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arXiv 2024年

作者： Wang, Meng Lin, Tian Lin, Aidi Yu, Kai Peng, Yuanyuan Wang, Lianyu Chen, Cheng Zou, Ke Liang, Huiyu Chen, Man Yao, Xue Zhang, Meiqin Huang, Binwei Zheng, Chaoxin Zhang, Peixin Chen, Wei Luo, Yilong Chen, Yifan Xia, Honghe Shi, Tingkun Zhang, Qi Guo, Jinming Chen, Xiaolin Wang, Jingcheng Chung Tham, Yih Liu, Dianbo Wong, Wendy Thakur, Sahil Fenner, Beau Fang, Danqi Liu, Siying Liu, Qingyun Huang, Yuqiang Zeng, Hongqiang Meng, Yanda Zhou, Yukun Jiang, Zehua Qiu, Minghui Zhang, Changqing Chen, Xinjian Wang, Sophia Y. Lee, Cecilia S. Sobrin, Lucia Cheung, Carol Y. Pang, Chi Pui Keane, Pearse A. Cheng, Ching-Yu Chen, Haoyu Fu, Huazhu Centre for Innovation & Precision Eye Health Yong Loo Lin School of Medicine National University of Singapore Singapore117549 Singapore Department of Ophthalmology Yong Loo Lin School of Medicine National University of Singapore Singapore117549 Singapore Joint Shantou International Eye Center Shantou University Chinese University of Hong Kong Guangdong Shantou515041 China Department of Radiology University of Pennsylvania PhiladelphiaPA19104 United States School of Biomedical Engineering Anhui Medical University Anhui Hefei230032 China College of Computer Science and Technology Nanjing University of Aeronautics and Astronautics Jiangsu Nanjing211100 China Center of Advanced Medical Computing and Analysis Massachusetts General Hospital Harvard Medical School BostonMA02114 United States National Key Laboratory of Fundamental Science on Synthetic Vision College of Computer Science Sichuan University Sichuan Chengdu610065 China Big Vision Medical Technology Ltd. Suzhou China Singapore Eye Research Institute Singapore National Eye Centre Singapore Duke-NUS Medical School Singapore Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong 999077 Hong Kong Shenzhen Longgang E.N.T Hospital Guangdong Shenzhen518172 China Dongguan Songshan Lake Central Hospital Guangdong Dongguan523326 China Department of Computer Science University of Exeter ExeterEX4 4RN United Kingdom Centre for Medical Image Computing University College London London United Kingdom NIHR Biomedical Research Centre Moorfields Eye Hospital NHS Foundation Trust London United Kingdom Institute of Ophthalmology University College London London United Kingdom Tsinghua Medicine of Tsinghua University Beijing100084 China School of Clinical Medicine Beijing Tsinghua Changgung Hospital Beijing102218 China Foshan Aier Eye Hospital Guangdong Foshan528000 China College of Intelligence and Computing Tianjin University Tianjin300350 China School of Electr

Previous foundation models for retinal images were pre-trained with limited disease categories and knowledge base. Here we introduce RetiZero, a vision-language foundation model that leverages knowledge from over 400 fundus diseases. For RetiZero's pre-training, we compiled 341,896 fundus images paired with text descriptions, sourced from public datasets, ophthalmic literature, and online resources, encompassing a diverse range of diseases across multiple ethnicities and countries. RetiZero exhibits superior performance in several downstream tasks, including zero-shot disease recognition, image-to-image retrieval, and internal- and cross-domain disease identification. In zero-shot scenarios, RetiZero achieves Top5 accuracy scores of 0.8430 for 15 fundus diseases and 0.7561 for 52 fundus diseases. For image retrieval, it achieves Top5 scores of 0.9500 and 0.8860 for the same disease sets, respectively. Clinical evaluations show that RetiZero's Top3 zero-shot performance surpasses the average of 19 ophthalmologists from Singapore, China, and the United States. Furthermore, RetiZero significantly enhances clinicians' accuracy in diagnosing fundus disease. These findings underscore the value of integrating the RetiZero foundation model into clinical settings, where a variety of fundus diseases are encountered. © 2024, CC0.

