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P18.04.B SINGLE CELL TRANSCRIPTOMIC ANALYSIS IDENTIFIES DISTINCT INTRATUMORAL SUBCLONES IN MENINGIOMA

Neuro-Oncology 2023年第SUPPLEMENT_2期25卷 ii122–ii122页

作者： Blume, C Tang, Y Dogan, H Ritter, M Dentro, S von Deimling, A Gerstung, M Schlesner, M Sahm, F Maas, S L N University Hospital Heidelberg Dept. of Neuropathology Heidelberg Germany German Cancer Research Center (DKFZ) German Consortium for Translational Cancer Research (DKTK) Clinical Cooperation Unit Neuropathology Heidelberg Germany Division of AI in Oncology German Cancer Research Center (DKFZ) Heidelberg Germany European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Hinxton United Kingdom Biomedical Informatics Data Mining and Data Analytics Faculty of Applied Computer Science and Medical Faculty University of Augsburg Augsburg Germany Department of Pathology Leiden University Medical Center Leiden Netherlands Department of Pathology Erasmus Medical Center Rotterdam Netherlands

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OS06.7.A PLATFORM-AGNOSTIC METHYLATION CLASSIFICATION OF 184 CLASSES OF CNS TUMOURS

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Neuro-Oncology 2024年第SUPPLEMENT_5期26卷 v21-v22页

作者： Patel, A Schrimpf, D Jäger, N Loose, M Wick, W Krieg, S Schlesner, M Pfister, S M von Deimling, A Jones, D T W Sill, M Sahm, F Clinical Cooperation Unit Neuropathology German Consortium for Translational Cancer Research (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Dept. of Neuropathology University Hospital Heidelberg Heidelberg Germany Hopp Children’s Cancer Center (KiTZ) Heidelberg Germany Division of Pediatric Neurooncology German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Germany School of Life Sciences University of Nottingham Nottingham United Kingdom Clinical Cooperation Unit Neurooncology German Cancer Consortium within German Cancer Research Center (DKFZ) Heidelberg Germany Department of Neurosurgery University Hospital Heidelberg Heidelberg Germany Biomedical Informatics Data Mining and Data Analytics Augsburg University Augsburg Germany Department of Pediatric Hematology and Oncology Heidelberg University Hospital Heidelberg Germany Division of Pediatric Glioma Research German Cancer Research Center (DKFZ) Heidelberg Germany Hopp Children’s Tumor Center (KiTZ) Heidelberg Germany

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Attenuation of oxidative stress-induced neuronal cell death by Hydnophytum formicar-um Jack.

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Asian Pacific Journal of Tropical Medicine 2018年第7期11卷 415-422页

作者： Naw Hser Gay Kamonrat Phopin Wilasinee Suwanjang Waralee Ruankham Prapimpun Wongchitrat Supaluk Prachayasittikul Virapong Prachayasittikul Department of Clinical Microbiology and Applied Technology Faculty of Medical Technology Mahidol University Department of Medical Laboratory Technology University of Medical TechnologyYangon Center for Research and Innovation Faculty of Medical Technology Mahidol University Center of Data Mining and Biomedical Informatics Faculty of Medical Technology Mahidol University

Objective: To investigate protective effects of Hydnophytum formicarum Jack.(H. formicarum) extracts via regulation of SIRT1-FOXO3a-ADAM10 signaling and antioxidant activity against H_2O_2-induced neurotoxicity in neuroblastoma SH-SY5Y cells. Methods: Cell viability and apoptosis of neuronal cells pretreated with H. formicarum Jack. extracts under oxidative stress were determined by MTT assay and flow cytometry. The intracellular reactive oxygen species(ROS) was performed using Carboxy-DCFDA assay. Additionally, a profile of protein expressions related to neuroprotection was detected by western blot analysis. Results: The plant extracts(methanol and ethyl acetate) elicited protective effects on the neuronal cell death as performed by the MTT assay and by apoptosis analysis via the activation of BCL-2. Both ethyl acetate and methanol extracts exerted inhibitory effects against H_2O_2-induced ROS generation in the SH-SY5Y cells. Furthermore, the possible mechanism of neuroprotection of H. formicarum Jack. was observed through its antioxidant properties by maintaining the levels of catalase and SOD2 proteins as well as activating SIRT1-FOXO3a pathway. Importantly, pretreatment of neuronal cells with H. formicarum Jack. significantly recovered the levels of ADAM10 protein compared with the H_2O_2 treatment alone. Conclusions: The recent findings suggest the protective effects of H. formicarum Jack. plant extracts on attenuating H_2O_2-induced neurotoxicity in human SH-SY5Y cells.

