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Targeted and pH-sensitive polyzwitterionic liposomes for oral anticancer drug delivery

Particuology 2025年第3期98卷 13-20页

作者： Mingyang Hu Rui Zheng Qi Pan Chen Peng Xinyue Zhang Wei He Wenlong Yao Yan Li Beijing Key Laboratory for Bioengineering and Sensing Technology School of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing100083China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesChemical Biology CenterPeking UniversityBeijing100191China School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China

Compared to intravenous injection,oral administration is attractive due to its many advantages for cancer *** physiological barriers and other profiles of oral anticancer drug carriers into consideration,targeted and pH-sensitive polyzwitterionic liposomes(ZL)based on zwitterionic poly(carboxybetaine)(PCB)were constructed for oral delivery of doxorubicin hydrochloride(DOX·HCl)for cancer *** DOX-ZL with 40%trehalose had good lyophilization stability,which would be packaged into enteric capsules to enhance their stability in *** addition,DOX-ZL exhibited good storage stability and serum *** DOX-ZL could achieve controlled release of DOX·HCl at the endosomal pH 5.0 due to the pH-sensitive of zwitterionic ***,DOX-ZL could targeted deliver DOX·HCl to Caco-2 cells to cross the intestinal epithelial cell *** empty ZL had good biocompatibility,while DOX-ZL significantly inhibited tumor cells growth due to their high cellular uptake and controlled drug release ***,this work provided a promising approach for oral cancer therapy.

关键词： Polyzwitterionic liposomes Poly(carboxybetaine) Doxorubicin hydrochloride Oral administration Cancer therapy

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Polyoxometalate-based peroxidase-like nanozymes

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Nano Materials Science 2025年第1期7卷 24-48页

作者： Xiangwei Liu Tiedong Sun Yuan Sun Alina Manshina Lei Wang College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbin150040China School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin150001China Center of Pharmaceutical Engineering and Technology Harbin University of CommerceHarbin150076China Institute of Chemistry Saint Petersburg State UniversityUniversitetskii pr.26St.PetersburgRussian Federation

Nanozymes,as a new generation of artificial enzymes,exhibit similar chemical properties,catalytic efficiency,and reaction kinetics to natural *** can offer several advantages over natural enzymes,including the decreased cost,the increased stability,and the enhanced catalytic *** advantages have positioned nanozymes as a research focus in the fields of chemistry,materials and ***(POMs)and their composites have been found to possess excellent catalytic capabilities as peroxidase *** this,this review aims to provide a comprehensive overview of the POM-based nanozymes,covering their structural categorization,evolution,and various applications over the past *** dynamic nature of this field would promise the intriguing challenges and opportunities in the ***,we address the existing issues with the POM-based peroxidase-like enzymes and suggest the potential directions for future *** review would serve as a valuable resource for researchers seeking to develop the improved therapeutic and diagnostic technologies using the POM-based nanozymes,thereby advancing the fields of biochemistry and materials science.

关键词： Polyoxometalates,Peroxidase Nanozymes Nanomaterials H_(2)O_(2)

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Advancing antibiotic detection and degradation:recent innovations in graphitic carbon nitride(g-C_(3)N_(4))applications

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Journal of Environmental Sciences 2025年第4期150卷 657-675页

作者： Rui Liu Chaojun Zhang Rijia Liu Yuan Sun Binqiao Ren Yuhang Tong Yu Tao Center of Pharmaceutical Engineering and Technology Harbin University of CommerceHarbin 150076China Institute of Advanced Technology Heilongjiang Academy of SciencesHarbin 150080China School of Environment Harbin Institute of TechnologyHarbin 150090China Materials Science and Physical Chemistry Department University of BarcelonaBarcelona 08028Spain State Key Laboratory of Urban Water Resource and Environment School of Civil&Environmental EngineeringHarbin Institute of Technology ShenzhenShenzhen 518055China

The uncontrolled release of antibiotics into the environment would be extremely harmful to human health and ***,it is in urgent need to monitor the environment and promote the detection and degradation of antibiotics to the relatively harmless by-products to a feasible *** carbon nitride(g-C_(3)N_(4))is a non-metallic n-type semiconductor that can be used for the antibiotic detection and degradation due to its easy synthesis process,excellent chemical stability and unique optical ***,the utilization of visible light,electron-hole recombination and electron conductivity have hindered its potential applications in the fields of photocatalytic degradation and electrochemical *** previous publications have highlighted the diverse modification methods for the g-C_(3)N_(4)-based materials,the underlying structure-performance relationships of g-C_(3)N_(4),especially for the detection and degradation of antibiotics,remains to be further *** view of this,the current review centered on the recent progress in the modification techniques of g-C_(3)N_(4),the detection and degradation of antibiotics using the g-C_(3)N_(4)-based materials,as well as the potential antibiotic degradation mechanisms of the g-C_(3)N_(4)-based ***,the underlying applications of the g-C_(3)N_(4)-based materials for antibiotic detection and degradation were also *** review would provide a valuable research foundation and the up-to-date information for the g-C_(3)N_(4)-based materials to combat antibiotic pollution in the environment.