关键词： Ophthalmology

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Learning an Effective Charging Scheme for Mobile Devices

Learning an Effective Charging Scheme for Mobile Devices

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International Symposium on Parallel and Distributed Processing (IPDPS)

作者： Tang Liu Baijun Wu Wenzheng Xu Xianbo Cao Jian Peng Hongyi Wu Visual Computing and Virtual Reality Key Laboratory of Sichuan Province Sichuan Normal University Chengdu China University of Louisiana at Lafayette Lafayette LA USA College of Computer Science Sichuan University Chengdu China Center for Cybersecurity Education and Research Dominion University Norfolk VA USA

ISBN: (数字)9781728168760

ISBN: (纸本)9781728168777

Wireless charging has been demonstrated as a promising technology for prolonging device operational lifetimes in Wireless Rechargeable Networks (WRNs). To schedule a mobile charger to move along a predesigned trajectory to charge devices, most existing studies assume that the precise location information of devices is already known. Unfortunately, this assumption does not always hold in real mobile application, because the activities of vast majority of mobile devices carried by mobile agents appear dynamic and random. To the best of our knowledge, this is the first work to study how to wirelessly charge mobile devices with non-deterministic mobility. We aim to provide effective charging service to them, subject to the energy capacity of the mobile charger. Then, we formalize the effective charging problem as a charging reward maximization problem (CRMP), where the amount of reward obtained by charging a de-vice is inversely proportional to the residual lifetime of the device. To derive an effective charging heuristic, an algorithm based on Reinforcement Learning (RL) is proposed. The evaluation results show that the RL-based charging algorithm achieves excellent charging effectiveness. We further interpret the learned heuristic to gain deep and valuable insights into the design options.

关键词： Mobile handsets Heuristic algorithms Batteries Trajectory Wireless communication Energy consumption Wireless sensor networks

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Why is the Winner the Best?

Why is the Winner the Best?

引用

Conference on computer Vision and Pattern Recognition (CVPR)

作者： M. Eisenmann A. Reinke V. Weru M. D. Tizabi F. Isensee T. J. Adler S. Ali V. Andrearczyk M. Aubreville U. Baid S. Bakas N. Balu S. Bano J. Bernal S. Bodenstedt A. Casella V. Cheplygina M. Daum M. De Bruijne A. Depeursinge R. Dorent J. Egger D. G. Ellis S. Engelhardt M. Ganz N. Ghatwary G. Girard P. Godau A. Gupta L. Hansen K. Harada M. Heinrich N. Heller A. Hering A. Huaulmé P. Jannin A. E. Kavur O. Kodym M. Kozubek J. Li H. Li J. Ma C. Martín-Isla B. Menze A. Noble V. Oreiller N. Padoy S. Pati K. Payette T. Rädsch J. Rafael-Patiño V. Singh Bawa S. Speidel C. H. Sudre K. Van Wijnen M. Wagner D. Wei A. Yamlahi M. H. Yap C. Yuan M. Zenk A. Zia D. Zimmerer D. Aydogan B. Bhattarai L. Bloch R. Brüngel J. Cho C. Choi Q. Dou I. Ezhov C. M. Friedrich C. Fuller R. R. Gaire A. Galdran Á. García Faura M. Grammatikopoulou S. Hong M. Jahanifar I. Jang A. Kadkhodamohammadi I. Kang F. Kofler S. Kondo H. Kuijf M. Li M. Luu T. Martinčič P. Morais M. A. Naser B. Oliveira D. Owen S. Pang J. Park S. Park S. Płotka E. Puybareau N. Rajpoot K. Ryu N. Saeed A. Shephard P. Shi D. Štepec R. Subedi G. Tochon H. R. Torres H. Urien J. L. Vilaça K. A. Wahid H. Wang J. Wang L. Wang X. Wang B. Wiestler M. Wodzinski F. Xia J. Xie Z. Xiong S. Yang Y. Yang Z. Zhao K. Maier-Hein P. F. Jäger A. Kopp-Schneider L. Maier-Hein Division of Intelligent Medical Systems German Cancer Research Center (DKFZ) Heidelberg Germany Helmholtz Imaging German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Mathematics and Computer Science Heidelberg University Heidelberg Germany Division of Biostatistics German Cancer Research Center (DKFZ) Heidelberg Germany Division of Medical Image Computing German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Engineering and Physical Sciences School of Computing University of Leeds Leeds UK Institute of Informatics School of Management HES-SO Valais-Wallis University of Applied Sciences and Arts Western Switzerland Sierre Switzerland Department of Nuclear Medicine and Molecular Imaging Lausanne University Hospital Lausanne Switzerland Technische Hochschule Ingolstadt Ingolstadt Germany Center for Artificial Intelligence and Data Science for Integrated Diagnostics (AI2D) and Center for Biomedical Image Computing and Analytics (CBICA) University of Pennsylvania Philadelphia PA USA Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Radiology University of Washington Seattle WA USA Department of Computer Science Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS) University College London London UK Universitat Autònoma de Barcelona & Computer Vision Center Barcelona Spain Division of Translational Surgical Oncology National Center for Tumor Diseases (NCT/UCC) Dresden Dresden Germany Department of Advanced Robotics Istituto Italiano di Tecnologia Italy Department of Electronics Information and Bioengineering Politecnico di Milano Milan Italy IT University of Copenhagen Copenhagen Denmark Department of General Visceral and Transplantation Surgery Heidelberg University Hospital Heidelberg Germany Department of Radiology and Nuc

