Ahmed El-Arabey Merve Denizli Pinar Kanlikilicer Recep Bayraktar Cristina Ivan Mohammed Rashed Nashwa Kabil Bulent Ozpolat George A Calin Salama Abdou Salama Adel Rashad Abd-Allah Anil K Sood Gabriel Lopez-Berestein Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX USA Department of Pharmacology and Toxicology Al-Azhar University Faculty of Pharmacy Cairo Egypt. Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX USA. Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX USA. Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX USA Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston TX USA Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX USA.

来源：评论

学校读者我要写书评

暂无评论

Oncogenic lncrna downregulates cancer cell antigen presentation and intrinsic tumor suppression

引用

NATURE IMMUNOLOGY 2019年第7期20卷 835-+页

作者： Hu, Qingsong Ye, Youqiong Chan, Li-Chuan Li, Yajuan Liang, Ke Lin, Aifu Egranov, Sergey D. Zhang, Yaohua Xia, Weiya Gong, Jing Pan, Yinghong Chatterjee, Sujash S. Yao, Jun Evans, Kurt W. Nguyen, Tina K. Park, Peter K. Liu, Jiewei Coarfa, Cristian Donepudi, Sri Ramya Putluri, Vasanta Putluri, Nagireddy Sreekumar, Arun Ambati, Chandrashekar R. Hawke, David H. Marks, Jeffrey R. Gunaratne, Preethi H. Caudle, Abigail S. Sahin, Aysegul A. Hortobagyi, Gabriel N. Meric-Bernstam, Funda Chen, Lieping Yu, Dihua Hung, Mien-Chie Curran, Michael A. Han, Leng Lin, Chunru Yang, Liuqing Univ Texas MD Anderson Canc Ctr Dept Mol & Cellular Oncol Houston TX 77030 USA Univ Texas Hlth Sci Ctr Houston McGovern Med Sch Dept Biochem & Mol Biol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Grad Sch Biomed Sci Houston TX 77030 USA Univ Houston Dept Biochem & Biol Houston TX USA Univ Texas MD Anderson Canc Ctr Div Canc Med Dept Invest Canc Therapeut Houston TX 77030 USA Baylor Coll Med Dept Mol & Cell Biol Houston TX 77030 USA Baylor Coll Med Alkek Ctr Mol Discovery Adv Technol Core Dan L Duncan Canc Ctr Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Syst Biol Houston TX 77030 USA Duke Univ Sch Med Div Surg Sci Dept Surg Durham NC USA Univ Texas MD Anderson Canc Ctr Div Surg Dept Breast Surg Oncol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Div Pathol & Lab Med Dept Pathol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Div Canc Med Dept Breast Med Oncol Houston TX 77030 USA Yale Univ Sch Med Dept Immunobiol New Haven CT USA China Med Univ Taichung Taiwan Univ Texas MD Anderson Canc Ctr Div Basic Sci Dept Immunol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Ctr RNA Interference & Non Coding RNAs Houston TX 77030 USA Zhejiang Univ Coll Life Sci Hangzhou Zhejiang Peoples R China UPMC Genome Ctr Pittsburgh PA USA

How tumor cells genetically lose antigenicity and evade immune checkpoints remains largely elusive. We report that tissue-specific expression of the human long noncoding rna LINK-A in mouse mammary glands initiates metastatic mammary gland tumors, which phenotypically resemble human triple-negative breast cancer (TNBC). LINK-A expression facilitated crosstalk between phosphatidylinositol-(3,4,5)-trisphosphate and inhibitory G-protein-coupled receptor (GPCR) pathways, attenuating protein kinase A-mediated phosphorylation of the E3 ubiquitin ligase TRIM71. Consequently, LINK-A expression enhanced K48-polyubiquitination-mediated degradation of the antigen peptide-loading complex (PLC) and intrinsic tumor suppressors Rb and p53. Treatment with LINK-A locked nucleic acids or GPCR antagonists stabilized the PLC components, Rb and p53, and sensitized mammary gland tumors to immune checkpoint blockers. Patients with programmed ccll death protein-1(PD-1) blockade-resistant TNBC exhibited elevated LINK-A levels and downregulated PLC components. Hence we demonstrate lncrna-dependent downregulation of antigenicity and intrinsic tumor suppression, which provides the basis for developing combinational immunotherapy treatment regimens and early TNBC prevention.