关键词： g-C_(3)N_(4) Antibiotics Modification techniques Photocatalytic degradation Electrochemical detection

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Ferulic acid alleviates long-term avermectin-induced damage to the spleen of carp and restores its inflammatory response and oxidative balance

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Journal of Environmental Sciences 2025年第5期151卷 616-626页

作者： Hanyu Wang Shenye Feng Enzhuang Pan Xiaomeng Ji Mengyuan Zhou Shuai Zhang Baoshi Xu Huimiao Feng Jilei Yin Zibo Dong Jiangsu Key Laboratory of Marine Bioresources and Environment Co-Innovation Center of Jiangsu Marine Bio-industry TechnologyJiangsu Marine Pharmaceutical Resources Development Engineering Research CenterJiangsu Key Laboratory of Marine Pharmaceutical Compound ScreeningCollege of PharmacyJiangsu Ocean UniversityLianyungang 222005China Department of Traditional Chinese Medicine Jiangsu Union Technical Institute Lianyungang Branch institute of Traditional Chinese MedicineLianyungang 222006China

Extensive use of avermectin(AVM)in agriculture can seriously contaminate fish in *** acid(FA)is a strong antioxidant sourced from plants and is widely applied in food and medicine,but its protective function on the immunological damage caused by AVM is still *** this study,carp were chronically exposed to(1/1096 hr LC_(50))AVM for 30 day(s),with a dietary supplement of FA(400 mg/kg)to assess its effects on carp *** experimental groups(n=10)included:control,AVM-exposed(2.404μg/L),FA+AVM co-treated,and FA ***-term AVM exposure altered spleen tissue,reducing serum complement C3(p<0.01)and immunoglobulin M levels(p<0.001),and increasing proinflammatory tnf-α(p<0.001),il-6(p<0.001),il-1β(p<0.001),and inos mRNA levels,whilst down-regulating the anti-inflammatory tgf-β(p<0.05).Additionally,it disrupted the balance of oxidative stress indicators such asMDA(p<0.001),T-AOC,GSH,and CAT,leading to spleen tissue apoptosis(42.4%).However,the addition of FA reversed these conditions,elevated the anti-inflammatory factor,and improved spleen immune function following chronic exposure to AVMin ***,the ability to restore oxidative homeostasis in carp by adjusting the Nrf2/NQO-1 axis protected the health of spleen *** discovery also supports the development of fish feed for aquaculture.

关键词： Avermectin Ferulic acid Oxidative stress Inflammation response

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Photolabile ortho-Nitro-Benzyl Carbonate as a Permanent Hydroxyl Protecting Group for the Synthesis of Digalactosyl Diacylglycerol

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Chinese Journal of Chemistry 2025年第2期43卷 169-174页

作者： Jibin Zheng Hongyu Chen Jintao Shang Lvfeng Zhang Youling Liang Dongsheng Chang You Yang Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Shanghai Key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and Technology130 Meilong RoadShanghai200237 China Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationEast China University of Science and Technology130 Meilong RoadShanghai200237 China

Traditional protecting groups are often removed under harsh conditions with potentially hazardous reagents,thereby impeding the convenient synthesis of oligosaccharides and ***,we present to utilize the photolabile ortho-nitro-benzyl carbonate(oNBC)as a permanent hydroxyl protecting group for stereocontrolled synthesis of *** Ph3PO-modulated glycosylation with strongly disarmed per-O-oNBC-protected glycosyl ynenoates preferred to afford glycosides with excellentα-selectivities via theβ-phosphonium transition *** on the oNBC-mediated galactosylation,synthesis of the glycolipid digalactosyl diacylglycerol(DGDG)containing six double bonds and two esters was achieved in a straightforward manner.