International benchmarking competitions have become fundamental for the comparative performance assessment of image analysis methods. However, little attention has been given to investigating what can be learnt from these competitions. Do they really generate scientific progress? What are common and successful participation strategies? What makes a solution superior to a competing method? To address this gap in the literature, we performed a multicenter study with all 80 competitions that were conducted in the scope of IEEE ISBI 2021 and MICCAI 2021. Statistical analyses performed based on comprehensive descriptions of the submitted algorithms linked to their rank as well as the underlying participation strategies revealed common characteristics of winning solutions. These typically include the use of multi-task learning (63%) and/or multi-stage pipelines (61%), and a focus on augmentation (100%), image preprocessing (97%), data curation (79%), and post-processing (66%). The “typical” lead of a winning team is a computer scientist with a doctoral degree, five years of experience in biomedical image analysis, and four years of experience in deep learning. Two core general development strategies stood out for highly-ranked teams: the reflection of the metrics in the method design and the focus on analyzing and handling failure cases. According to the organizers, 43% of the winning algorithms exceeded the state of the art but only 11% completely solved the respective domain problem. The insights of our study could help researchers (1) improve algorithm development strategies when approaching new problems, and (2) focus on open research questions revealed by this work.

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Author Correction: Reconstruction of diploid higher-order human 3D genome interactions from noisy Pore-C data using Dip3D

引用

Nature structural & molecular biology 2025年 2025 Apr 28页

作者： Ying Chen Zhuo-Bin Lin Shao-Kai Wang Bo Wu Longjian Niu Jia-Yong Zhong Yi-Meng Sun Zhenxian Zheng Xin Bai Luo-Ran Liu Wei Xie Wei Chi Tiantian Ye Ruibang Luo Chunhui Hou Feng Luo Chuan-Le Xiao State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou China. Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-sen University Guangzhou China. Shenzhen Eye Hospital Shenzhen Eye Medical Center Southern Medical University Shenzhen China. David R. Cheriton School of Computer Science University of Waterloo Waterloo Ontario Canada. Department of Computer Science The University of Hong Kong Hong Kong China. Center for Stem Cell Biology and Regenerative Medicine MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing China. Xianghu Laboratory Hangzhou China. yetiantian@***. Department of Computer Science The University of Hong Kong Hong Kong China. rbluo@cs.hku.hk. State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China. houchunhui@***. School of Computing Clemson University Clemson SC USA. luofeng@clemson.edu. State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou China. xiaochuanle@***.

