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Rücktitelbild: PD-L1 Aptamer-Functionalized Metal–Organic Framework Nanoparticles for Robust Photo-Immunotherapy against Cancer with Enhanced Safety (Angew. Chem. 5/2023)

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Angewandte Chemie 2023年第5期135卷

作者： Dr. Jingfang Zhang Dr. Wenzhe Li Dr. Yafei Qi Dr. Guorong Wang Prof. Lele Li Prof. Zhengyu Jin Prof. Jie Tian Prof. Yang Du Beijing Key Laboratory for Bioengineering and Sensing Technology School of Chemistry and Biological Engineering University of Science and Technology Beijing Beijing 100083 China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing 100191 China CAS Key Laboratory of Molecular Imaging Beijing Key Laboratory of Molecular Imaging the State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing 100190 China Department of Radiology Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of Medicine Beihang University Beijing 100191 China

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Author Correction: Malaria elimination on Hainan Island despite climate change

Communications Medicine

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Communications Medicine 2022年第1期2卷 1页

作者： Huaiyu Tian Naizhe Li Yonghong Liu Yidan Li Ben Wang Peiyi Wu Yapin Li Dongqi Gao Wenjing Song Moritz U. G. Kraemer José Lourenço Oliver G. Pybus Christopher Dye Hua Tan Bernard Cazelles Dingwei Sun Yuchun Li Guangze Wang State Key Laboratory of Remote Sensing Science Center for Global Change and Public Health College of Global Change and Earth System Science Beijing Normal University Beijing China Central Theater Center for Disease Control and Prevention of PLA Beijing China Department of Zoology University of Oxford Oxford UK Department of Pathobiology and Population Science The Royal Veterinary College London UK Oxford Martin School University of Oxford Oxford UK School of Biomedical Informatics the University of Texas Health Science Center at Houston Houston TX USA Institut de Biologie de l’École Normale Supérieure Unité Mixte de Recherche Centre National de la Recherche Scientifique et École Normale Supérieure Paris France Unité Mixte Internationnale Mathematical and Computational Modeling of Complex Systems Institut de Recherche pour le Développement et Sorbonne Université Bondy France Hainan Center for Disease Control and Prevention Haikou China

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Overcoming catastrophic forgetting with self-adaptive identifiers 25th

Overcoming catastrophic forgetting with self-adaptive identi...

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25th International Conference on Neural Information Processing, ICONIP 2018

作者： Xiong, Fangzhou Liu, Zhiyong Yang, Xu The State Key Lab of Management and Control for Complex Systems Institute of Automation Chinese Academy of Science Beijing100190 China Beijing100049 China Centre for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai200031 China Cloud Computing Center Chinese Academy of Sciences DongGuanGuangDong523808 China

ISBN: (纸本)9783030041816

Catastrophic forgetting is a tough issue when the agent faces the sequential multi-task learning scenario without storing previous task information. It gradually becomes an obstacle to achieve artificial general intelligence which is generally believed to behave like a human with continuous learning capability. In this paper, we propose to utilize the variational Bayesian inference method to overcome catastrophic forgetting. By pruning the neural network according to the mean and variance of weights, parameters are vastly reduced, which mitigates the storage problem of double parameters required in variational Bayesian inference. Based on this lightweight version, autoencoders trained on different tasks are employed to self-adaptively match the corresponding task parameters to tackle sequential multi-task learning problem. We show experimentally on several fundamental datasets that the proposed method can perform substantial improvements without catastrophic forgetting over other classic methods especially in the setting where the probability distributions between tasks present more different. © Springer Nature Switzerland AG 2018.

关键词： Probability distributions

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PD-L1 Aptamer-Functionalized Metal–Organic Framework Nanoparticles for Robust Photo-Immunotherapy against Cancer with Enhanced Safety

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Angewandte Chemie 2022年第5期135卷

Immune checkpoint blockade has become a paradigm-shifting treatment modality to combat cancer, while conventional administration of immune checkpoint inhibitors, such as anti-PD-L1 antibody (α-PD-L1), often shows unsatisfactory immune responses and lead to severe immune-related adverse effects (irAEs). Herein, we develop a PD-L1 aptamer-based spherical nucleic acids (SNAs), which consists of oxaliplatin (OXA) encapsulated in a metal–organic framework nanoparticle core and a dense shell of aptPD-L1 (denoted as M@O-A). Upon light irradiation, this nanosystem enables concurrent photodynamic therapy (PDT), chemotherapy, and enhanced immunotherapy in one shot to inhibit both primary colorectal tumors and untreated distant tumors in mice. Notably, M@O-A shows scarcely any systemic immunotoxicity in a clinical irAEs-mimic transgenic mouse model. Collectively, this study presents a novel strategy for priming robust photo-immunotherapy against cancer with enhanced safety.