关键词： Carbohydrates Protecting groups Glycosylation Glycolipids Glycosides Photocatalysis Gold catalysis Synthetic methods

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Design and Synthesis of Novel Piperidine Urea Derivatives with Neuroprotective Properties

Pharmaceutical Fronts

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pharmaceutical Fronts 2025年第1期7卷 e32-e40页

作者： Li, Jiayi Wang, Mengfei Jiang, Ling Peng, Xinyan Han, Bo Zhang, Qingwei Novel Technology Center of Pharmaceutical Chemistry Shanghai Institute of Pharmaceutical Industry Co. Ltd. China State Institute of Pharmaceutical Industry Co. Ltd. Shanghai China School of Chemistry and Chemical Engineering Shanghai University of Engineering Science Shanghai China National Key Laboratory of Lead Druggability Research Shanghai Institute of Pharmaceutical Industry Co. Ltd. Shanghai China

Ischemic stroke remains the leading cause of death worldwide, and in experimental studies of ischemic stroke, neuroprotective agents may display good efficacy. In our previous work, Fenazinel showed promising neuroprotective effects and entered phase I clinical trials in China. However, some side effects have limited its further study. To explore novel neuroprotective agents with higher potency and lower cardiotoxicity, in this work, a series of Fenazinel derivatives with piperidine urea groups (A1-A13) were designed and synthesized. The neuroprotective effect of A1-A13 was evaluated in human neuroblastoma cells (SH-SY5Y) by assessing cell survivals, and then in a rat model of middle cerebral artery occlusion (MCAO) by assessing the cerebral infarction area. The hERG (human ether-a-go-go -related gene) inhibitory activity was conducted to predict the cardiotoxicity of compounds. The hypoxia tolerance assay of mice was assessed by determining the survival time of mice in a sealed bottle. Our experimental data suggested that among the compounds, compound A10 demonstrated superior protective activity against SH-SY5Y cells at different concentrations, lower cytotoxicity compared with Fenazinel, and additionally, a weak cardiotoxicity (hERG IC ₅₀ > 40 μmol/L). Compound A10 not only effectively prolonged the survival time of mice, but also significantly reduced the percentage of cerebral infarction in MCAO rats with a dose-dependent tendency. In summary, this paper provides a reference for the rational structural medication of Fenazinel to reduce cardiotoxicity and finds compound A10 with better neuroprotective activity. © 2025 The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited.

关键词： Fenazinel ischemic stroke neuroprotection piperidine urea derivatives

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Eliminating Nonideal Transfer Characteristics of Polymer Field-Effect Transistors by Isoindigo-Based Molecular Electron Acceptors

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ACS Applied Polymer Materials 2025年第9期7卷 5448-5455页

作者： Qiu, Xuejun Tang, Yu Shi, Shilong Cai, Yang Zhang, Qiaoming Deng, Ping Lei, Yanlian Guangdong Provincial Engineering and Technology Research Center for Light and Health School of Health Science Guangdong Pharmaceutical University Guangzhou510000 China School of Physical Science and Technology Chongqing Key Lab of Micro&Nano Structure Optoelectronics Southwest University Chongqing400715 China College of Materials Science and Engineering Fuzhou University Fuzhou350108 China

High-mobility organic field-effect transistors (OFETs), particularly those based on donor-acceptor polymers, often exhibit nonideal transfer characteristics, limiting their practical applications. Doping these semiconductors with specifically designed organic molecular electron acceptors can effectively address these deficiencies. By employing isoindigo-based acceptors with appropriate electron-withdrawing groups as dopants in diketopyrrolopyrrole-thienothiophene-based OFETs, we achieve an outstanding transistor performance with ideal transfer characteristics. Comprehensive analyses using ultraviolet-visible absorption, X-ray diffraction, ultraviolet photoelectron spectroscopy, and electrical measurements demonstrate that p-dopants play crucial roles in enhancing electron transfer, reducing charge carrier traps, and lowering contact resistance, thereby eliminating the typical "double slope" and hysteresis in OFET transfer characteristics. © 2025 American Chemical Society.

关键词： Ultraviolet photoelectron spectroscopy

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Oscillatory flow reactor facilitates fast photochemical Wolff rearrangement toward synthesis ofα-substituted amides in flow

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Chinese Chemical Letters 2025年第2期36卷 361-365页

作者： Huashan Huang Jingze Chen Luyun Zhang Hong Yan Siqi Li Fen-Er Chen Institute of Pharmaceutical Science and Technology College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of EducationMolecular Medicine Research CenterCollege of PharmacyYanbian UniversityYanji 133002China Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs Shanghai 200433China

A visible light-promoted fast photochemical Wolff rearrangement was developed toward synthesis ofα-substituted amides in continuous flow with the use of a photochemical oscillatory flow reactor(POFR).The control experiment indicates that a fast process of the Wolff rearrangement(<40 s)is ***,this protocol does not require excess use of any reactants,and the resultingα-substituted amides could be isolated by recrystallization in good to excellent yields.