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Asymmetric CNN for image super-resolution

arXiv

引用

arXiv 2021年

作者： Tian, Chunwei Xu, Yong Zuo, Wangmeng Lin, Chia-Wen Zhang, David The Bio-Computing Research Center Harbin Institute of Technology ShenzhenShenzhenGuangdong518055 China Shenzhen Key Laboratory of Visual Object Detection and Recognition ShenzhenGuangdong518055 China The School of Computer Science and Technology Harbin Institute of Technology HarbinHeilongjiang150001 China The Peng Cheng Laboratory ShenzhenGuangdong518055 China Shenzhen Key Laboratory of Visual Object Detection and Recognition Shenzhen Guangdong518055 China The Department of Electrical Engineering The Institute of Communications Engineering National Tsing Hua University Hsinchu Taiwan ShenzhenGuangdong518172 China The Shenzhen Institute of Artificial Intelligence and Robotics for Society Shenzhen China

Deep convolutional neural networks (CNNs) have been widely applied for low-level vision over the past five years. According to nature of different applications, designing appropriate CNN architectures is developed. However, customized architectures gather different features via treating all pixel points as equal to improve the performance of given application, which ignores the effects of local power pixel points and results in low training efficiency. In this paper, we propose an asymmetric CNN (ACNet) comprising an asymmetric block (AB), a memory enhancement block (MEB) and a high-frequency feature enhancement block (HFFEB) for image super-resolution. The AB utilizes one-dimensional asymmetric convolutions to intensify the square convolution kernels in horizontal and vertical directions for promoting the influences of local salient features for SISR. The MEB fuses all hierarchical low-frequency features from the AB via residual learning (RL) technique to resolve the long-term dependency problem and transforms obtained low-frequency features into high-frequency features. The HFFEB exploits low- and high-frequency features to obtain more robust super-resolution features and address excessive feature enhancement problem. Additionally, it also takes charge of reconstructing a high-resolution (HR) image. Extensive experiments show that our ACNet can effectively address single image super-resolution (SISR), blind SISR and blind SISR of blind noise problems. The code of the ACNet is shown at https://***/hellloxiaotian/ACNet. © 2021, CC BY-NC-ND.

关键词： Image enhancement

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Aging prediction of cultural heritage samples based on surface microgeometry

Aging prediction of cultural heritage samples based on surfa...

引用

2018 Eurographics Workshop on Graphics and Cultural Heritage, GCH 2018

作者： Ciortan, I.M. Marchioro, G. Daffara, C. Pintus, R. Gobbetti, E. Giachetti, A. Computer Science Department University of Verona Italy Visual Computing Group Center for Advanced Studies Research and Development in Sardinia Italy

ISBN: (纸本)9783038680574

A critical and challenging aspect for the study of Cultural Heritage (CH) assets is related to the characterization of the materials that compose them and to the variation of these materials with time. In this paper, we exploit a realistic dataset of artificially aged metallic samples treated with different coatings commonly used for artworks' protection in order to evaluate different approaches to extract material features from high-resolution depth maps. In particular, we estimated, on microprofilometric surface acquisitions of the samples, performed at different aging steps, standard roughness descriptors used in materials science as well as classical and recent image texture descriptors. We analyzed the ability of the features to discriminate different aging steps and performed supervised classification tests showing the feasibility of a texture-based aging analysis and the effectiveness of coatings in reducing the surfaces' change with time. © 2018 GCH 2018 - Eurographics Workshop on Graphics and Cultural Heritage. All rights reserved.

