The design and application of learning feedforward controllers (LFFC) for the one-staged refrigeration cycle model described in the PID2018 Benchmark Challenge is presented, and its effectiveness is evaluated. The con...
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This article's main contributions are twofold: 1) to demonstrate how to apply the general European Union's High-Level Expert Group's (EU HLEG) guidelines for trustworthy AI in practice for the domain of he...
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In the field of large-scale SLAM for autonomous driving and mobile robotics, 3D point cloud based place recognition has aroused significant research interest due to its robustness to changing environments with drastic...
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Majority of type 2 diabetes mellitus(T2DM)patients are highly susceptible to several forms of cognitive impairments,particularly ***,the underlying neural mechanism of these cognitive impairments remains *** aimed to ...
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Majority of type 2 diabetes mellitus(T2DM)patients are highly susceptible to several forms of cognitive impairments,particularly ***,the underlying neural mechanism of these cognitive impairments remains *** aimed to investigate the correlation between whole brain resting state functional connections(RSFCs)and the cognitive status in 95 patients with *** constructed an elastic net model to estimate the Montreal Cognitive Assessment(MoCA)scores,which served as an index of the cognitive status of the patients,and to select the RSFCs for further ***,we utilized a machine learning technique to evaluate the discriminative ability of the connectivity pattern associated with the selected *** estimated and chronological MoCA scores were significantly correlated with R=0.81 and the mean absolute error(MAE)=***,cognitive impairments of patients with T2DM can be identified using the RSFC pattern with classification accuracy of 90.54%and the area under the receiver operating characteristic(ROC)curve(AUC)of *** connectivity pattern not only included the connections between regions within the default mode network(DMN),but also the functional connectivity between the task-positive networks and the DMN,as well as those within the task-positive *** results suggest that an RSFC pattern could be regarded as a potential biomarker to identify the cognitive status of patients with T2DM.
Thanks to the emerging 3D integration technology, The multiprocessor system on chips （MPSoCs） can now integrate more IP cores on chip with improved energy efficiency. However, several severe challenges also rise up ...
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Thanks to the emerging 3D integration technology, The multiprocessor system on chips （MPSoCs） can now integrate more IP cores on chip with improved energy efficiency. However, several severe challenges also rise up for 3D ICs due to the die-stacking architecture. Among them, power supply noise becomes a big concern. In the paper, we investigate power supply noise （PSN） interactions among different cores and tiers and show that PSN variations largely depend on task assignments. On the other hand, high integration density incurs a severe thermal issue on 3D ICs. In the paper, we propose a novel task scheduling framework considering both the PSN and the thermal issue. It mainly consists of three parts. First, we extract current stimuli of running tasks by analyzing their power traces derived from architecture level simulations. Second, we develop an efficient power delivery network （PDN） solver to evaluate PSN magnitudes efficiently. Third, we propose a heuristic algorithm to solve the formulated task scheduling problem. Compared with the state-of-the-art task assignment algorithm, the proposed method can reduce PSN by 12% on a 2 × 2 × 2 3D MPSoCs and by 14% on a 3 × 3 × 3 3D MPSoCs. The end-to-end task execution time also improves as much as 5.5% and 7.8% respectively due to the suppressed PSN.
Validation metrics are key for tracking scientific progress and bridging the current chasm between artificial intelligence (AI) research and its translation into practice. However, increasing evidence shows that parti...
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Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, ...
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INTRODUCTION:Understanding the neurometabolic changes associated with amyloid-β (Aβ) deposition is important for early Alzheimer's disease (AD) diagnosis, but their spatial relationships remained unexplored due ...
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INTRODUCTION:Understanding the neurometabolic changes associated with amyloid-β (Aβ) deposition is important for early Alzheimer's disease (AD) diagnosis, but their spatial relationships remained unexplored due to technical limitations.
METHODS:We investigated the relationship between Aβ deposition and neuronal and glial metabolites using high-resolution 3D magnetic resonance spectroscopic imaging (MRSI) (8-min scan, 2 × 3 × 3 mm resolution) and Aβ-positron emission tomography (Aβ-PET) imaging. N-acetylaspartate, myo-inositol, and creatine maps were obtained from 174 participants: 39 controls, 65 mild cognitive impairment (MCI), and 70 AD patients.
RESULTS:N-Acetylaspartate levels were negatively correlated with Aβ, while myo-inositol levels were positively correlated globally. Regional associations with Aβ include N-acetylaspartate reductions in frontal cortex, anterior cingulate cortex, and precuneus, and myo-inositol increases in precuneus, lateral temporal, and lateral parietal cortices. Combined MRSI and PET biomarkers achieved the highest diagnostic accuracy for MCI and AD .
DISCUSSION:Hybrid high-resolution 3D MRSI and Aβ-PET imaging provides valuable insights into Aβ's impact on neurometabolic changes, improving early AD diagnosis.
HIGHLIGHTS:Hybrid 3D magnetic resonance spectroscopic imaging-positron emission tomography (MRSI-PET) imaging reveals Aβ deposition impact on neurometabolism in Alzheimer's disease (AD). N-acetylaspartate (NAA) as a neuronal metabolic marker is negatively associated with Aβ globally and locally. Myo-inositol (mI) as a glial metabolic marker is positively associated with Aβ globally and locally. Combining 3D magnetic resonance spectroscopic imaging (MRSI) and PET biomarkers improves diagnostic accuracy for mild cognitive impairment (MCI) and AD.
Synchronization phenomena are of broad interest across disciplines and increasingly of interest in a multiplex network setting. For the multiplex network of coupled Rössler oscillators, here we show how the maste...
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Synchronization phenomena are of broad interest across disciplines and increasingly of interest in a multiplex network setting. For the multiplex network of coupled Rössler oscillators, here we show how the master stability function, a celebrated framework for analyzing synchronization on a single network, can be extended to certain classes of multiplex networks with different intralayer and interlayer coupling functions. We derive three master stability equations that determine, respectively, the necessary regions of complete synchronization, intralayer synchronization, and interlayer synchronization. We calculate these three regions explicitly for the case of a two-layer network of Rössler oscillators and show that the overlap of the regions determines the type of synchronization achieved. In particular, if the interlayer or intralayer coupling function is such that the interlayer or intralayer synchronization region is empty, complete synchronization cannot be achieved regardless of the coupling strength. Furthermore, for any network structure, the occurrence of intralayer and interlayer synchronization depends mainly on the coupling functions of nodes within a layer and across layers, respectively. Our mathematical analysis requires that the intralayer and interlayer supra-Laplacians commute. But, we show this is only a sufficient, and not necessary, condition and that the results can be applied more generally.
Increasing evidence shows that flaws in machine learning (ML) algorithm validation are an underestimated global problem. Particularly in automatic biomedical image analysis, chosen performance metrics often do not ref...
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