关键词：

来源：评论

学校读者我要写书评

暂无评论

HINCUTs in cancer: hypoxia-induced noncoding ultraconserved transcripts

引用

CELL DEATH AND DIFFERENTIATION 2013年第12期20卷 1675-1687页

作者： Ferdin, J. Nishida, N. Wu, X. Nicoloso, M. S. Shah, M. Y. Devlin, C. Ling, H. Shimizu, M. Kumar, K. Cortez, M. A. Ferracin, M. Bi, Y. Yang, D. Czerniak, B. Zhang, W. Schmittgen, T. D. Voorhoeve, M. P. Reginato, M. J. Negrini, M. Davuluri, R. V. Kunej, T. Ivan, M. Calin, G. A. Univ Texas MD Anderson Canc Ctr Dept Expt Therapeut Ctr RNA Interference & Non Coding RNAs Houston TX 77030 USA Univ Ljubljana Biotech Fac Dept Anim Sci Chair Genet Anim Biotechnol & Immunol Domzale 1230 Slovenia Osaka Univ Dept Surg Gastroenterol Grad Sch Med Suita Osaka Japan Indiana Univ Sch Med Dept Med Indianapolis IN 46202 USA Univ Ferrara Dept Morphol Surg & Expt Med LTTA I-44100 Ferrara Italy Wistar Inst Anat & Biol Mol & Cellular Oncogenesis Program Ctr Syst & Computat Biol Philadelphia PA 19104 USA Univ Texas MD Anderson Canc Ctr Dept Pathol Houston TX USA Ohio State Univ Coll Pharm Columbus OH 43210 USA Duke NUS Grad Med Sch Canc & Stem Cell Biol Program Singapore Singapore Natl Univ Singapore Yong Loo Lin Sch Med Dept Biochem Singapore 117595 Singapore Drexel Univ Coll Med Dept Biochem & Mol Biol Philadelphia PA 19104 USA

Recent data have linked hypoxia, a classic feature of the tumor microenvironment, to the function of specific micrornas (mirnas);however, whether hypoxia affects other types of noncoding transcripts is currently unknown. Starting from a genome-wide expression profiling, we demonstrate for the first time a functional link between oxygen deprivation and the modulation of long noncoding transcripts from ultraconserved regions, termed transcribed-ultraconserved regions (T-UCRs). Interestingly, several hypoxia-upregulated T-UCRs, henceforth named 'hypoxia-induced noncoding ultraconserved transcripts' (HINCUTs), are also overexpressed in clinical samples from colon cancer patients. We show that these T-UCRs are predominantly nuclear and that the hypoxia-inducible factor (HIF) is at least partly responsible for the induction of several members of this group. One specific HINCUT, uc.475 (or HINCUT-1) is part of a retained intron of the host protein-coding gene, O-linked N-acetylglucosamine transferase, which is overexpressed in epithelial cancer types. Consistent with the hypothesis that T-UCRs have important function in tumor formation, HINCUT-1 supports cell proliferation specifically under hypoxic conditions and may be critical for optimal O-GlcNAcylation of proteins when oxygen tension is limiting. Our data gives a first glimpse of a novel functional hypoxic network comprising protein-coding transcripts and noncoding rnas (ncrnas) from the T-UCRs category.