关键词： Coatings

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Is an Ultra Large Natural Image-Based Foundation Model Superior to a Retina-Specific Model for Detecting Ocular and Systemic Diseases?

arXiv

引用

arXiv 2025年

作者： Hou, Qingshan Zhou, Yukun Goh, Jocelyn Hui Lin Zou, Ke Yew, Samantha Min Er Srinivasan, Sahana Wang, Meng Lo, Thaddaeus Lei, Xiaofeng Wagner, Siegfried K. Chia, Mark A. Yang, Dawei Jiang, Hongyang Ran, AnRan Santos, Rui Somfai, Gabor Mark Zhou, Juan Helen Chen, Haoyu Chen, Qingyu Cheung, Carol Yim-Lui Keane, Pearse A. Tham, Yih Chung Department of Ophthalmology Yong Loo Lin School of Medicine National University of Singapore Singapore School of Computer Science and Engineering Northeastern University Shenyang China Centre for Innovation and Precision Eye Health Yong Loo Lin School of Medicine National University of Singapore Singapore Centre for Medical Image Computing University College London London United Kingdom NIHR Biomedical Research Centre Moorfields Eye Hospital NHS Foundation Trust London United Kingdom Department of Medical Physics and Biomedical Engineering University College London London United Kingdom Singapore Eye Research Institute Singapore National Eye Centre Singapore Singapore Singapore Institute of Ophthalmology University College London London United Kingdom Department of Ophthalmology and Visual Sciences Chinese University of Hong Kong Hong Kong Department of Ophthalmology Stadtspital Zürich Zurich Switzerland Spross Research Institute Zurich Switzerland Department of Ophthalmology Semmelweis University Budapest Hungary Centre for Sleep and Cognition Centre for Translational MR Research Yong Loo Lin School of Medicine National University of Singapore Singapore Department of Electrical and Computer Engineering National University of Singapore Singapore Joint Shantou International Eye Center Shantou University the Chinese University of Hong Kong Guangdong Shantou China Shantou University Medical College Guangdong Shantou China Department of Biomedical Informatics and Data Science Yale School of Medicine Yale University New Haven United States Duke-NUS Medical School Singapore

The advent of foundation models (FMs) is transforming medical domain. In ophthalmology, RETFound, a retina-specific FM pre-trained sequentially on 1.4 million natural images and 1.6 million retinal images, has demonstrated high adaptability across clinical applications. Conversely, DINOv2, a general-purpose vision FM pre-trained on 142 million natural images, has shown promise in non-medical domains. However, its applicability to clinical tasks remains underexplored. To address this, we conducted head-to-head evaluations by finetuning RETFound and three DINOv2 models (large, base, small) for ocular disease detection and systemic disease prediction tasks, across eight standardized open-source ocular datasets, as well as the Moorfields AlzEye and the UK Biobank datasets. DINOv2-large model outperformed RETFound in detecting diabetic retinopathy (AUROC=0.850–0.952 vs. 0.823-0.944, across three datasets, all P≤0.007) and multi-class eye diseases (AUROC=0.892 vs. 0.846, P Copyright © 2025, The Authors. All rights reserved.

关键词： Ophthalmology

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GAMMA Challenge: Glaucoma grAding from Multi-Modality imAges

arXiv

引用

arXiv 2022年

作者： Wu, Junde Fang, Huihui Li, Fei Fu, Huazhu Lin, Fengbin Li, Jiongcheng Huang, Yue Yu, Qinji Song, Sifan Xu, Xinxing Xu, Yanyu Wang, Wensai Wang, Lingxiao Lu, Shuai Li, Huiqi Huang, Shihua Lu, Zhichao Ou, Chubin Wei, Xifei Liu, Bingyuan Kobbi, Riadh Tang, Xiaoying Lin, Li Zhou, Qiang Hu, Qiang Bogunović, Hrvoje Orlando, José Ignacio Zhang, Xiulan Xu, Yanwu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou China Intelligent Healthcare Unit Baidu Inc. Beijing China Singapore School of Informatics Xiamen University Xiamen China Shanghai Jiao Tong University Shanghai China Xi'an Jiaotong-Liverpool University Suzhou China Institute of High Performance Computing A*STAR Singapore Institute of Biomedical Engineering Chinese Academy of Medical Sciences Peking Union Medical College Tianjin China School of Medical Technology Beijing Institute of Technology Beijing China Department of Computing Hong Kong Polytechnic University Hong Kong Department of Computer Science and Engineering Southern University of Science and Technology Shenzhen China Weizhi Medical Technology Company Suzhou China École de Technologie Supérieure Montreal Montreal Canada DIAGNOS Inc. Quebec Canada Department of Electrical and Electronic Engineering Southern University of Science and Technology Shenzhen China Department of Electrical and Electronic Engineering The University of Hong Kong Hong Kong Technology Co. Ltd. Shanghai China School of Information and Electronics Beijing Institute of Technology Beijing China Christian Doppler Lab for Artificial Intelligence in Retina Department of Ophthalmology Medical University of Vienna Austria Yatiris Group PLADEMA Institute CONICET UNICEN Tandil Argentina