关键词： DNA Nanotechnology Immunotherapy Metal–Organic Frameworks PD-L1 Aptamer Spherical Nucleic Acids (SNAs)

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An Assist-as-Needed controller for Robotic Rehabilitation Therapy Based on RBF Network

An Assist-as-Needed Controller for Robotic Rehabilitation Th...

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International Joint Conference on Neural Networks

作者： Lincong Luo Liang Peng Chen Wang Zengguang Hou Weiqun Wang University of Chinese Academy of Sciences Beijing China State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing China CAS Center for Excellence in Brain Science and Intelligence Technology Beijing China

The rehabilitation training with active involvement and efforts of impaired subjects can enhance the outcome of rehabilitation therapies. To promote patients' voluntary engagement, a variety of assist as needed (AAN) controllers have been proposed for robot-aided therapy. However, patients' impairment level is not taken into account in the implementation of those control schemes. In this study, a novel AAN controller is developed for upper limb rehabilitation therapy. The control paradigm uses Gaussian radial basis function (RBF) network to learn the model of subjects' motor capability in workspace. The update of weight vectors of RBF network is based on a greedy strategy, which has the potential to promote subjects' voluntary engagement by providing task challenge for them. Considering the difference in the impairment degree of patients, the assistance and impedance level of robot control is regulated based on the task performance of patients. The results of experiments at four healthy subjects verify the feasibility and adaptability of the proposed AAN controller.

关键词： Radial basis function networks Robot sensing systems Training Medical treatment Task analysis Mathematical model

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

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Nature 2024年第8003期627卷 347-357页

作者： Ken Suzuki Konstantinos Hatzikotoulas Lorraine Southam Henry J Taylor Xianyong Yin Kim M Lorenz Ravi Mandla Alicia Huerta-Chagoya Giorgio E M Melloni Stavroula Kanoni Nigel W Rayner Ozvan Bocher Ana Luiza Arruda Kyuto Sonehara Shinichi Namba Simon S K Lee Michael H Preuss Lauren E Petty Philip Schroeder Brett Vanderwerff Mart Kals Fiona Bragg Kuang Lin Xiuqing Guo Weihua Zhang Jie Yao Young Jin Kim Mariaelisa Graff Fumihiko Takeuchi Jana Nano Amel Lamri Masahiro Nakatochi Sanghoon Moon Robert A Scott James P Cook Jung-Jin Lee Ian Pan Daniel Taliun Esteban J Parra Jin-Fang Chai Lawrence F Bielak Yasuharu Tabara Yang Hai Gudmar Thorleifsson Niels Grarup Tamar Sofer Matthias Wuttke Chloé Sarnowski Christian Gieger Darryl Nousome Stella Trompet Soo-Heon Kwak Jirong Long Meng Sun Lin Tong Wei-Min Chen Suraj S Nongmaithem Raymond Noordam Victor J Y Lim Claudia H T Tam Yoonjung Yoonie Joo Chien-Hsiun Chen Laura M Raffield Bram Peter Prins Aude Nicolas Lisa R Yanek Guanjie Chen Jennifer A Brody Edmond Kabagambe Ping An Anny H Xiang Hyeok Sun Choi Brian E Cade Jingyi Tan K Alaine Broadaway Alice Williamson Zoha Kamali Jinrui Cui Manonanthini Thangam Linda S Adair Adebowale Adeyemo Carlos A Aguilar-Salinas Tarunveer S Ahluwalia Sonia S Anand Alain Bertoni Jette Bork-Jensen Ivan Brandslund Thomas A Buchanan Charles F Burant Adam S Butterworth Mickaël Canouil Juliana C N Chan Li-Ching Chang Miao-Li Chee Ji Chen Shyh-Huei Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Mary Cushman John Danesh Swapan K Das H Janaka de Silva George Dedoussis Latchezar Dimitrov Ayo P Doumatey Shufa Du Qing Duan Kai-Uwe Eckardt Leslie S Emery Daniel S Evans Michele K Evans Krista Fischer James S Floyd Ian Ford Oscar H Franco Timothy M Frayling Barry I Freedman Pauline Genter Hertzel C Gerstein Vilmantas Giedraitis Clicerio González-Villalpando Maria Elena González-Villalpando Penny Gordon-Larsen Myron Gross Lindsay A Guare Sophie Hackinger Liisa Hakaste Sohee Han Andrew T Hattersley Christian Herder Momoko Horikoshi Annie-Green Howard Willa Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research Division of Musculoskeletal and Dermatological Sciences University of Manchester Manchester UK. Department of Diabetes and Metabolic Diseases Graduate School of Medicine University of Tokyo Tokyo Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. konstantinos.hatzikotoulas@helmholtz-munich.de. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA. British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Heart and Lung Research Institute University of Cambridge Cambridge UK. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA. Corporal Michael J. Crescenz VA Medical Center Philadelphia PA USA. Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London L