关键词： Flow photochemistry Oscillatory flow reactor Wolff rearrangement Ketene α-Substituted amides

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Cyclometalated iridium(III) complex based on isoquinoline alkaloid synergistically elicits the ICD response and IDO inhibition via autophagydependent ferroptosis

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Acta Pharmaceutica Sinica B 2025年第1期15卷 424-437页

作者： Yuan Lu Shan-Shan Wang Meng-Ya Li Rong Liu Meng-Fan Zhu Liang-Mei Yang Feng-Yang Wang Ke-Bin Huang Hong Liang State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)Collaborative Innovation Center for Guangxi Ethnic MedicineSchool of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China Department of Pharmacy School of MedicineGuangxi University of Science and TechnologyLiuzhou 545005China

The development of anticancer drugs to treat triple-negative breast cancer(TNBC)is an ongoing *** cell death(ICD)has garnered considerable interest worldwide as a promising synergistic modality for cancer ***,only few drugs or treatment modalities can trigger an ICD response and none of them exert a considerable clinical effect against ***,new agents with potentially effective chemoimmunotherapeutic response are *** this study,five new cyclometalated Ir(III)complexes containing isoquinoline alkaloid C^N ligands were designed and *** them,Ir-1 exhibited the highest in vitro ***,Ir-1 could trigger autophagy-dependent ferroptosis and a subsequent ferroptosis-dependent ICD response as well as indoleamine 2,3-dioxygenase(IDO)inhibition via reactive oxygen species(ROS)-mediated endoplasmic reticulum(ER)stress in MDA-MB-231 *** immunocompetent BALB/c mice were vaccinated with Ir-1-treated dying TNBC cells,antitumor CD8^(+)T-cell response and Foxp3þT-cell depletion were induced,resulting in long-lasting antitumor immunity in TNBC ***,combination therapy with Ir-1 and anti-PD1 could substantially augment in vivo therapeutic *** on these results,Ir-1 is a promising candidate for chemoimmunotherapy against TNBC and its effects are mediated synergistically via ICD induction and IDO blockage.

关键词： Organometallic complex Cyclometalated iridium complex Isoquinoline alkaloid ER stress Autophagy-dependent ferroptosis Immunogenic cell death IDO inhibition Chemoimmunotherapy

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Unassisted photoelectrochemical CO_(2)reduction by employingⅢ-Ⅴphotoelectrode with 15%solar-to-fuel efficiency

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Carbon Energy 2025年第3期7卷 1-10页

作者： Karthik Peramaiah Purushothaman Varadhan Vinoth Ramalingam Bilawal Khan Pradip Kumar Das Hao Huang Hui-Chun Fu Xiulin Yang Vincent Tung Kuo-Wei Huang Jr-Hau He Chemistry Program Center for Renewable Energy and Storage Technologies(CREST)and Division of Physical Science and EngineeringKing Abdullah University of Science and Technology(KAUST)ThuwalSaudi Arabia Institute of Sustainability for Chemicals Energyand Environment(ISCE2)Agency for ScienceTechnologyand Research(A*STAR)Singapore School of Computing Engineering and TechnologyRobert Gordon UniversityAberdeenUK Department of Materials Science and Engineering City University of Hong KongKowloonSARHong KongChina Guangxi Key Laboratory of Low Carbon Energy Materials School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilinChina Department of Chemical System and Engineering University of TokyoTokyoJapan

Solar-driven carbon dioxide reduction reaction(CO_(2)RR)provides an oppor tunity to produce value-added chemical feedstocks and ***,achieving efficient and stable photoelectrochemical(PEC)CO_(2)RR into selec tive products is challenging owing to the difficulties associated with the optical and the electrical configuration of PEC devices and electrocatalyst ***,we construct an efficient,concentrated sunlight-driven CO_(2)RR setup consisting of InGaP/GaAs/Ge triple-junction cell as a photoanode and oxide-derived Au(Ox-Au)as a cathode to perform the unassisted PEC CO_(2)*** one-sun illumination,a maximum operating current density of 11.5 mA cm^(-2) with an impressive Faradaic efficiency(FE)of~98%is achieved for carbon monoxide(CO)production,leading to a solar-to-fuel conversion efficiency of~15%.Under concentrated intensity of 10 sun,the photoanode records a maximum current density of~124 mAcm^(-2) and maintains~60%of FE for CO *** results demonstrate crucial advancements in usingⅢ-Ⅴbased photoanodes for concentrated PEC CO_(2)RR.

关键词： photoelectrochemical oxide derived Au concentrated sunlight selec tive products III V photoelectrode pec devices CO reduction solar fuel efficiency

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