Glaucoma is a chronic neuro-degenerative condition that is one of the world's leading causes of irreversible but preventable blindness. The blindness is generally caused by the lack of timely detection and treatment. Early screening is thus essential for early treatment to preserve vision and maintain life quality. Color fundus photography and Optical Coherence Tomography (OCT) are the two most cost-effective tools for glaucoma screening. Both imaging modalities have prominent biomarkers to indicate glaucoma suspects, such as the vertical cup-to-disc ratio (vCDR) on fundus images and retinal nerve fiber layer (RNFL) thickness on OCT volume. In clinical practice, it is often recommended to take both of the screenings for a more accurate and reliable diagnosis. However, although numerous algorithms are proposed based on fundus images or OCT volumes for the automated glaucoma detection, there are few methods that leverage both of the modalities to achieve the target. To fulfill the research gap, we set up the Glaucoma grAding from Multi-Modality imAges (GAMMA) Challenge to encourage the development of fundus & OCT-based glaucoma grading. The primary task of the challenge is to grade glaucoma from both the 2D fundus images and 3D OCT scanning volumes. As part of GAMMA, we have publicly released a glaucoma annotated dataset with both 2D fundus color photography and 3D OCT volumes, which is the first multi-modality dataset for machine learning based glaucoma grading. In addition, an evaluation framework is also established to evaluate the performance of the submitted methods. During the challenge, 1272 results were submitted, and finally, ten best performing teams were selected for the final stage. We analyze their results and summarize their methods in the paper. Since all the teams submitted their source code in the challenge, we conducted a detailed ablation study to verify the effectiveness of the particular modules proposed. Finally, we identify the proposed techniqu

关键词： Grading

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Integrating AR and VR for Mobile Remote Collaboration

Integrating AR and VR for Mobile Remote Collaboration

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IEEE International Symposium on Mixed and Augmented Reality Workshops (ISMARW)

作者： Jeremy Venerella Tyler Franklin Lakpa Sherpa Hao Tang Zhigang Zhu Dept.of CIS Borough of Manhattan Community College - CUNY Visual Computing Lab The City College of New York - CUNY Dept. of Computer Science The CUNY Graduate Center

ISBN: (纸本)9781728147666

In many complex tasks, a remote expert may need to assist a local user or to guide his or her actions in the local user's environment. Existing solutions also allow multiple users to collaborate remotely using high-end Augmented Reality (AR) and Virtual Reality (VR) head-mounted displays (HMD). In this paper, we propose a portable remote collaboration approach, with the integration of AR and VR devices, both running on mobile platforms, to tackle the challenges of existing approaches. The AR mobile platform processes the live video and measures the 3D geometry of the local environment of a local user. The 3D scene is then transited and rendered in the remote side on a mobile VR device, along with a simple and effective user interface, which allows a remote expert to easily manipulate the 3D scene on the VR platform and to guide the local user to complete tasks in the local environment.