关键词： ultraconserved genes colorectal cancer glioblastoma hypoxia OGT

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Regulation of hnRNPA1 by micrornas controls the miR-18a-K-RAS axis in chemotherapy-resistant ovarian cancer

引用

Cell discovery 2023年第1期9卷 111页

作者： Cristian Rodriguez-Aguayo Paloma Del C Monroig Roxana S Redis Emine Bayraktar Maria I Almeida Cristina Ivan Enrique Fuentes-Mattei Mohammed H Rashed Arturo Chavez-Reyes Bulent Ozpolat Rahul Mitra Anil K Sood George A Calin Gabriel Lopez-Berestein Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX USA. Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX USA. Instituto de Investigação e Inovação em Saúde/Institute for Research and Innovation in Health (I3S) and Instituto de Engenharia Biomédica (INEB) University of Porto Porto Portugal. Department of Pharmacology and Toxicology Faculty of Pharmacy The University of Al-Azhar Cairo Egypt. Center for Research and Advanced Studies National Polytechnic Institute (CINVESTAV del IPN) Monterrey Mexico. Department of Gynecologic Oncology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX USA. glopez@***. Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX USA. glopez@***. Department of Gynecologic Oncology The University of Texas MD Anderson Cancer Center Houston TX USA. glopez@***.

来源：评论

学校读者我要写书评

暂无评论

Corrigendum to 'Exosomal mirna confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in ovarian cancer' [EBioMedicine 38 (2018) 100-112]

引用

EBioMedicine 2020年 52卷 102630页

作者： Pinar Kanlikilicer Recep Bayraktar Merve Denizli Mohammed H Rashed Cristina Ivan Burcu Aslan Rahul Mitra Kubra Karagoz Emine Bayraktar Xinna Zhang Cristian Rodriguez-Aguayo Amr Ahmed El-Arabey Nermin Kahraman Seyda Baydogan Ozgur Ozkayar Michael L Gatza Bulent Ozpolat George A Calin Anil K Sood Gabriel Lopez-Berestein Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center 1901 East Road Unit 1950 Houston TX 77030 USA Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center 1901 East Road Unit 1950 Houston TX 77030 USA. Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX USA Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. Rutgers Cancer Institute of New Jersey New Brunswick NJ USA. Pharmacology and Toxicology Department Faculty of Pharmacy Al-Azhar University Nasr City Cairo Egypt. Hacettepe University Ankara Turkey. Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX USA. Electronic address: glopez@***.

来源：评论

学校读者我要写书评

暂无评论

Corrigendum to "PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis" [EBioMedicine 40 (2019) 290-304]

引用

EBioMedicine 2022年 83卷 104194页

作者： Cristian Rodriguez-Aguayo Emine Bayraktar Cristina Ivan Burcu Aslan Junhua Mai Guangan He Lingegowda S Mangala Dahai Jiang Archana S Nagaraja Bulent Ozpolat Arturo Chavez-Reyes Mauro Ferrari Rahul Mitra Zahid H Siddik Haifa Shen Xianbin Yang Anil K Sood Gabriel Lopez-Berestein Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Medical Biology Faculty of Medicine University of Gaziantep Gaziantep 27310 Turkey. Department of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USA. Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Center for RNA Interference and Non-Coding RNA The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Department of Gynecologic Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Centro de Investigación y Estudios Avanzados del IPN Unidad Monterrey Apodaca NL CP. 66600 Mexico. AM Biotechnologies LLC 12521 Gulf Freeway Houston TX 77034 USA. Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Electronic address: glopez@***.

来源：评论

学校读者我要写书评

暂无评论

Corrigendum to “ApoptomiRs expression modulated by BCR–ABL is linked to CML progression and imatinib resistance” [Blood Cells Mol. Dis. 53 (1–2) (June–August 2014) 47–55]

引用

Blood Cells, Molecules, and Diseases 2015年第4期55卷 420-420页

作者： A.F. Ferreira L.G. Moura I. Tojal L. Ambrósio B. Pinto-Simões N. Hamerschlak G.A. Calin C. Ivan D.T. Covas S. Kashima F.A. Castro Departamento de Análises Clínicas Toxicológicas e Bromatológicas Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo Brazil Centro Regional de Hemoterapia de Ribeirão Preto Brazil Departamento de Clínica Médica Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo Brazil Hospital Israelita Albert Einstein São Paulo Brazil Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX USA Center for RNA Interference and Non-Coding RNAs The University of Texas MD Anderson Cancer Center Houston TX USA