关键词： Hydnophytum formicarum Jack. Antioxidant enzymes SIRT1 ADAM10 Neuroprotection

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PL02.2.A RAPID, COMPREHENSIVE REPORTING OF MOLECULAR DIAGNOSTICS WITH RAPID-CNS2: A PROSPECTIVE VALIDATION COHORT

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Neuro-Oncology 2023年第SUPPLEMENT_2期25卷 ii2-ii2页

作者： Patel, A Hinz, F Dogan, H Payne, A Göbel, K Schrimpf, D Ritter, M Krause, E Pfeifer, L Krech, M Blume, C Stichel, D Goidts, V Schweizer, L Unterberg, A Wick, W Pfister, S Sill, M Loose, M von Deimling, A Jones, D T W Schlesner, M Sahm, F Clinical Cooperation Unit Neuropathology German Cancer Consortium (DKTK) German Cancer Research Center Heidelberg Germany and Dept. of Neuropathology University Hospital Heidelberg Heidelberg Germany Heidelberg Germany Hopp Children's Cancer Center (KiTZ) Heidelberg Germany University of Nottingham Nottingham United Kingdom Charité – Universitätsmedizin Berlin Berlin Germany Neurological Institute (Edinger Institute) University Hospital Frankfurt Frankfurt Germany Department of Neurosurgery University Hospital Heidelberg Heidelberg Germany Clinical Cooperation Unit Neurooncology German Consortium for Translational Cancer Research (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany and Department of Neurology and Neurooncology Program NCT University Hospital Heidelberg Heidelberg Germany Division of Pediatric Neurooncology German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Heidelberg Germany Pediatric Glioma Research Group German Cancer Research Center (DKFZ) Heidelberg Germany Biomedical Informatics Data Mining and Data Analytics University of Augsburg Augsburg Germany

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TMOD-04. IMAGE-BASED DRUG RESPONSE PROFILING FROM PEDIATRIC TUMOR CELL SPHEROIDS USING PATIENT-BY-PATIENT DEEP TRANSFER LEARNING

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Neuro-Oncology 2021年第SUPPLEMENT_1期23卷 i36-i36页

作者： Berker, Yannick ElHarouni, Dina Peterziel, Heike Oehme, Ina Schlesner, Matthias Witt, Olaf Oppermann, Sina Hopp Children’s Cancer Center Heidelberg (KiTZ) Heidelberg Germany Translational Pediatric Pharmacology Clinical Cooperation Unit Pediatric Oncology German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Heidelberg Germany Clinical Bioinformatics Pediatric Neurooncology German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Heidelberg Germany Clinical Cooperation Unit Pediatric Oncology German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Heidelberg Germany Biomedical Informatics Data Mining and Data Analytics University of Augsburg Augsburg Germany

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JS08.6.A A connectivity signature for glioblastoma

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Neuro-Oncology 2022年第SUPPLEMENT_2期24卷 ii8-ii9页