关键词： Three-dimensional displays Annotations Collaboration Task analysis Solid modeling Google Cloud computing

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A Clinician-Friendly Platform for Ophthalmic Image Analysis Without Technical Barriers

arXiv

引用

arXiv 2025年

作者： Wang, Meng Lin, Tian Hou, Qingshan Lin, Aidi Wang, Jingcheng Peng, Qingsheng Nguyen, Truong X. Fang, Danqi Zou, Ke Xu, Ting Xue, Cancan Quek, Ten Cheer Yu, Qinkai Liu, Minxin Zhou, Hui Xiao, Zixuan He, Guiqin Liang, Huiyu Shi, Tingkun Chen, Man Liu, Linna Peng, Yuanyuan Wang, Lianyu Hu, Qiuming Chen, Junhong Zhang, Zhenhua Chen, Cheng Zhao, Yitian Liu, Dianbo Wu, Jianhua Chen, Xinjian Zhang, Changqing Nguyen, Triet Thanh Meng, Yanda Zheng, Yalin Tham, Yih Chung Cheung, Carol Y. Fu, Huazhu Chen, Haoyu Cheng, Ching-Yu Centre for Innovation and Precision Eye Health Yong Loo Lin School of Medicine National University of Singapore Singapore119228 Singapore Department of Ophthalmology Yong Loo Lin School of Medicine National University of Singapore Singapore119228 Singapore Joint Shantou International Eye Center Shantou University The Chinese University of Hong Kong Guangdong Shantou515041 China Shantou University Medical College Guangdong Shantou515041 China School of Computer Science and Engineering Northeastern University Liaoning Shenyang110819 China Big Vision Medical Technology Ltd. Suzhou215011 China Singapore Eye Research Institute Singapore National Eye Centre Singapore169856 Singapore Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong 999077 Hong Kong Binh Dinh Eye Hospital Viet Nam Department of Computer Science University of Exeter ExeterEX4 4RN United Kingdom University of Science and Technology Hospital Guangdong Shenzhen518000 China Shenzhen Qianhai Shekou Free Trade Zone Hospital Guangdong Shenzhen518000 China Department of Ophthalmology Meizhou People’s Hospital Meizhou Academy of Medical Sciences Guangdong Meizhou514000 China Department of Ophthalmology Yeungnam University College of Medicine Daegu42417 Korea Republic of Aier Eye Hospital of Wuhan University Hubei Wuhan430000 China School of Biomedical Engineering Anhui Medical University Anhui Hefei230032 China College of Computer Science and Technology Nanjing University of Aeronautics and Astronautics Jiangsu Nanjing211100 China Guangxi Jingliang Eye Hospital Guangxi Nanning530021 China Puning People’s Hospital Guangdong Jieyang522000 China Shandong Qingdao266042 China Department of Electrical and Electronic Engineering the University of Hong Kong Hong Kong Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Zhejiang Ningbo315201 China School of Electronics and Information Engineering Soochow University

Artificial intelligence (AI) shows remarkable potential in medical imaging diagnostics, but current models typically require retraining when deployed across different clinical centers, limiting their widespread adoption. We introduce GlobeReady, a clinician-friendly AI platform that enables ocular disease diagnosis without retraining/fine-tuning or technical expertise. GlobeReady achieves high accuracy across imaging modalities: 93.9–98.5% for an 11-category fundus photo dataset and 87.2–92.7% for a 15-category OCT dataset. Through training-free local feature augmentation, it addresses domain shifts across centers and populations, reaching an average accuracy of 88.9% across five centers in China, 86.3% in Vietnam, and 90.2% in the UK. The built-in confidence-quantifiable diagnostic approach further boosted accuracy to 94.9–99.4% (fundus) and 88.2–96.2% (OCT), while identifying out-of-distribution cases at 86.3% (49 CFP categories) and 90.6% (13 OCT categories). Clinicians from multiple countries rated GlobeReady highly (average 4.6 out of 5) for its usability and clinical relevance. These results demonstrate GlobeReady’s robust, scalable diagnostic capability and potential to support ophthalmic care without technical barriers. © 2025, CC0.

关键词： Ophthalmology

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