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

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A joint call for actions to advance taxonomy in China

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Zoological Systematics 2022年第3期47卷 188-197页

作者： Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu CAS Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Mycology(SKLM) Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Aquatic Biodiversity and Conservation Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074China Department of Marine Organism Taxonomy&Phylogeny Institute of OceanologyChinese Academy of SciencesQingdao 266071China CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China State Key Laboratory of Genetic Resources and Evolution&Yunnan Key Laboratory of Biodiversity and Ecological Security of Gaoligong Mountain Kunming Institute of ZoologyChinese Academy of SciencesKunming 650221China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China CAS Key Laboratory of Plant Resource Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China CAS Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMenglaYunnan 66630

Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China.

关键词： Endangered taxonomists morphology-based taxonomy integrative taxonomy capacity building systematics

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Burdens of type 2 diabetes and cardiovascular disease attributable to sugar-sweetened beverages in 184 countries (06 Jan, 10.1038/s41591-024-03345-4, 2025)

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NATURE MEDICINE 2025年第2期31卷 696-696页

作者： Lara-Castor, Laura O'Hearn, Meghan Cudhea, Frederick Miller, Victoria Shi, Peilin Zhang, Jianyi Sharib, Julia R. Cash, Sean B. Barquera, Simon Micha, Renata Mozaffarian, Dariush Food Is Medicine Institute Friedman School of Nutrition Science and Policy Tufts University Boston MA USA Institute of Health Metrics and Evaluation University of Washington Seattle WA USA Food Systems for the Future Institute Chicago IL USA Department of Medicine McMaster University Hamilton Ontario Canada Population Health Research Institute Hamilton Ontario Canada University of Thessaly Volos Greece Tufts University School of Medicine Boston MA USA Department of Medicine Tufts Medical Center Boston MA USA Center for Surgery and Public Health Brigham and Women’s Hospital Boston MA USA Friedman School of Nutrition Science and Policy Tufts University Boston MA USA Research Center on Nutrition and Health National Institute of Public Health Cuernavaca Mexico National Institute of Public Health (INSP) Cuernavaca Mexico Academy of Athens Athens Greece Acibadem University Istanbul Turkey Addis Ababa University Addis Ababa Ethiopia Aga Khan Foundation Geneva Switzerland All India Institute of Medical Sciences New Delhi India American University of Beirut Beirut Lebanon Amrita School of Dentistry Eranakulum India Andalas University Padang Indonesia Arab Center for Nutrition Manama Bahrain Ardabil University of Medical Sciences Ardabil Iran Bacha Khan University Charsadda Pakistan Biodiversity International Nairobi Kenya Brighton and Sussex Medical School Brighton UK Center for Studies of Sensory Impairment Aging and Metabolism (CeSSIAM) Guatemala City Guatemala Centre For Media Studies New Delhi India Centro de Atencion Nutricional Antimano (CANIA) Miami FL USA Centro de Estudios sobre Nutrición Infantil (CESNI) Buenos Aires Argentina Child Growth and Development Research Center Isfahan University of Medical Sciences Isfahan Iran College of Applied Sciences Department of Food Science and Applied Nutrition Addis Ababa Science and Technology University Addis Ababa Ethiopia Consultative Group on International Agricultural Research (CGIAR) M