作者： Hoffmann, D C Hai, L Wagener, R Mandelbaum, H Xie, R Hausmann, D Dominguez Azorín, D Weil, S Sievers, P Cebulla, G Ito, J Warnken, U Venkataramani, V Ernst, K Reibold, D Will, R Suvà, M L Herold-Mende, C Sahm, F Winkler, F Schlesner, M Wick, W Kessler, T Clinical Cooperation Unit Neurooncology German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Department of Neurology and Neurooncology Program National Center for Tumor Diseases Heidelberg University Hospital Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany Bioinformatics and Omics Data Analytics DKFZ Heidelberg Germany Department of Neuropathology Institute of Pathology University Hospital Heidelberg Heidelberg Germany Clinical Cooperation Unit Neuropathology DKTK DKFZ Heidelberg Germany Department of Neuroanatomy Institute for Anatomy and Cell Biology Heidelberg University Heidelberg Germany Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ) Heidelberg Germany Division of Pediatric Neurooncology DKTK DKFZ Heidelberg Germany Genomics and Proteomics Core Facility DKTK DKFZ Heidelberg Germany Broad Institute of Harvard and MIT Cambridge MA United States Department of Pathology and Center for Cancer Research Massachusetts General Hospital and Harvard Medical School Boston MA United States Department of Neurosurgery Heidelberg University Hospital Heidelberg Germany Biomedical Informatics Data Mining and Data Analytics Faculty of Applied Computer Science and Medical Faculty University of Augsburg Augsburg Germany

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Corrigendum to "Structural and biochemical characterization of two heme binding sites on α1-microglobulin using site directed mutagenesis and molecular simulation" [BBAPAP 1864/1 (2016) Page 29 to 41]

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Biochimica et biophysica acta. Proteins and proteomics 2020年第6期1868卷 140394页

作者： Sigurbjörg Rutardottir Elena Karnaukhova Chanin Nantasenamat Napat Songtawee Virapong Prachayasittikul Mohsen Rajabi Lena Wester Rosenlöf Abdu I Alayash Bo Åkerström Division of Infection Medicine Lund University Lund Sweden. Laboratory of Biochemistry and Vascular Biology Division of Hematology Research and Review Center for Biologics Evolution and Research Food and Drug Administration MD USA. Center of Data Mining and Biomedical Informatics Faculty of Medical Technology Mahidol University Bangkok Thailand Department of Clinical Microbiology and Applied Technology Faculty of Medical Technology Mahidol University Bangkok Thailand. Center of Data Mining and Biomedical Informatics Faculty of Medical Technology Mahidol University Bangkok Thailand. Division of Infection Medicine Lund University Lund Sweden. Electronic address: bo.akerstrom@med.lu.se.

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PATH-46. COMPUTATIONAL HISTOPATHOLOGY INFORMED RAPID TARGETED NANOPORE SEQUENCING ENABLES AFFORDABLE NEXT DAY REPORTING OF COMPREHENSIVE MOLECULAR MARKERS FOR CNS TUMOUR DIAGNOSTICS

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Neuro-Oncology 2022年第SUPPLEMENT_7期24卷 vii161–vii161页

作者： Patel, Areeba Dogan, Helin Jung, Alexander Seferbekova, Zaira Payne, Alexander Ritter, Michael Schrimpf, Daniel Stichel, Damian Hamelmann, Stefan Blume, Christina Euskirchen, Philipp Goidts, Violaine Sill, Martin Pfister, Stefan Loose, Matthew Wick, Wolfgang von Deimling, Andreas Jones, David T Schlesner, Matthias Gerstung, Moritz Sahm, Felix Department of Neuropathology University Hospital Heidelberg and Clinical Cooperation Unit Neuropathology German Consortium for Translational Cancer Research (DKTK) and German Cancer Research Center (DKFZ) Heidelberg Baden-Wurttemberg Germany Department of Neuropathology University Hospital Heidelberg and Clinical Cooperation Unit Neuropathology German Consortium for Translational Cancer Research (DKTK) and German Cancer Research Center (DKFZ) Heidelberg Germany European Molecular Biology Laboratory European Bioinformatics Institute EMBL-EBI Cambridge United Kingdom Division of Artificial Intelligence in Oncology German Cancer Research Center (DKFZ) Heidelberg Germany DeepSeq School of Life Sciences University of Nottingham Nottingham United Kingdom Department of Neurology Charité-Universitätsmedizin Berlin Berlin Germany Brain Tumor Translational Targets German Cancer Research Center (DKFZ) Heidelberg Germany Hopp Children's Cancer Center (KiTZ) Heidelberg Germany German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Heidelberg Germany Heidelberg Germany Neurology Clinic and National Center for Tumor Diseases University Hospital Heidelberg Heidelberg Baden-Wurttemberg Germany Hopp Children’s Cancer Center Heidelberg (KiTZ) Heidelberg University Hospital and German Cancer Research Center (DKFZ) Heidelberg Germany Biomedical Informatics Data Mining and Data Analytics Augsburg University Augsburg Germany