来源：评论

学校读者我要写书评

暂无评论

Regulation of cellular sterol homeostasis by the oxygen responsive noncoding rna lincNORS (vol 1, 4755, 2020)

引用

NATURE COMMUNICATIONS 2020年第1期11卷 1-17页

作者： Wu, Xue Niculite, Cristina M. Preda, Mihai Bogdan Rossi, Annalisa Tebaldi, Toma Butoi, Elena White, Mattie K. Tudoran, Oana M. Petrusca, Daniela N. Jannasch, Amber S. Bone, William P. Zong, Xingyue Fang, Fang Burlacu, Alexandrina Paulsen, Michelle T. Hancock, Brad A. Sandusky, George E. Mitra, Sumegha Fishel, Melissa L. Buechlein, Aaron Ivan, Cristina Oikonomopoulos, Spyros Gorospe, Myriam Mosley, Amber Radovich, Milan Dave, Utpal P. Ragoussis, Jiannis Nephew, Kenneth P. Mari, Bernard McIntyre, Alan Konig, Heiko Ljungman, Mats Cousminer, Diana L. Macchi, Paolo Ivan, Mircea Department of Microbiology and Immunology Indiana University School of Medicine Indianapolis USA Department of Medicine Indiana University School of Medicine Indianapolis USA “Victor Babes” National Institute of Pathology Bucharest Romania Institute of Cellular Biology and Pathology “Nicolae Simionescu” Bucharest Romania Laboratory of Molecular and Cellular Neurobiology Department of Cellular Computational and Integrative Biology - CIBIO University of Trento Trento Italy Laboratory of Translational Genomics Department of Cellular Computational and Integrative Biology - CIBIO University of Trento Trento Italy Yale Cancer Center Yale University School of Medicine New Haven USA The Oncology Institute “Prof Dr. Ion Chiricuta” Cluj-Napoca Romania Metabolite Profiling Facility Bindley Bioscience Center Purdue University West Lafayette USA Department of Genetics Department of Systems Pharmacology and Translational Therapeutics Institute of Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia USA Department of Cellular and Integrative Physiology Indiana University School of Medicine Indianapolis USA Departments of Radiation Oncology and Environmental Health Sciences Center for RNA Biomedicine University of Michigan Ann Arbor USA Department of Surgery Indiana University School of Medicine Indianapolis USA Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis USA Melvin and Bren Simon Cancer Center Indiana University Indianapolis USA Department of Obstetrics and Gynecology Indiana University School of Medicine Indianapolis USA Department of Pharmacology and Toxicology Department of Pediatrics Wells Center for Pediatric Research Indiana University School of Medicine Indianapolis USA Indiana University Center for Genomics and Bioinformatics Bloomington USA Center for RNA Interference and Non-coding RNAs The University of Texas MD Anderson Cancer Center Houston USA

We hereby provide the initial portrait oflincNORS, a spliced lincrna generated by the MIR193BHG locus, entirely distinct from the previously described miR-193b-365a tandem. While inducible by low O2in a variety of cells and associated with hypoxia in vivo, our studies show thatlincNORSis subject to multiple regulatory inputs, including estrogen signals. Biochemically, this lincrna fine-tunes cellular sterol/steroid biosynthesis by repressing the expression of multiple pathway components. Mechanistically, the function oflincNORSrequires the presence of RALY, an rna-binding protein recently found to be implicated in cholesterol homeostasis. We also noticed the proximity between this locus and naturally occurring genetic variations highly significant for sterol/steroid-related phenotypes, in particular the age of sexual maturation. An integrative analysis of these variants provided a more formal link between these phenotypes andlincNORS, further strengthening the case for its biological relevance.

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：