The consumption of sugar-sweetened beverages (SSBs) is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). However, an updated and comprehensive assessment of the global burden attributable to SSBs remains scarce. Here we estimated SSB-attributable T2D and CVD burdens across 184 countries in 1990 and 2020 globally, regionally and nationally, incorporating data from the Global Dietary Database, jointly stratified by age, sex, educational attainment and urbanicity. In 2020, 2.2 million (95% uncertainty interval 2.0–2.3) new T2D cases and 1.2 million (95% uncertainty interval 1.1–1.3) new CVD cases were attributable to SSBs worldwide, representing 9.8% and 3.1%, respectively, of all incident cases. Globally, proportional SSB-attributable burdens were higher among men versus women, younger versus older adults, higher- versus lower-educated adults, and adults in urban versus rural areas. By world region, the highest SSB-attributable percentage burdens were in Latin America and the Caribbean (T2D: 24.4%; CVD: 11.3%) and sub-Saharan Africa (T2D: 21.5%; CVD: 10.5%). From 1990 to 2020, the largest proportional increases in SSB-attributable incident T2D and CVD cases were in sub-Saharan Africa (+8.8% and +4.4%, respectively). Our study highlights the countries and subpopulations most affected by cardiometabolic disease associated with SSB consumption, assisting in shaping effective policies and interventions to reduce these burdens globally.

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Enhanced biologically inspired model for image recognition based on a novel patch selection method with moment

arXiv

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arXiv 2017年

作者： Lu, Yan-Feng Jia, Li-Hao Qaio, Hong Li, Yi Research Center for Brain-inspired Intelligence Institute of Automation Chinese Academy of Sciences Beijing China State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai China School of Information Engineering Nanchang University Nanchang China

Biologically inspired model (BIM) for image recognition is a robust computational architecture, which has attracted widespread attention. BIM can be described as a four-layer structure based on the mechanisms of the visual cortex. Although the performance of BIM for image recognition is robust, it takes the randomly selected ways for the patch selection, which is sightless, and results in heavy computing burden. To address this issue, we propose a novel patch selection method with oriented Gaussian-Hermite moment (PSGHM), and we enhanced the BIM based on the proposed PSGHM, named as PBIM. In contrast to the conventional BIM which adopts the random method to select patches within the feature representation layers processed by multi-scale Gabor filter banks, the proposed PBIM takes the PSGHM way to extract a small number of representation features while offering promising distinctiveness. To show the effectiveness of the proposed PBIM, experimental studies on object categorization are conducted on the CalTech05, TU Darmstadt (TUD), and GRAZ01 databases. Experimental results demonstrate that the performance of PBIM is a significant improvement on that of the conventional BIM. Copyright © 2017, The Authors. All rights reserved.

关键词： Image enhancement

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A fast and compact saliency score regression network based on fully convolutional network

arXiv

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arXiv 2017年

作者： Xi, Xuanyang Luo, Yongkang Li, Fengfu Wang, Peng Qiao, Hong State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing100190 China University of Chinese Academy of Sciences Beijing100049 China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai200031 China Research Center of Precision Sensing and Control Institute of Automation Chinese Academy of Sciences Beijing100190 China LSEC Institute of Applied Mathematics AMSS Chinese Academy of Sciences Beijing100190 China

Visual saliency detection aims at identifying the most visually distinctive parts in an image, and serves as a pre-processing step for a variety of computer vision and image processing tasks. To this end, the saliency detection procedure must be as fast and compact as possible and optimally processes input images in a real time manner. It is an essential application requirement for the saliency detection task. However, contemporary detection methods often utilize some complicated procedures to pursue feeble improvements on the detection precession, which always take hundreds of milliseconds and make them not easy to be applied practically. In this paper, we tackle this problem by proposing a fast and compact saliency score regression network which employs fully convolutional network, a special deep convolutional neural network, to estimate the saliency of objects in images. It is an extremely simplified end-to-end deep neural network without any pre-processings and post-processings. When given an image, the network can directly predict a dense full-resolution saliency map (image-to-image prediction). It works like a compact pipeline which effectively simplifies the detection procedure. Our method is evaluated on six public datasets, and experimental results show that it can achieve comparable or better precision performance than the state-of-the-art methods while get a significant improvement in detection speed (35 FPS, processing in real time). Copyright © 2017, The Authors. All rights reserved.

关键词： Deep neural networks

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