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OS12.7.A Characterization of intra-tumoral heterogeneity and differential immune activation during malignant progression of meningiomas on single cell level

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Neuro-Oncology 2021年第SUPPLEMENT_2期23卷 ii15-ii16页

作者： Blume, C Dogan, H Schweizer, L Wick, W Weller, M Mann, M Kalamarides, M von Deimling, A Schlesner, M Sahm, F CCU Neuropathology German Cancer Research Centre (DKFZ) Heidelberg Germany Dept. of Neuropathology University Hospital Heidelberg Heidelberg Germany Department of Proteomics and Signal Transduction Max Planck Institute of Biochemistry Martinsried Germany German Cancer Research Centre (DKFZ) Heidelberg Germany Department of Neurology and Neurooncology Program National Center for Tumor Diseases Heidelberg University Hospital Heidelberg Germany Department of Neurology Clinical Neuroscience Center University Hospital and University of Zürich Zürich Switzerland NNF Center for Protein Research Faculty of Health Sciences University of Copenhagen Copenhagen Denmark Sorbonne Université and Department of Neurosurgery Pitié Salpêtrière Hospital Paris France Biomedical Informatics Data Mining and Data Analytics Faculty of Applied Computer Science and Medical Faculty University of Augsburg Augsburg Germany

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Neuroprotective effect of Spilanthes acmella Murr. on pesticide-induced neuronal cells death

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Asian Pacific Journal of Tropical Medicine 2017年第1期10卷 35-41页

作者： Wilasinee Suwanjang Bongkot Khongniam Sujittra Srisung Supaluk Prachayasittikul Virapong Prachayasittikul Center for Research and Innovation Faculty of Medical TechnologyMahidol University Department of Chemistry Faculty of ScienceSrinakharinwirot University Center of Data Mining and Biomedical Informatics Faculty of Medical TechnologyMahidol University Department of Clinical Microbiology and Applied Technology Faculty of Medical TechnologyMahidol University

Objective: To investigate protective effects of Spilanthes acmella(S,acmella) Murr,extracts against pesticide-induced neuronal cells death and to elucidate the underlying molecular mechanism in dopaminergic(SH-SY5Y) cells lines,Methods: Cell viability of SH-SY5 Y cells was studied by treating the cells with various concentration of pirimicarb for 24 hr,Neuroprotective effect of S,acmella Murr,extracts was investigated by adding the plant extracts to the medium for 24 hr prior to the incubation with 100 μM H_2O_2 or with pirimicarb for 24 hr,Control-untreated cells were incubated with the culture medium,Cell viability was measured by MTT assay,calpain and calpastatin expressions were analyzed by Western blotting and immunocytochemistry,Results: Pretreatment of SH-SY5 Y cells with S,acmella Murr,extracts(1 μg/m L) for 24 hr significantly increased the dopaminergic neurons in pirimicarb-induced neurotoxicity,In addition,pretreatment with the S,acmella Murr,extracts led to decreased calpain but increased calpastatin protein levels,Conclusion: S,acmella Murr,extracts exerted neuroprotective effect,via an alteration of calcium homeostasis,against pirimicarb induced neurotoxicity,The S,acmella Murr,might be a potential natural candidate with neuroprotective activity.

关键词： Spilanthes acmella Murr. Pirimicarb Pesticide Neuronal cell Calpain Calpastatin

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